Preserved Capacity for Adaptations in Strength and Muscle Regulatory Factors in Elderly in Response to Resistance Exercise Training and Deconditioning

Fritzen, Andreas Mæchel; Thøgersen, Frank D.; Qadri, Khaled Abdul Nasser; Krag, Thomas; Sveen, Marie-Louise; Vissing, John; Jeppesen, Tina D.

doi:10.3390/jcm9072188

Open AccessArticle

Preserved Capacity for Adaptations in Strength and Muscle Regulatory Factors in Elderly in Response to Resistance Exercise Training and Deconditioning

by

Andreas Mæchel Fritzen

^1,2,*

,

Frank D. Thøgersen

¹,

Khaled Abdul Nasser Qadri

¹,

Thomas Krag

¹

,

Marie-Louise Sveen

^1,3,

John Vissing

¹ and

Tina D. Jeppesen

¹

Department of Neurology, Copenhagen Neuromuscular Center, Rigshospitalet, DK-2100 Copenhagen, Denmark

²

Molecular Physiology Group, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark

³

Novo Nordisk A/S, DK-2860 Søborg, Denmark

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2020, 9(7), 2188; https://doi.org/10.3390/jcm9072188

Submission received: 4 June 2020 / Revised: 7 July 2020 / Accepted: 9 July 2020 / Published: 10 July 2020

(This article belongs to the Special Issue Prevention and Treatment of Sarcopenia)

Download

Browse Figures

Versions Notes

Abstract

Aging is related to an inevitable loss of muscle mass and strength. The mechanisms behind age-related loss of muscle tissue are not fully understood but may, among other things, be induced by age-related differences in myogenic regulatory factors. Resistance exercise training and deconditioning offers a model to investigate differences in myogenic regulatory factors that may be important for age-related loss of muscle mass and strength. Nine elderly (82 ± 7 years old) and nine young, healthy persons (22 ± 2 years old) participated in the study. Exercise consisted of six weeks of resistance training of the quadriceps muscle followed by eight weeks of deconditioning. Muscle biopsy samples before and after training and during the deconditioning period were analyzed for MyoD, myogenin, insulin-like growth-factor I receptor, activin receptor IIB, smad2, porin, and citrate synthase. Muscle strength improved with resistance training by 78% (95.0 ± 22.0 kg) in the elderly to a similar extent as in the young participants (83.5%; 178.2 ± 44.2 kg) and returned to baseline in both groups after eight weeks of deconditioning. No difference was seen in expression of muscle regulatory factors between elderly and young in response to exercise training and deconditioning. In conclusion, the capacity to gain muscle strength with resistance exercise training in elderly was not impaired, highlighting this as a potent tool to combat age-related loss of muscle function, possibly due to preserved regulation of myogenic factors in elderly compared with young muscle.

Keywords: resistance exercise training; muscle regulatory factors; sarcopenia; muscle strength; deconditioning; skeletal muscle; elderly; hypertrophy

Share and Cite

MDPI and ACS Style

Fritzen, A.M.; Thøgersen, F.D.; Qadri, K.A.N.; Krag, T.; Sveen, M.-L.; Vissing, J.; Jeppesen, T.D. Preserved Capacity for Adaptations in Strength and Muscle Regulatory Factors in Elderly in Response to Resistance Exercise Training and Deconditioning. J. Clin. Med. 2020, 9, 2188. https://doi.org/10.3390/jcm9072188

AMA Style

Fritzen AM, Thøgersen FD, Qadri KAN, Krag T, Sveen M-L, Vissing J, Jeppesen TD. Preserved Capacity for Adaptations in Strength and Muscle Regulatory Factors in Elderly in Response to Resistance Exercise Training and Deconditioning. Journal of Clinical Medicine. 2020; 9(7):2188. https://doi.org/10.3390/jcm9072188

Chicago/Turabian Style

Fritzen, Andreas Mæchel, Frank D. Thøgersen, Khaled Abdul Nasser Qadri, Thomas Krag, Marie-Louise Sveen, John Vissing, and Tina D. Jeppesen. 2020. "Preserved Capacity for Adaptations in Strength and Muscle Regulatory Factors in Elderly in Response to Resistance Exercise Training and Deconditioning" Journal of Clinical Medicine 9, no. 7: 2188. https://doi.org/10.3390/jcm9072188

APA Style

Fritzen, A. M., Thøgersen, F. D., Qadri, K. A. N., Krag, T., Sveen, M.-L., Vissing, J., & Jeppesen, T. D. (2020). Preserved Capacity for Adaptations in Strength and Muscle Regulatory Factors in Elderly in Response to Resistance Exercise Training and Deconditioning. Journal of Clinical Medicine, 9(7), 2188. https://doi.org/10.3390/jcm9072188

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Preserved Capacity for Adaptations in Strength and Muscle Regulatory Factors in Elderly in Response to Resistance Exercise Training and Deconditioning

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI