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Keywords = AEC-FM

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19 pages, 2221 KB  
Article
Challenges in Asset Management and Digital Twins: Industry Insights
by Abdelmoneim Mohamed Abdelmoti, Muhammad Tariq Shafiq, Abdul Rauf and Malik Mansoor Ali Khalfan
Buildings 2025, 15(11), 1809; https://doi.org/10.3390/buildings15111809 - 25 May 2025
Cited by 2 | Viewed by 879
Abstract
Effective asset management in the architecture, engineering, and construction/facilities management (AEC/FM) industry is crucial for improving asset performance and lifespan, as well as reducing downtimes and maintenance costs. Current asset management practices mostly rely on outdated paper-based approaches that are prone to data [...] Read more.
Effective asset management in the architecture, engineering, and construction/facilities management (AEC/FM) industry is crucial for improving asset performance and lifespan, as well as reducing downtimes and maintenance costs. Current asset management practices mostly rely on outdated paper-based approaches that are prone to data loss, security attacks, and missing information. Emerging technologies, such as digital twins, are being proposed to solve existing asset management problems in the AEC industry. However, the industry perspective is often missing in the evaluation of such technology-led approaches regarding actual applications and implementation challenges. This study seeks to understand the potential of digital twins in solving current asset management issues and challenges within the United Arab Emirates (UAE) context. To achieve this aim, structured interviews were conducted with 14 industry experts to capture their understanding of current digital technologies and existing issues in asset management. The findings of this study underscore the transformative potential of digital twins as a tool for optimizing asset performance and decision-making throughout the asset lifecycle. Full article
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26 pages, 17330 KB  
Article
Research on Automated On-Site Construction of Timber Structures: Mobile Construction Platform Guided by Real-Time Visual Positioning System
by Kang Bi, Xinyu Shi, Da Wan, Haining Zhou, Wenxuan Zhao, Chengpeng Sun, Peng Du and Hiroatsu Fukuda
Buildings 2025, 15(10), 1594; https://doi.org/10.3390/buildings15101594 - 8 May 2025
Viewed by 1465
Abstract
In recent years, the AEC industry has increasingly sought sustainable solutions to enhance productivity and reduce environmental pollution, with wood emerging as a key renewable material due to its excellent carbon sequestration capability and low ecological footprint. Despite significant advances in digital fabrication [...] Read more.
In recent years, the AEC industry has increasingly sought sustainable solutions to enhance productivity and reduce environmental pollution, with wood emerging as a key renewable material due to its excellent carbon sequestration capability and low ecological footprint. Despite significant advances in digital fabrication technologies for timber construction, on-site assembly still predominantly relies on manual operations, thereby limiting efficiency and precision. To address this challenge, this study proposes an automated on-site timber construction process that integrates a mobile construction platform (MCP), a fiducial marker system (FMS) and a UWB/IMU integrated navigation system. By deconstructing traditional modular stacking methods and iteratively developing the process in a controlled laboratory environment, the authors formalize raw construction experience into an effective workflow, supplemented by a self-feedback error correction system to achieve precise, real-time end-effector positioning. Extensive experimental results demonstrate that the system consistently achieves millimeter-level positioning accuracy across all test scenarios, with translational errors of approximately 1 mm and an average repeat positioning precision of up to 0.08 mm, thereby aligning with on-site timber construction requirements. These findings validate the method’s technical reliability, robustness and practical applicability, laying a solid foundation for a smooth transition from laboratory trials to large-scale on-site timber construction. Full article
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17 pages, 3794 KB  
Article
Stretch Causes cffDNA and HMGB1-Mediated Inflammation and Cellular Stress in Human Fetal Membranes
by Justin Gary Padron, Chelsea A. Saito Reis, Po’okela K. Ng, Nainoa D. Norman Ing, Hannah Baker, Kamalei Davis, Courtney Kurashima and Claire E. Kendal-Wright
Int. J. Mol. Sci. 2024, 25(10), 5161; https://doi.org/10.3390/ijms25105161 - 9 May 2024
Viewed by 1433
Abstract
Danger-associated molecular patterns (DAMPs) are elevated within the amniotic cavity, and their increases correlate with advancing gestational age, chorioamnionitis, and labor. Although the specific triggers for their release in utero remain unclear, it is thought that they may contribute to the initiation of [...] Read more.
Danger-associated molecular patterns (DAMPs) are elevated within the amniotic cavity, and their increases correlate with advancing gestational age, chorioamnionitis, and labor. Although the specific triggers for their release in utero remain unclear, it is thought that they may contribute to the initiation of parturition by influencing cellular stress mechanisms that make the fetal membranes (FMs) more susceptible to rupture. DAMPs induce inflammation in many different tissue types. Indeed, they precipitate the subsequent release of several proinflammatory cytokines that are known to be key for the weakening of FMs. Previously, we have shown that in vitro stretch of human amnion epithelial cells (hAECs) induces a cellular stress response that increases high-mobility group box-1 (HMGB1) secretion. We have also shown that cell-free fetal DNA (cffDNA) induces a cytokine response in FM explants that is fetal sex-specific. Therefore, the aim of this work was to further investigate the link between stretch and the DAMPs HMGB1 and cffDNA in the FM. These data show that stretch increases the level of cffDNA released from hAECs. It also confirms the importance of the sex of the fetus by demonstrating that female cffDNA induced more cellular stress than male fetuses. Our data treating hAECs and human amnion mesenchymal cells with HMGB1 show that it has a differential effect on the ability of the cells of the amnion to upregulate the proinflammatory cytokines and propagate a proinflammatory signal through the FM that may weaken it. Finally, our data show that sulforaphane (SFN), a potent activator of Nrf2, is able to mitigate the proinflammatory effects of stretch by decreasing the levels of HMGB1 release and ROS generation after stretch and modulating the increase of key cytokines after cell stress. HMGB1 and cffDNA are two of the few DAMPs that are known to induce cytokine release and matrix metalloproteinase (MMP) activation in the FMs; thus, these data support the general thesis that they can function as potential central players in the normal mechanisms of FM weakening during the normal distension of this tissue at the end of a normal pregnancy. Full article
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32 pages, 5001 KB  
Review
Integration of Industry Foundation Classes and Ontology: Data, Applications, Modes, Challenges, and Opportunities
by Jing Jia, Hongxin Ma and Zijing Zhang
Buildings 2024, 14(4), 911; https://doi.org/10.3390/buildings14040911 - 27 Mar 2024
Cited by 16 | Viewed by 4409
Abstract
Industry Foundation Classes (IFCs), as the most recognized data schema for Building Information Modeling (BIM), are increasingly combined with ontology to facilitate data interoperability across the whole lifecycle in the Architecture, Engineering, Construction, and Facility Management (AEC/FM). This paper conducts a bibliometric analysis [...] Read more.
Industry Foundation Classes (IFCs), as the most recognized data schema for Building Information Modeling (BIM), are increasingly combined with ontology to facilitate data interoperability across the whole lifecycle in the Architecture, Engineering, Construction, and Facility Management (AEC/FM). This paper conducts a bibliometric analysis of 122 papers from the perspective of data, model, and application to summarize the modes of IFC and ontology integration (IFCOI). This paper first analyzes the data and models of the integration from IFC data formats and ontology development models to the IfcOWL data model. Next, the application status is summed up from objective and phase dimensions, and four frequent applications with maturity are identified. Based on the aforementioned multi-dimensional analysis, three integration modes are summarized, taking into account various data interoperability requirements. Accordingly, ontology behaves as the representation of domain knowledge, an enrichment tool for IFC model semantics, and a linkage between IFC data and other heterogeneous data. Finally, this paper points out the challenges and opportunities for IFCOI in the data, domain ontology, and integration process and proposes a building lifecycle management model based on IFCOI. Full article
(This article belongs to the Section Construction Management, and Computers & Digitization)
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18 pages, 1971 KB  
Article
Critical Factors for Effective BIM-Enabled Education: An Adaptive Structuration Theory Perspective
by Theophilus Olowa, Emlyn Witt, Irene Lill, Abdulkadir Rasheed, Abdulazeez Abdulmumin and Ranti Adebiyi
Buildings 2023, 13(12), 3044; https://doi.org/10.3390/buildings13123044 - 7 Dec 2023
Cited by 2 | Viewed by 3523
Abstract
Educational systems of the 21st century require agility and flexibility for construction graduates to have the skills, knowledge, and abilities required for effective performance in the construction industry, especially with the global digitalization of the industry. With reference to adaptive structuration theory (AST) [...] Read more.
Educational systems of the 21st century require agility and flexibility for construction graduates to have the skills, knowledge, and abilities required for effective performance in the construction industry, especially with the global digitalization of the industry. With reference to adaptive structuration theory (AST) as a theoretical lens and a survey research design, this research examined the relationship between building information modeling (BIM) as an advanced information technology and educators’ attitudes toward implementing BIM for construction education to prepare local graduates for global relevance and employment. Data collected were analyzed using Statistical Package for the Social Sciences (SPSS Ver 25). The findings of the study showed that group internal system, structure of BIM, and task and organizational environment play important roles in implementing BIM for construction education in the architecture, engineering, construction, and facilities management (AEC/FM) disciplines. It was recommended that policymakers, academics, and curriculum developers pay attention to these factors for rapid development in the realm of BIM education. The development of a robust BIM education framework that considers these factors should also be studied. Full article
(This article belongs to the Special Issue BIM Application in Construction Management)
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21 pages, 8064 KB  
Article
Geometry and Topology Reconstruction of BIM Wall Objects from Photogrammetric Meshes and Laser Point Clouds
by Fan Yang, Yiting Pan, Fangshuo Zhang, Fangyuan Feng, Zhenjia Liu, Jiyi Zhang, Yu Liu and Lin Li
Remote Sens. 2023, 15(11), 2856; https://doi.org/10.3390/rs15112856 - 31 May 2023
Cited by 14 | Viewed by 3829
Abstract
As the foundation for digitalization, building information modeling (BIM) technology has been widely used in the field of architecture, engineering, construction, and facility management (AEC/FM). Unmanned aerial vehicle (UAV) oblique photogrammetry and laser scanning have become increasingly popular data acquisition techniques for surveying [...] Read more.
As the foundation for digitalization, building information modeling (BIM) technology has been widely used in the field of architecture, engineering, construction, and facility management (AEC/FM). Unmanned aerial vehicle (UAV) oblique photogrammetry and laser scanning have become increasingly popular data acquisition techniques for surveying buildings and providing original data for BIM modeling. However, the geometric and topological reconstruction of solid walls, which are among the most important architectural structures in BIM, is still a challenging undertaking. Due to noise and missing data in 3D point clouds, current research mostly focuses on segmenting wall planar surfaces from unstructured 3D point clouds and fitting the plane parameters without considering the thickness or 3D shape of the wall. Point clouds acquired only from the indoor space are insufficient for modeling exterior walls. It is also important to maintain the topological relationships between wall objects to meet the needs of complex BIM modeling. Therefore, in this study, a geometry and topology modeling method is proposed for solid walls in BIM based on photogrammetric meshes and laser point clouds. The method uses a kinetic space-partitioning algorithm to generate the building footprint and indoor floor plan. It classifies interior and exterior wall segments and infers parallel line segments to extract wall centerlines. The topological relationships are reconstructed and maintained to build wall objects with consistency. Experimental results on two datasets, including both photogrammetric meshes and indoor laser point clouds, exhibit more than 90% completeness and correctness, as well as centimeter-level accuracy of the wall surfaces. Full article
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19 pages, 697 KB  
Review
Digital Tools for Revealing and Reducing Carbon Footprint in Infrastructure, Building, and City Scopes
by Jiayi Yan, Qiuchen Lu, Junqing Tang, Long Chen, Jingke Hong and Tim Broyd
Buildings 2022, 12(8), 1097; https://doi.org/10.3390/buildings12081097 - 26 Jul 2022
Cited by 26 | Viewed by 7055
Abstract
The climate change issue has been striking and bringing pressure on all countries and industries. The responsibility of the Architecture, Engineering, Construction and Facility Management (AEC/FM) industry is heavy because it accounts for over one-third of global energy use and greenhouse gas emissions. [...] Read more.
The climate change issue has been striking and bringing pressure on all countries and industries. The responsibility of the Architecture, Engineering, Construction and Facility Management (AEC/FM) industry is heavy because it accounts for over one-third of global energy use and greenhouse gas emissions. At the same time, the development of digital technology brings the opportunity to mitigate environmental issues. Therefore, this study intended to examine the state-of-the-art of digital development and transformation in the AEC/FM industry by collecting and reviewing the developed digital carbon footprint analysis tools in infrastructure, building, and city scopes. Specifically, this study (1) generated a review methodology for carbon footprint analysis results; (2) demonstrated the review results from the infrastructure, building, and city scopes, analysed and compared the results crossing the scopes from four aspects: carbon footprint analysis strategy, standards and protocols, rating systems, and general development level of digital tools; and (3) discussed the potential directions in the industry to address the environmental issues. This study indicated that the digitalisation level regarding carbon-related areas is still at an early stage, and efforts should be taken both academically and practically to drive the digital development confronting the harsh climate change issue. Full article
(This article belongs to the Special Issue AI-Aided Carbon Engineering in the AEC Industry)
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20 pages, 2334 KB  
Article
Process View to Innovate the Management of the Social Housing System: A Multiple Case Study
by Giovanna Mangialardi, Angelo Corallo, Mariangela Lazoi and Barbara Scozzi
Sustainability 2022, 14(14), 8294; https://doi.org/10.3390/su14148294 - 6 Jul 2022
Cited by 7 | Viewed by 3347
Abstract
All countries recognize the right to adequate housing for all human beings. Yet, in many countries, social housing is in a critical state: most buildings need to be restored and better services should be guaranteed. Such actions should be part of a larger [...] Read more.
All countries recognize the right to adequate housing for all human beings. Yet, in many countries, social housing is in a critical state: most buildings need to be restored and better services should be guaranteed. Such actions should be part of a larger plan aimed to overcome the organizational and technological backwardness of the agencies that manage the social housing system. With a not large, but old public asset, the Italian context may represent an interesting case to start investigating difficulties and problems in the management of the social housing system that, as it occurs in most Mediterranean countries, arise when the public housing rental model is adopted. In the paper, a multiple case study on five Italian regional public Agencies responsible for the social housing system is discussed. In particular, the theoretical lens of process theory and ambidextrous business process management are adopted to study the Agencies’ “problematic situation” and identify innovative solutions to address it. The paper contributes to research and practice on process innovation and digital transformation of public administrations: three important lessons are derived and discussed also taking into consideration Industry 5.0, the vision on the future of industry recently proposed by the European Commission. Finally, the adoption of process theory combined with ambidextrous Business Process Management is an underexplored research method in the field of Architecture, Engineering, Construction, and Facility Management (AEC/FM) research. The results reported in the study reaffirm the potential deriving from its adoption also in such a field. Full article
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14 pages, 417 KB  
Article
Comparisons between Bioelectrical Impedance Variables, Functional Tests and Blood Markers Based on BMI in Older Women and Their Association with Phase Angle
by Rafael Oliveira, César Leão, Ana Filipa Silva, Filipe Manuel Clemente, Carlos Tadeu Santamarinha, Hadi Nobari and João Paulo Brito
Int. J. Environ. Res. Public Health 2022, 19(11), 6851; https://doi.org/10.3390/ijerph19116851 - 3 Jun 2022
Cited by 10 | Viewed by 2895
Abstract
The aim of the present study was to compare electrical bioimpedance variables, blood markers and functional tests based on Body Mass Index (BMI) in older women. Associations between Phase Angle (PhA) with functional tests and blood markers were also analyzed. A total of [...] Read more.
The aim of the present study was to compare electrical bioimpedance variables, blood markers and functional tests based on Body Mass Index (BMI) in older women. Associations between Phase Angle (PhA) with functional tests and blood markers were also analyzed. A total of 46 independent elderly people participated in the study, and they were divided into four groups according to BMI values: Group 1 (G1, BMI < 25 kg/m2); Group 2 (G2, BMI > 25–30 kg/m2); Group 3 (G3, BMI > 30–35 kg/m2); Group 4 (G4, BMI > 35 kg/m2). In addition to the weight and height used to calculate the BMI, the following body composition variables were collected: fat mass (FM), fat-free mass, intracellular water (ICW), extracellular water (ECW), total body water (TBW) and PhA (50 kHz) through InBody S10 equipment. Functional capacity was assessed using the Fullerton battery of tests: arm-curl; chair-stand; 6 min walking test (6MWT); time up-and-go test (TUG); standing on one leg (SOOL) and take 10 foot-lines (10FL). The main results showed differences between groups in the tests: 6MWT, SOOL and 10FL between G1 vs. G3 and G2 vs. G3 (p < 0.05); ACT, AIC and AEC between G1 vs. G4 (p < 0.05); FM among all groups (p < 0.05). Negative correlations were found between PhA and the agility test in G1 (r = −0.848; p = 0.008) and G4 (r = −0.909; p = 0.005); PhA and chair-stand in G3 (r = 0.527; p = 0.044); PhA and forearm flexion in G3 (r = 0.641; p = 0.010) and G4 (r = 0.943; p = 0.001); PhA and 6MWT in G4 (r = 0.771; p = 0.042). This study found that there is a clear trend towards better functional capacities with better parameters of body composition. Although there were no differences between groups in PhA, associations were found between different functional tests with PhA, which reveals the importance of this variable as a marker of health status. Full article
(This article belongs to the Section Exercise and Health)
19 pages, 1427 KB  
Article
Defining a BIM-Enabled Learning Environment—An Adaptive Structuration Theory Perspective
by Theophilus Olowa, Emlyn Witt, Caterina Morganti, Toni Teittinen and Irene Lill
Buildings 2022, 12(3), 292; https://doi.org/10.3390/buildings12030292 - 2 Mar 2022
Cited by 18 | Viewed by 4919
Abstract
Digitalization of the AEC-FM industry has resulted in the reassessment of knowledge, knowledge management, teaching and learning, workflows and networks, roles, and relevance. Consequently, new approaches to teaching and learning to meet the demands of new jobs and abilities, new channels of communication, [...] Read more.
Digitalization of the AEC-FM industry has resulted in the reassessment of knowledge, knowledge management, teaching and learning, workflows and networks, roles, and relevance. Consequently, new approaches to teaching and learning to meet the demands of new jobs and abilities, new channels of communication, and a new awareness are required. Building Information Modelling (BIM) offers opportunities to address some of the current challenges through BIM-enabled education and training. This research defines the requisite characteristics of a BIM-enabled Learning Environment (BLE)—a web-based platform that facilitates BIM-enabled education and training—in order to develop a prototype version of the BLE. Using a mixed-methods research design and an Adaptive Structuration Theory (AST) perspective for interpreting the findings, 33 features and 5 distinct intentions behind those features were identified. These findings are valuable in taking forward the development of the BLE as they suggest a BLE requires the integration of functions from three existing types of information technology application (virtual learning environments, virtual collaboration platforms, and BIM applications). This study will inform the design of a web-based BLE for enhanced AEC-FM education and training, and it also provides a starting point for researchers to apply AST to evaluate the use of a BLE in different educational and training contexts. Full article
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19 pages, 2524 KB  
Systematic Review
A Review of Building Information Modelling (BIM) for Facility Management (FM): Implementation in Public Organisations
by Lidia Pinti, Ricardo Codinhoto and Serena Bonelli
Appl. Sci. 2022, 12(3), 1540; https://doi.org/10.3390/app12031540 - 31 Jan 2022
Cited by 38 | Viewed by 12531
Abstract
Building Information Modelling (BIM) has been extensively studied and applied within the AEC sector, particularly in design and construction. In recent years, Facility Management (FM) processes are becoming more digitalised, thus requiring effective BIM-FM integration. BIM adoption in many countries, such as the [...] Read more.
Building Information Modelling (BIM) has been extensively studied and applied within the AEC sector, particularly in design and construction. In recent years, Facility Management (FM) processes are becoming more digitalised, thus requiring effective BIM-FM integration. BIM adoption in many countries, such as the UK, Italy and Brazil, has been publicly driven. Generally, adoption was targeted at design and construction implementation, with little effort in framing public action for FM implementation. The lack of an integrated approach for BIM-FM implementation resulted in numerous bespoken implementation approaches that mimic the private sector and hinder knowledge exchange. Therefore, there is a need for assessing and amalgamating knowledge about BIM-FM for public organisations. This research aims to leverage knowledge about BIM-FM in the public domain by analysing and classifying articles published between 2010–2021. The research was carried out through a systematic review and comparative thematic analysis investigating the use of BIM for different public buildings (e.g., schools and hospitals) and the implementation for FM purposes. Research results outline prevalent trends and areas of research from three perspectives: people, process and technology. Results show an increasing number of publications about BIM-FM. However, the divide between BIM-FM for public and private organisations is unequal. BIM-FM research for public organisations is still limited and lacks standardisation. This state-of-the-art review makes an incremental contribution to knowledge by identifying progress, gaps and new industry directions on the subject matter. Full article
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14 pages, 2052 KB  
Article
Fetal Membranes Contribute to Drug Transport across the Feto-Maternal Interface Utilizing the Breast Cancer Resistance Protein (BCRP)
by Ananthkumar Kammala, Meagan Benson, Esha Ganguly, Enkhtuya Radnaa, Talar Kechichian, Lauren Richardson and Ramkumar Menon
Life 2022, 12(2), 166; https://doi.org/10.3390/life12020166 - 23 Jan 2022
Cited by 21 | Viewed by 4200
Abstract
During pregnancy, the placenta is established as a primary organ for drug transport at the maternal-fetal interface. The fetal membranes (FM) also form an interface with maternal tissues; however, their role in drug transport has not been previously investigated. Knowledge of drug transport [...] Read more.
During pregnancy, the placenta is established as a primary organ for drug transport at the maternal-fetal interface. The fetal membranes (FM) also form an interface with maternal tissues; however, their role in drug transport has not been previously investigated. Knowledge of drug transport across this feto-maternal interface along with the placenta can improve new drug development and testing for use during pregnancy. We also hypothesize that extracellular vesicles (exosomes 30–160 nm) released from the FM and placental cells may also contain drug transport proteins and might impact drug trafficking across the feto-maternal interfaces. The objectives were to (1) localize the breast cancer resistance protein (BCRP) in human FM; (2) determine the drug transport function of BCRP in chorion trophoblast cells (CTCs) of the FM; and (3) investigate the presence of BCRP in FM cell-derived exosomes, as a paracrine modifier of the tissue environment for transport functions. The gene and protein expressions of ABCG2/BCRP in FMs were determined by quantitative real-time PCR (qRT-PCR) and western blotting (WB) and were localized by immunohistochemistry (IHC). The surface expression of BCRP in FM cells was determined by flow cytometry. The functional role of BCRP was assessed by an EFFLUX dye multidrug resistance assay. The presence of BCRP in exosomes derived from CTCs and BeWo cells was examined using ExoView®. Data derived from CTCs are compared with placental trophoblast cells (BeWo). BCRP is expressed and localized in the fetal membrane, primarily in the chorion trophoblast cell layer and scarcely in the amnion epithelial layer (AEC), and primarily localized on both AEC and CTC cell surfaces. Efflux assay data showed that FM cells have similar drug resistance activity as BeWo cells, suggesting that FM also have drug transportation capabilities. BeWo- and CTC-derived exosomes expressed limited BCRP protein on the surface, so it was predominantly contained in the exosomal lumen. As far as we are aware, this is the first study to report BCRP expression in fetal membrane cells and as cargo in fetal membrane-derived exosomes. We report that fetal membrane cells are capable of drug transportation. Based on these results, investigational drug trials should include the FM and its exosomes as possible drug transportation routes in pregnancy. Full article
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19 pages, 1719 KB  
Article
The BIM-Based Building Permit Process: Factors Affecting Adoption
by Kaleem Ullah, Emlyn Witt and Irene Lill
Buildings 2022, 12(1), 45; https://doi.org/10.3390/buildings12010045 - 4 Jan 2022
Cited by 42 | Viewed by 10147
Abstract
Public organizations responsible for building permits are increasingly considering the potential applications of Building Information Modelling (BIM) in their workflows, but BIM adoption still remains a complex challenge. This research aims to investigate the factors affecting BIM adoption for building permits through a [...] Read more.
Public organizations responsible for building permits are increasingly considering the potential applications of Building Information Modelling (BIM) in their workflows, but BIM adoption still remains a complex challenge. This research aims to investigate the factors affecting BIM adoption for building permits through a case study of a public organization currently developing and piloting a BIM-based building permit process. A thematic analysis of semi-structured interview data revealed ten factors that influence BIM adoption for building permits: complexity (in both development and use) of a BIM-based building permit system; relative advantages/disadvantages of BIM for building permits; the existing building permit system; management support for a BIM-based building permit process; organizational culture; BIM awareness; training and learning; available expertise for a BIM-based building permit process; external pressure; and legal context. The findings are important for public authorities’ understanding of both the enablers and challenges of the BIM-based building permit process, and have practical implications for professionals in public authorities in particular, and also the Architecture Engineering Construction/Facilities Management (AEC/FM) industry in general, to guide their steps towards adopting BIM. This research also highlights the potential benefits of BIM adoption for the building permit process. Full article
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15 pages, 2608 KB  
Article
Cigarette Smoke Condensate Exposure Induces Receptor for Advanced Glycation End-Products (RAGE)-Dependent Sterile Inflammation in Amniotic Epithelial Cells
by Helena Choltus, Régine Minet-Quinard, Corinne Belville, Julie Durif, Denis Gallot, Loic Blanchon and Vincent Sapin
Int. J. Mol. Sci. 2021, 22(15), 8345; https://doi.org/10.3390/ijms22158345 - 3 Aug 2021
Cited by 8 | Viewed by 5048
Abstract
Maternal smoking is a risk factor of preterm prelabor rupture of the fetal membranes (pPROM), which is responsible for 30% of preterm births worldwide. Cigarettes induce oxidative stress and inflammation, mechanisms both implicated in fetal membranes (FM) weakening. We hypothesized that the receptor [...] Read more.
Maternal smoking is a risk factor of preterm prelabor rupture of the fetal membranes (pPROM), which is responsible for 30% of preterm births worldwide. Cigarettes induce oxidative stress and inflammation, mechanisms both implicated in fetal membranes (FM) weakening. We hypothesized that the receptor for advanced glycation end-products (RAGE) and its ligands can result in cigarette-dependent inflammation. FM explants and amniotic epithelial cells (AECs) were treated with cigarette smoke condensate (CSC), combined or not with RAGE antagonist peptide (RAP), an inhibitor of RAGE. Cell suffering was evaluated by measuring lactate dehydrogenase (LDH) medium-release. Extracellular HMGB1 (a RAGE ligand) release by amnion and choriodecidua explants were checked by western blot. NF-κB pathway induction was determined by a luciferase gene reporter assay, and inflammation was evaluated by cytokine RT-qPCR and protein quantification. Gelatinase activity was assessed using a specific assay. CSC induced cell suffering and HMGB1 secretion only in the amnion, which is directly associated with a RAGE-dependent response. CSC also affected AECs by inducing inflammation (cytokine release and NFκB activation) and gelatinase activity through RAGE engagement, which was linked to an increase in extracellular matrix degradation. This RAGE dependent CSC-induced inflammation associated with an increase of gelatinase activity could explain a pathological FM weakening directly linked to pPROM. Full article
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34 pages, 32269 KB  
Review
Integration of BIM and Immersive Technologies for AEC: A Scientometric-SWOT Analysis and Critical Content Review
by Ayaz Khan, Samad Sepasgozar, Tingting Liu and Rongrong Yu
Buildings 2021, 11(3), 126; https://doi.org/10.3390/buildings11030126 - 19 Mar 2021
Cited by 107 | Viewed by 17019
Abstract
With the outset of Industrial Revolution 4.0 (IR 4.0), every sector is escalating to get enrichment out of it, whether they are research- or industry-oriented. The Architecture Engineering and Construction (AEC) industry lags a bit in adopting it because of its multi-faceted dependencies [...] Read more.
With the outset of Industrial Revolution 4.0 (IR 4.0), every sector is escalating to get enrichment out of it, whether they are research- or industry-oriented. The Architecture Engineering and Construction (AEC) industry lags a bit in adopting it because of its multi-faceted dependencies and unique nature of work. Despite this, a trend has been seen recently to hone the IR 4.0 multitudes in the AEC industry. The upsurge has been seen in the usage of Immersive Technologies (ImTs) as one of the disruptive techniques. This paper studies the literature based on ImTs, which are Virtual Reality (VR), Augmented Reality (AR), and Mixed Reality (MR) integrating with Building Information Modelling (BIM) in the AEC sector. A total number of 444 articles were selected from Scopus following the preferred reporting items for systematic reviews and meta-analysis (PRISMA) protocol of reviewing the literature. Among the selected database, 64 papers are identified as the result of following the protocol, and the articles are divided into eight domains relevant to the AEC industry, namely client/stakeholder, design exploration, design analysis, construction planning, construction monitoring, construction health/safety, facility/management, and education/training. This study adopts both a scientometric analysis for bibliometrics visualization and a critical review using Strength Weakness Opportunity Threat (SWOT) analysis for finding gaps and state of play. The novelty of this paper lies in the analysis techniques used in the literature to provide an insight into the literature, and it provides directions for the future with an emphasis on developing sustainable development goals (SDGs). In addition, research directions for the future growth on the adoption of ImTs are identified and presented based on categorization in immersive devices, graphical/non-graphical data and, responsive/integrative processes. In addition, five subcategories for each direction are listed, citing the limitations and future/needs. This study presents the roadmap for the successful adoption of ImTs for industry practitioners and stakeholders in the AEC industry for various domains. The paper shows that there are studies on ImTs with or without BIM; however, future studies should focus on the usage of ImTs in various sectors such as modular integrated construction (MiC) or emerging needs such as SDGs. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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