Search Results (244)

Quality-of-life (QoL) needs among gynecologic cancer survivors are multifaceted and culturally mediated, yet limited research has examined how survivors in the Middle East prioritize key domains such as sexual function, emotional well-being, and relational quality. This study aimed to identify subgroups of survivors based on the perceived importance of these domains and to explore demographic and clinical predictors of subgroups within the Saudi Arabian context. We conducted a cross-sectional, survey-based study among 129 women with a history of breast or cervical cancer attending a tertiary oncology center in Jeddah, Saudi Arabia. Participants rated the importance of sexual, emotional, and relational QoL domains using a 4-point Likert scale. Latent class analysis (LCA) was used to segment survivors based on their perceived domain importance. Differences in demographic and clinical characteristics across classes were assessed using chi-square tests. A decision tree classifier was employed. Three latent classes emerged: Class 0 (48.8%) prioritized all domains highly; Class 1 (17.8%) reported low importance across domains; and Class 2 (33.3%) emphasized emotional and relational domains while downplaying sexual function. Class group was significantly associated with age (p = 0.001), education (p = 0.04), nationality (p = 0.03), and number of children (p < 0.001). Decision tree analysis identified number of children, age, and marital status as the strongest predictors of high-importance class group. Gynecologic cancer survivors in Saudi Arabia hold diverse priorities regarding QoL domains, primarily shaped by sociocultural context than clinical variables. Tailored survivorship interventions that reflect survivors’ lived values, particularly in relation to age, family structure, and cultural norms, are critical for person-centered oncology care in the region. Full article

Background/Objectives: Understanding the relationship between plasma connecting peptide (C-peptide) levels and health-related quality of life (HRQoL) can inform diabetes management strategies. This study aimed to assess plasma C-peptide levels, HRQoL, and their association in patients with prediabetes, type 1 diabetes (T1D), and type 2 diabetes (T2D) attending outpatient departments (OPDs) in tertiary care hospitals. Methods: A cross-sectional survey was conducted between 1 January and 30 June 2023, using the EuroQoL Five Dimensions (EQ-5D-5L) instrument. Participants with prediabetes, T1D, or T2D were recruited from OPDs in diabetology, endocrinology, general practice, and family medicine at Sheikh Zayed Hospital (SZH) and Mayo Hospital (MH) in Pakistan. Plasma C-peptide levels were measured and HRQoL was assessed using EQ-5D-5L and the EQ Visual Analog Scale (VAS). Results: A total of 301 patients were included: 42 with prediabetes (14%), 70 with T1D (23.2%), and 189 with T2D (62.8%). The median C-peptide level was 0.46 nmol/L (IQR 0.13–0.85), the HRQoL score was 78.5% (IQR 63.2–100%), and the EQ VAS score was 85% (IQR 70–90%). C-peptide levels were significantly correlated with HRQoL scores (r = 0.14, p < 0.02) and differed across mobility, daily activity, pain/discomfort, and anxiety/depression domains (all p < 0.02). HRQoL scores significantly varied among the three groups (p < 0.0001), particularly in the aforementioned domains. Conclusions: C-peptide levels and HRQoL differ significantly across diabetes types, with lower C-peptide associated with reduced mobility, increased pain, and mental health issues. These findings underscore the importance of targeting C-peptide regulation to enhance HRQOL in diabetic populations. Full article

MXenes, a rapidly emerging family of two-dimensional transition metal carbides and nitrides, have attracted considerable attention in recent years for their potential in next-generation energy storage technologies. In solid-state batteries (SSBs), they combine metallic-level conductivity (>10³ S cm⁻¹), adjustable surface terminations, and mechanical resilience, which makes them suitable for diverse functions within the cell architecture. Current studies have shown that MXene-based anodes can deliver reversible lithium storage with Coulombic efficiencies approaching ~98% over 500 cycles, while their use as conductive additives in cathodes significantly improves electron transport and rate capability. As interfacial layers or structural scaffolds, MXenes effectively buffer volume fluctuations and suppress lithium dendrite growth, contributing to extended cycle life. In solid polymer and composite electrolytes, MXene fillers have been reported to increase Li⁺ conductivity to the 10⁻³–10⁻² S cm⁻¹ range and enhance Li⁺ transference numbers (up to ~0.76), thereby improving both ionic transport and mechanical stability. Beyond established Ti-based systems, double transition metal MXenes (e.g., Mo₂TiC₂, Mo₂Ti₂C₃) and hybrid heterostructures offer expanded opportunities for tailoring interfacial chemistry and optimizing energy density. Despite these advances, large-scale deployment remains constrained by high synthesis costs (often exceeding USD 200–400 kg⁻¹ for Ti₃C₂T_x at lab scale), restacking effects, and stability concerns, highlighting the need for greener etching processes, robust quality control, and integration with existing gigafactory production lines. Addressing these challenges will be crucial for enabling MXene-based SSBs to transition from laboratory prototypes to commercially viable, safe, and high-performance energy storage systems. Beyond summarizing performance, this review elucidates the mechanistic roles of MXenes in SSBs—linking lithiophilicity, field homogenization, and interphase formation to dendrite suppression at Li|SSE interfaces, and termination-assisted salt dissociation, segmental-motion facilitation, and MWS polarization to enhanced electrolyte conductivity—thereby providing a clear design rationale for practical implementation. Full article

Introduction: Due to the inherent difficulty in obtaining information using language-based questionnaires, research on the quality of life (QOL) for persons with aphasia (PWAs) is lacking. The purpose of this study was to investigate which factors have an impact on a PWA and to investigate the reliability of using proxy responses from either spouse/caregivers or speech-language pathologists (SLPs). Methods: A QOL scale was developed with 11 factors identified in the literature as having an impact on the QOL of PWAs. Data were collected through interviews with 31 PWAs and 26 spouse/caregivers recruited from a community aphasia therapy center. Thirty-six SLPs responded to an online survey. Results: Vocation was identified by PWAs as having the most impact on their QOL and family as having the least impact. Cronbach’s alpha and intraclass correlation coefficients (ICCs) showed decreased internal consistency and reliability across ratings and respondents. Conclusions: Overall results suggest that proxy responses may not accurately reflect the factors that impact the QOL of a PWA but that spouse/caregiver responses may be more representative than those of SLPs. Full article

Heart transplantation represents a pivotal intervention for end-stage heart failure, extending survival. However, it imposes profound physical, psychological, and social challenges that often undermine recipients’ quality of life (QoL). These challenges are especially pronounced in collectivist cultural contexts like China, where familial obligations and stigma surrounding chronic illness intensify existential burdens. Grounded in theoretical frameworks including Coping Theory, Self-Determination Theory, Socioemotional Selectivity Theory, and Terror Management Theory, this cross-sectional study explored the interplay between social support and QoL among Chinese heart transplant recipients, elucidating the mediating roles of self-esteem and death anxiety, as well as their sequential chain-mediating pathway. Employing validated psychometric instruments, including the Social Support Rating Scale (SSRS), Rosenberg Self-Esteem Scale (RSES), Templer Death Anxiety Scale (T-DAS) and SF-36 Health Survey, along with chain-mediation modeling, the analysis revealed that social support exerts a direct positive influence on QoL, supplemented by indirect effects through enhanced self-esteem, reduced death anxiety, and a chained cognitive-existential mechanism linking these factors. These insights highlight the complex psychosocial dynamics of post-transplant adaptation, advocating for targeted and culturally attuned interventions. These interventions include family-based support programs, self-esteem enhancement strategies, and death anxiety counseling. The aim is to promote holistic rehabilitation and sustained well-being among heart transplant recipients in China’s context. Full article

Prematurity, defined as a birth before 37 weeks of gestation, affects approximately 15 million infants worldwide yearly. Beyond the Neonatal Intensive Care Unit and the possibility of long-term developmental challenges affecting children’s quality of life, prematurity influences family dynamics, including parental mental health, financial stability, employment, and daily life. On a broader scale, research highlights the significant socioeconomic consequences of preterm birth that influence public healthcare policies, healthcare systems, and long-term costs. Addressing these challenges requires a multidisciplinary approach, beginning in the NICUs, with parental inclusion as a key component. The shift toward parental inclusion in the NICU may represent a fundamental transition from a medical to a social model of prematurity. The concept of a social model of prematurity parallels the social model of disability, from disability studies, focusing on premature babies, strengthening their abilities and nurturing early caregiver—infant relationships. It highlights how societal structures, such as accessibility and support systems, shape developmental outcomes and inclusion of premature infants, rather than framing prematurity solely in terms of survival and treatment. Full article

Background/Objectives: Post-discharge interventions addressing psychological, informational, and practical needs of brain tumor surgery patients are limited. This study aimed to develop and examine the effects of a post-discharge care program for patients with benign brain tumors who underwent surgery. Methods: A quasi-experimental study with a nonequivalent control group pretest–post-test non-synchronized design was employed. The post-discharge care program was developed using the ADDIE model and delivered as an 8-week, 8-session program to 65 discharged patients (Intervention: n = 33, Control: n = 32). Outcomes were measured using the Memorial Symptom Assessment Scale (MSAS) for symptom clusters, Post-Discharge Coping Difficulty Scale (PDCDS) for post-discharge adaptation, and Functional Assessment of Chronic Illness Therapy (FACIT) for quality of life. Results: Significant group × time interactions were found between intervention and control groups for symptom clusters (F = 74.878, p < 0.001), post-discharge adaptation (F = 144.687, p < 0.001), and all quality of life domains: physical (F = 38.996, p < 0.001), social/family (F = 50.865, p < 0.001), emotional (F = 39.110, p < 0.001), and functional (F = 38.917, p < 0.001). The intervention group showed clinically meaningful improvements across all outcomes. Conclusions: This study demonstrates that the post-discharge care program was effective in improving symptom clusters, post-discharge adaptation, and quality of life in patients with benign brain tumors who underwent surgery. The program can contribute to achieving better health outcomes for this population in clinical practice. Full article

Background: Dental professionals are particularly susceptible to occupational stress and burnout, which are amplified during armed conflicts. Civilian dentists continuing to provide care under wartime conditions face unique psychological challenges. This study aimed to evaluate their psychological wellbeing and professional quality of life during military conflict. Methods: A cross-sectional study was conducted using an anonymous online questionnaire distributed through the national dental association. The survey included the Professional Quality of Life Scale (ProQOL, version 5) to assess compassion satisfaction, burnout, and secondary traumatic stress; and the Generalized Anxiety Disorder 7-item scale (GAD-7) to measure anxiety severity. Additional items captured demographic information, professional experience, pre-conflict workload, current work status, family circumstances, and subjective financial impact. The final sample included 239 civilian dentists. Statistical analysis included descriptive statistics, Pearson correlations, chi-square tests for categorical variables, Mann-Whitney U and Kruskal-Wallis tests for between-group comparisons, and multiple regression to identify predictors of psychological outcomes. Results: High compassion satisfaction was reported by 38.9% of respondents, while 70.3% exhibited average burnout levels; only 0.4% had high burnout. Secondary traumatic stress was low in 85.4% of participants. Minimal anxiety was found in 54% of respondents. Significant correlations were found between professional satisfaction and lower anxiety (p < 0.001), lower burnout (p < 0.001), and higher compassion satisfaction (p < 0.001). Dentists with more years of experience and older age reported lower anxiety and burnout levels. Higher pre-conflict workloads were associated with increased anxiety during the conflict (p < 0.001). Dentists working in Health Maintenance Organizations (HMOs) reported significantly higher anxiety levels compared to their non-HMO counterparts (p = 0.022), although reported income loss was similar between groups. Conclusions: Civilian dentists demonstrated resilience and overall positive professional functioning during prolonged conflict. However, public sector dentists, especially those in HMOs, showed greater vulnerability to anxiety. These findings underscore the need for systemic strategies to support dental professionals’ mental health during national crises, with emphasis on those in the public health system. Full article

Background/Objectives: Patients with heart failure (HF) experience increased morbidity, limited daily activities, and diminished quality of life (QoL), thus relying on a family member, widely known as informal caregiver, for support. The objective of this study was to explore (a) QoL, anxiety, and depression; (b) factors associated with QoL; and (c) the impact of associated factors on QoL among HF caregivers. Materials and methods: Data collection was performed using the 36-Item Short Form Survey (SF-36), the Hospital Anxiety and Depression Scale (HADs), and the European Heart Failure Self-care Behavior Scale (EHFScBS). Also recorded were characteristics of caregivers and patients. Results: In the present study, 110 HF caregivers and the family members they provided care to were enrolled. The majority of caregivers were patients’ spouses (60%) and were female (71.8%). Within a QoL score range of 0–100, caregivers showed moderate to high levels in role-physical, role-emotional, emotional well-being, and pain (median: 75, 66.7, 64, and 67.5, respectively); moderate QoL levels in energy/fatigue, social functioning, and general health (median: 55, 56.3, and 62, respectively); and poor QoL levels in physical functioning (median: 18). Moreover, 64.5% of caregivers had anxiety and 41.8% had depression. Caregivers with HADs scores that indicate anxiety and depression had worse QoL (p = 0.001). No association was detected between caregivers’ QoL and patients’ HADs and self-care. Conclusions: QoL and anxiety/depression merit further research by clinicians, health systems, and policymakers so that evidence-based policies and interventional programs tailored to their needs can be implemented. Full article

This study examines differences in perceived parental emotional availability, emotion regulation (ER), and health-related quality of life (HRQoL) among adolescents, considering gender, age, and family structure. It also assesses contextual differences in ER (at home vs. at school) and investigates the mediating role of ER in the relationship between perceived parental emotional availability and HRQoL. The sample consisted of 202 Portuguese adolescents (M age = 13.44 years, SD = 1.01; 52.5% girls) who participated in this cross-sectional study. Self-report scales were used to assess perceived emotional availability, ER, and HRQoL, with data collected during classes using a paper-and-pencil procedure. The results showed that girls’ perceptions of mother and father emotional availability were smaller than perceptions reported by boys; girls reported lower HRQoL. Also, adolescents from divorced/separated families reported higher levels of expressive suppression at home and lower HRQoL. Both maternal and paternal perceived emotional availability were positively associated with better HRQoL in adolescents. Furthermore, expressive suppression (within the home context) and cognitive reappraisal (within the school context) partially explained these associations. These findings have important implications for both practice and research, highlighting the significance of perceived parental emotional availability and the role of ER in enhancing adolescents’ HRQoL. Full article

Gray snapper (Lutjanus griseus; Family: Lutjanidae) local habitat preferences have been assessed, but the biotic and abiotic factors influencing age and growth rates in Mosquito Lagoon, Florida, have not been quantified. To address this knowledge gap, the goal of this study was to estimate mean age and growth rate of gray snapper, and use generalized linear mixed models to investigate if prey and/or other environmental factors (e.g., abiotic/biotic conditions, time, location, or habitat restoration status) impact size at both the lagoon- and habitat-specific scales. Age data were extracted via otolith microstructural analyses, and incorporated with size into a lagoon-scale linear growth model. Based on microstructural analyses, mean age of gray snapper at the lagoon scale was 175 ± 66 days (range = 56–350 days). The results indicate the most common life stage of gray snapper in Mosquito Lagoon is juveniles, with living shoreline habitats having a greater proportion of relatively young juveniles (111 ± 36 days) and oyster reef habitats having a greater proportion of relatively older juveniles (198 ± 58 days). The estimated growth rate was 0.43 mm/day. Body mass and body length were correlated positively with habitat quality and lagged salinity levels. Hence future studies should strive to characterize benthic habitat characteristics, and investigate biotic and abiotic factors that potentially influence gray snapper growth. Collectively, this study increases our understanding of environmental drivers affecting juvenile gray snapper development and shows that the restoration of benthic habitats can produce conditions conducive to gray snapper growth. The age-, size-, and habitat-specific growth rates of juveniles from this study can be incorporated into stock assessments, and thereby be used to refine and develop more effective ecosystem-based management strategies for gray snapper fisheries. Full article

Neurodegenerative, neurodevelopmental, and psychiatric disorders, as well as epilepsy, affect millions of people. Due to their impact on patients’ quality of life, they represent a major health issue. Natural compounds are arising as new treatments for these diseases. Particularly, glucosinolates (GLS) are secondary metabolites found in Cruciferae family plants. Their basic structure consists of a glucose unit linked to a thiohydroximate-O-sulfonate group and an aliphatic, aralkyl, or indolyl side chain, depending on their precursor amino acid. Specifically, aliphatic GLS derive from methionine, aromatic ones from phenylalanine, and indolic ones from tryptophan. Myrosinase (thioglucoside glucohydrolase) is the crucial enzyme for GLS degradation, leading to the production of isothiocyanates (ITCs). ITCs attracted considerable scientific interest for their protective effects against various diseases, thanks to their antioxidant, anti-inflammatory, and neuroprotective properties. Here, we collected the latest evidence regarding ITC effects in neurodegenerative, neurodevelopmental, and psychiatric disorders, including preclinical and clinical studies published in the last decade. These studies evidenced ITCs’ neuroprotective effects, exerted mainly through antioxidant and anti-inflammatory mechanisms. Thus, ITCs’ integration, also through the diet, may represent a safe and efficacious strategy to improve health and limit the risk of neurological and psychiatric disorders. However, new large-scale trials are needed to determine their therapeutic potential, particularly for diseases with no clinical evidence. Full article

The type of non-professional or professional support received affects the quality of life of the patient and their caregivers. Social support is the type of interaction that is taken by the patient and his caregivers in a problematic, difficult, stressful, or critical situation. Aim: The aim of the study was to assess the impact of social support on the functioning of patients under nursing home care. Material and methods: The study included 148 chronically ill patients under home nursing care. The study used the diagnostic survey method; the research technique was a questionnaire containing basic data about the respondent and the Social Support Scale (SWS) by Krystyna Kmiecik-Baran. Results: The need to continue the causal treatment at home means that the main source of support for care beneficiaries are nurses who provide medical services at the patient’s home, supported by doctors and family members of the patient. According to patients’ subjective assessment of the support they received from nurses, patients rated the informational support provided by nurses highest at 14.3 points and emotional support at 13.3 points (SD 1.776). on a scale where the maximum score was 16 points. In the opinion of the surveyed patients, the value-added support provided was the lowest-rated category by patients, 9.74 points (SD 2.505). Instrumental support was also rated very poorly by the respondents (10.17 points (SD 2.069). In each category, there was no statistically significant difference at the p < 0.05 level in the respondents’ evaluation, which means that the expressed opinion on each type of support from the highest to the lowest evaluation: informational, emotional, instrumental, and evaluative—overlapped in the patient group and the family group. Conclusions: Patients under home care highly appreciated the support provided to them by the nursing staff. Social support for a chronically ill person who requires constant care and care by the nursing staff is a form of direct impact that relieves stress and tension, minimizes the effects of the disease, directly affects the course of treatment and care, and prevents stigmatization. Full article

Background: Sickle cell disease (SCD) is associated with high physical and psychosocial burden among patients and their families. Hydroxyurea (HU) improves health-related quality of life by preventing SCD complications. Despite its availability, HU is underutilised in Tanzania. Perceived self-efficacy for appropriate medication use influences medication usage among individuals with chronic illnesses. We studied factors associated with caregivers’ perceived self-efficacy for appropriate use of HU and its association with HU usage among children with SCD in Dar-es-Salaam. Methods: We conducted a cross-sectional study from May to August 2023. We enrolled 374 caregivers of children with SCD from two regional and two national hospitals. We adapted the self-efficacy for appropriate medication use scale, a multidimensional perceived social support scale, and a patient health questionnaire for assessment of self-efficacy, social support, and depressive symptoms, respectively. Results: Three-quarters of caregivers had high perceived self-efficacy scores for medication use. Attending national hospitals, high social support, and absence of depressive symptoms were positively associated with perceived self-efficacy (adjusted beta coefficient aβ 2.3, 95% CI 0.5–4.2; aβ 9, 95% CI 7.1–10.9; and aβ 5.3, 95% CI 2.8–7.8, respectively). Caregivers with high self-efficacy were 5.3 times more likely to give HU to their children compared with those with low self-efficacy (incidence rate ratio 5.3, 95% CI 3.3–8.3). Conclusions: Hospital levels and psychosocial factors influence caregivers’ perceived self-efficacy for appropriate HU use. We recommend targeted interventions to enhance psychosocial support among caregivers to increase caregivers’ perceived self-efficacy and HU utilization among children with SCD in Tanzania. Full article

Objective: This study aimed to explore the unmet palliative care needs among young and middle-aged (YMA) Chinese patients with advanced cancer. Methods: We used the principle of maximum difference. A total of 16 YMA patients with advanced cancer from cancer hospital were recruited. Semi-structured, in-depth, and face-to-face interviews were conducted from 28 August 2023 to 23 October 2023. The recorded audio of each interview was typed into Word software with each personal code. The interview transcripts were coded using the method of inductive content analysis. Results: Four themes and 14 sub-themes were identified in participants’ descriptions of care needs: (1) symptom management needs: need for pain relief, need for anti-emetics, and need for aid in managing fatigue; (2) psychological support needs: help reducing fear of pain, help achieving a better death, and help with parents’ negative reactions; (3) social support needs: taking care of children, emotional support from family members, consultation and emotional support from other cancer patients, and company and guidance of healthcare personnel; (4) information needs: better understanding of disease trajectory and future care needs, better access to palliative care information, and more participation in medical decision-making. Conclusions: According to the results of this study, the unmet palliative care needs of YMA patients with advanced cancer are diverse, but they have not been fully recognized and met. Therefore, medical staff should develop effective management strategies and explore patients’ needs in an all-around way. Future studies will further develop the scale of unmet needs for palliative care to accurately identify needs and improve patients’ quality of life. Full article