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Vitamins and Nutraceuticals for the Maintenance of Brain Health and Treatment of Neurodegenerative Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 788

Special Issue Editor

Special Issue Information

Dear Colleagues,

The word “nutraceutical” (from “nutrition” and “pharmaceutical”) encompasses the pharmacological action of nutritional elements which are identified as useful for the prevention or treatment of conditions or diseases. Neurological diseases have a major impact on the population; as such, it is good to know that there is a very close link between the mind and nutrition. Many food-based substances are potentially useful in the prevention and treatment of cognitive decline in pre-clinical studies; however, further studies are needed to confirm their beneficial effects in humans.

A nutraceutical approach useful for improving cognitive abilities must consider an adequate dietary intake of vitamins and micro- and macronutrients.

The main objective of this Special Issue will be to improve our understanding of the functions of vitamins and/or nutraceuticals in brain health, by regulating pertinent molecules and signaling pathways, reducing oxidative stress, modulating molecular mechanism of neuroinflammation, suppressing the formation and aggregation of the pathogenic protein, etc. Specifically, we will publish high-quality reviews or original research articles that examine the role of vitamins and nutraceuticals in cognitive functions and/or neurodegenerative diseases, identifying molecular pathways as pharmacological targets aimed at therapeutic strategies.

We are pleased to invite you to contribute original articles, reviews, communications, etc. We look forward to your contributions to this Special Issue.

Dr. Maria Antonietta Panaro
Guest Editor

Manuscript Submission Information

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Keywords

  • vitamin
  • nutraceutics
  • brain
  • neuroinflammation
  • neurodegeneration
  • cognitive function

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Published Papers (1 paper)

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Research

13 pages, 575 KiB  
Article
Can Vitamin D Reduce Inflammation? The Influence of Supplementation on Selected Immunological Markers
by Martyna Lis, Natalia Niedziela, Jowita Adamczyk-Zostawa, Jolanta Zalejska-Fiolka, Michał Błachut, Jarosław Szczygieł, Agata Świętek and Monika Adamczyk-Sowa
Int. J. Mol. Sci. 2024, 25(14), 7592; https://doi.org/10.3390/ijms25147592 - 11 Jul 2024
Viewed by 586
Abstract
There is increasing evidence that vitamin D (VitD) supplementation may reduce inflammation in individuals with multiple sclerosis (MS). The aim of this study was to evaluate the effect of different doses of VitD on selected markers of inflammation in patients with relapsing–remitting MS [...] Read more.
There is increasing evidence that vitamin D (VitD) supplementation may reduce inflammation in individuals with multiple sclerosis (MS). The aim of this study was to evaluate the effect of different doses of VitD on selected markers of inflammation in patients with relapsing–remitting MS (RRMS). Participants were divided depending on the supplemented dose of VitD into a high-dose (2000 IU/d; HD) group and a low-dose (15,960 IU/month; LD) group (n = 23 and n = 29, respectively). The concentration of 25(OH)D and the levels of CXCL16, PTX3, ALCAM, IL-1RA, and OPG were measured initially and after six months of VitD supplementation in blood serum. A significant increase in the concentrations of CXCL16, PTX3, and OPG was observed during the study (p = 0.02, p = 0.01, and p < 0.01, respectively). Furthermore, a higher increase in PTX3 and OPG in the LD group was observed (p = 0.04 and p = 0.03, respectively). A significant positive correlation was observed between the 25(OH)D serum concentration and PTX3 (R = 0.28, p < 0.05) and OPG (R = 0.28, p < 0.05) only at the beginning of the study. In patients with RRMS, such doses of VitD might be too low to induce obvious beneficial effects on the pro-inflammatory and inflammatory balance. Full article
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