Search Results (1,552)

Background: Chronic shoulder pain is a prevalent musculoskeletal disorder often associated with central sensitisation, which limits the effectiveness of conventional therapies. Transcranial direct current stimulation (tDCS) has emerged as a non-invasive neuromodulatory intervention to modulate cortical excitability and potentially improve pain and functional outcomes. Methods: This scoping review followed the Joanna Briggs Institute (JBI) framework and PRISMA-ScR guidelines. A systematic search was conducted across MEDLINE, CENTRAL, Scopus, PEDro, and Web of Science to identify studies evaluating the effects of tDCS on pain and function in adults with rotator cuff disorders, myofascial pain syndrome (MPS), or subacromial pain syndrome (SAPS). Data were extracted and synthesised qualitatively. Results: Four studies met the inclusion criteria. tDCS demonstrated variable efficacy: some trials reported no additional benefit when used alongside corticosteroid injections or sensorimotor training (e.g., SAPS and rotator cuff tendinopathy), while others showed enhanced pain reduction and functional gains, particularly in MPS. Targeting the dorsolateral prefrontal cortex (DLPFC) appeared more effective than stimulating the primary motor cortex (M1) in modulating pain. Functional improvements were generally observed, though not consistently superior to sham interventions. Conclusions: Preliminary evidence suggests that tDCS may represent a promising adjunctive treatment for chronic shoulder pain, particularly in MPS. However, due to the limited number of studies and heterogeneity in methods, conclusions should be interpreted with caution. However, heterogeneity in study protocols, stimulation targets, and patient populations limits conclusive recommendations. Standardised protocols and larger trials are needed to determine the optimal application of tDCS in clinical shoulder pain management. Full article

In recent years, the incidence of colorectal cancer has been increasing annually. During the research on tumor treatment strategies, the translation of fundamental research findings into clinical applications has often been constrained by the limitations of existing tumor models, with few breakthroughs achieved to date. Therefore, our objective is to explore the feasibility of utilizing self-assembling short peptides (SAPs) to construct a three-dimensional (3D) culture system for colorectal adenocarcinoma cells for anticancer drug screening. By characterizing the physicochemical properties and biocompatibility of SAP SCIOBIO III, we demonstrated that it can rapidly self-assemble into a nanofibrous scaffold under ionic triggers, supporting 3D cell culture. Subsequently, anticancer drug sensitivity tests were conducted on both 2D and 3D culture systems of colorectal adenocarcinoma cells. The results indicate that SCIOBIO III can mimic the extracellular matrix and serves as an ideal scaffold for constructing a 3D cell culture microenvironment. We successfully established a 3D culture model for colorectal adenocarcinoma cells and effectively screened anticancer drugs, which holds promise for advancing the development of personalized anticancer drug screening technologies. Full article

During the flowering period of mango trees, pests often hide in the inflorescences to suck sap, affecting fruit formation. By accurately detecting the number and location of mango inflorescences in the early stages, it can help target-specific spraying equipment to perform precise pesticide application. This study focuses on mango panicles and addresses challenges such as high crop planting density, poor image quality, and complex backgrounds. A series of improvements were made to the YOLOv8 model to enhance performance for this type of detection task. Firstly, a mango panicle dataset was constructed by selecting, augmenting, and correcting samples based on actual agricultural conditions. Second, the backbone network of YOLOv8 was replaced with FasterNet. Although this led to a slight decrease in accuracy, it significantly improved inference speed and reduced model parameters, demonstrating that FasterNet effectively reduced computational complexity while optimizing accuracy. Further, the GAM (Global Attention Module) attention mechanism was introduced as an attention module in the backbone network to enhance feature extraction capabilities. Experimental results indicated that the addition of GAM improved the average precision by 2.2 percentage points, outperforming other attention mechanisms such as SE, CA, and CBAM. Finally, the model’s bounding box localization ability was enhanced by replacing the loss function with WIoU, which also accelerated model convergence and improved the mAP@.5 metric by 1.1 percentage points. Our approach demonstrates a discrepancy of less than 10% compared to manual counted results. Full article

Stress-associated proteins (SAPs), belonging to the A20/AN1 zinc finger protein family, are key regulators in plant stress responses. Despite their importance, studies on the SAP gene family in Pinus massoniana are still relatively scarce. This study aimed to systematically identify and characterize SAP genes in P. massoniana and to explore their potential roles in stress response mechanisms. A total of 17 PmSAP genes were identified from P. massoniana. Phylogenetic analysis revealed that these genes group into five distinct clades, and 10 conserved motifs were identified. Using transcriptome data and qRT-PCR, we analyzed their expression patterns and employed yeast systems to validate their transcriptional activities. The responses of PmSAP gene family members to different stress treatments showed significant differences. For example, PmSAP8 and PmSAP12 responded strongly to ABA, MeJA, and H₂O₂ treatments, while PmSAP3 and PmSAP5 showed significant upregulation under ETH and NaCl stress. Yeast experiments indicated that PmSAP6/8/12 were transcriptional activators, and PmSAP3 and PmSAP5 were transcriptional suppressors. The identification and preliminary analysis of PmSAP genes provided a theoretical foundation for understanding stress resistance mechanisms in P. massoniana. Full article

As the average age of the population increases, memory impairment has become an increasingly prevalent issue. This study investigates the effects of 14 days of oral birch sap administration on memory functions in healthy rats using the Morris water maze (MWM) test and explores the underlying mechanisms. A compositional analysis revealed that birch soap is rich in polysaccharides, specifically a low-molecular weight polysaccharide (MW 1.29 kDa), and exhibits no hepatotoxicity or renal toxicity at the tested dose. The results from the MWM test demonstrated that the time and distance required to reach the platform were significantly shorter in the birch sap-treated group compared to the control group, suggesting that birch sap supports memory preservation. Moreover, rats treated with birch sap showed improved cerebral blood flow compared to the control rats. Additionally, in hippocampal nerve terminals (synaptosomes), rats treated with birch sap exhibited a significant increase in evoked glutamate release, as well as elevated levels of presynaptic proteins, including vesicular glutamate transporter 1 (VGluT1), synaptophysin, synaptobrevin, synaptotagmin, syntaxin, synapsin I, and the 25 kDa synaptosome-associated protein (SNAP-25). Transmission electron microscopy also revealed a notable increase in the number of synaptic vesicles in hippocampal synaptosomes of the birch-sap-treated rats. These findings suggest that birch sap enhances hippocampal presynaptic glutamatergic functions and cerebral blood flow, contributing to its memory-preserving effects in rats. Full article

Fast-growing technology and the development of IT services give the idea of founding a new application of stochastic processes and their properties. We give a new connection between electronic process management and a stochastic process named the bivariate Pólya–Aeppli counting process. This process is applied as a counting process in the mathematical construction of the given model and it has been introduced as a counting process in electronic process management. In our current study, we assume a company that has two locations in two countries—Bulgaria and Romania. For seamless communication and data sharing, the integrated factories leverage the System Applications and Products in Data Processing (SAP) system. By combining these functions into one structure, we optimize coordination, streamline operations, and improve the company’s productivity and profitability. The automated tools within the system facilitate uninterrupted production and secure supply chains and thus the decision making is improved. A key benefit of these tools is to boost production and procurement activities for success in today’s competitive market which results in cost savings, will increase visibility, and also will improve rapid decision making. Full article

This study identifies key drivers for ERP implementation in small- and medium-sized enterprises (SMEs) in Austro–Ecuador and examines their impact on operational efficiency, strategic adaptability, and digital transformation. Motivated by the limited empirical evidence on ERP adoption in Latin American SMEs, this research aims to provide Austro–Ecuadorian insights that contribute to innovation management practices in emerging economies. To identify the critical success factors (CSFs) influencing ERP implementation, a four-phase methodology was employed, encompassing a CSF literature review, data collection and case analysis from 55 SMEs, multiple correspondence analysis (MCA), and descriptive ERP analysis. Statistical analysis of the surveyed SMEs, primarily from manufacturing sectors, revealed that while a significant portion (37%) lacked ERP experience, 22.9% were in the process of implementing or actively using systems such as Oracle’s J.D. Edwards Enterprise One and SAP. The MCA highlighted ERP system configuration, vendor relationships, and user training as significant factors for successful ERP implementation, reported by 54.5% of the companies. Quadrant analysis further emphasized the influence of IT structure and legacy systems on implementation characteristics, with cluster analysis identifying three distinct groups of companies based on their ERP strategies. The findings underscore the importance of top management support, business process re-engineering, and external consultants for successful ERP adoption in SMEs, providing practical insights for optimizing innovation management in the digital era. Future research should investigate the long-term impacts of ERP systems on organizational performance and innovation sustainability. Full article

The aim of this research is to determine the effect of nanocoating retrofitting on the dynamic responses of industrial steel chimneys. A 20 m high industrial steel chimney was selected for nanocoating retrofitting. First, a three-dimensional finite element model of the chimney was created, and modal analysis was performed in SAP2000 software, and frequency values and mode shapes were obtained. Later, linear analyses of the chimney were made using the 1995 Kobe earthquake ground motion recording. Then, the outer surface of the chimney was retrofitted with a 1 mm MgO nanocoating, and dynamic analyses were made. Finally, the chimney’s dynamic responses before and after the MgO retrofit, such as minimum–maximum von Mises stresses and displacements, were compared. At the end of the study, it was observed that the displacements along the chimney height, especially maximum displacements, decreased from 150 mm to 140 mm, and the minimum von Mises stress at the bottom of the chimney decreased from 37.20 kPa to 30.19 kPa, and the maximum von Mises stress from 1519.27 kPa to 1332.33 kPa stresses in the analyses results. The decrease in frequency values revealed that MgO nanocoating had a positive effect on the stiffness of the chimney. It can be understood from this study that nanocoatings will be very useful in retrofitting industrial steel chimneys and have an effect on dynamic parameters. Full article

Superabsorbent polymers (SAPs) are widely employed as an internal curing agent to enhance the durability and shrinkage–cracking resistance of concrete. However, while its macroscopic effects on concrete properties (e.g., strength reduction) have been documented, the nanoscale mechanisms governing the mechanical behavior of calcium silicate hydrate (C-S-H) gel in SAP-modified concrete remain poorly understood. This knowledge gap limits the optimization of SAP content for balancing durability and strength, a critical challenge in high-performance concrete design. In this paper, we address this scientific problem by combining experimental characterization and molecular dynamics (MD) simulations to systematically investigate how SAP-induced pore structure modifications dictate the mechanical performance of C-S-H gel. First, we analyzed the effects of SAP on concrete pore structure and compressive strength, revealing its role in refining capillary pores into gel pores. Next, MD simulations were employed to construct C-S-H gel models with controlled pore size distributions at three SAP contents (0.2%, 0.3%, and 0.5%), to establish a quantitative relationship between pore characteristics and material performance. The results reveal that pores of ~0.74 nm diameter, predominantly located in weak interfacial regions, critically govern the mechanical behavior of C-S-H gel. At 0.2% SAP content, the C-S-H gel exhibits the highest bulk modulus (10.61 GPa) and optimal mechanical properties, whereas 0.3% SAP leads to a dominant pore cluster at 1.12 nm, resulting in significant reductions in bulk modulus (30.8%), shear modulus (29%), and Young’s modulus (22.3%). These findings establish a quantitative pore-property relationship, providing a mechanistic basis for tailoring SAP content to enhance both durability and mechanical performance in concrete, ultimately advancing the design of longer-lasting infrastructure. Full article

Background/Objectives: In the past, FhSAP-2, an 11.5 kDa recombinant protein belonging to the Fasciola hepatica saposin-like/NK-lysin family, has been shown to induce over 60% partial protection in immunized rabbits and mice when challenged with F. hepatica metacercariae. However, despite FhSAP-2 being a promising vaccine candidate, its hydrophobic nature has made its purification a challenging process. The present study aimed to determine whether a modified 9.8 kDa variant of protein (mFhSAP-2), lacking a string of 16 hydrophobic amino acids at the amino terminus and a dominant Th1 epitope, could retain its immunogenic and Th1-inducing properties. Methods: RAW264.7 cells were stimulated with mFhSAP-2, and TNFα levels were determined. C57BL/6 mice were immunized with mFhSAP-2 alone or emulsified with Montanide ISA50. Total anti-mFhSAP-2 IgG subtypes, along with their avidity and titers, were measured using ELISA. The T cell proliferation index and levels of CD4+/CD8+ and IFNγ/IL-4 ratios were determined. Results: In vitro, mFhSAP-2 induced dose-dependent TNFα production in RAW264.7 cells. In vivo, mice immunized with mFhSAP-2 or mFhSAP-2+ISA50 developed high-avidity IgG2a and IgG2c antibodies at levels that were significantly higher than IgG1 antibody levels. However, the mFhSAP-2+ISA50 formulation induced higher and more homogenous antibody titers than mFhSAP-2, suggesting that an adjuvant may be required to enhance mFhSAP-2 immunogenicity. Immunization with mFhSAP-2+ISA50 also induced significantly higher activated CD4+/CD8+ T cell ratios and IFNγ/IL-4 ratios compared to naïve mice. Conclusions: Our results demonstrate that mFhSAP-2 retained its immunogenicity and Th1-polarizing properties, which were enhanced by the Montanide ISA50 adjuvant. The present study highlights the feasibility of inducing Th1-associated immune responses in mice using mFhSAP-2 as an antigen. Further studies are required to assess the potential application of the mFhSAP-2+ISA50 formulation as a vaccine against F. hepatica in natural hosts such as cattle and sheep, which could contribute to improved control and aid in the prevention and eradication of F. hepatica infection. Full article

Grains stored in silos and pellets for injection molding deteriorate in quality due to increased moisture in the particles when exposed to air for a long period of time, so it is necessary to reduce the moisture in the particles through the mixing process. However, few studies have conducted parallel experiments and simulations to understand the behavior of particles depending on their moisture content. In this study, mixing experiments were conducted using superabsorbent polymer (SAP) beads that expand depending on the moisture content, and the interparticle friction coefficient and interface friction coefficient required for simulation were derived. As a result, it was found that moisture generates an adhesive force that causes interparticle cohesion, and as the moisture content increases further, the particles adhere to the vessel wall due to the adhesive force. In addition, particles with high moisture content (e.g., 90%) showed faster mixing behavior similar to dry particles, as indicated by the Lacey Mixing Index (LMI), while low moisture particles (e.g., 60%) showed the slowest mixing. It is expected that the mixing characteristics of particles depending on the moisture content can be understood and will be useful for the design of horizontal shaft mixers. Full article

Superabsorbent polymers have been introduced into cementitious materials to solve issues related to early-age cracking, caused by shrinkage, and manual repair. A general improvement of autogenous healing is noticed, while the extent and effectiveness depend on the type of hydrogel and the amount included. To evaluate the self-healing effectiveness, the regain of mechanical performance needs to be assessed. However, such evaluation requires destructive testing, meaning that the healing progress cannot be followed over time. As a solution, air-coupled ultrasonic testing was used within this study, adopting a novel laser interferometer as a receiver, to estimate the regained properties of cementitious mixtures with and without superabsorbent polymers. The sensitivity of ultrasonic waves to the elastic properties of the material under study allows us to monitor the crack healing progress, while the semi-contactless nature of the procedure enables an easy and reliable measurement. Up to 80% recovery in ultrasonic velocity was achieved with reference concrete, while SAP concrete demonstrated up to 100% recovery after wet–dry curing. Following microscopic analysis, up to 19% visual crack closure was obtained for reference concrete, compared to a maximum of 50% for SAP mixtures, for average crack widths between 250 µm and 450 µm. Full article

European mistletoe is a hemi-parasitic plant increasingly infesting forests in Central Europe, causing premature tree death, and is anticipated to expand its range due to global warming. This study aimed to describe the unique anatomical features of mistletoe and examine the morpho-anatomical response of pine trees to infestation. Anatomical analyses were conducted on mistletoe internodes and the branch wood of affected pines. The findings revealed that mistletoe infestation triggers callose deposition in the cell walls of pine tracheids, a defense mechanism that restricts water flow to the mistletoe. Unique structural features of mistletoe were also identified, including structural dimorphism with the inner system forming only vessels and parenchyma cells, in contrast to the outer system, composed of protective, ground, and conductive tissues, and which displays an uneven distribution of chlorophyll and starch grains along the plant axis. Additionally, starch and chlorophyll were present in the parenchyma cells of the haustorium. Starch presence there may potentially enable internal photosynthesis, and the compounds formed after starch hydrolysis may facilitate water uptake from the host’s xylem sap. These results provide new insights into the anatomical adaptations of mistletoe and the defensive responses of pine trees, contributing to a deeper understanding of host–parasite interactions in forest ecosystems. Full article

This study evaluates the seismic fragility and code compliance of reinforced concrete buildings in Turkey following the 6 February 2023 Kahramanmaraş earthquake. Sixty representative buildings were modeled in SAP2000, consisting of thirty structures designed according to TEC-1975 and thirty according to TEC-1998. These models were subjected to three-dimensional nonlinear time history analyses using ground motions scaled to match the seismic characteristics of the earthquake. Structural performance was assessed by comparing calculated displacement demands with capacity thresholds defined by modern code provisions. The results show that buildings designed under TEC-1998 generally performed better than those constructed according to TEC-1975, particularly in terms of deformation capacity and collapse resistance. Fragility curves and exceedance probabilities were developed to quantify damage likelihoods across different performance levels. When compared with post-earthquake field observations, the analytical models produced lower collapse rates, which may suggest the presence of widespread code noncompliance in the actual building stock. These findings highlight the critical importance of ensuring adherence to seismic design regulations to improve the resilience of existing structures. Full article

Implied by the terminologies “Harang Reversal” and “Harang Discontinuity”, there are two significant features of the Harang region: (i) the reversal of auroral electrojets along with the underlying plasma convection flow and electric (E) fields, and (ii) the discontinuity between the electrojets/convection flows/E-fields. Even the earliest studies reported the discontinuity observed in the meridional E-field. Conversely, some of the previous studies state that convection flow and E-field reversals do not involve any physical discontinuity. We investigate these two features (i–ii) observed in five topside-ionosphere Harang scenarios. Each scenario occurred during a sequence of events that led to the onset of the substorm expansion phase, when the Harang region was newly formed. Our results show (1) the newly formed Harang region between the dusk and dawn convection cells, where one convection cell wraps around the other, (2) the zonal drift- and E-field reversals, (3) the discontinuity between the dusk and dawn convection flows and also between the reversing E-field components, and (4) the Earthward electromagnetic energy deposition locally minimizing or diminishing within the discontinuity and peaking within the reversing zonal drift and E-fields. Thus, the observed convection flow and E-field reversals involved the development of discontinuity. Full article