Fish Oil Supplementation Reduces Inflammation but Does Not Restore Renal Function and Klotho Expression in an Adenine-Induced CKD Model
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Model
2.2. Real-Time PCR
2.3. Histological Evaluation
2.4. Western Blotting
2.5. Statistical Analyses
3. Results
3.1. Adenine Supplementation Induces Inflammation, Loss of Renal Function, and Klotho Reduction
3.2. Fish Oil Supplementation Reduces Pro-Inflammatory Markers but Does Not Improve Renal Function
3.3. Fish Oil Supplementation Does Not Revert Progressive Renal Fibrosis
3.4. Fish Oil Does Not Restore Renal Klotho
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Henao Agudelo, J.S.; Baia, L.C.; Ormanji, M.S.; Santos, A.R.P.; Machado, J.R.; Saraiva Câmara, N.O.; Navis, G.J.; De Borst, M.H.; Heilberg, I.P. Fish Oil Supplementation Reduces Inflammation but Does Not Restore Renal Function and Klotho Expression in an Adenine-Induced CKD Model. Nutrients 2018, 10, 1283. https://doi.org/10.3390/nu10091283
Henao Agudelo JS, Baia LC, Ormanji MS, Santos ARP, Machado JR, Saraiva Câmara NO, Navis GJ, De Borst MH, Heilberg IP. Fish Oil Supplementation Reduces Inflammation but Does Not Restore Renal Function and Klotho Expression in an Adenine-Induced CKD Model. Nutrients. 2018; 10(9):1283. https://doi.org/10.3390/nu10091283
Chicago/Turabian StyleHenao Agudelo, Juan S., Leandro C. Baia, Milene S. Ormanji, Amandda R. P. Santos, Juliana R. Machado, Niels O. Saraiva Câmara, Gerjan J. Navis, Martin H. De Borst, and Ita P. Heilberg. 2018. "Fish Oil Supplementation Reduces Inflammation but Does Not Restore Renal Function and Klotho Expression in an Adenine-Induced CKD Model" Nutrients 10, no. 9: 1283. https://doi.org/10.3390/nu10091283