Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Patients
4.2. Methods
4.3. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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SNP | Genotype/Allele | AIT (%) | Controls (%) | p Value | OR (95% CI) |
---|---|---|---|---|---|
rs2071399 | AA | 51 (21.52) | 37 (28.46) | 0.21 * 0.52 *** | |
AG | 123 (51.90) | 56 (43.08) | |||
GG | 63 (26.58) | 37 (28.46) | |||
GG vs. AA + AG | 63 (26.58) vs. 174 (73.42) | 37 (28.46) vs. 93 (71.54) | 0.70 * | 0.91 (0.56–1.47) | |
AG + GG vs. AA | 186 (78.48) vs. 51 (21.52) | 93 (71.54) vs. 37 (28.460 | 0.14 * | 1.45 (0.89–2.37) | |
A allele | 225 (47.47) | 130 (50.00) | 0.51 * | 1.11 (0.82–1.50) | |
G allele | 249 (52.53) | 130 (50.00) | |||
rs2071400 | CC | 203 (85.65) | 116 (89.23) | 0.62 ** 0.29 *** | |
CT | 33 (13.92) | 14 (10.77) | |||
TT | 1 (0.42) | 0 (0) | |||
TT vs. CC + CT | 1 (0.42) vs. 236 (99.58) | 0 (0) vs. 130 (100) | 1.0 ** | 1.66 (0.07–40.93) | |
CT + TT vs. CC | 34 (14.35) vs. 203 (85.65) | 14 (10.77) vs. 116 (89.23) | 0.33 * | 1.39 (0.72–2.69) | |
C allele | 439 (92.62) | 246 (94.62) | 0.35 ** | 1.40 (0.74–2.65) | |
T allele | 35 (7.38) | 14 (5.38) | |||
rs2071402 | AA | 42 (17.80) | 26 (20.00) | 0.86 * 0.78 *** | |
AG | 118 (50.00) | 62 (47.69) | |||
GG | 76 (32.20) | 42 (32.31) | |||
GG vs. AG + AA | 76 (32.20) vs. 160 (67.80) | 42 (32.31) vs. 88 (67.69) | 0.98 * | 1.00 (0.63–1.57) | |
GG + AG vs. AA | 194 (82.20) vs. 42 (17.80) | 104 (80.00) vs. 26 (20.00) | 0.60 * | 1.15 (0.67–1.99) | |
A allele | 202 (42.80) | 114 (43.85) | 0.78 * | 1.04 (0.77–1.42) | |
G allele | 270 (57.20) | 146 (56.15) | |||
rs2071403 | AA | 56 (23.73) | 35 (27.13) | 0.75 * 0.47 *** | |
AG | 118 (50.00) | 63 (48.84) | |||
GG | 62 (26.27) | 31 (24.03) | |||
GG vs. AA + AG | 62 (26.27) vs. 174 (73.73) | 31 (24.03) vs. 98 (75.97) | 0.64 * | 1.13 (0.69–1.85) | |
AG + GG vs. AA | 180 (76.27) vs. 56 (23.73) | 94 (72.87) vs. 35 (27.13) | 0.47 * | 1.20 (0.73–1.95) | |
A allele | 230 (48.73) | 133 (51.55) | 0.47 * | 1.12 (0.83–1.52) | |
G allele | 242 (51.27) | 125 (48.45) |
Haplotype | AIT (%) | Controls (%) | p Value |
---|---|---|---|
CGA | 48.1 | 51.2 | 0.4269 |
CAG | 42.3 | 43.0 | 0.8586 |
TGG | 7.2 | 5.4 | 0.3472 |
CGG | 1.7 | 0.0 | 0.0356 |
Study | Population | Studied Group | Studied SNP | Results | Method |
---|---|---|---|---|---|
Tomari S. et al. Endocrine J, 2017 [13] | Japanese | AIT 147 Controls 92 | rs2071399 G/A rs2071400 C/T rs2071402 A/G rs2071403 A/G |
| RFLP |
Ahmed H.S. et al. Endocr Metab Immune Disord Drug Targets, 2021 [15] | Egyptian | AIT 200 Controls 100 | rs2071400 C/T |
| RFLP |
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Lacka, K.; Maciejewski, A.; Jarecki, P.; Herman, W.; Lacki, J.K.; Żaba, R.; Kowalczyk, M.J. Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population? Int. J. Mol. Sci. 2024, 25, 3312. https://doi.org/10.3390/ijms25063312
Lacka K, Maciejewski A, Jarecki P, Herman W, Lacki JK, Żaba R, Kowalczyk MJ. Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population? International Journal of Molecular Sciences. 2024; 25(6):3312. https://doi.org/10.3390/ijms25063312
Chicago/Turabian StyleLacka, Katarzyna, Adam Maciejewski, Piotr Jarecki, Waldemar Herman, Jan K. Lacki, Ryszard Żaba, and Michał J. Kowalczyk. 2024. "Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?" International Journal of Molecular Sciences 25, no. 6: 3312. https://doi.org/10.3390/ijms25063312