Search Results (2,247)

Background: Hypercalcemia is a rare etiology of acute pancreatitis; only a few cases have been reported in the literature, and the severity of hypercalcemia-induced AP is unknown. We aimed to assess the occurrence and severity of hypercalcemia-induced AP and compare it with the clinical characteristics of AP caused by other etiological factors. Methods: We collected data from patients from the Hungarian Acute Pancreatitis Registry who had AP, a serum calcium level above 2.6 mmol/L, and no other AP etiology. AP patients with etiologies other than hypercalcemia served as control. Results: A total of 1.20% of our AP patients (16/1328) had a clear hypercalcemic etiology, 5.05% (67/1328) had a mixed etiology, and 1245 patients were in the control group. Severe AP, organ failure, and renal failure were significantly more common in patients with hypercalcemia-induced AP than in the control or the mixed etiology groups. Heart failure was significantly more frequent in the clear hypercalcemia-induced group than in patients with normal serum calcium AP. Respiratory failure was significantly more common in the clear hypercalcemia-induced AP group than in the mixed etiology-induced group. There was no significant difference in other analyzed parameters. The outcome of AP was not associated with the severity of hypercalcemia within the hypercalcemic group. Conclusions: Compared with AP of different etiologies, hypercalcemia-induced AP is more likely to develop into severe AP and organ failure (heart and kidneys). Full article

Background/Objectives: Increasing the bioavailability of poorly absorbed drugs is a continuous challenge in modern pharmaceutical technology. This is due to the problematic nature of BCS class IV active pharmaceutical ingredients: these drugs possess poor solubility and membrane permeability. Moreover, many undergo immediate efflux and/or rapid systemic metabolism after absorption. This project aimed to improve the bioavailability of BCS class IV drugs by formulating gastroretentive self-emulsifying systems using curcumin as a model drug. Methods: The base of the systems was created by melting emulsifying agents, dissolution retardants, and PEGs together. Curcumin was added after the mixture was cooled slightly. Aqueous dispersions of several compositions were characterized by dynamic light scattering. After screening these results, the viscosities of the selected formulations were evaluated. Dissolution retardants were selected and added to the most superior samples, and their dissolution profiles were compared. Gastroretention of the final formulation was achieved by dispersing air in the molten system through melt foaming; internal structure was assessed by microCT, and physicochemical properties by PXRD and DSC. Cytotoxicity was measured in Caco-2 cells using MTT and Neutral Red assays, and transcellular transport was also studied. Results: Based on these results, a homogeneous gastric floating system was developed. We observed an advantageous cytotoxic profile and increased bioavailability. Conclusions: Overall, we were able to create a self-emulsifying gastroretentive formulation displaying extended release and gastric retention with a low amount of cost-efficient excipients. Full article

The article explores how pro-environmental action relates to knowledge processes and fosters transformative changes in vulnerable settings. Drawing on eleven pro-environmental initiatives in five countries (Bulgaria, Hungary, Portugal, Romania and Türkiye), the study focuses on locally embedded actions responding to environmental threats, biodiversity loss and traditional practices. Based on 71 semi-structured interviews with citizens, we captured how environmental stewardship is shaped through lived experience, situated knowledge and shifting roles of actors under variable, often adverse governance conditions. We found that knowledge emerges as a co-produced and relational process, blending scientific, traditional, experiential and process-related knowledge. This supports participation and legitimacy and enables transformative (or behavioural) change. Transformative outcomes appear as behavioural shifts, self-empowerment, increased community agency and broader societal signals evolving from participation. The article contributes to the debate on sustainability transformation as it showcases potentially uncharted factors in current sustainability transition studies, i.e., emotional, political and relational dimensions of local pro-environmental actions in vulnerable settings. Even if systemic conditions limit transformative processes, this practical knowledge might be scaled up or adapted to other local or regional contexts to confront dominant socio-economic models and propose more inclusive, just and sustainable alternatives. Full article

Background/Objectives: The intranasal (IN) route of administration is a promising non-invasive approach for brain targeting, bypassing the blood–brain barrier and enhancing bioavailability. Citalopram hydrobromide (CT), a widely prescribed sparingly water-soluble selective serotonin reuptake inhibitor (SSRI), faces challenges with oral and intravenous administration, including delayed onset, adverse effects, and patient compliance issues. Methods: This study aimed to develop a novel thermoresponsive polymeric micelle (PM) system based on Pluronic^® copolymers (Pluronic F127 and Poloxamer 188) improving CT’s solubility, stability, and nasal permeability for enhanced antidepressant efficacy. A preliminary study was conducted to select the optimized formulation. The preparation process involved using the thin-film hydration method, followed by freeze-drying. Comprehensive evaluations of optimized formulation characteristics included Z-average, polydispersity index (PdI), thermal behavior (lower critical solution temperature, LCST), encapsulation efficiency, X-ray powder diffraction (XRPD), thermodynamic solubility, and biological stability. Additionally, in vitro CT release and CT permeability in nasal conditions were studied. Stability under storage was also evaluated. Results: The optimized CT-PM formulation showed nanoscale micelle size (Z-average of 31.41 ± 0.99 nm), narrow size distribution (polydispersity index = 0.241), and a suitable thermal behavior for intranasal delivery (lower critical solution temperature (LCST) ~31 °C). Encapsulation efficiency reached approximately 90%, with an amorphous structure confirmed via XRPD, leading to a 95-fold increase in CT solubility. The formulation demonstrated appropriate biological and physical stability. In vitro studies showed a 25-fold faster CT release from optimized formulation compared to the initial CT, while CT-PM permeability in nasal conditions increased four-fold. Conclusions: This novel nanoscale thermosensitive formulation is a value-added strategy for nasal drug delivery systems, offering enhanced drug solubility, rapid drug release, stability, and improved permeability. This smart nanosystem represents a promising platform to overcome the limitations of conventional CT administration, improving therapeutic outcomes and patient compliance in depression management. Full article

Automated optical inspection (AOI) of wood surfaces is critical for ensuring product quality in the furniture and manufacturing industries; however, existing defect detection systems often struggle to generalize across complex grain patterns and diverse defect types. This study proposes a wood defect recognition model employing a Gabor Convolutional Network (GCN) that integrates convolutional neural networks (CNNs) with Gabor filters. To systematically optimize the network’s architecture and improve both detection accuracy and computational efficiency, the Taguchi method is employed to tune key hyperparameters, including convolutional kernel size, filter number, and Gabor parameters (frequency, orientation, and phase offset). Additionally, image tiling and augmentation techniques are employed to effectively increase the training dataset, thereby enhancing the model’s stability and accuracy. Experiments conducted on the MVTec Anomaly Detection dataset (wood category) demonstrate that the Taguchi-optimized GCN achieves an accuracy of 98.92%, outperforming a baseline Taguchi-optimized CNN by 2.73%. Results confirm that Taguchi-optimized GCNs enhance defect detection performance and computational efficiency, making them valuable for smart manufacturing. Full article

This study investigates the transformations of the Hungarian Catholic clergy during the 20th century in its social relations, self-perception, and attitudes, with a particular focus on the Diocese of Pécs. It concentrates on events that caused collective shock, such as the advance of the front and the Soviet occupation during World War II; the confiscation of church property; the enforced migration processes; and the impact of the Communist regime’s ecclesiastical and social policies. The analysis emphasizes the role- and context-dependent patterns discernible in the documents produced by the clergy concerning these events, particularly in the parish Historia Domus. The study models the impact of these violent reconfigurations on clergy dispositions within the framework of Bourdieu’s concept of habitus, specifically the notions of “cleft” and “plural habitus”, highlighting the significance of behavior patterns in praxis transmitted through generations of clergy. It interprets the discrepancy between the altered context of action and the long-established, “interiorized” habitus, considering the phenomenon of asynchronicity, and identifies general and context-specific characteristics through a method of historical comparison. Overall, the study offers a perspective that perceives the historically evolved specificities of the norm as intrinsically linked to the local context. Full article

Effective ocular drug delivery is still a challenge for pharmaceutical technologists due to the complex elimination mechanisms of the eye. In situ gels and polymeric micelles are among the pharmaceutical technologies that may enable us to overcome these challenges. Therefore, the objective of this study was to evaluate the ocular applicability of in situ gels and polymeric micelles, as well as their combinations, containing a steroidal anti-inflammatory drug, dexamethasone. The developed formulations were compared on the basis of their physicochemical characteristics, rheological behavior, mucoadhesion, in vitro drug release profile, and in vitro and ex vivo permeability. The developed formulations exhibited moderate stability according to the zeta potential measurements; however, they demonstrated appropriate mucoadhesion and sustained drug release. Furthermore, the results of the permeability studies suggest that combining thermoresponsive in situ gels and polymeric micelles represents a promising strategy for enhancing the therapeutic efficacy of ocular drug delivery. Full article

After the end of the Second World War, Hungary, like other war-torn countries, was left with countless orphaned children. The collapsed state structures were unable to care for them, so only various private or church initiatives—such as Gaudopolis, a children’s home set up by the Lutheran pastor Gábor Szehló—provided a means of survival. However, in East-Central Europe—including Hungary, Poland and Romania—where the Soviet Union had a sphere of influence, the emerging Soviet-style system was aimed at the political re-education of society. Ideological goals categorically excluded the possibility of churches being involved in the care and education of youth beyond the existing legal framework. Any person who engaged in such activities was cracked down upon. This study examines the role and responsibility of church persons in the care and upbringing of orphaned children through the fate of the Roman Catholic priest István Regőczi. In the decades of communist dictatorship, István Regőczi repeatedly reorganised orphanages, where he carried out youth education activities based on principles similar to scouting. The values he imparted to the children—such as the Christian religion, family protection, mutual help and social solidarity—were all values of Christian socialism. However, the communist dictatorship—promoting its own political ideology, Marxism—sought to take control of the upbringing and education of children by nationalising all institutions involved in this activity. Anyone who resisted this—as István Regőczi did—was made impossible in the people’s democracy of the 1950s and 1960s, and his child-saving, educating and teaching activities were prevented, even if the courts sentenced him to longer or shorter prison sentences for the crimes of illegal youth organisation, incitement and the abuse of freedom of association. This study, comparing what is described in István Regőczi’s memoirs with the surviving archival sources, shows how during these terrible decades it was possible to save orphaned, needy children and raise them in a Christian spirit, even against the will of the authorities. Full article

Background: Sacubitril/valsartan (S/V) improves left ventricular (LV) function and clinical outcome in heart failure (HF) with reduced ejection fraction (HFrEF). Data on its clinical value in the specific cohort of HFrEF patients demonstrating no adequate response to cardiac resynchronization therapy (CRT nonresponders; CRT-NRs) are limited. Herein, we investigated the impact of S/V initiated as a replacement for ACEi/ARB therapy in CRT nonresponder (CRT-NR) patients. Methods: Our HF database was searched to identify CRT-NRs who received S/V treatment for at least 6 months as a replacement for ACEi/ARB (Group I; 70 patients) and CRT-NRs who remained on ACEi/ARB (Group II, 70). In addition, HFrEF patients without CRT indication who received S/V therapy for at least 6 months (Group III; 135) were also included in this analysis. The primary endpoint was the composite of all-cause mortality including heart transplantation (HTx) or left ventricular assist device implantation (LVAD) and HF hospitalization (HFH). Secondary endpoints were (i) all-cause mortality+HTx+LVAD and (ii) HFH analyzed separately. Results: Over a median follow-up of 22 months, the primary composite endpoint occurred in 27 out of 70 patients (38.57%) in Group I, 43 out of 70 patients (61.42%) in Group II, and 60 out of 135 patients (44.42%) in Group III. The differences were significant between Groups I and II (p: 0.005), as well as between Group II and III (p: 0.012), while the two groups on S/V (Group I and III) demonstrated similar outcomes (p = 0.465). HFH analyzed separately as a secondary endpoint occurred in 19 out of 70 patients (27.14%) in Group I, 38 out of 70 patients (54.28%) in Group II, and 36 out of 135 patients (26.66%) in Group III (Group I vs. II p: 0.001; Groups II vs. III p: 0.001, Group I vs. III, p: 0.896). All-cause mortality+HTx+LVAD analyzed separately as the other secondary endpoint demonstrated no significant differences among the three groups. Conclusions: S/V therapy improved HFH but not mortality in CRT-NR patients. Comparable improvement was demonstrated after SV in the CRT-NR and in the general HFrEF cohort with no CRT indication. Full article

Dominant species form species-specific fine-scale vegetation matrices in grasslands that regulate community dynamics, diversity and ecosystem functioning. The structure of these dynamic microscale landscapes was analyzed and compared between primary and secondary plant communities. We explored fine-scale monitoring data along permanent transects over seven consecutive years. Spatial and temporal patterns of dominant grass species (Festuca valesiaca, Alopecurus pratensis and Poa angustifolia) were analyzed using information theory models. These matrix-forming species showed high spatiotemporal variability in all grasslands. However, consistent differences were found between primary and secondary grasslands in the spatial and temporal organization of the vegetation matrix. Alopecurus pratensis and Poa angustifolia had coarse-scale patchiness with stronger aggregation in secondary grasslands. The spatial patterns of Festuca valesiaca were nearly random in both types of grasslands. Strong associations were observed among the spatial patterns of each species across years, with a stronger dependence in secondary grasslands. In contrast, the rate of fine-scale dynamics was higher in primary grasslands. The complexity of microhabitats within the matrix was higher in primary grasslands, often involving two to three dominant species, while, in secondary grasslands, patches formed by a single dominant species were more frequent. In the spatial variability of small-scale subordinate species richness, significant, temporally consistent differences were found. Higher variability in secondary grasslands suggests stronger and more spatially variable microhabitat filtering. We recommend that grassland management and restoration practices be guided by preliminary information on the spatial organization of primary grasslands. Enhancing the complexity of the matrix formed by dominant species can further improve the condition of secondary grasslands. Full article

Aneurysmal subarachnoid hemorrhage (aSAH) is a severe stroke subtype often complicated by symptomatic cerebral vasospasm (sVP), contributing to delayed cerebral ischemia and poor outcomes. Immune dysregulation, particularly T-cell imbalances and pro-inflammatory cytokines, is implicated in vasospasm development. Soluble immune checkpoint proteins—CTLA-4 (sCTLA-4) and PD-L1 (sPD-L1)—regulate immune homeostasis and may serve as biomarkers or modulators of inflammation in aSAH. This prospective cohort study included 179 aSAH patients, divided into sVP+ (n = 48) and sVP− (n = 131), plus 50 healthy controls. Serum sCTLA-4 and sPD-L1 levels were measured on days 1, 5, and 9 post-ictus using Luminex xMAP. Associations with clinical outcomes were analyzed using non-parametric statistics and hierarchical clustering. Both sCTLA-4 and sPD-L1 were significantly elevated in sVP+ patients versus sVP− and controls, increasing over time. sCTLA-4 was significantly higher in sVP+ on days 5 (p = 0.001) and 9 (p < 0.001), and sPD-L1 on days 5 and 9 (both p < 0.001). Clustering revealed distinct expression patterns between sVP+ and sVP− groups. Elevated sCTLA-4 and sPD-L1 levels are associated with sVP after aSAH and may serve as biomarkers for early immune dysfunction, offering insights into potential therapeutic targets. Full article

Diabetic retinopathy (DR), a critical ocular disease that can lead to blindness, demands early and accurate diagnosis to prevent vision loss. Current automated DR diagnosis methods face two core challenges: first, subtle early lesions such as microaneurysms are often missed due to insufficient feature extraction; second, there is a persistent trade-off between model accuracy and efficiency—lightweight architectures often sacrifice precision for real-time performance, while high-accuracy models are computationally expensive and difficult to deploy on resource-constrained edge devices. To address these issues, this study presents a novel deep learning framework integrating depthwise separable convolution and a multi-view attention mechanism (MVAM) for efficient DR diagnosis using retinal images. The framework employs multi-scale feature fusion via parallel 3 × 3 and 5 × 5 convolutions to capture lesions of varying sizes and incorporates Gabor filters to enhance vascular texture and directional lesion modeling, improving sensitivity to early structural abnormalities while reducing computational costs. Experimental results on both the diabetic retinopathy (DR) dataset and ocular disease (OD) dataset demonstrate the superiority of the proposed method: it achieves a high accuracy of 0.9697 on the DR dataset and 0.9669 on the OD dataset, outperforming traditional methods such as CNN_eye, VGG, and UNet by more than 1 percentage point. Moreover, its training time is only half that of U-Net (on DR dataset) and VGG (on OD dataset), highlighting its potential for clinical DR screening. Full article

Background/Objectives: There is clear evidence that maternal micronutrient deficiencies result in adverse maternal and fetal health outcomes. Therefore, corrective supplementation should be considered when dietary intake is insufficient, particularly for vitamin D (VD), omega-3 fatty acids (O3), folic acid (FA), or prenatal multiple micronutrient products (PMM). Despite its significance, intake patterns in Hungary remain largely unexplored, and evaluating adherence to recommended intake levels would be of even greater importance. This is the first Hungarian study to provide a comprehensive overview of the frequency and adherence patterns of micronutrient supplementation among pregnant women, while also analyzing their association with predictors and outcomes. Methods: This cross-sectional study involved 300 pregnant women who delivered in a university hospital. Data were collected using a self-reported questionnaire and clinical maternal and neonatal records. Results: The prevalence of FA, VD, O3, and PMM intake among the participants was 89.0%, 76.4%, 58.7%, and 67.6%, respectively. However, adherence to recommendations was notably lower: 41.1% for VD, 37.5% for O3, 36% for PMM, and 31% for FA. Higher adherence was associated with older maternal age, higher educational level, county town residence, planned pregnancy, primiparity, previous spontaneous abortion, and early initiation of antenatal care. Our findings refute concerns about the obesogenic effect of supplementation for both mothers and newborns. FA intake correlated with a lower likelihood of cesarean section, while O3 use was associated with improved uterine contractility and reduced risk of gestational diabetes mellitus. Conclusions: Our study underscores the need for individualized counselling on micronutrient supplementation, with particular emphasis on appropriate timing, dosage, and potential benefits. Full article

This study proposes an image processing framework based on Bionic principles to optimize 3D visual perception in virtual reality (VR) systems. By simulating the physiological mechanisms of the human visual system, the framework significantly enhances depth perception and visual fidelity in VR content. The research focuses on three core algorithms: Gabor texture feature extraction algorithm based on directional selectivity of neurons in the V1 region of the visual cortex, which enhances edge detection capability through fourth-order Gaussian kernel; improved Retinex model based on adaptive mechanism of retinal illumination, achieving brightness balance under complex illumination through horizontal–vertical dual-channel decomposition; the RGB adaptive adjustment algorithm, based on the three color response characteristics of cone cells, integrates color temperature compensation with depth cue optimization, enhances color naturalness and stereoscopic depth. Build a modular processing system on the Unity platform, integrate the above algorithms to form a collaborative optimization process, and ensure per-frame processing time meets VR real-time constraints. The experiment uses RMSE, AbsRel, and SSIM metrics, combined with subjective evaluation to verify the effectiveness of the algorithm. The results show that compared with traditional methods (SSAO, SSR, SH), our algorithm demonstrates significant advantages in simple scenes and marginal superiority in composite metrics for complex scenes. Collaborative processing of three algorithms can significantly improve depth map noise and enhance the user’s subjective experience. The research results provide a solution that combines biological rationality and engineering practicality for visual optimization in fields such as implantable metaverse, VR healthcare, and education. Full article

Background: Modern implantable cardioverter-defibrillators (ICDs) utilize single-chamber (SC) or dual-chamber (DC) discrimination algorithms to differentiate between tachyarrhythmias and minimize the risk of inappropriate therapies. While modern SC algorithms, especially those with morphology detection, are considered comparable to DC algorithms, the available data are limited. We aimed to compare the efficacy of SC and DC discrimination algorithms in malignant tachyarrhythmias. Methods: We retrospectively analyzed data from all patients with ICDs from a single manufacturer (Biotronik, Berlin, Germany) who were remotely monitored and followed up at two tertiary centers. Patients were divided into SC and DC groups, based on the programmed discrimination algorithm. The primary outcome was the risk of inappropriate therapies comparing SC vs. DC discriminators. A sensitivity analysis was also conducted, including only a subgroup of SC patients with active morphology discrimination. Results: A total of 557 patients were included. The distribution of the implanted ICDs was as follows: 76 VVI; 226 VDD; 76 DDD; and 179 CRT-D devices. A total of 124 ICDs were programmed utilizing SC and 433 were programmed into the DC discriminators group. Among the SC group, 47 (39%) ICDs used active morphology discrimination. The incidence of inappropriate ICD therapies did not differ among the SC and DC discrimination groups (Hazard Ratio [HR] 1.165; 95% Confidence Interval [CI] 0.393–3.448; p = 0.783). The predefined sensitivity analysis did not reveal any significant difference regarding this outcome (HR 1.809; 95% CI 0.241–13.577; p = 0.564). Conclusions: In this bicentric, remote monitoring-based study, the risk of inappropriate therapy in the SC group was similar to that of the DC group. Based on our results, SC discrimination is a suitable option, even for patients with dual-chamber devices. Full article