Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review
Abstract
:1. Introduction
2. Case Presentation
3. Literature Review
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Study | Type of Study | Patients | Age | History | First Treatment | Latency Period Months | Clinical Features | Skin Region | Re-Treatment | Histology | C myc Amplification |
---|---|---|---|---|---|---|---|---|---|---|---|
Cencelj-Arnez 2020 [14] | CR | 1 | 63 | Syncronus bilateral Luminal BC (right breast) | Mastectomy + 6 cycles x 5-fluorouracil, epirubicin, Cyclophosphamide + letrozole + RT 25Gy | 60 | Ulcerated red lesion | Lower-medial quadrant In right breast | Excision + ECT + doxorubicin | High grade RAS | Yes |
Campana 2019 [12] | CS | 20 (10 breast RAS) | / | / | / | / | / | / | / | / | / |
Benevento 2015 [17] | CR | 1 | 76 | Invasive ductal carcinoma Luminal BC (left breast) pT1 pN0 M0 G2 | BCS + 50 Gy in 25 fractions of 200 cGy/daily with boost of 10 Gy in 5 fractions of 200 cGy/daily + Tamoxifene | 48 | painful, violet, multi-nodular mass | Left > right breast | Excision + Mastectomy (after 4 years) + doxorubicin | grade-II RAS | / |
Guida 2016 [19] | RS | 19 (6 breast RAS) | 69 | / | / | 96 | / | Scalp (5) Breast (8) Skin (3) Soft tissue (3) | ECT (19/19)+ Surgery (17/19) + RT (5/19) + CT (3/19) | RAS | / |
Mocerino 2016 [23] | CR | 1 | 77 | invasive ductal carcinoma pT1N0M0 ER + 15%; PgR + 30%; HER2 IHC 1 + (left breast) | BCL + 60 Gy in 30 fractions + tamoxifen | 84 | ecchymotic lesion (1.3 cm) | near the scar | Excision + left mastectomy (after 1 year) + right mastectomy (after 2 years) + ECT + 69 Gy + Doxorubicin | low-grade RAS | / |
Laurino 2022 [24] | CR | 1 | 61 | infiltrating ductal carcinoma, pT1cN0, grade G2, ER 98%, PGR 20%, HER2 +, left breast | BCL + 50 Gy in 25 fractions + 10 Gy in 5 fractions by photons + Adjuvant CT + letrozole | 72 | / | Left breast | Neoadjuvant CT + mastectomy (after 1 year) + ECT + Re-excision | high-grade RAS (G3), positive for Factor VIII and CD31, with extensive areas of necrosis and ulceration. | / |
Laurino 2022 [24] | CR | 1 | 63 | infiltrating ductal breast cancer pT1cN1(1/18), G2, ER: 90%, PGR: 60%, Ki67 index at 15%, and HER2 negative Left breast | BCS+ 5-fluorouracil, epidoxorubicin, and cyclophosphamide+ 50 Gy in 25 fractions + 10 Gy in 5 fractions by photons+ letrozole | 108 | ulcerated and bleeding left breast lump, 7 cm in diameter, adherent to the chest wall | Left breast | Radiofrequency termoablation + gemcitabine and docetaxel + ECT + | RAS | / |
Current case report | CR | 1 | 59 | breast invasive ductal Luminal B carcinoma pT1c N0 M0 (right breast) | BCL + 60 Gy in 30 fractions+ femara | 60 | exophytic lump | near the scar | Excision + right mastectomy + Paclitaxel (doxorubicin contraindicated) + 40.5 Gy in 15 fractions + ECT | Grade II RAS | / |
Study | ECT | ||||||
---|---|---|---|---|---|---|---|
Cycles | Drug | Dose | Adverse Reactions | Overall Survival | Free-Progression Survival (Months) | Results | |
Cencelj-Arnez 2020 [14] | 3 | Bleomicin | 30,000 | edema | 19 | 1 | CR = 100% |
Campana 2019 [12] | 24 (10 Breast RAS; 1 ECT per patient) | Bleomicin | 250–1000 IU/cm3 or 15,000/m2 | Skin ulceration (25%) pain (30%) | 12.5 | 1.8 | CR 40% (8/20) PR, 40% (8/20) |
Benevento 2015 [17] | 8 | Bleomicin | 15,000 IU/m2 | / | 18 | 18 | CR = 100% |
Guida 2016 [19] | / | Bleomicin | 15,000 IU/m2 | Pain | 29.9 | / | CR = 42% PR = 21% |
Mocerino 2016 [23] | 2 | Bleomicin | 15,000 IU/m2 | / | 21 | 21 | CR = 100% |
Laurino 2022 [24] | / | / | / | / | 3 | 3 | Local condition improvement |
Laurino 2022 [24] | 2 | / | / | / | 24 | 24 | Local condition improvement |
Parisi 2023 | 3 | Bleomicin | 15,000 IU/m2 | Pain Edema necrosis | 24 | 17 | Local condition improvement |
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Parisi, S.; Gambardella, C.; Iovino, F.; Ruggiero, R.; Lucido, F.S.; Nesta, G.; Tolone, S.; Brusciano, L.; Fisone, F.; Mongardini, F.M.; et al. Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review. J. Clin. Med. 2024, 13, 567. https://doi.org/10.3390/jcm13020567
Parisi S, Gambardella C, Iovino F, Ruggiero R, Lucido FS, Nesta G, Tolone S, Brusciano L, Fisone F, Mongardini FM, et al. Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review. Journal of Clinical Medicine. 2024; 13(2):567. https://doi.org/10.3390/jcm13020567
Chicago/Turabian StyleParisi, Simona, Claudio Gambardella, Francesco Iovino, Roberto Ruggiero, Francesco Saverio Lucido, Giusiana Nesta, Salvatore Tolone, Luigi Brusciano, Francesca Fisone, Federico Maria Mongardini, and et al. 2024. "Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review" Journal of Clinical Medicine 13, no. 2: 567. https://doi.org/10.3390/jcm13020567