Zingiber officinale Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice
Abstract
:1. Introduction
2. Results
2.1. Oxaliplatin Administration Induces Cold and Mechanical Allodynia in Mice
2.2. Anti-Allodynic Effect of Z. officinale on Oxaliplatin-Induced Neuropathic Pain in Mice
2.3. Spinal 5-HT Receptors Are Involved in the Neuropathic Pain-Alleviating Effect of Z. officinale
2.4. Spinal 5-HT1A but Not 5-HT2A is Involved in the Anti-Allodynic Effect of Z. officinale
2.5. Identification of Active Components in Z. officinale by Using HPLC
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Oxaliplatin Administration
4.3. Preparation of and Treatment with Z. Officinale
4.4. Treatment with Serotonergic Antagonists
4.5. Behavioral Assessments
4.6. Behavioral Tests Schedules
4.7. High-Performance Liquid Chromatography (HPLC) Analysis of the Z. officinale Extract
4.8. RNA Extraction and Real-Time PCR
4.9. Statistical Analysis
5. Conclusions
6. Patent
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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Type | Sequence |
---|---|
GAPDH (Forward) | 5′-GGAGGTAGCTCCTGATTCGC-3′ |
GAPDH (Reverse) | 5′-CACATTGGGGGTAGGAACAC-3′ |
HTR1A (Forward) | 5′-TACTCCACTTTCGGCGCTTT-3′ |
HTR1A (Reverse) | 5′-GGAGGTAGCTCCTGATTCGC-3′ |
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Lee, J.H.; Min, D.; Lee, D.; Kim, W. Zingiber officinale Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice. Molecules 2021, 26, 548. https://doi.org/10.3390/molecules26030548
Lee JH, Min D, Lee D, Kim W. Zingiber officinale Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice. Molecules. 2021; 26(3):548. https://doi.org/10.3390/molecules26030548
Chicago/Turabian StyleLee, Ji Hwan, Daeun Min, Donghun Lee, and Woojin Kim. 2021. "Zingiber officinale Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice" Molecules 26, no. 3: 548. https://doi.org/10.3390/molecules26030548