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Search Results (14,861)

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Keywords = 4D-technology

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28 pages, 3575 KB  
Article
Toward Automatic 3D Model Reconstruction of Building Curtain Walls from UAV Images Based on NeRF and Deep Learning
by Zeyu Li, Qian Wang, Hongzhe Yue and Xiang Nie
Remote Sens. 2025, 17(19), 3368; https://doi.org/10.3390/rs17193368 (registering DOI) - 5 Oct 2025
Abstract
The Automated Building Information Modeling (BIM) reconstruction of existing building curtain walls is crucial for promoting digital Operation and Maintenance (O&M). However, existing 3D reconstruction technologies are mainly designed for general architectural scenes, and there is currently a lack of research specifically focused [...] Read more.
The Automated Building Information Modeling (BIM) reconstruction of existing building curtain walls is crucial for promoting digital Operation and Maintenance (O&M). However, existing 3D reconstruction technologies are mainly designed for general architectural scenes, and there is currently a lack of research specifically focused on the BIM reconstruction of curtain walls. This study proposes a BIM reconstruction method from unmanned aerial vehicle (UAV) images based on neural radiance field (NeRF) and deep learning-based semantic segmentation. The proposed method compensates for the lack of semantic information in traditional NeRF methods and could fill the gap in the automatic reconstruction of semantic models for curtain walls. A comprehensive high-rise building is selected as a case study to validate the proposed method. The results show that the overall accuracy (OA) for semantic segmentation of curtain wall point clouds is 71.8%, and the overall dimensional error of the reconstructed BIM model is less than 0.1m, indicating high modeling accuracy. Additionally, this study compares the proposed method with photogrammetry-based reconstruction and traditional semantic segmentation methods to further validate its effectiveness. Full article
(This article belongs to the Section AI Remote Sensing)
41 pages, 1929 KB  
Review
The Evolution and Taxonomy of Deep Learning Models for Aircraft Trajectory Prediction: A Review of Performance and Future Directions
by NaeJoung Kwak and ByoungYup Lee
Appl. Sci. 2025, 15(19), 10739; https://doi.org/10.3390/app151910739 (registering DOI) - 5 Oct 2025
Abstract
Accurate aircraft trajectory prediction is fundamental to air traffic management, operational safety, and intelligent aerospace systems. With the growing availability of flight data, deep learning has emerged as a powerful tool for modeling the spatiotemporal complexity of 4D trajectories. This paper presents a [...] Read more.
Accurate aircraft trajectory prediction is fundamental to air traffic management, operational safety, and intelligent aerospace systems. With the growing availability of flight data, deep learning has emerged as a powerful tool for modeling the spatiotemporal complexity of 4D trajectories. This paper presents a comprehensive review of deep learning-based approaches for aircraft trajectory prediction, focusing on their evolution, taxonomy, performance, and future directions. We classify existing models into five groups—RNN-based, attention-based, generative, graph-based, and hybrid and integrated models—and evaluate them using standardized metrics such as the RMSE, MAE, ADE, and FDE. Common datasets, including ADS-B and OpenSky, are summarized, along with the prevailing evaluation metrics. Beyond model comparison, we discuss real-world applications in anomaly detection, decision support, and real-time air traffic management, and highlight ongoing challenges such as data standardization, multimodal integration, uncertainty quantification, and self-supervised learning. This review provides a structured taxonomy and forward-looking perspectives, offering valuable insights for researchers and practitioners working to advance next-generation trajectory prediction technologies. Full article
(This article belongs to the Section Aerospace Science and Engineering)
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19 pages, 4017 KB  
Article
Tunable Ultra-Wideband VO2–Graphene Hybrid Metasurface Terahertz Absorption Devices Based on Dual Regulation
by Kele Chen, Zhengning Wang, Meizhang Guan, Shubo Cheng, Hongyu Ma, Zao Yi and Boxun Li
Photonics 2025, 12(10), 987; https://doi.org/10.3390/photonics12100987 (registering DOI) - 5 Oct 2025
Abstract
In this study, a dynamically tunable terahertz device based on a VO2–graphene hybrid metasurface is proposed, which realizes the dual functions of ultra-wideband absorption and efficient transmission through VO2 phase transformation. At 345 K (metallic state), the device attains an [...] Read more.
In this study, a dynamically tunable terahertz device based on a VO2–graphene hybrid metasurface is proposed, which realizes the dual functions of ultra-wideband absorption and efficient transmission through VO2 phase transformation. At 345 K (metallic state), the device attains an absorption efficiency exceeding 90% (average 97.06%) in the range of 2.25–6.07 THz (bandwidth 3.82 THz), showing excellent absorption performance. At 318 K (insulated state), the device achieves 67.66–69.51% transmittance in the 0.1–2.14 THz and 7.51–10 THz bands while maintaining a broadband absorption of 3.6–5.08 THz (an average of 81.99%). Compared with traditional devices, the design breaks through the performance limitations by integrating phase change material control with 2D materials. The patterned graphene design simplifies the fabrication process. System analysis reveals that the device is polarization-insensitive and tunable via graphene Fermi energy and relaxation time. The device’s excellent temperature response and wide angular stability provide a novel solution for terahertz switching, stealth technology, and sensing applications. Full article
(This article belongs to the Special Issue Photonics Metamaterials: Processing and Applications)
24 pages, 1782 KB  
Article
Point Cloud Completion Network Based on Multi-Dimensional Adaptive Feature Fusion and Informative Channel Attention Mechanism
by Di Tian, Jiahang Shi, Jiabo Li and Mingming Gong
Sensors 2025, 25(19), 6173; https://doi.org/10.3390/s25196173 (registering DOI) - 5 Oct 2025
Abstract
With the continuous advancement of 3D perception technology, point cloud data has found increasingly widespread application. However, the presence of holes in point cloud data caused by device limitations and environmental interference severely restricts algorithmic performance, making point cloud completion a research topic [...] Read more.
With the continuous advancement of 3D perception technology, point cloud data has found increasingly widespread application. However, the presence of holes in point cloud data caused by device limitations and environmental interference severely restricts algorithmic performance, making point cloud completion a research topic of high interest. This study observes that most existing mainstream point cloud completion methods primarily focus on capturing global features, while often underrepresenting local structural details. Moreover, the generation process of complete point clouds lacks effective control over fine-grained features, leading to insufficient detail in the completed outputs and reduced data integrity. To address these issues, we propose a Set Combination Multi-Layer Perceptron (SCMP) module that enables the simultaneous extraction of both local and global features, thereby reducing the loss of local detail information. In addition, we introduce the Squeeze Excitation Pooling Network (SEP-Net) module, an informative channel attention mechanism capable of adaptively identifying and enhancing critical channel features, thus improving the overall feature representation capability. Based on these modules, we further design a novel Feature Fusion Point Fractal Network (FFPF-Net), which fuses multi-dimensional point cloud features to enhance representation capacity and progressively refines the missing regions to generate a more complete point cloud. Extensive experiments conducted on the ShapeNet-Part and MVP datasets compared to L-GAN and PCN showed average prediction error improvements of 1.3 and 1.4, respectively. The average completion errors on the ShapeNet-Part and MVP datasets are 0.783 and 0.824, highlighting the improved fine-detail reconstruction capability of our network. These results indicate that the proposed method effectively enhances point cloud completion performance and can further promote the practical application of point cloud data in various real-world scenarios. Full article
(This article belongs to the Section Intelligent Sensors)
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18 pages, 6931 KB  
Article
Research on Multi-Sensor Data Fusion Based Real-Scene 3D Reconstruction and Digital Twin Visualization Methodology for Coal Mine Tunnels
by Hongda Zhu, Jingjing Jin and Sihai Zhao
Sensors 2025, 25(19), 6153; https://doi.org/10.3390/s25196153 (registering DOI) - 4 Oct 2025
Abstract
This paper proposes a multi-sensor data-fusion-based method for real-scene 3D reconstruction and digital twin visualization of coal mine tunnels, aiming to address issues such as low accuracy in non-photorealistic modeling and difficulties in feature object recognition during traditional coal mine digitization processes. The [...] Read more.
This paper proposes a multi-sensor data-fusion-based method for real-scene 3D reconstruction and digital twin visualization of coal mine tunnels, aiming to address issues such as low accuracy in non-photorealistic modeling and difficulties in feature object recognition during traditional coal mine digitization processes. The research employs cubemap-based mapping technology to project acquired real-time tunnel images onto six faces of a cube, combined with navigation information, pose data, and synchronously acquired point cloud data to achieve spatial alignment and data fusion. On this basis, inner/outer corner detection algorithms are utilized for precise image segmentation, and a point cloud region growing algorithm integrated with information entropy optimization is proposed to realize complete recognition and segmentation of tunnel planes (e.g., roof, floor, left/right sidewalls) and high-curvature feature objects (e.g., ventilation ducts). Furthermore, geometric dimensions extracted from segmentation results are used to construct 3D models, and real-scene images are mapped onto model surfaces via UV (U and V axes of texture coordinate) texture mapping technology, generating digital twin models with authentic texture details. Experimental validation demonstrates that the method performs excellently in both simulated and real coal mine environments, with models capable of faithfully reproducing tunnel spatial layouts and detailed features while supporting multi-view visualization (e.g., bottom view, left/right rotated views, front view). This approach provides efficient and precise technical support for digital twin construction, fine-grained structural modeling, and safety monitoring of coal mine tunnels, significantly enhancing the accuracy and practicality of photorealistic 3D modeling in intelligent mining applications. Full article
(This article belongs to the Section Sensing and Imaging)
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21 pages, 4282 KB  
Article
PoseNeRF: In Situ 3D Reconstruction Method Based on Joint Optimization of Pose and Neural Radiation Field for Smooth and Weakly Textured Aeroengine Blade
by Yao Xiao, Xin Wu, Yizhen Yin, Yu Cai and Yuanhan Hou
Sensors 2025, 25(19), 6145; https://doi.org/10.3390/s25196145 (registering DOI) - 4 Oct 2025
Abstract
Digital twins are essential for the real-time health management and monitoring of aeroengines, and the in situ three-dimensional (3D) reconstruction technology of key components of aeroengines is an important support for the construction of a digital twin model. In this paper, an in [...] Read more.
Digital twins are essential for the real-time health management and monitoring of aeroengines, and the in situ three-dimensional (3D) reconstruction technology of key components of aeroengines is an important support for the construction of a digital twin model. In this paper, an in situ high-fidelity 3D reconstruction method, named PoseNeRF, for aeroengine blades based on the joint optimization of pose and neural radiance field (NeRF), is proposed. An aeroengine blades background filtering network based on complex network theory (ComBFNet) is designed to filter out the useless background information contained in the two-dimensional (2D) images and improve the fidelity of the 3D reconstruction of blades, and the mean intersection over union (mIoU) of the network reaches 95.5%. The joint optimization loss function, including photometric loss, depth loss, and point cloud loss is proposed. The method solves the problems of excessive blurring and aliasing artifacts, caused by factors such as smooth blade surface and weak texture information in 3D reconstruction, as well as the cumulative error problem caused by camera pose pre-estimation. The PSNR, SSIM, and LPIPS of the 3D reconstruction model proposed in this paper reach 25.59, 0.719, and 0.239, respectively, which are superior to other general models. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
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20 pages, 1980 KB  
Review
Augmented Reality in Engineering Education: A Bibliometric Review
by Georgios Lampropoulos, Antonio del Bosque, Pablo Fernández-Arias and Diego Vergara
Information 2025, 16(10), 859; https://doi.org/10.3390/info16100859 (registering DOI) - 4 Oct 2025
Abstract
The aim of this study is to examine the role and use of augmented reality in engineering education by examining the existing literature. A total of 235 studies from Scopus and Web of Science published during 2011–2025 were examined. The study focused on [...] Read more.
The aim of this study is to examine the role and use of augmented reality in engineering education by examining the existing literature. A total of 235 studies from Scopus and Web of Science published during 2011–2025 were examined. The study focused on analyzing the main characteristics of the studies, identifying the main topics, and exploring the use of augmented reality in engineering education. The study also highlighted current challenges and limitations and suggested future research directions. Based on the results, 7 main topics arose which were related to (i) Immersive technologies in engineering education, (ii) Gamified learning experiences, (iii) Remote and virtual laboratories, (iv) Visualization and 3D modeling, (v) Student motivation, (vi) Collaborative and interactive learning environments, and (vii) User-centered design and user experience. Augmented reality emerged as an effective educational tool that can positively impact engineering education and support both students and teachers. Specifically, physical, remote, and virtual laboratories that can improve students’ learning performance, motivation, creativity, engagement, and satisfaction can be created through augmented reality. Using augmented reality, students can develop their practical skills and knowledge within low-risk and secure learning environments. Additionally, via the realistic and interactive visualization, students’ knowledge acquisition and understanding can be enhanced. Finally, its ability to effectively support collaborative learning and experiential learning arose. Full article
(This article belongs to the Collection Augmented Reality Technologies, Systems and Applications)
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21 pages, 25531 KB  
Article
Effect of Processing Parameters on the Mechanical Behavior of 3D-Printed Basalt Moon Dust Reinforced Polylactic Acid Composites
by Lucian Alexander-Roy, Meelad Ranaiefar, Mrityunjay Singh and Michael Halbig
Polymers 2025, 17(19), 2685; https://doi.org/10.3390/polym17192685 (registering DOI) - 4 Oct 2025
Abstract
Advanced composite materials and manufacturing technologies are critical to sustain human presence in space. Mechanical testing and analysis are needed to elucidate the effect of processing parameters on composites’ material properties. In this study, test specimens are 3D printed via a fused-filament fabrication [...] Read more.
Advanced composite materials and manufacturing technologies are critical to sustain human presence in space. Mechanical testing and analysis are needed to elucidate the effect of processing parameters on composites’ material properties. In this study, test specimens are 3D printed via a fused-filament fabrication (FFF) approach from a basalt moon dust-polylactic acid (BMD-PLA) composite filament and from pure PLA filament. Compression and tensile testing were conducted to determine the yield strength, ultimate strength, and Young’s modulus of specimens fabricated under several processing conditions. The maximum compressive yield strength for the BMD-reinforced samples is 27.68 MPa with print parameters of 100% infill, one shell, and 90° print orientation. The maximum compressive yield strength for the PLA samples is 63.05 MPa with print parameters of 100% infill, three shells, and 0° print orientation. The composite samples exhibit an increase in strength when layer lines are aligned with loading axis, whereas the PLA samples decreased in strength. This indicates a fundamental difference in how the composite behaves in comparison to the pure matrix material. In tension, test specimens have unpredictable failure modes and often broke outside the gauge length. A portion of the tension test data is included to help guide future work. Full article
(This article belongs to the Section Polymer Processing and Engineering)
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19 pages, 6432 KB  
Article
Storage and Production Aspects of Reservoir Fluids in Sedimentary Core Rocks
by Jumana Sharanik, Ernestos Sarris and Constantinos Hadjistassou
Geosciences 2025, 15(10), 386; https://doi.org/10.3390/geosciences15100386 - 3 Oct 2025
Abstract
Understanding the fluid storage and production mechanisms in sedimentary rocks is vital for optimising natural gas extraction and subsurface resource management. This study applies high-resolution X-ray computed tomography (≈15 μm) to digitise rock samples from onshore Cyprus, producing digital rock models from DICOM [...] Read more.
Understanding the fluid storage and production mechanisms in sedimentary rocks is vital for optimising natural gas extraction and subsurface resource management. This study applies high-resolution X-ray computed tomography (≈15 μm) to digitise rock samples from onshore Cyprus, producing digital rock models from DICOM images. The workflow, including digitisation, numerical simulation of natural gas flow, and experimental validation, demonstrates strong agreement between digital and laboratory-measured porosity, confirming the methods’ reliability. Synthetic sand packs generated via particle-based modelling provide further insight into the gas storage mechanisms. A linear porosity–permeability relationship was observed, with porosity increasing from 0 to 35% and permeability from 0 to 3.34 mD. Permeability proved critical for production, as a rise from 1.5 to 3 mD nearly doubled the gas flow rate (14 to 30 fm3/s). Grain morphology also influenced gas storage. Increasing roundness enhanced porosity from 0.30 to 0.41, boosting stored gas volume by 47.6% to 42 fm3. Although based on Cyprus retrieved samples, the methodology is applicable to sedimentary formations elsewhere. The findings have implications for enhanced oil recovery, CO2 sequestration, hydrogen storage, and groundwater extraction. This work highlights digital rock physics as a scalable technology for investigating transport behaviour in porous media and improving characterisation of complex sedimentary reservoirs. Full article
(This article belongs to the Special Issue Advancements in Geological Fluid Flow and Mechanical Properties)
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48 pages, 3488 KB  
Systematic Review
From Static to Adaptive: A Systematic Review of Smart Materials and 3D/4D Printing in the Evolution of Assistive Devices
by Muhammad Aziz Sarwar, Nicola Stampone and Muhammad Usman
Actuators 2025, 14(10), 483; https://doi.org/10.3390/act14100483 - 3 Oct 2025
Abstract
People with disabilities often face challenges like moving around independently and depending on personal caregivers for daily life activities. Traditional assistive devices are universally accepted by these communities, but they are designed with one-size-fits-all approaches that cannot adjust to individual human sizes, are [...] Read more.
People with disabilities often face challenges like moving around independently and depending on personal caregivers for daily life activities. Traditional assistive devices are universally accepted by these communities, but they are designed with one-size-fits-all approaches that cannot adjust to individual human sizes, are not easily customized, and are made from rigid materials that do not adapt as a person’s condition changes over time. This systematic review examines the integration of smart materials, sensors, actuators, and 3D/4D printing technologies in advancing assistive devices, with a particular emphasis on mobility aids. In this work, the authors conducted a comparative analysis of traditional devices with commercially available innovative prototypes and research stage assistive devices by focusing on smart adaptable materials and sustainable additive manufacturing techniques. The results demonstrate how artificial intelligence drives smart assistive devices in hospital decentralized additive manufacturing, and policy frameworks agree with the Sustainable Development Goals, representing the future direction for adaptive assistive technology. Also, by combining 3D/4D printing and AI, it is possible to produce adaptive, affordable, and patient centered rehabilitation with feedback and can also provide predictive and preventive healthcare strategies. The successful commercialization of adaptive assistive devices relies on cost effective manufacturing techniques clinically aligned development supported by cross disciplinary collaboration to ensure scalable, sustainable, and universally accessible smart solutions. Ultimately, it paves the way for smart, sustainable, and clinically viable assistive devices that outperform conventional solutions and promote equitable access for all users. Full article
(This article belongs to the Section Actuators for Robotics)
19 pages, 4587 KB  
Article
Wet Media Milling Preparation and Process Simulation of Nano-Ursolic Acid
by Guang Li, Wenyu Yuan, Yu Ying and Yang Zhang
Pharmaceutics 2025, 17(10), 1297; https://doi.org/10.3390/pharmaceutics17101297 - 3 Oct 2025
Abstract
Background/Objectives: Pharmaceutical preparation technologies can enhance the bioavailability of poorly water-soluble drugs. Ursolic acid (UA) has been found to possess anti-cancer and hepatoprotective properties, demonstrating its potential as a therapeutic agent; however, its hydrophobicity and low solubility present challenges in the development [...] Read more.
Background/Objectives: Pharmaceutical preparation technologies can enhance the bioavailability of poorly water-soluble drugs. Ursolic acid (UA) has been found to possess anti-cancer and hepatoprotective properties, demonstrating its potential as a therapeutic agent; however, its hydrophobicity and low solubility present challenges in the development of drug formulations. This study investigates the preparation of a nano-UA suspension by wet grinding, researches the influence of process parameters on particle size, and explores the rules of particle breakage and agglomeration by combining model fitting. Methods: Wet grinding experiments were conducted using a laboratory-scale grinding machine. The particle size distributions (PSDs) of UA suspensions under different grinding conditions were measured using a laser particle size analyzer. A single-factor experimental design was employed to optimize operational conditions. Model parameters for a population balance model considering both breakage and agglomeration were determined by an evolutionary algorithm optimization method. By measuring the degree to which UA inhibits the colorimetric reaction between salicylic acid and hydroxyl radicals, its antioxidant capacity in scavenging hydroxyl radicals was indirectly evaluated. Results: Wet grinding process conditions for nano-UA particles were established, yielding a UA suspension with a D50 particle size of 122 nm. The scavenging rate of the final grinding product was improved to three times higher than that of the UA raw material (D50 = 14.2 μm). Conclusions: Preparing nano-UA suspensions via wet grinding technology can significantly enhance their antioxidant properties. Model regression analysis of PSD data reveals that increasing the grinding mill’s stirring speed leads to more uniform particle size distribution, indicating that grinding speed (power) is a critical factor in producing nanosuspensions. Full article
(This article belongs to the Special Issue Advanced Research on Amorphous Drugs)
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20 pages, 5116 KB  
Article
Design of Portable Water Quality Spectral Detector and Study on Nitrogen Estimation Model in Water
by Hongfei Lu, Hao Zhou, Renyong Cao, Delin Shi, Chao Xu, Fangfang Bai, Yang Han, Song Liu, Minye Wang and Bo Zhen
Processes 2025, 13(10), 3161; https://doi.org/10.3390/pr13103161 - 3 Oct 2025
Abstract
A portable spectral detector for water quality assessment was developed, utilizing potassium nitrate and ammonium chloride standard solutions as the subjects of investigation. By preparing solutions with differing concentrations, spectral data ranging from 254 to 1275 nm was collected and subsequently preprocessed using [...] Read more.
A portable spectral detector for water quality assessment was developed, utilizing potassium nitrate and ammonium chloride standard solutions as the subjects of investigation. By preparing solutions with differing concentrations, spectral data ranging from 254 to 1275 nm was collected and subsequently preprocessed using methods such as multiple scattering correction (MSC), Savitzky–Golay filtering (SG), and standardization (SS). Estimation models were constructed employing modeling algorithms including Support Vector Machine-Multilayer Perceptron (SVM-MLP), Support Vector Regression (SVR), random forest (RF), RF-Lasso, and partial least squares regression (PLSR). The research revealed that the primary variation bands for NH4+ and NO3 are concentrated within the 254–550 nm and 950–1275 nm ranges, respectively. For predicting ammonium chloride, the optimal model was found to be the SVM-MLP model, which utilized spectral data reduced to 400 feature bands after SS processing, achieving R2 and RMSE of 0.8876 and 0.0883, respectively. For predicting potassium nitrate, the optimal model was the 1D Convolutional Neural Network (1DCNN) model applied to the full band of spectral data after SS processing, with R2 and RMSE of 0.7758 and 0.1469, respectively. This study offers both theoretical and technical support for the practical implementation of spectral technology in rapid water quality monitoring. Full article
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32 pages, 14159 KB  
Article
Microwave Breast Imaging System Modules, Enhancing Scan Quality and Reliability of Diagnostic Outputs During Clinical Testing
by Giannis Papatrechas, Angie Fasoula, Petros Arvanitis, Luc Duchesne, Alexis Raveneau, Julio Daniel Gil Cano, John O’ Donnell, Sami Abd Elwahab and Michael Kerin
Bioengineering 2025, 12(10), 1079; https://doi.org/10.3390/bioengineering12101079 - 3 Oct 2025
Abstract
Microwave Breast Imaging (MWBI) is an emerging imaging modality aiming to detect breast lesions, which are dielectrically contrasted against the background healthy tissue, in the microwave frequency spectrum. MWBI holds potential to outperform X-ray mammography’s low sensitivity in young and dense breasts, thus [...] Read more.
Microwave Breast Imaging (MWBI) is an emerging imaging modality aiming to detect breast lesions, which are dielectrically contrasted against the background healthy tissue, in the microwave frequency spectrum. MWBI holds potential to outperform X-ray mammography’s low sensitivity in young and dense breasts, thus supporting timelier detection of interval cancers, as a supplemental screening or diagnostic imaging method. The specificity of MWBI remains unknown, however, as management of false positives has not been systematically addressed yet. An earlier First-In-Human clinical investigation on 24 symptomatic patients provided proof-of-concept for the Wavelia MWBI sectorized multi-static radar imaging technology, which generates clinically meaningful 3D images of the breast, performs semi-automated detection of breast lesions and extracts diagnostic features to distinguish malignant from benign lesions. This paper focuses on a set of technological upgrades, accessories and data processing modules, designed and implemented in the 2nd generation prototype of Wavelia, to handle the diversity in breast geometry, tissue consistency and deformability, in a larger clinical investigation reporting on the bilateral MWBI scan of 62 patients. The presented add-on modules contribute to enhanced quality of scan and a more valid reference reporting space for the MWBI imaging outputs, with a direct positive impact on overall specificity. Full article
(This article belongs to the Special Issue Breast Cancer: From Precision Medicine to Diagnostics)
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15 pages, 993 KB  
Review
Antioxidants in Cardiovascular Health: Implications for Disease Modeling Using Cardiac Organoids
by Gracious R. Ross and Ivor J. Benjamin
Antioxidants 2025, 14(10), 1202; https://doi.org/10.3390/antiox14101202 - 3 Oct 2025
Abstract
Cardiovascular disease remains the leading cause of mortality worldwide, and at its molecular core lies a silent disruptor: oxidative stress. This imbalance between reactive oxygen species (ROS) and antioxidant defenses not only damages cellular components but also orchestrates a cascade of pathological events [...] Read more.
Cardiovascular disease remains the leading cause of mortality worldwide, and at its molecular core lies a silent disruptor: oxidative stress. This imbalance between reactive oxygen species (ROS) and antioxidant defenses not only damages cellular components but also orchestrates a cascade of pathological events across diverse cardiac cell types. In cardiomyocytes, ROS overload impairs contractility and survival, contributing to heart failure and infarction. Cardiac fibroblasts respond by promoting fibrosis through excessive collagen deposition. Macrophages intensify inflammatory responses, such as atherosclerosis, via ROS-mediated lipid oxidation—acting both as mediators of damage and targets for antioxidant intervention. This review examines how oxidative stress affects cardiac cell types and evaluates antioxidant-based therapeutic strategies. Therapeutic approaches include natural antioxidants (e.g., polyphenols and vitamins) and synthetic agents (e.g., enzyme modulators), which show promise in experimental models by improving myocardial remodeling. However, clinical trials reveal inconsistent outcomes, underscoring translational challenges (e.g., clinical biomarkers). Emerging strategies—such as targeted antioxidant delivery, activation of endogenous pathways, and disease modeling using 3D organoids—aim to enhance efficacy. In conclusion, we spotlight innovative technologies—like lab-grown heart tissue models—that help scientists better understand how oxidative stress affects heart health. These tools are bridging the gap between early-stage research and personalized medicine, opening new possibilities for diagnosing and treating heart disease more effectively. Full article
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17 pages, 312 KB  
Review
Current Applications and Future Directions of Technologies Used in Adult Deformity Surgery for Personalized Alignment: A Narrative Review
by Janet Hsu, Taikhoom M. Dahodwala, Noel O. Akioyamen, Evan Mostafa, Rami Z. AbuQubo, Xiuyi Alexander Yang, Priya K. Singh, Daniel C. Berman, Rafael De la Garza Ramos, Yaroslav Gelfand, Saikiran G. Murthy, Jonathan D. Krystal, Ananth S. Eleswarapu and Mitchell S. Fourman
J. Pers. Med. 2025, 15(10), 480; https://doi.org/10.3390/jpm15100480 - 3 Oct 2025
Abstract
Patient-specific technologies within the field of adult spinal deformity (ASD) aid surgeons in pre-surgical planning, accurately help identify anatomical landmarks, and can project optimal post-surgical sagittal alignment. This narrative review aims to discuss the current uses of patient-specific technologies in ASD and identify [...] Read more.
Patient-specific technologies within the field of adult spinal deformity (ASD) aid surgeons in pre-surgical planning, accurately help identify anatomical landmarks, and can project optimal post-surgical sagittal alignment. This narrative review aims to discuss the current uses of patient-specific technologies in ASD and identify new innovations that may very soon be integrated into patient care. Pre-operatively, machine learning or artificial intelligence helps surgeons to simulate post-operative alignment and provide information for the 3D-printing of pre-contoured rods and patient-specific cages. Intraoperatively, robotic surgery and intraoperative guides allow for more accurate positioning of implants. Implant materials are being developed to allow for better osseointegration and patient outcome monitoring. Despite the significant promise of these technologies, work still needs to be performed to ensure their accuracy, safety, and cost efficacy. Full article
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