Search Results (267)

Rapid urbanization and industrialization have intensified the contradiction between water scarcity and economic growth. Achieving synergy between economic development and water conservation through taxation and subsidy policies has emerged as a critical research focus. This study develops an extended Computable General Equilibrium (CGE) model incorporating a water resource module to evaluate the impacts of production tax and subsidy policies in Wenling City, Zhejiang Province, China, a typical water-scarce city. By integrating a nested Constant Elasticity of Substitution (CES) production function for various water sources, the model captures the interactions between water supply and industrial output. Six policy scenarios of taxations and subsidies are designed. The impacts on macroeconomic aggregates, industrial output, and water usage are simulated. Results indicate that standalone taxation policies (Water Conservation Taxation Policy A1/Industrial Transformation Taxation Policy B1) reduce water usage by 3.35–3.80% but suppress Gross Domestic Product (GDP) growth by 0.37–0.76%. Among combined policies, the Water Conservation Combined Policy A3 achieves the optimal synergy between water conservation and economic growth, increasing real GDP by 1.00% while reducing water usage by 4.97%. This study reveals that taxation curbs the expansion of water-intensive industries, whereas subsidies redirect production factors toward water-efficient industries. Combining these policies effectively balances water conservation and economic development objectives. This study demonstrates how differentiated tax instruments drive water conservation through industrial transformation, providing a quantitative framework for production tax policy formulation in water-scarce regions. Full article

This study evaluates growth and income distribution targets needed to alleviate poverty and eradicate hunger, and assesses strategies to achieve these goals in rural areas in South Africa. Most development policy studies concentrate on growth, inequality, and poverty reduction, while explicit SDG-related applications receive less attention, especially in Africa. To fill this gap, we apply a framework that combines a recursive dynamic CGE model with a microeconomic simulation model in a top-down and bottom-up fashion. We explore two scenarios: a business-as-usual simulation and an agricultural growth simulation that tests investment, export enhancement, productivity improvements, and social assistance extension. The agriculture policy includes targeted social assistance. Halving poverty and eradicating extreme hunger requires 2.7% annual economic growth and 3.6% agricultural growth from 2018 to 2030. In the business-as-usual scenario, poverty is expected to rise from 55.2% in 2015 to 56.1% by 2030, with 24% still below the food poverty line. The agricultural growth scenario can advance hunger and poverty goals if individual consumption increases by 2.6% annually. Achieving SDG targets for hunger and poverty demands interventions beyond agricultural policy. South Africa can achieve its hunger and poverty SDG goals through a combination of agricultural investments, social assistance, and labour policies. Full article

China’s healthcare expenditure tripled during 2010–2019, prompting the nationwide implementation of centralized volume-based procurement (CVBP). While effective in reducing drug prices, CVBP introduces sustainability challenges including supply chain vulnerabilities and welfare trade-offs. This study develops a pharmaceutical sector-embedded computable general equilibrium (CGE) model to quantify CVBP’s multidimensional sustainability impacts. Using China’s 2020 Social Accounting Matrix (SAM) with simulated 10–50% price reductions, key findings reveal that (1) >40% price reductions trigger sectoral output reversal; (2) GDP exhibits an inverted U-shape; (3) household income declines despite corporate/government gains; and (4) industrial contraction impairs innovation capacity and employment stability. Our analysis identifies potential sustainability risks, emphasizing the need for rigorous empirical validation prior to implementing aggressive price reduction policies, and underscores the importance of integrating supply chain considerations into procurement policy design. This approach maximizes resource allocation efficiency while advancing socioeconomic resilience in healthcare systems. Full article

Agriculture is the primary sector sustaining the Indonesian economy. However, appropriate policies are also required to support the service sector. Therefore, this study aims to analyze two central policies: the impact of trade openness and the role of the service sector on agriculture and agro-industry in Indonesia. A Computable General Equilibrium (CGE) model with 2016 input–output tables cover 141 regions and 65 sectors based on the Global Trade Analysis Project (GTAP) Version 10 database. The results show that trade openness in the services sector significantly improves the performance and quality of service provision. The improved performance of the services sector will, in turn, encourage increased production in the agricultural and agro-industrial sectors, which rely heavily on service inputs in the production process. This suggests that trade openness in the services sector is important to sustain the performance of the agricultural sector. Full article

This study explores how carbon pricing and electricity market liberalization jointly contribute to China’s sustainable energy transition. Using a dynamic computable general equilibrium (CGE) model (CEEEA2.0), we simulate three policy scenarios—business as usual, emissions trading scheme (ETS) with regulated electricity prices, and ETS with market-based pricing—under a unified emissions cap. The results demonstrate that electricity market liberalization enhances carbon pricing efficiency by eliminating price distortions, leading to a 0.06% increase in GDP and a 12% reduction in emission abatement costs. However, liberalization also raises electricity and consumer prices, disproportionately affecting rural and low-income households. These findings underscore the need to balance economic efficiency and social equity in sustainability-oriented energy reforms. Our analysis emphasizes the importance of designing inclusive and just transition policies to ensure that carbon mitigation efforts support long-term environmental, economic, and social sustainability goals. Full article

In this study, red mud oxygen carriers were obtained by varying the preparation temperature and characterized using XRD, SEM, BET, and H₂-TPR. The results showed that the oxygen carrier prepared at 1000 °C exhibited high reactivity due to clear grain boundaries, uniform size, high porosity, and smooth grain morphology. Additionally, the release of oxygen was accelerated, as indicated by the H₂-TPR results. The water hyacinth, an aquatic plant of agroforestry waste, was selected as the research object, and the chemical looping gasification (CLG) reaction performance with prepared red mud carriers was investigated. The experiment results showed that the total gas yield (Y_g) of the carriers prepared at 1000 °C reached a maximum of 1.02 Nm^3/kg, had a high low-level heating value (LHV) of 12.06 MJ/Nm³, cold gas efficiency (CGE) of 91.49%, and carbon conversion rate (η_c) of 82.65%. This indicated that the red mud carriers synthesized at 1000 °C have a faster oxygen release rate, more concentrated oxygen release, and stronger reaction activity. Full article

Proton beam therapy for head and neck cancers traditionally employs a fixed relative biological effectiveness (RBE) of 1.1, which may underestimate actual biological effects in critical structures. This study evaluates how Linear Energy Transfer (LET) optimization could potentially prevent radiation-induced brachial plexopathy (RIBP). (1) Case presentation: A 65-year-old male with stage IVA p16-positive oropharyngeal squamous cell carcinoma received pencil-beam-scanning intensity-modulated proton therapy with concurrent cisplatin. Due to a right level 4 neck node, the high-risk target volume overlapped with the brachial plexus, resulting in a D0.1cc of 70.3 Gy (RBE = 1.1). Four years post-treatment, the patient developed progressive right upper extremity paresthesia, weakness, and dysesthesia. Electromyography revealed myokymia consistent with brachial plexopathy, while MRI showed hyperintensity of the right brachial plexus corresponding to the radiation field. Conservative treatment with pentoxifylline, gabapentin, and physical therapy improved his symptoms. (2) Methods: The original treatment plan was retrospectively analyzed using Monte Carlo dose algorithms and LET-dependent RBE models from McMahon and McNamara. An LET-optimized plan was created to limit LET_d to 2.0 keV/µm in the brachial plexus. (3) Results: The relative biological equivalent (RBE) dose to 0.1cc of the brachial plexus was 77.8 Gy (CGE RBE), exceeding tolerance. The LET-optimized plan reduced the brachial plexus D0.1cc to 59.4 Gy (RBE = 1.1) and 63.2 Gy (CGE RBE), an 18.8% decrease, while maintaining target coverage. LET_d, within the brachial plexus enhancement, decreased from 5.3 to 2.6 keV/μm. (4) Conclusion: This case highlights the potential clinical importance of LET optimization in proton therapy planning, particularly when organs-at-risk overlap with target volumes. By reducing LET_d from 5.3 to 2.6 keV/μm and biological equivalent dose by 18.8%, LET optimization could potentially prevent late toxicities, like RIBP, while maintaining target coverage. Full article

Probiotics play a pivotal role in animal production by promoting growth, enhancing gut health, and modulating immune responses. Bacillus subtilis, a widely utilized probiotic, forms robust spores that exhibit exceptional resistance, making it ideal for feed applications. While B. subtilis spores have been shown to stimulate innate immune signaling, the specific contributions of spore coat proteins to immune modulation remain poorly characterized. In this study, we investigated the immunostimulatory effects of spores deficient in six key coat proteins: SpoIVA, SafA, CotE, CotX, CotZ, and CgeA. These proteins are essential for the assembly and structural integrity of the spore’s multi-layered coat, and are involved in recruiting other coat components. Deletion of these genes result in defects in spore coat architecture, potentially altering spore–host interactions. Using porcine alveolar macrophages (MΦ3D4/2), we assessed cytokine responses to each mutant strain. Our findings demonstrate that the absence of specific structural proteins significantly impacts immune activation, particularly through Toll-like receptor pathways. This work provides novel insights into the immunomodulatory functions of spore coat proteins and lays the foundation for the rational design of next-generation B. subtilis-based probiotics with enhanced immunological properties for agricultural applications. Full article

This study uses a computable general equilibrium (CGE) model to analyze the impact of skilled and semi-skilled labor supply shocks on the Ethiopian economy and sectoral outputs. The study examines three policy scenarios: a 10% increase, a 15% increase, and a 20% increase in skilled and semi-skilled labor supply compared to a business-as-usual (BAU) scenario. The findings show that all three scenarios contribute to higher economic growth, investment, and exports. The impact on sectoral outputs is also significant, with the industry and services sectors performing better than the agriculture sector. In the 20% increase scenario, the real annual gross domestic product (GDP) growth rate is projected to be 0.79 percentage points higher than the business-as-usual scenario. Additionally, the annual growth rates of investments and exports are expected to be 2.69 and 2.31 percentage points higher, respectively, compared to their business-as-usual scenario counterparts. The agriculture sector experiences a slight increase of 0.16 percentage points in annual production compared to the business-as-usual scenario. Output in the industry sector also sees a rise of 1.61 percentage points higher than the business-as-usual scenario, while outputs in the services sector improve significantly. Overall, the study highlights the positive impact of increasing the supply of skilled and semi-skilled labor on the economy. This is mainly due to the higher productivity of skilled and semi-skilled workers, which contributes to increased economic growth. The findings suggest that governments should implement policies to enhance the supply of skilled and semi-skilled labor, such as investing in education and training programs. These measures would promote economic growth and improve living standards. Full article

Background: Centranthera grandiflora Benth is commonly utilized in China to take advantage of its purported health benefits. Methods: Here, the chemical composition, nutritional value, and bioactivity of C. grandiflora Benth extract (CGE) are characterized, and the mechanisms through which it functions were explored. Results: CGE was found to exhibit a favorable nutritional and biosafety profile, especially due to its high amino acid and mineral contents. A UPLC-ESI-Q-TOF/MS approach identified 20 compounds. Through network pharmacology analyses, the antioxidant activity of CGE was found to be mediated through the PI3K/Akt pathway, with molecular docking results providing support for mussaenoside and azafrin as important bioactive compounds. At the cellular level, antioxidant activity of key protective antioxidants including GSH-Px and SOD while suppressing ROS accumulation, levels of damage-related factors (MDA, NO, TNF-α, IL-1β, and IL-6), and iNOS and COX-2 in RAW264.7 cells treated with LPS. These findings offer potential evidence for using CGE to lower oxidative stress and inflammation. Further analyses demonstrated the ability of CGE to promote Nrf2 and HO-1 upregulation, whereas Keap1 levels were suppressed, as were PI3K/Akt/NF-κB proteins. In light of these results, CGE appears to be able to act via simultaneously enhancing Nrf2/HO-1 activity and reducing that of PI3K/Akt/NF-κB. Conclusions: CGE, as a rich source of iridoid glycosides and other nutrients, may thus be a valuable dietary supplement for use in food applications. Full article

The global coronavirus (COVID-19) pandemic in early 2020 caused the amount of medical waste, especially plastic waste, to increase. The pandemic exacerbated the plastic waste management problem, including the need to find more sustainable treatment methods. This study investigated the sustainable conversion of plastic waste (FFP2-type face masks) to syngas via pure CO₂ plasma gasification to recover energy and reduce environmental pollution. A direct current (DC) thermal arc plasma torch of 40.6–68.4 kW power generated the plasma stream. Carbon dioxide (CO₂), as a greenhouse gas (GHG), was used as the main plasma-forming gas and gasifying agent. The 140_thermal feedstock input plasma gasification system was used in the study. The effect of the CO₂-to-C ratio on the gasification performance efficiency was investigated. The best CO₂ plasma gasification process performance was obtained at a CO₂-to-C ratio of 2.34. In these conditions, the main syngas components (H₂ + CO) comprised 80.46 vol.% (H₂: 24.62 vol.% and CO: 55.84 vol.%) and the following values were seen for the heating value of the syngas (LHV_syngas: 13.88 MJ/Nm³), the syngas yield (3.13 Nm³/kg_FFP2), the tar content in the syngas (23.0 g/Nm³), the carbon conversion efficiency (CCE: 70.6%), and the cold gas efficiency (CGE: 47.8%). Additionally, the plasma gasification process mass and energy balance were evaluated. It was demonstrated that CO₂ plasma gasification could be a promising thermochemical treatment technology for sustainable plastic waste disposal and the simultaneous utilization of greenhouse gases, such as carbon dioxide. Full article

Land, as the foundation of all productive activities, plays a crucial role in achieving high-quality development across regions. China’s current land allocation model, which focuses on land quota distribution, has several drawbacks and does not address the conflict between limited land availability and increasing demand. To maximize land use benefits, it is essential to develop scientifically sound allocation plans that effectively adjust land structure and layout. However, existing research often relies on single-attribute geographic or linear programming models which do not meet the multidimensional needs of modern territorial planning. Additionally, commonly used CGE models often overlook the critical role of construction land. To address these gaps, this study introduces a multi-scale, multi-type China Territorial Spatial Planning Simulation Model (CTSPM). This model integrates cultivated, forest, grassland, and construction land, simulating the land use changes driven by socioeconomic impacts through price mechanisms. By employing a land use transition matrix, the CTSPM enhances practical applicability and improves predictions for residential and non-agricultural construction land. It provides a scientific tool for evaluating land policies, supporting interdepartmental negotiations on land quotas, and contributing to natural resource governance and territorial spatial planning. Using the CTSPM, we simulated various high-quality development scenarios and derived the following conclusions: (1) An increase in Total Factor Productivity (TFP) significantly boosts regional economic development and the demand for non-agricultural land; a 1% increase in TFP leads to a 1.48% rise in actual GDP and a 0.19% increase in total non-agricultural land demand. (2) At the regional level, eastern regions experience a greater impact on total land demand compared to central and western regions. (3) In terms of land use types, cultivated and grassland areas show a decreasing trend, while forest and construction land areas are increasing. Full article

The pathway towards carbon neutrality in regions with a relatively light industrial structure and scarce renewable energy resources presents a challenge when balancing energy efficiency improvements with the expansion of renewable energy. Therefore, this study investigates the effectiveness of carbon pricing and carbon quota control as regional carbon abatement policies. The findings demonstrate that carbon taxes are less effective than carbon emission quota control in economic growth and carbon abatement due to their weaker impact on energy efficiency enhancement and structural transition in the energy and industrial sectors. Moreover, stricter carbon pricing, determined by carbon emission goals, leads to greater reduction in sectoral carbon intensity but slower GDP growth caused by the accelerated decline of manufacturing and infrastructure industries compared to carbon intensity quota policies. In addition, carbon pricing derived from carbon emission and intensity quota policies increases reliance on domestically imported electricity, which is constrained by the availability of renewable energy resources. Full article

Purpose: Proton irradiation is used to treat choroidal melanoma of the eye. The impact on non-malignant retinal cells is currently understudied. Therefore, we here report a mouse model to investigate the impact of proton irradiation on the retina. Methods: We performed a proton beam irradiation of 5–15 Cobalt-Gray-Equivalent (CGE) of the eyes of female C57Bl6/J (Cx3cr1^+/+), Cx3cr1^gfp/+ and Cx3cr1^gfp/gfp mice mimicking the clinical situation and evaluated the structure, function and cellular composition of the retina up to 24 weeks after irradiation. Results: Proton beam irradiation of the eye with 15 CGE leads to cataract formation after 24 weeks without affecting the gross anatomy of the retinal vasculature as shown by Fundus imaging in all genotypes respectively. However, 10 and 15 CGE, lead to a significant decrease in NG2 positive cell numbers and all three dosages induced an increase in GFAP immunoreactivity. At 24 weeks a dosage of 15 CGE resulted in functional impairment and a decrease of NG2 positive cells in both WT and Cx3cr1 animals. Iba1 cell immunoreactivity was increased in all genotypes. However, in the Cx3cr1 animals the invasion of Iba1 cells into the deep vascular layer was partially prevented. This was accompanied by a less severe functional impairment in the irradiated Cx3cr1^gfp/gfp vs. WT. Conclusions: Although the gross anatomy of the retina does not seem to be affected by proton beam irradiation, the cellular composition and retinal function changed significantly in both WT and Cx3cr1 mice reflecting the clinical situation. Moreover, cataract formation was one of the major long-term effects of irradiation. We conclude that the murine model (WT and Cx3cr1 genotype) can be used to investigate proton-beam associated side effects in vivo as well as to test prospective interventions. Moreover, the loss of Cx3cr1 seems to be partially protective. Full article

Background/Objectives: The domestication of the grey wolf (Canis lupus) and subsequent creation of modern dog breeds have significantly shaped the genetic landscape of domestic canines. This study investigates the genomic effects of hybridization and breeding management practices in two hybrid wolfdog breeds: the Czechoslovakian Wolfdog (CSW) and the Saarloos Wolfdog (SAW). Methods: We analyzed the genomes of 46 CSWs and 20 SAWs, comparing them to 12 German Shepherds (GSHs) and 20 wolves (WLFs), which served as their ancestral populations approximately 70–90 years ago. Results: Our findings highlight that hybridization can increase genetic variability and mitigate the effects of inbreeding, as evidenced by the observed heterozygosity levels in both wolfdog breeds. However, the SAW genome revealed a higher coefficient of inbreeding and longer runs of homozygosity compared to the CSW, reflecting significant inbreeding during its development. Discriminant Analysis of Principal Components and fixation index analyses demonstrate that the CSW exhibits closer genetic proximity to the GSH than the SAW, likely due to differences in the numbers of GSHs used during their creation. Maximum likelihood clustering further confirmed clear genetic differentiation between these hybrid breeds and their respective ancestors, while shared ancestral polymorphism was detectable in all populations. Conclusions: These results highlight the role of controlled hybridization with captive-bred wolves and peculiar breeding strategies in shaping the genetic structure of wolfdog breeds. To ensure the long-term genetic health of these breeds, it is recommended to promote adequate and sustainable breeding practices to maintain genetic diversity, minimize inbreeding, and incorporate the careful selection of unrelated individuals from diverse lineages, while avoiding additional, uncontrolled crossings with wild wolves. Full article