Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function

Guillen-Chable, Francisco; Bayona, Andrea; Rodríguez-Zapata, Luis Carlos; Castano, Enrique

doi:10.3390/ijms222313095

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Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function

by

Francisco Guillen-Chable

¹

,

Andrea Bayona

¹,

Luis Carlos Rodríguez-Zapata

²

and

Enrique Castano

^1,*

¹

Biochemistry and Molecular Plant Biology Department, Centro de Investigación Científica de Yucatán A.C., Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida C.P. 97200, Yucatán, Mexico

²

Biotechnology Department, Centro de Investigación Científica de Yucatán A.C., Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida C.P. 97200, Yucatán, Mexico

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(23), 13095; https://doi.org/10.3390/ijms222313095

Submission received: 14 October 2021 / Revised: 11 November 2021 / Accepted: 28 November 2021 / Published: 3 December 2021

(This article belongs to the Special Issue Intrinsically Disordered Proteins (IDPs): From Physical Chemistry to Pathogenic Mechanisms)

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Abstract

The process of phase separation allows for the establishment and formation of subcompartmentalized structures, thus enabling cells to perform simultaneous processes with precise organization and low energy requirements. Chemical modifications of proteins, RNA, and lipids alter the molecular environment facilitating enzymatic reactions at higher concentrations in particular regions of the cell. In this review, we discuss the nucleolus as an example of the establishment, dynamics, and maintenance of a membraneless organelle with a high level of organization.

Keywords: nucleolus; intrinsically disordered; phase separation; fibrillarin; phosphoinositides

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Guillen-Chable, F.; Bayona, A.; Rodríguez-Zapata, L.C.; Castano, E. Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function. Int. J. Mol. Sci. 2021, 22, 13095. https://doi.org/10.3390/ijms222313095

AMA Style

Guillen-Chable F, Bayona A, Rodríguez-Zapata LC, Castano E. Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function. International Journal of Molecular Sciences. 2021; 22(23):13095. https://doi.org/10.3390/ijms222313095

Chicago/Turabian Style

Guillen-Chable, Francisco, Andrea Bayona, Luis Carlos Rodríguez-Zapata, and Enrique Castano. 2021. "Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function" International Journal of Molecular Sciences 22, no. 23: 13095. https://doi.org/10.3390/ijms222313095

APA Style

Guillen-Chable, F., Bayona, A., Rodríguez-Zapata, L. C., & Castano, E. (2021). Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function. International Journal of Molecular Sciences, 22(23), 13095. https://doi.org/10.3390/ijms222313095

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Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function

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