Search Results (18,898)

Background and Objective: The availability of money to purchase food within the school setting has been identified as a factor associated with children’s nutritional status. The aim of this study was to analyze the relationship between spending on snacks and the nutritional status of Chilean schoolchildren living in a region in the far south. Methods: This was a descriptive, correlational, cross-sectional study. A total of 596 schoolchildren and adolescents (12.1 ± 1.3 years) from three public schools in the Magallanes Region, Chile, participated. Nutritional status was assessed using body mass index (BMI) for age, and a validated questionnaire was applied to assess frequency and type of food purchases within the school environment. To determine associations, ANOVA and Chi-square tests were used, with statistical significance set at p < 0.05. Results: Among boys, 25.8% were overweight, 36.4% with obesity, and 8.6% severely with obesity; among girls, 34.9% were overweight, 30.5% with obesity, and 5.5% severely with obesity. The average snack expenditure was 642.7 ± 658 CLP (Approximately USD 0.67). Weekly purchase frequency was once in 29.5% and twice in 26.9% of cases (p < 0.001), with no differences across BMI categories (ANOVA p = 0.469). Food preferences were unhealthy snacks in 46.5% and healthy snacks in 24.0% of cases, with no association with nutritional status (χ² = 6.073; df = 10; p = 0.728). Conclusion: Although no direct association was found between snack spending and nutritional status, high consumption of unhealthy foods reflects a persistent risk. The results highlight the importance of strengthening public and educational policies regarding school meals. A comprehensive approach is needed that combines regulation, nutrition education, and family involvement. This study provides novel evidence for the design of interventions in southern and isolated regions. Full article

Biodegradable composites obtained by reinforcing thermoplastic starch (TPS) with lignocellulosic fibers show great potential, but their strong sensitivity to water still limits practical applications. Among possible reinforcements, Helianthus tuberosus (topinambur) represents an underutilized agricultural residue that has been scarcely explored in this context. In this work, we demonstrate for the first time that topinambur fiber can improve the water vapor barrier properties of cassava starch films, while also providing a detailed analysis of sorption isotherms and the humidity-dependent relationship between surface roughness and contact angle, aspects rarely addressed in previous studies. SEM revealed uniform fiber dispersion and integration. Water sorption kinetics showed that fiber addition reduces both hydration and sorption time constant, indicating lower water affinity and greater water mobility. Water sorption isotherms confirmed that fiber incorporation significantly alters overall hydration and water–matrix interactions, revealing reduced effective water solubility in films. Water vapor permeability also decreased with fiber addition, mainly due to decreased water solubility, rather than changes in water diffusivity. While fiber addition enhanced surface-water repellency across all humidity levels, roughness exhibited a humidity-dependent response FTIR analysis confirmed fiber–matrix compatibility and suggested new hydrogen bonding. Overall, these findings identify topinambur fiber as a novel reinforcement for designing biodegradable films with improved humidity resistance for agroecological applications. Full article

We present a study based on first-principles calculations of the vibrational and spectroscopic properties of four types of layered boron nitride (BN) polymorphs: e-BN (AA), h-BN (${\mathrm{AA}}^{\prime }$), r-BN (ABC), and b-BN (AB). By using density functional perturbation theory with van der Waals corrections, we calculate phonon frequencies and Raman/infrared (IR) activities at the $\mathsf{\Gamma }$ point and extract specific spectral fingerprints for each stack. In e-BN, we observe a sharp, isolated high-frequency $E^{\prime }$ mode at $1420.9{\mathrm{cm}}^{-1}$ that is active in both Raman and IR. For h-BN, the characteristic Raman $E_{2g}$ line occurs at $1415.5{\mathrm{cm}}^{-1}$. The out-of-plane IR-active $A_{2u}$ branch shows a mid-frequency TO/LO pair at 673.5/$806.6{\mathrm{cm}}^{-1}$, which closely matches experimental results. Rhombohedral r-BN has a strong, coincident Raman/IR high-frequency feature (E) at $1418.5{\mathrm{cm}}^{-1}$, along with a large IR LO partner at $1647.3{\mathrm{cm}}^{-1}$, consistent with observed Raman and IR signatures. Bernal b-BN displays the most complicated pattern. It combines a robust mid-frequency $A_2^{″}$ pair (TO/LO at 697.9/$803.5{\mathrm{cm}}^{-1}$) with multiple high-frequency $E^{\prime }$ modes (TO near 1416.9 and $1428.1{\mathrm{cm}}^{-1}$, each with LO counterparts). These stack-dependent Raman and IR fingerprints match existing experimental data for h-BN and r-BN and provide clear predictions for e-BN and b-BN. The results offer a consistent framework for identifying and interpreting vibrational spectra in layered $s{p}^2$ boron nitride and related materials. Full article

Background/Objectives: Dysgeusia is a taste disorder commonly associated with chronic inflammation, reducing the quality of life, particularly in ageing populations or individuals with non-communicable chronic diseases. This study aimed to evaluate the effect of β-Caryophyllene, a natural sesquiterpene and agonist of the cannabinoid receptor 2 (CB2), on dysgeusia through an analysis of inflammation, Renin–Angiotensin System (RAS) and taste perception. Methods: Male BALB/c mice were subjected to a dysgeusia model induced by molecular mimicry with lipopolysaccharide. Animals received intraperitoneal injections of lipopolysaccharide in a chronic–persistent regimen, starting at a dose of 35 μg/100 g body weight for 7 days until reaching a final concentration of 250 μg/100 g and a daily oral administration of β-Caryophyllene at a dose of 10 mg/kg. The effect of β-Caryophyllene on taste perception, inflammatory biomarkers, RAS key-elements, CB2 expression and physiological parameters was evaluated. Results: Data indicate that β-Caryophyllene attenuates systemic inflammation by decreasing IL-1β and IL-6 and increasing ACE2 enzymatic activity in lingual tissue. Also, it was shown that the sesquiterpene reduced taste cell apoptosis and improved sucrose preference, suggesting a feasible restoration of taste dysfunction. Conclusions: These findings demonstrate that β-Caryophyllene could be a potential candidate for treating dysgeusia due to its putative anti-inflammatory and angiotensinergic effects. Full article

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CFTR gene, which encodes a cAMP-activated chloride channel essential for epithelial function. Beyond its canonical role, evidence suggests CFTR also influences mitochondrial function. Previous studies have identified CFTR- and Cl-dependent genes, including MTND4 and CISD1, which are downregulated in CF cells and play a critical role in mitochondrial function. CF cells exhibit altered mitochondrial complex I (mCx-I) activity and impaired electron transport chain function, although the underlying mechanisms remain unclear. In this study, the impact of the CFTR modulators lumacaftor (VX-809) and ivacaftor (VX-770) on mitochondrial morphology and function was investigated in heterozygous ΔF508/W1282X CF IB3-1 cells. Combined treatment with VX-809 (10 μM, CFTR corrector) and VX-770 (0.1 μM, CFTR potentiator) induced a fragmented mitochondrial morphology in both CF and CF expressing wt-CFTR cells, without affecting cell viability or mitochondrial membrane potential (ΔΨm). While individual treatments differentially modulated ROS production and ΔΨm, these effects were not statistically significant under combined treatment. These results highlight a previously unrecognized role for CFTR modulators in shaping mitochondrial morphology. A better understanding of these effects may reveal novel mechanisms underlying the regulation of mitochondrial structure and function. Full article

Under the discourses of sustainable development and modernization of the Amazon, an iron triangle of governments, companies, and investors often impose large-scale infrastructure projects (LSIPs) on Indigenous peoples to facilitate commodity extraction and market transactions in a context of capitalist market expansion. Indigenous resistance to LSIPs can be understood as a power struggle against coloniality and towards decolonizing environmental justice (DEJ). This study merges DEJ and power frameworks, while involving Indigenous leaders as co-researchers to provide a critical, insider perspective on the (i) motivations, (ii) strategies, and (iii) agency of two effective Indigenous resistance processes: the luchas led by Yunguillo Indigenous Reserve against roads, and by the Mancomunidad de Comunidades de los ríos Beni, Tuichi y Quiquibey against hydroelectric dams. In both cases, motivations reflected DEJ goals: the defense of Indigenous autonomy and territorial sovereignty, as well as Indigenous ontologies and epistemologies, reflecting an alternative vision of sustainability and development. However, locals’ positions regarding the projects were convoluted, partly due to the patronizing and divisive strategies of the iron triangle. To challenge the coloniality of power, both groups applied a diverse, synergistic, and adaptative set of strategies. External and internal alliances (i.e., with other actors and within communities), as well as actions to empower themselves as groups (e.g., self-governance) and individuals (e.g., spirituality) constituted key organizational leveraging strategies to increase their power-with and power-within. The instrumental strategies of collective action, civil disobedience, and direct resistance, in a climate of highly unjust and poorly trusted official institutions, showed great effectiveness to exert pressure on the iron triangle (power-over) and halt the projects (power-to, or agency). Success, nevertheless, was partial and uncertain: one battle won in an unequal war and in a changing context. This study seeks to contribute to previous efforts to decolonize and repoliticize academia, environmentalism, and sustainability, advance debates on strategies that challenge official systems and entrenched power structures, and validate Indigenous perspectives and experiences, producing scientific evidence that contributes to their luchas. Full article

Avian influenza A viruses pose ongoing threats to human and animal health, with H7 subtypes causing outbreaks globally. In Mexico, highly pathogenic H7N3 viruses have circulated in poultry since 2012, causing sporadic human infections. Here we analyzed genetic markers in hemagglutinin sequences from Mexican H7N3 isolates and conducted serological assays on human populations with poultry exposure. Our results show conserved avian-like receptor binding sites, thus limiting human adaptation, alongside antigenic drift and acquisition of glycosylation sites likely driven by vaccination. Serological testing of 1103 individuals revealed no detectable antibodies against H7N3, indicating a naïve population. Phylogenetic analyses revealed multiple virus clades circulating regionally. These findings suggest that while current H7N3 viruses have limited capacity for sustained human transmission, the lack of population immunity underscores the importance of continued surveillance and risk assessment to mitigate potential pandemic threats. Full article

Multi-view inverse synthetic aperture radar (ISAR) image sequences provide multi-dimensional observation information about space targets, enabling precise attitude estimation that is fundamental to both non-cooperative target monitoring and critical space operations including active debris removal and space collision avoidance. However, directly utilizing all images within an ISAR sequence for attitude estimation can result in a substantial data preprocessing workload and reduced algorithm efficiency. Given the inherent overlap and redundancy in the target information provided by these ISAR images, this paper proposes a novel space target attitude estimation method based on the selection of multi-view ISAR image sequences. The proposed method begins by establishing an ISAR imaging projection model, then characterizing the target information differences through variations in imaging plane normal, and proposing an image selection method based on the uniform sampling across elevation and azimuth angles of the imaging plane normal. On this basis, the method utilizes a high-resolution network (HRNet) to extract the feature points of typical components of the space target. This method enables simultaneous feature point extraction and matching association within ISAR images. The attitude estimation problem is subsequently modeled as an unconstrained optimization problem. Finally, the particle swarm optimization (PSO) algorithm is employed to solve this optimization problem, thereby achieving accurate attitude estimation of the space target. Experimental results demonstrate that the proposed methodology effectively filters image data, significantly reducing the number of images required while maintaining high attitude estimation accuracy. The method provides a more informative sequence than conventional selection strategies, and the tailored HRNet + PSO estimator resists performance degradation in sparse-data conditions, thereby ensuring robust overall performance. Full article

Carnosic acid (CA) is a phenolic diterpene with high antioxidant activity that supports its radioprotective capacity. This study aims to determine whether the radiosensitizing effect of CA established in B16F10 melanoma cells also occurs in other melanin-producing cells. Cell survival analysis, apoptosis, intracellular glutathione levels, and cell cycle progression were evaluated by comparing radiosensitive cells (PNT2) with radioresistant melanin-producing cells (MELAN A, SK-MEL-1, and B16F10). In PNT2 cells, CA exhibited radioprotective capacity, with 100% cell survival after exposure to 20 Gy of X-rays (p < 0.001), decreasing apoptosis (p < 0.001) and increasing the GSH/GSSG ratio (p < 0.01), without significant modification in cell cycle progression. However, CA administration to irradiated cells failed to exert radioprotection in MELAN A and SK-MEL-1 cells, and even doubled cell death in B16F10 cells (p < 0.001). Specifically, CA did not alter apoptosis or prevent the decrease in GSH/GSSG ratio in MELAN A and SK-MEL-1 cells, while it intensified radiation-induced cell cycle disruptions in all melanin-producing cells. All of these led to a loss of radioprotective capacity in the melanin-producing cells (MELAN A and SK-MEL-1) and even induced a radiosensitizing effect in B16F10 cells. Understanding the mechanisms of action of substances such as CA could promote new applications that protect healthy cells and exclusively damage neoplastic cells when both are present within the same irradiated volume in cancer patients requiring radiotherapy. Full article

Background/Objectives: Overweight and obesity during pregnancy are metabolic risk factors that may compromise offspring brain development. The first 1000 days of life represent a critical window in which neurodevelopmental trajectories are shaped by intrauterine and early-life exposures. The 6- and 12-month milestones are key checkpoints where deviations may emerge, and interventions are most effective. This study evaluated the association between maternal pregestational weight status and infant neurodevelopment at 6 and 12 months of age. Methods: Mother and infant pairs from the OBESO perinatal cohort in Mexico City were included. Women in the first trimester of pregnancy were classified as normal weight and overweight/obesity according to their pregestational body mass index (pBMI), calculated from self-reported pre-pregnancy weight. Infant neurodevelopment was assessed at 6 and 12 months using the Bayley Scales of Infant Development III, Third Edition (BSID-III). Descriptive, bivariate and multiple linear regression analyses with mixed effects correction were conducted. Results: Among 97 mother–infant pairs, infants of mothers with overweight/obesity had lower language and socio-emotional scores at 12 months. Higher maternal pBMI was correlated with lower motor scores at 6 and 12 months, and with lower language scores at 12 months. Longitudinal analysis showed that maternal overweight/obesity was associated with a significant decline in language development from 6 to 12 months. (p = 0.002). Conclusions: Maternal pregestational overweight or obesity may negatively influence early neurodevelopment, particularly affecting language and cognitive domains during the first year of life. These early deficits could reflect alterations in intrauterine programming associated with maternal metabolic status. Full article

Stress is a predisposing factor for pulmonary diseases; however, its effects on the lungs of healthy individuals have not been fully elucidated. Since bovine lactoferrin (bLf) is a powerful immunomodulator, this study aimed to evaluate whether lactoferrin can modulate the effects of chronic stress on humoral and cellular immunity in the lungs. We performed chronic restraint stress (RS) and oral administration of bLf in a BALB/c model, assessing serum corticosterone, body weight, and various lung immunity parameters, including immunoglobulin concentrations in serum and tracheobronchial lavages (TBLs), secretory IgA (S-IgA) levels in TBLs, IgA-secreting plasma cells, relative expression of pIgR, CD4⁺ lymphocyte Th1 and Th2 populations, and antigen-presenting cell (APC) populations in the lungs. Our results demonstrate that stress increases corticosterone and production of total IgA and IgG, while decreasing levels of IgM and S-IgA, promotes a Th1/Th2 profile imbalance, and decreases APC populations. Interestingly, bLf modulates serum corticosterone levels and stress-induced weight loss, and it also modulates humoral and cellular effects produced by chronic stress. These results demonstrate that bLf should be considered a new therapeutic target for further studies, focusing on prophylactic and co-therapeutic administration to treat and prevent respiratory diseases. Full article

We propose a novel mathematical model of a multistable erbium-doped fiber laser based on Caputo fractional derivative equations. The model is used to investigate how the laser dynamics evolve as the derivative order is varied. Our results demonstrate that the fractional-order formulation provides a more accurate description of the experimentally observed laser dynamics compared to conventional integer-order models. This study highlights the importance of fractional calculus in modeling complex nonlinear photonic systems and offers new insights into the dynamics of multistable lasers. Full article

Hyperuricemia, characterized by elevated serum uric acid levels, is a major risk factor for gout and kidney disease. This study evaluated the antihyperuricemic effects of Cornus officinalis extract (COE) using urate transporter 1 (URAT1)-expressing oocytes and a hyperuricemia rat model. COE effectively inhibited uric acid absorption by modulating URAT1, with an IC₅₀ value of 3.24 µg/mL. In the hyperuricemia model, COE administration (100 and 200 mg/kg) significantly reduced serum uric acid levels and increased urinary uric acid excretion. The primary constituents of COE, morroniside (MO) and loganin (LO) exerted similar effects, with MO exhibiting potent inhibition of uric acid absorption even at low concentrations. Kidney tissue analysis revealed a reduction in blood urea nitrogen (BUN) levels, indicating improved renal function. Liver function parameters (ALT, AST, and LDH) remained unchanged, suggesting an absence of hepatotoxicity. Ultra-high-performance liquid chromatography with charged aerosol detection (UHPLC-CAD) analysis identified MO (17.8 mg/g), LO (9.8 mg/g), and cornin (1.4 mg/g) as the principal components of COE. These findings suggest that COE enhances uric acid excretion via URAT1 regulation and exerts renoprotective effects, highlighting its potential as an antihyperuricemic agent. Furthermore, MO and LO were identified as the primary active constituents, and COE appears to be a promising therapeutic candidate with a favorable safety profile. Full article

Health professionals commonly reference race and ethnicity to inform health care and administrative decisions. However, health researchers (and, arguably, society at large) misapply race and ethnicity when assuming an inherent relationship of these concepts with biological and health outcomes of interest. Misapplication of race potentially results from socially embedded identification predicated upon race essentialism, the belief that people within a racial group share “inherent” biological traits that define them as distinct from other racial groups. This false belief is often associated with implied racial hierarchies obscuring authentic causal disease relationships. Similarly, ethnicity is a socially and politically constructed group descriptor for people from a similar national or regional background who may share common cultural, historical, and social experiences. Thus, as for race, no inherent biological information is contained within such group definitions. This article summarizes the Research Centers for Minority Institutions (RCMI) 2025 Annual Grantee Meeting keynote session on Race and Ethnicity in Medicine. The session described how society originated and subsequently applied/misapplied race and ethnicity in various domains of policy and public health. The keynote session also considered the use of race and ethnicity in describing and envisioning biomedical research, clinical trials, clinical practice, and health services research. The authors summarize a more tenable use of race and ethnicity to advance biomedical research and health by focusing upon social and environmental drivers of health, population representation in clinical trials, and other factors. Associated recommendations from the keynote session are provided. Full article

Alterations in both oral and gut microbiomes have been associated with Alzheimer’s disease and related dementia (ADRD). While extensive research has focused on the role of gut dysbiosis in ADRD, the contribution of the oral microbiome remains relatively understudied. This study aims to evaluate distinct patterns and potential synergistic effects of oral and gut microbiomes in a cohort of predominantly Hispanic individuals with cognitive impairment (CI) and without cognitive impairment (NC). We conducted 16S rRNA gene sequencing on stool and saliva samples from 32 participants (17 CI, 15 NC; 62.5% female, mean age = 70.4 ± 6.2 years) recruited in San Antonio, Texas, USA. Differential abundance analysis evaluated taxa with significant differences between both groups. While diversity metrics showed no significant differences between CI and NC groups, differential abundance analysis revealed an increased presence of oral genera such as Dialister, Fretibacterium, and Mycoplasma in CI participants. Conversely, CI individuals exhibited a decreased abundance of gut genera, including Shuttleworthia, Holdemania, and Subdoligranulum, which are known for their anti-inflammatory properties. No evidence was found for synergistic contributions between oral and gut microbiomes in the context of CI. Our findings suggest that like the gut microbiome, the oral microbiome of CI participants undergoes significant modifications. Notably, the identified oral microbes have been previously associated with periodontal diseases and gingivitis. These results underscore the necessity for further investigations with larger sample sizes to validate our findings and elucidate the complex interplay between oral and gut microbiomes in ADRD pathogenesis. Full article