Search Results (3,970)

Background: While TSH suppression is essential in patients with differentiated thyroid cancer (DTC) to reduce the risk of recurrence, it has also been linked to side effects, particularly a reduction in bone mineral density that may contribute to osteoporosis. However, previous studies investigating this association have yielded inconsistent results. This study aimed to evaluate bone density using Hounsfield units from PET/CT scans in a longitudinal analysis including both sexes. Methods: Patients with DTC under continuous TSH suppression who underwent two PET/CT scans were included. Hounsfield units were measured for each lumbar vertebra (L1–L5) in the CT by placing an elliptical region of interest (ROI) in the center of the vertebra, avoiding hyperdense edges. Laboratory parameters were also collected. Results: A total of 50 patients were included in the study (25 male, 25 female), with a mean age of 57.2 (±15.3) years at the time of the first scan. The mean duration of TSH suppression before the first scan was 3.7 ± 3.9 years, and the mean interval between both scans was 4.4 ± 4.0 years. At the follow-up scan, bone density was significantly lower compared with baseline for all lumbar vertebrae (L1–L5 combined and individually) (all p < 0.05). Subgroup analysis revealed a significant decline in women at L1, L2, L4, and L5 and for overall lumbar bone density, while men showed nonsignificant trends. Conclusions: Our study suggests a sustained reduction in vertebral bone density during TSH suppression. The results support routine monitoring in both sexes, risk stratification by age and duration of suppression, and, when oncologically appropriate, consideration of lower suppression intensity or initiation of bone-protective therapy in high-risk patients. Full article

Public-health campaigns have to capture and hold visual attention, but little is known about the influence of message framing and visual appeal on attention to bowel-cancer screening ad campaigns. In a within-subjects test, 42 UK adults aged 40 to 65 viewed 54 static adverts that varied by (i) slogan frame—anticipated regret (AR) vs. positive (P); (ii) image type—hand-drawn, older stock, AI-generated; and (iii) identity congruence—viewer ethnicity matched vs. unmatched to the depicted models. Remote eye-tracking measured time to first fixation (TTFF), dwell, fixations, and revisits on a priori pre-defined regions of interest (ROIs); analyses employed linear mixed-effects models (LMMs), generalized estimating equations (GEEs), and median quantile regressions with cluster at the participant level. Across models, the AR slogans produced faster orienting (smaller TTFF) and more intense maintained attention (longer dwell, more fixations and revisits) than the P slogans. Image type set baseline attention (hand-drawn > old stock > AI) but did not significantly decrease the AR benefit, which was equivalent for all visual styles. Identity congruence enhanced early capture (lower TTFF), with small effects for dwell-based measures, suggesting that tailoring benefits only the “first glance.” Anticipated-regret framing is a reliable, design-level alternative to improving both initial capture and sustained processing of screening messages. In practice, the results indicate that advertisers should pair regret-based slogans with warm, human-centred imagery; place slogans in high-salience, low-competition spaces, and, when incorporating AI-generated imagery, reduce composition complexity and exclude uncanny details. These findings ground regret framing as a visual-attention mechanism for public-health campaigns in empirical fact and provide practical recommendations for testing and production. Full article

Steel-reinforced thermoplastic pipe is widely used for water transportation in sour gas fields. However, under the combined effects of corrosive media, internal high pressure, and long-term environmental aging, premature failures such as leakage and bursting often occur. To clarify the failure causes and primary contributing factors of the composite pipes, this study conducted a comprehensive analysis through microscopic morphology examination of different typical failure cases, differential scanning calorimetry, Fourier transform infrared spectroscopy, and mechanical property testing. The main failure mechanisms were investigated, and targeted protective measures are proposed. Key findings reveal that the typical failure modes are ductile cracking, aging-induced brittle cracking, and aging creep cracking. These failures follow a mechanism of degradation of the inner and outer polyethylene protective layers, penetration of the medium and corrosion of the steel wires, reduction in pressure-bearing capacity, and eventual structural damage or leakage propagation through the pipe wall. Notably, oxidation induction time values dropped as low as 1.4–17 min—far below the standard requirement of >20 min—indicating severe antioxidant depletion and material aging. The main controlling factors are poor material quality, external stress or mechanical damage, and long-term aging. The polyethylene used for the inner and outer protective layers is critical to the overall pipe performance; therefore, emphasis should be placed on evaluating its anti-aging properties and on protecting the pipe body during installation to ensure the long-term safety and stable operation of the pipeline system. Full article

Since the early 19th century, linguists have collected enough linguistic data to draw a remarkably stable Uralic language family tree. However, the traditional Uralic language family tree has two main problems. First, it lacks a reliable chronology because linguistic data can suggest that some languages are closer or farther from each other, but that gives only a relative instead of a precise chronology of the branching events. Second, the extinct Mezhovskaya culture in the Ural region and the Minoan civilization on the island of Crete were not incorporated into the Uralic language family, although recent archaeogenetic and linguistic data indicate that their languages also belonged to the Uralic language family. Some recent studies took an essentially purely archaeogenetic approach to the study of the evolution of the Uralic language family. These purely archaeogenetic studies propose linguistically perplexing solutions. This is the first study of the development of the Uralic language family that fully integrates the archaeogenetic, archaeological and linguistic data and proposes a new chronology of the Uralic language family that avoids the above inconsistencies. The new chronology relies on the best current estimates of the formation of the mitochondrial DNA haplogroups that are found among present Uralic language speakers and in samples from various archaeological sites that are associated with Uralic speakers. The new chronology places the various branching events of the Uralic language family tree much earlier than usual, including the split between Proto-Finno-Permic and Proto-Ugric, which is shown to have taken place in the Mesolithic period. The new proposal makes the Bronze Age Minoan language better fit chronologically as well as linguistically into the Uralic language family. Full article

The COVID-19 pandemic imposed unprecedented restrictions on movement and daily life, testing the resilience and adaptability of existing housing stock, as families worldwide were forced to adapt their homes into multifunctional environments. In New Zealand, where lockdowns were among the most stringent globally, homes rapidly transformed into workplaces, schools, gyms, and places of refuge. Little is known about how these adaptations affected the sustainability of homes and occupants’ well-being, particularly in the context of future crises. This study examined the economic, environmental, and psychosocial impact of the COVID-19 lockdown on New Zealand households. A questionnaire survey was conducted, and a quantitative analysis method was employed using survey data from 92 valid responses from New Zealand respondents who experienced lockdowns in various types of housing. To find important patterns and connections, descriptive and inferential statistical analyses were conducted. Findings revealed that economic factors had the strongest influence on respondents’ perceived experience during the COVID-19 lockdown, with households reporting increased electricity and water use but reduced fuel costs. Environmental factors were also significant, with respondents noting the importance of fresh air, sunlight, acoustic privacy, and more spacious rooms, alongside the critical need for a dedicated workspace. Psychosocial effects included higher distraction levels, monotony, and heightened concern for health. Group differences highlighted the influence of age and the number of bedrooms on the perceived experience of lockdown. This pilot work offers a New Zealand perspective on the intersection of the pandemic with the sustainability of homes. The practical implications of this study highlight the need for sustainable housing retrofits, hybrid work policies that support ergonomic and acoustically adequate home offices, and demographic-sensitive interventions to enhance resilience and occupant well-being in future crises. Full article

Background: Access to and use of health services represent crucial issues/challenges for older people experiencing frailty with functional limitations and chronic diseases, especially when they age in place alone. Both access to and use of health services are also characterised by gender differences. The present study analysed these factors in three Italian regions (Lombardy, North; Marche, Centre; and Calabria, South), where in 2019, the “Inclusive Ageing in Place” (IN-AGE) project was carried out, involving 120 senior people aged 65 years and of both genders. Methods: In this mixed-methods study, both qualitative (predominant section) and some quantitative data (e.g., socio-demographic aspects and functional limitations) were collected through semi-structured interviews. In addition to basic quantitative analyses, content analysis and the quantification of statements were performed to process the qualitative data. The results for both men and women are presented. Possible barriers to accessing health services were also considered. Results: Women reported more cases of chronic diseases than men, especially arthritis/osteoporosis, and a greater use of drugs than men. Both genders used services provided by the general practitioner (GP) and medical specialist (MS), the latter being mostly private. More women than men used rehabilitation, especially in the private sector, and reported the issue of cost for private healthcare and the travel distance to reach medical units as barriers to access. The long waiting lists/times were complained about by both males and females. Conclusions: This study, despite its simple/descriptive qualitative approach with a limited sample, could provide, however, some insights for policymakers and healthcare professionals to plan prevention policies and deliver appropriate and timely health services to older people experiencing frailty and ageing in place alone, devoting attention to gender-related issues in the design and provision of such services. Full article

This study documents the first A1-type granite identified on the southern margin of the central Lhasa terrane: a two-mica syenogranite pluton in the Meibaqieqin region. Because A-type granite provides sensitive records of crustal melting and lithospheric extension, this pluton offers important insights into magmatic processes and tectonic evolution along the southern margin of the Lhasa terrane. We analyzed two sample suites collected from different sites within the same pluton using zircon U–Pb geochronology and Hf isotopes, whole-rock geochemistry and Nd isotope. Zircon U–Pb weighted mean ages were 130.5 ± 0.7 Ma and 130.0 ± 0.7 Ma, placing emplacement in the Early Cretaceous. Zircon ε_Hf(t) values ranged from −11.29 to −9.00 and −11.04 to −7.27, with two-stage Hf model ages (T_DM2) of 1.76–1.90 Ga and 1.65–1.89 Ga. Whole-rock ε_Nd(t) values clustered between −11.77 and −11.36, yielding two-stage Nd model ages (T_NdDM2) of 1.85–1.88 Ga. Geochemically, the pluton is high-K calc-alkaline. These isotopic signatures indicate derivation predominantly from ancient crustal sources with a little mantle material. Chondrite-normalized REE patterns are overall right-inclined and display a V-shaped profile. Together with trace-element characteristics, these features support classification as A1-type granite. Regional comprehensive data suggest that pluton emplacement was controlled mainly by lithospheric extension related to northward subduction of the Neo-Tethyan oceanic plate, with a lesser contribution from southward subduction along the Bangongco–Nujiang suture. The source characteristics and geodynamic context differ markedly from A2-type granites on the northern margin of the central Lhasa terrane, which reflect distinct magmatic sources and tectonic regimes. Full article

Background: In healthcare institutions, radiologists play an essential role in patients’ care, enabling them to begin treatment and start their recoveries. However, data on the characteristics and distribution of the radiology workforce in Saudi Arabia are limited. Therefore, this study aimed to conduct a comprehensive analysis of the radiology workforce in SA based on national data and identify key distributional and specialty trends relevant to workforce planning and radiology service delivery. Methods: The following data were obtained from the Saudi Commission for Health Specialties (SCFHS) Registry: total number of registered radiologists, age, subspecialty, professional classification, place of qualification, and geographical location. Descriptive statistics were used for data analysis. Additionally, the findings were compared with those of published international benchmarks. Results: There were 5150 radiologists registered with SCFHS in SA, which corresponded to 147 radiologists per 1,000,000 inhabitants. The mean age was 40.8 years (standard deviation [SD] 9.8), with 60% of them being aged 30–44 years. Most of the radiologists specialised in general diagnostic radiology (83.7%), with few of them specialising in interventional radiology (1.8%), paediatric radiology (1.1%), and breast imaging (0.9%). The workforce mainly comprised consultants (35.0%), followed by registrars (29.7%) and senior registrars (22.7%). Two-thirds (65.0%) of the radiologists had obtained their qualifications abroad. More than half of the radiologists resided in three provinces: Riyadh (29%), Mecca (23%), and the Eastern Region (15%), while several provinces had fewer than 2% of the available workforce. Conclusions: The radiology workforce in SA is relatively young and has a higher density than the average in the European Union. Further, most of the radiologists are professionally classified as consultants or registrars. However, there is a clear imbalance in their geographic distribution, which is consistent with the population sizes of the respective cities. Targeted training expansion and reduced reliance on foreign-trained professionals are warranted to meet future service demands in line with the Vision 2030 objectives. Full article

Low-emissivity (low-e) coatings are used in architectural and automotive glazing for energy-saving applications. These are used to minimise heat transmission through the windows by reflection. Low-e coatings are semi-transparent coatings that typically comprise a metallic layer that reflects infrared light, sandwiched between two dielectric layers that protect the metal and enhance its visible transmittance. Ag is usually used as the metallic layer because of its colour neutrality and low optical absorption in the visible range. However, Ag-based low-e coatings easily degrade upon atmosphere exposure; therefore, they need to be placed inside the cavities of multiple-pane windows. In this paper, Au was used as an alternative to Ag and was sandwiched between WO₃, SnO₂ and Nb₂O₅ dielectric layers. The thickness of each layer was optimised to achieve the highest visible transmittance and infrared reflectance. The durability of the coatings was assessed by means of corrosion and abrasion resistance tests. We demonstrate that the Nb₂O₅/Au/Nb₂O₅ coating system provides a visible light transmittance of 56%, an emissivity as low as 0.04 and outstanding corrosion resistance (1000 h of salt spray testing), indicating its excellent potential to be used as first surface low-e coating. Full article

Dementia and mild cognitive impairment (MCI) are growing health concerns in Canada’s aging population. Over 700,000 Canadians currently live with dementia, and this number is expected to rise. As the older adult population increases, coupled with an already strained healthcare system, there is a pressing need for innovative tools that support aging in place. This study explored the feasibility and acceptability of using a Digital Human (DH) conversational agent, combined with AI-driven speech analysis, to monitor cognitive function, anxiety, and depression in cognitively healthy community-dwelling older adults (CDOA) aged 65 and older. Sixty older adults participated in up to three in-person sessions over six months, interacting with the DH through journaling and picture description tasks. Afterward, 51 of the participants completed structured interviews about their experiences and perceptions of the DH and AI more generally. Findings showed that 84% enjoyed interacting with the DH, and 96% expressed interest in learning more about AI in healthcare. While participants were open and curious about AI, 67% voiced concerns about AI replacing human interaction in healthcare. Most found the DH friendly, though reactions to its appearance varied. Overall, participants viewed AI as a promising tool, provided it complements, rather than replaces, human interactions. Full article

The global population of older adults is growing rapidly, and refugees are now a significant proportion of the older adult population in Canada. Transnational healthcare practices (THPs)—seeking health information or services from the country of origin—may be an essential strategy used by refugee older adults in Canada, but few studies have explored this phenomenon. This is a protocol for a study, which is aimed at developing a comprehensive understanding of the role THPs play in the lives of older adults from three refugee groups (Afghan, Syrian and Ukrainian) (re)settled in the Greater Toronto Area (GTA), Canada. It will be informed by Constructivist Grounded Theory and will consist of three phases. Phase 1 will involve semi-structured individual interviews with Afghan, Syrian, and Ukrainian refugee older adults living in the GTA (n = 75–90) to explore their perspectives and experiences with various types of THP. Phase 2 will also involve semi-structured interviews with 75–90 refugee older adults from the three communities to examine the role of THP in stress, coping, and resilience in the context of health promotion, illness diagnosis, and disease management as well as the individual and contextual factors driving the use of THPs. Phase 3 will involve six focus groups (n = 36–48) with refugee older adults from these communities to explore what information, care, supports, technology, and services are needed to manage their health and illnesses locally. This project will advance knowledge in the areas of (re)settlement and integration, aging, local healthcare access, and THPs among refugee older adults in Canada. The findings will inform more effective integration policies and the delivery of efficient and equitable health information, care, support, technology, and services that address the healthcare needs of refugee older adults, enabling them to age well and age in place. Full article

Pandemics place extraordinary pressure on healthcare systems, particularly in identifying and prioritizing high-risk groups such as the elderly, pregnant women, and individuals with chronic diseases. Existing Artificial Intelligence models often fall short, focusing on single diseases, lacking interpretability, and overlooking patient-specific vulnerabilities. To address these gaps, we propose an Explainable Deep Learning approach for identifying at-risk patients during pandemics (AI-RiskX). AI-RiskX performs risk classification of patients diagnosed with COVID-19 or related infections to support timely intervention and resource allocation. Unlike previous models, AI-RiskX integrates five public datasets (asthma, diabetes, heart, kidney, and thyroid), employs the Synthetic Minority Over-sampling Technique (SMOTE) for class balancing, and uses a hybrid convolutional neural network–long short-term memory model (CNN–LSTM) for robust disease classification. SHAP (SHapley Additive exPlanations) enables both individual and population-level interpretability, while a post-prediction rule-based module stratifies patients by age and pregnancy status. Achieving 98.78% accuracy, AI-RiskX offers a scalable, interpretable solution for equitable classification and decision support in public health emergencies. Full article

Background/Objectives: Superficial bacterial skin infections are common, particularly among athletes. In swimming, data on folliculitis, impetigo, and pitted keratolysis are limited. This study aimed to evaluate the prevalence of superficial bacterial skin infections in young competitive swimmers from Greek clubs. Methods: An anonymous questionnaire was distributed to all swimming clubs through the Hellenic Swimming Federation, with a request to forward it to their members. It was completed by 1047 swimmers or their parents. Data collection included skin conditions along with explanatory notes, as well as additional information such as gender, swimming age category, season of occurrence, training routine details, and hygiene-related behaviors. Results: The study showed that 2.7% of participants reported being affected by folliculitis, 10.9% by impetigo, and 3.2% by pitted keratolysis. Infections were significantly correlated with age categories. Folliculitis and pitted keratolysis were less frequent and were mainly reported by adolescent and adult swimmers. In contrast, impetigo was more common and primarily affected younger age groups. Specific behaviors—such as placing towels and clothes on locker room benches—were significantly associated with pitted keratolysis (p = 0.036) and impetigo (p < 0.001). Sharing equipment was associated with all three infections. Conclusions: This study highlights the high prevalence of bacterial skin infections in Greek swimmers, likely due to moisture exposure, shared equipment, and specific hygiene habits. Full article

The method addresses the challenges of non-steady conditions at an early age by combining wavelet filtering and empirical mode decomposition (EMD) to separate strain components arising from shrinkage, expansive agent compensation, temperature variations, construction disturbances, and live loads. The approach incorporates construction logs as external constraints to ensure accurate correspondence between signal features and physical events. Scientifically, this study addresses the fundamental problem of identifying and quantifying multi-source strain components under transient and non-steady construction conditions, which remains a major challenge in the field of structural monitoring. Field monitoring was conducted on typical cast-in-place concrete components: a full-width bridge deck in the negative moment region. The results show that both structural types exhibit a distinct shrinkage–recovery process at an early age but differ in amplitude distribution, recovery rate, and restraint characteristics. During the construction procedure stage, the cast-in-place segment in the negative moment region was sensitive to prestressing and adjacent segment construction. Under variable loads, the former showed higher live load sensitivity, while the latter exhibited more pronounced temperature-driven responses. Total strain decomposition revealed that temperature and dead load were the primary long-term components in the structure, with differing proportional contributions. Representative strain variations observed in the field ranged from 10 to 50 µε during early-age shrinkage–expansion cycles to 80–100 µε reductions during prestressing operations, quantitatively illustrating the evolution characteristics captured by the proposed method. This approach demonstrates the method’s capability to reveal transient stress mechanisms that conventional steady-state analyses cannot capture, providing a reliable basis for strain monitoring, disturbance identification, and performance evaluation during construction, as well as for long-term prediction and optimization of operation–maintenance strategies. Full article

Background: Adolescence is characterized by rapid physical growth and neuromuscular reorganization, which may influence the development of postural control. Gender-specific differences in pubertal timing suggest that girls may achieve postural stability earlier than boys, but evidence remains inconsistent. This cross-sectional pilot study aimed to examine gender differences in static postural control among adolescents. Material and methods: A total of 59 students (28 females, 31 males; mean age 13.49 ± 0.97 years) from two schools in Bari, Italy, participated. Postural stability was assessed during bipedal and single-leg stance tasks under eyes-open and eyes-closed conditions using an inertial sensor placed at the lumbosacral region. The primary outcomes were sway path length and oscillation ellipse area. Results: Females demonstrated significantly shorter path length in eyes-open bipedal stance (p = 0.027, d = −0.51), as well as reduced ellipse area (p = 0.047, d = −0.44) and path length (p = 0.010, d = −0.62) in eyes-closed bipedal stance. No significant gender differences were observed in single-leg stance. Conclusions: These findings support the hypothesis that adolescent girls exhibit superior postural stability compared to boys, particularly under challenging sensory conditions. Such differences may reflect earlier maturational processes and suggest possible implications for motor development, injury prevention, and sports training. Full article