CTD profilers are used as reference instruments to qualify temperature and salinity data. Their metrological specifications can be controlled in a calibration bath, and calibration coefficients can be applied to correct the linearity of sensors and t...
Over 70% of the earth’s surface is covered by oceans; globally, oceans provides a huge source of wealth to humans. In the literature, several sensors have been developed to investigate oceans. Electrical conductivity temperature depth (CTD) sen...
Cell cycle control is vital for cell proliferation in all eukaryotic organisms. The entire cell cycle can be conceptually separated into four distinct phases, Gap 1 (G1), DNA synthesis (S), G2, and mitosis (M), which progress sequentially. The precis...
The knowledge of salinity in a specific sea area with high accuracy is required to solve several acoustic and hydrophysical problems on the ocean shelf. Unlike temperature, which can be measured continuously for a long time, with, for example, thermi...
In this pilot study, we aim to determine differences in pathogenetic pathways between interstitial pneumonia with autoimmune features (IPAF), connective-tissue-disease-associated interstitial lung diseases (CTD-ILDs), and idiopathic interstitial pneu...
The Bacteroidetes type IX secretion system (T9SS) consists of at least 20 components that translocate proteins with type A or type B C-terminal domain (CTD) signals across the outer membrane (OM). While type A CTD proteins are anchored to the cell su...
Connective Tissue Disease-Interstitial Lung Disease (CTD-ILD) is a severe and fatal manifestation of systemic autoimmune disorders. Therapies rely on immunomodulators but their efficacy in ILD progression remains uncertain. Nintedanib, an antifibroti...
Accurate measurement of temperature and salinity is a fundamental task with heavy implications in all the possible applications of the currently available datasets, for example, in the study of climate changes and modeling of ocean dynamics. In this...
Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control. Our prior work has shown that plant ROP and yeast Cdc42 GTPases similarly modulate Ser2 and Ser5 phosphoryl...
Rtr1 is an RNA polymerase II (RNA pol II) CTD-phosphatase that influences gene expression during the transition from transcription initiation to elongation and during transcription termination. Rtr1 interacts with the RNA pol II and this interaction...
The multinational Argo program, which was initiated in 1999, has completed its global requirement of 3000 floats deployed by 2007. This program has revolutionized ocean observations with the provision of varying data in the upper half of the ocean. H...
The radio-loud quasar CTD 135 (2234+282, J2236+2828) has been proposed as a candidate compact symmetric object (CSO), based on its symmetric radio structure revealed by multi-frequency very long baseline interferometry (VLBI) imaging observations on...
In mitochondria, the major subunits of oxidative phosphorylation complexes are translated by the mitochondrial ribosome (mito-ribosome). The correct insertion and assembly of these subunits into the inner mitochondrial membrane (IMM) are facilitated...
The diagnosis of interstitial lung disease (ILD) requires meticulous evaluation for an underlying connective tissue disease (CTD), with major implications for prognosis and management. CTD associated ILD (CTD-ILD) occurs most commonly in the context...
This paper presents a low-power continuous-time delta-sigma (CT-DS) analog-to-digital converter (ADC) for use in high-sensitivity automotive-grade sub-1 GHz receivers in emerging wireless sensors network applications. The proposed ADC employs a third...
Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a collection of systemic autoimmune disorders resulting in lung interstitial abnormalities or lung fibrosis. CTD-ILD pathogenesis is not well characterized because of disease...
We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in huma...
Post-translational modifications of the heptad repeat sequences in the C-terminal domain (CTD) of RNA polymerase II (Pol II) are well recognized for their roles in coordinating transcription with other nuclear processes that impinge upon transcriptio...
Retroviral integrase is a multimeric enzyme that catalyzes the integration of reverse-transcribed viral DNA into the cellular genome. Beyond integration, the Human immunodeficiency virus type 1 (HIV-1) integrase is also involved in many other steps o...
Pulmonary hypertension (PH) is a severe vascular complication of connective tissue diseases (CTD). Patients with CTD may develop PH belonging to diverse groups: (1) pulmonary arterial hypertension (PAH), (2) PH due to left heart disease, (3) secondar...
The NMDA receptor is a Ca2+-permeant glutamate receptor which plays key roles in health and disease. Canonical NMDARs contain two GluN2 subunits, of which 2A and 2B are predominant in the forebrain. Moreover, the relative contribution of 2A vs. 2B is...
Background and Objectives: The “interstitial pneumonia with autoimmune features” (IPAF) criteria have been criticized because of the exclusion of usual interstitial pneumonia (UIP) patients with a single clinical or serological feature. T...
This study evaluates the usefulness of serum KL-6, SP-D and TGF-β1 levels in assessing lung impairment and predicting interstitial lung disease (ILD) short-term progression in patients with interstitial pneumonia with autoimmune features (IPAF)....
Background and objectives: The aims of the study were to evaluate the utility of neutrophil-to-lymphocyte ratio (NLR) and the systemic immune-inflammation index (SII) as inflammation markers and prognostic factors in patients with known interstitial...
The microbiome can trigger and maintain immune-mediated diseases and is associated with the severity and prognosis of idiopathic pulmonary fibrosis, which is the prototype of interstitial lung diseases (ILDs). The latter can be a major cause of morbi...
One critical challenge facing the world is the need to satisfy the food requirements of the dramatically growing population. Drought stress is one of the main limiting factors in the wheat-producing regions; therefore, wheat yield stability is a majo...
In the field of biomedical engineering, the issue of drug delivery constitutes a multifaceted and demanding endeavor for healthcare professionals. The intravenous administration of pharmacological agents to patients and the normalization of average a...
In this paper, a fuzzy (F) proportional (P)–integral (I)–derivative (D) (PID) (FPID) controller optimized with a water cycle algorithm is proposed for load frequency control of a multi-area multi-fuel (MAMF) power system. The MAMF system...
Amphetamine is a psychostimulant drug with a high risk of toxicity and death when misused. Abuse of amphetamines is associated with an altered organic profile, which includes omega fatty acids. Low omega fatty acid levels are linked to mental disorde...
Seawater properties in two intense rings in the South Atlantic are considered. One ring separated from the Brazil Current and the other from the Malvinas Current. The analysis is based on the CTD casts and SADCP measurements from the onboard velocity...
Bacillus genetics need more versatile promoters for gene circuit engineering. UP elements are widely distributed in noncoding regions and interact with the α-subunit of RNA polymerase (RNAP). They can be applied as a standard element for synthe...
This paper presents in situ methods used in the search for areas of modern hydrothermal activity, as well as the results of their long-term use during cruises within the Russian exploration area of the Mid-Atlantic Ridge (MAR). In this study, the fol...
Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content s...
Shortly after the beginning of the year 2000, multiple legal changes with impacts on the regulatory framework of clinical trials became effective almost simultaneously. They included the European Union (EU) Clinical Trial Directive (CTD) 2001/20 foll...
Due to the rapid mutation of porcine epidemic diarrhea virus (PEDV), existing vaccines cannot provide sufficient immune protection for pigs. Therefore, it is urgent to design the affinity peptides for the prevention and control of this disease. In th...
Clostridioides difficile, formerly known as Clostridium difficile, is a spore-forming bacterium considered as the most common cause of nosocomial infections in developed countries. The spore of C. difficile is involved in the transmission of the path...
RNA pol II assembly occurs in the cytoplasm before translocation of the enzyme to the nucleus. Affecting this assembly influences mRNA transcription in the nucleus and mRNA decay in the cytoplasm. However, very little is known about the consequences...
Background: There is still an unmet need for therapeutic drugs for patients with an abdominal aortic aneurysm (AAA), especially for candidates unsuitable for surgical or interventional repair. Therefore, the purpose of this in silico study is to iden...
Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue diseases (CTD). Its early diagnosis is essential to start effective treatment. In the present paper, we aimed to evaluate the role of plasma osteopontin (OPN) as a ca...
Obtaining real-time data from the deep ocean remains a major challenge in marine observation. This study presents a deep-sea mooring system that integrates inductive telemetry (EUM6000 modules) with Tiantong satellite communication to achieve real-ti...
Properties of the abyssal current of Antarctic Bottom Water (AABW) from the Vema Channel are studied based on temperature, salinity, and velocity profiler (CTD/LADCP) data. Previous studies over a period of almost 30 years revealed that very intense...
Wicked problems defy simple solutions. From climate change to mass shootings, their causes are not singular but systemic, interconnected, and often politicized. Yet in both public discourse and policy design, one-cause and root-cause thinking continu...
As one of the most important physical parameters of seawater, salinity is essential to study climatological change, to trace seawater masses and to model ocean dynamics. The traditional way to conduct salinity measurement in hydrographical observatio...
Accurate pressure measurement is crucial for understanding ocean dynamics in marine research. However, pressure sensors based on strain measurement principles are significantly affected by temperature variations, impacting the accuracy of depth measu...
N6-methyladenine (6mA) of DNA is an emerging epigenetic mark in the genomes of Chlamydomonas, Caenorhabditis elegans, and mammals recently. Levels of 6mA undergo drastic fluctuation and thus affect fertility during meiosis and early embryogenesis. He...
Measurements of temperature, salinity, and currents in the Amazon River plume over a section in the open ocean of the western tropical North Atlantic (38°48′ W) are considered. The measurements were carried out using an AML Base X CTD probe...
This paper puts forward the implementation of an intelligent type II fuzzy PID (T2-FPID) controller tweaked with a water cycle algorithm (WCA), subjected to an error multiplied with time area over integral (ITAE) objective index for regularizing the...
The Bransfield Strait is a relatively deep and narrow channel between the South Shetland Islands and the Antarctic Peninsula contributing to the water transport between the Pacific and Atlantic sectors of the Southern Ocean. The strait can be divided...
Rapid industrialization has introduced a range of chemicals into the environment, posing significant risks to fetal and child brain development. Using the Comparative Toxicogenomics Database (CTD), we constructed chemical exposome frameworks for seve...
Background: The early reliable detection and quantification of autoantibodies play an important role in autoimmune disease diagnosis and in disease-course monitoring. New technologies, such as the multiplexed determination of autoantibodies, have rec...
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