Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease
Abstract
:1. Introduction
2. Results
2.1. Screening of Candidate Compounds and Predicting Putative Target Proteins
2.2. Exploration of A. oxyphylla Molecular Mechanism of Action
2.3. Construction and Analysis of the Integrated Network Model
2.4. Molecular Docking
3. Discussion
4. Materials and Methods
4.1. Compound Database Building
4.2. AD Associated Proteins and Putative Target Protein Screening
4.3. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway Enrichment and Network Constructions
4.4. Molecular Docking
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Xu, J.; Wang, F.; Guo, J.; Xu, C.; Cao, Y.; Fang, Z.; Wang, Q. Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease. Int. J. Mol. Sci. 2020, 21, 2071. https://doi.org/10.3390/ijms21062071
Xu J, Wang F, Guo J, Xu C, Cao Y, Fang Z, Wang Q. Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease. International Journal of Molecular Sciences. 2020; 21(6):2071. https://doi.org/10.3390/ijms21062071
Chicago/Turabian StyleXu, Jia, Fang Wang, Jiejie Guo, Chunshuang Xu, Yanzi Cao, Zhiling Fang, and Qinwen Wang. 2020. "Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease" International Journal of Molecular Sciences 21, no. 6: 2071. https://doi.org/10.3390/ijms21062071