Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = Roskamp reaction

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
21 pages, 11946 KB  
Review
The Versatility of the Roskamp Homologation in Synthesis
by Margherita Miele, Aljoša Smajić and Vittorio Pace
Molecules 2025, 30(6), 1192; https://doi.org/10.3390/molecules30061192 - 7 Mar 2025
Cited by 1 | Viewed by 3276
Abstract
Modern organic synthesis continues to benefit from the flexibility of α-diazo carbonyl intermediates. In the context of homologation processes, the Roskamp reaction—first introduced in 1989—has become a valuable tool due to its selectivity and mild condition reactions for accessing important synthons amenable to [...] Read more.
Modern organic synthesis continues to benefit from the flexibility of α-diazo carbonyl intermediates. In the context of homologation processes, the Roskamp reaction—first introduced in 1989—has become a valuable tool due to its selectivity and mild condition reactions for accessing important synthons amenable to further functionalization as β-keto esters. The fine-tuning of reaction parameters—including the nature of Lewis acids, solvents, and temperature—has enabled the development of catalyzed continuous-flow methodologies, as well as a series of asymmetric variants characterized by high transformation rates, excellent stereocontrol, and formidable chemoselectivity. This review aims to emphasize the attractive features of the Roskamp reaction and its applicability for addressing challenging homologation processes. Full article
(This article belongs to the Section Organic Chemistry)
Show Figures

Figure 1

Back to TopTop