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54 pages, 3153 KB  
Review
Beyond GLP-1 Agonists: An Adaptive Ketogenic–Mediterranean Protocol to Counter Metabolic Adaptation in Obesity Management
by Cayetano García-Gorrita, Nadia San Onofre, Juan F. Merino-Torres and Jose M. Soriano
Nutrients 2025, 17(16), 2699; https://doi.org/10.3390/nu17162699 - 20 Aug 2025
Viewed by 704
Abstract
Background/Objectives: Long-term obesity management consistently fails due to two major barriers: poor adherence, exacerbated by ultra-processed foods with addictive potential, and post-weight loss metabolic adaptation that reduces energy expenditure by approximately 500 kcal/day. Current paradigms—static diets and GLP-1 receptor agonists—address these barriers only [...] Read more.
Background/Objectives: Long-term obesity management consistently fails due to two major barriers: poor adherence, exacerbated by ultra-processed foods with addictive potential, and post-weight loss metabolic adaptation that reduces energy expenditure by approximately 500 kcal/day. Current paradigms—static diets and GLP-1 receptor agonists—address these barriers only partially. The objectives of this thesis-driven review are: (1) to conduct a focused evidence-mapping of Ketogenic–Mediterranean Diet (KMD) protocols; (2) to analyze why existing protocols have not explicitly countered metabolic adaptation; and (3) to present the Adaptive Ketogenic–Mediterranean Protocol (AKMP). Methods: Hybrid methodology—an argumentative narrative review anchored by a structured evidence-mapping search (PRISMA-style flow for transparency). Results: We identified 29 studies implementing KMD protocols with significant weight loss and superior adherence. However, none of the published protocols explicitly implement anti-adaptive strategies, despite an estimated ketogenic metabolic advantage (≈100–300 kcal/day), context-dependent and more consistently observed in longer trials and during weight-maintenance settings. Conclusions: Unlike GLP-1 receptor agonists—which primarily suppress appetite, require ongoing pharmacotherapy, and do not directly mitigate the decline in energy expenditure—the AKMP couples a Mediterranean foundation for adherence with a ketogenic metabolic advantage and a biomarker-guided adjustment system explicitly designed to counter metabolic adaptation, aiming to improve the durability of weight loss and patient self-management. As a theoretical construct, the AKMP requires confirmation in prospective, controlled studies; accordingly, we outline a pragmatic 24-week pilot design in “Pragmatic Pilot Trial to Validate the AKMP–Incretin Sequencing”. Full article
(This article belongs to the Special Issue The Ketogenic Diet: Biochemical Mechanisms and Clinical Applications)
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19 pages, 1330 KB  
Article
Reflections on How Adults Respond to Children’s Contributions in Children–Adult Argumentative Interactions
by Elisa Angiolini and Céline Miserez-Caperos
Educ. Sci. 2025, 15(8), 1069; https://doi.org/10.3390/educsci15081069 - 20 Aug 2025
Viewed by 235
Abstract
This paper aims to analyze adults’ responses to children’s argumentative contributions within children–adult dialogic interactions. More precisely, we focus on the phenomenon of children opening subdiscussions within argumentative interactions with peers and adults. This phenomenon occurs when a child problematizes and calls into [...] Read more.
This paper aims to analyze adults’ responses to children’s argumentative contributions within children–adult dialogic interactions. More precisely, we focus on the phenomenon of children opening subdiscussions within argumentative interactions with peers and adults. This phenomenon occurs when a child problematizes and calls into question some proposition in the ongoing discussion, hence the opening of a subdiscussion is an initiative that comes as unexpected from the perspective of the adult. In this contribution, we examine what happens after a child opens a subdiscussion and how the adult’s reaction to such initiatives can shape the development of dialogue. This means that we observe adult behaviour in dialogic interactions with children, given the complexity of the adult’s role in such interactions. Drawing on the dialogical approach to argumentation, we present and discuss some excerpts of children–adult subdiscussions at a kindergarten. The data analysis uses concepts and tools from a linguistics-based approach to argumentation, i.e., the pragma-dialectical theory, and it highlights conversational dynamics of children–adult argumentative discourse. The study’s contribution is twofold: (1) it presents the important and delicate role of the adult in dialogic children–adult interactions; (2) it shows how the development of children’s arguments is intrinsically linked to the flexibility of the discussion space organized by the adult. Full article
(This article belongs to the Special Issue Dialogic Pedagogy in Early Childhood Education)
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35 pages, 493 KB  
Article
A Study of Grammatical Gradience in Relation to the Distributional Properties of Verbal Nouns in Scottish Gaelic
by Avelino Corral Esteban
Languages 2025, 10(8), 199; https://doi.org/10.3390/languages10080199 - 20 Aug 2025
Viewed by 298
Abstract
Verbal nouns in Insular Celtic languages have long been a subject of interest because they are capable of exhibiting both nominal and verbal properties, posing a persistent challenge when it comes to determining their precise categorization. This study therefore seeks to examine the [...] Read more.
Verbal nouns in Insular Celtic languages have long been a subject of interest because they are capable of exhibiting both nominal and verbal properties, posing a persistent challenge when it comes to determining their precise categorization. This study therefore seeks to examine the intersective gradience of verbal nouns in Scottish Gaelic from a functional-typological and multidimensional perspective, providing an insight into the interaction between their morphosyntactic, semantic, and pragmatic properties and their lexical categorization, and, consequently, encouraging a broader discussion on linguistic gradience. This hybrid category plays a central role in the clause structure of Scottish Gaelic, as it appears in a wide range of distinct grammatical constructions. Drawing on a range of diagnostic tests revealing the morphosyntactic and semantic properties of verbal nouns across various contexts (e.g., etymology, morphological structure, inflection, case marking, TAM features, syntactic function, types of modification, form and position of objects, distributional patterns, cleft constructions, argument structure, subcategorization, etc.), this line of research identifies two key environments, depending on whether the construction features a verbal noun functioning either as a verb or a noun. This distinction aims to illustrate the way in which these contexts condition the gradience of verbal nouns. By doing so, it provides strong evidence for their function along a continuum ranging from fully verbal to fully nominal depending on their syntactic context and semantic and pragmatic interpretation. In conclusion, the findings of this study suggest that the use of verbal nouns blurs the line between two lexical categories, often displaying mixed properties that challenge a rigid categorization. Full article
18 pages, 1562 KB  
Article
Continuous Symmetry Breaking and Complexity of Biological Membranes
by Samo Kralj, Veronika Kralj-Iglič and Aleš Iglič
Crystals 2025, 15(8), 737; https://doi.org/10.3390/cryst15080737 - 20 Aug 2025
Viewed by 253
Abstract
We consider domain-type patterns in biological membranes that possess an in-plane membrane order. Domains are inseparably linked to topological defects, and many features related to them can be guessed based on universal topological arguments. However, much more complex membrane patterns are typically observed. [...] Read more.
We consider domain-type patterns in biological membranes that possess an in-plane membrane order. Domains are inseparably linked to topological defects, and many features related to them can be guessed based on universal topological arguments. However, much more complex membrane patterns are typically observed. As possible generators of such configurations, we analyze two relatively simple and universal phenomena. Both are based on continuous symmetry breaking (CSB), which manifests ubiquitously in all branches of physics. We present the Imry–Ma argument which, in addition to CSB, requests the presence of uncorrelated random-field-type disorder. Next, we discuss the Kibble–Zurek mechanism. In addition to CSB it considers dynamical slowing when a relevant phase transition is approached. These approaches were originally introduced in magnetism and cosmology, respectively. We adapt them to effectively two-dimensional membranes and discuss their potential role in membrane structure formation. Full article
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21 pages, 337 KB  
Article
Materially Dispossessing the Troubled Theologian
by John C. McDowell
Religions 2025, 16(8), 1076; https://doi.org/10.3390/rel16081076 - 19 Aug 2025
Viewed by 192
Abstract
Linn Tonstad’s paper, ‘(Un)wise Theologians’, identifies a theological approach that puts pressure on its ability to handle its materiality sufficiently in a number of ways. However, following the trajectory of Tonstad’s discovery of “the deformations to which theology is susceptible in the university” [...] Read more.
Linn Tonstad’s paper, ‘(Un)wise Theologians’, identifies a theological approach that puts pressure on its ability to handle its materiality sufficiently in a number of ways. However, following the trajectory of Tonstad’s discovery of “the deformations to which theology is susceptible in the university” and elsewhere, a supplementation is required to specify where its thesis needs more rigorous development. Firstly, the paper’s argument locates what Tonstad describes as “self-securitization and self-assertion” in a form of a subjectivity characterisable as a docility making possessive form of divine givenness, and it draws the papal encyclical Fides et Ratio into Tonstad’s critique of the theology of John Webster to make this case. Secondly, Tonstad’s appeal to the reparative mode of contextualisation necessitates a differentiation to be made between modes of what is commonly called ‘contextual theology’ since there are forms that shelter under this umbrella term that echo the subjectivity of that which Tonstad uncompromisingly critiques. Thirdly, while ‘(Un)wise Theologians’ only lightly indexes a reparative direction properly “chastened” theology, a kenotically interrogative sensibility may prove to be sufficiently capacious for the critical conduct of “theological therapy”. If so, then it can function to constantly trouble the theological in an appropriate manner without flight into a premature dematerialised fixation point. Full article
(This article belongs to the Special Issue Nature, Functions and Contexts of Christian Doctrine)
17 pages, 302 KB  
Article
God, Ethics, and Evolution: An Islamic Rejoinder to Sterba’s Moral Critique
by Elif Nur Balci
Religions 2025, 16(8), 1070; https://doi.org/10.3390/rel16081070 - 19 Aug 2025
Viewed by 379
Abstract
This paper engages with James Sterba’s arguments from an Islamic theological perspective, particularly drawing on the Mu‘tazilite tradition. It focuses on three central themes: (1) the position of God in the face of horrendous evils, (2) the relationship between divine command theory and [...] Read more.
This paper engages with James Sterba’s arguments from an Islamic theological perspective, particularly drawing on the Mu‘tazilite tradition. It focuses on three central themes: (1) the position of God in the face of horrendous evils, (2) the relationship between divine command theory and moral objectivity, and (3) the compatibility of Darwinian evolution with objective morality. First, I challenge Sterba’s claim that the existence of a wholly good and powerful God is logically incompatible with horrendous evils by proposing a “theistic structuralist” framework inspired by the Mu‘tazilite scholar Qadi Abd al-Jabbar. Second, while largely agreeing with Sterba’s critique of divine command theory, I incorporate a Mu‘tazilite view that grounds moral objectivity in God’s inherently good nature. Third, I support Sterba’s argument—against Sharon Street—that Darwinian evolution does not undermine moral objectivity, but I further argue that a consistent defense of this view ultimately requires the existence of God. Full article
(This article belongs to the Special Issue Is an Ethics without God Possible?)
22 pages, 483 KB  
Article
Is Proximity to Parks Associated with Physical Activity and Well-Being? Insights from 15-Minute Parks Policy Initiative in Bangkok, Thailand
by Sigit D. Arifwidodo, Orana Chandrasiri and Putthipanya Rueangsom
Sustainability 2025, 17(16), 7457; https://doi.org/10.3390/su17167457 - 18 Aug 2025
Viewed by 282
Abstract
The proximity of urban green spaces to residential areas has become a central principle in contemporary urban planning, with cities worldwide adopting “15-minute city” concepts that prioritize walking-distance access to parks. This study examined whether proximity to different types of parks influences park [...] Read more.
The proximity of urban green spaces to residential areas has become a central principle in contemporary urban planning, with cities worldwide adopting “15-minute city” concepts that prioritize walking-distance access to parks. This study examined whether proximity to different types of parks influences park visitation, physical activity, and mental well-being in Bangkok, Thailand, where the government recently launched a 15-minute parks policy initiative to improve the proximity of urban residents to green spaces. Using a cross-sectional survey of 615 residents across Bangkok’s 50 districts, we measured proximity to six park types using GIS network analysis and assessed health outcomes through validated instruments (Global Physical Activity Questionnaire, GPAQ for physical activity GPAQ for physical activity, and WHO-5 for well-being). Our findings revealed that only proximity to community parks (5–20 ha) was significantly associated with park visitation, sufficient physical activity, and good well-being. Proximity to smaller parks, including the new 15-minute parks, pocket parks, and neighborhood parks, showed no significant associations with any health outcomes, despite being within walking distance. These results suggest a critical size threshold below which parks cannot generate health and well-being benefits in Bangkok’s environment. The findings challenge the argument commonly used in proximity-based green space policies that assume closer parks automatically improve park visitation and public health benefits, indicating that cities facing similar constraints should balance between providing small park networks and securing larger, functional parks to support meaningful recreational use or health improvements. Full article
(This article belongs to the Special Issue Well-Being and Urban Green Spaces: Advantages for Sustainable Cities)
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20 pages, 1341 KB  
Review
Regional Perspectives on Service Learning and Implementation Barriers: A Systematic Review
by Stephanie Lavaux, José Isaias Salas, Andrés Chiappe and Maria Soledad Ramírez-Montoya
Appl. Sci. 2025, 15(16), 9058; https://doi.org/10.3390/app15169058 (registering DOI) - 17 Aug 2025
Viewed by 397
Abstract
Service learning (SL) is at a pivotal moment as education systems worldwide confront the challenges and opportunities posed by artificial intelligence (AI) and digital technologies. This scoping review synthesizes regional perspectives on SL and examines the barriers to its implementation in higher education. [...] Read more.
Service learning (SL) is at a pivotal moment as education systems worldwide confront the challenges and opportunities posed by artificial intelligence (AI) and digital technologies. This scoping review synthesizes regional perspectives on SL and examines the barriers to its implementation in higher education. This study adopts a methodological approach widely used in prior educational research, enriched with selected PRISMA processes, namely identification, screening, and eligibility, to enhance its transparency and rigor. A total of 101 peer-reviewed articles were analyzed, using a mixed methods approach. Results are presented for six regions, Africa, Asia, Latin America, Europe, North America, and Oceania, revealing context-specific constraints, such as technological infrastructure, policy frameworks, linguistic diversity, and socio-economic disparities. Common barriers across regions include limited faculty training, insufficient institutional support, and misalignment with community needs. AI is explored as a potential enabler of SL, not as an empirical outcome, but as part of a reasoned argument emerging from the documented complexity of SL implementation in the literature. Ethical considerations, including algorithmic bias, equitable access, and the preservation of human agency, are addressed, alongside mitigation strategies that are grounded in participatory design and community engagement. This review offers a comparative, context-sensitive understanding of SL implementation challenges, providing actionable insights for educators, policymakers, and researchers, aiming to integrate technology-enhanced solutions responsibly. Full article
(This article belongs to the Special Issue Applications of Digital Technology and AI in Educational Settings)
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15 pages, 219 KB  
Article
The Moral Hope Argument
by Eric Reitan
Religions 2025, 16(8), 1060; https://doi.org/10.3390/rel16081060 - 16 Aug 2025
Viewed by 170
Abstract
This essay develops a distinct moral argument for the reasonableness of believing in God (conceived as a perfectly good creator) inspired by the pragmatic argument for “the religious hypothesis” advanced by William James in “The Will to Believe.” It also contextualizes the argument [...] Read more.
This essay develops a distinct moral argument for the reasonableness of believing in God (conceived as a perfectly good creator) inspired by the pragmatic argument for “the religious hypothesis” advanced by William James in “The Will to Believe.” It also contextualizes the argument relative to familiar moral arguments, notably those of C.S. Lewis and Kant. Briefly, the argument developed here holds that when facing more than one coherent picture of reality, each of which could be true based on the arguments and evidence but only one of which fulfills the hope that in a fundamental way reality is on the side of moral goodness (what I call “the ethico-religious hope”), a reasonable person could opt to believe in the hope’s fulfillment and live accordingly. Following James’ approach, however, this argument does not imply that others who do not adopt such a picture are necessarily irrational or less rational. Full article
(This article belongs to the Special Issue Is an Ethics without God Possible?)
29 pages, 919 KB  
Article
Hegel’s Souls: Aristotle, Kant, and the Climax of Life
by Antonios Kalatzis
Philosophies 2025, 10(4), 92; https://doi.org/10.3390/philosophies10040092 - 16 Aug 2025
Viewed by 383
Abstract
The article aspires to delineate Hegel’s appropriation of Aristotle’s concept of soul in post-Kantian European Philosophy. It showcases the way that Hegel fuses central aspects of Aristotle’s theory and Kant’s account of inner purposiveness in order to deliver a hierarchical account of vegetative-, [...] Read more.
The article aspires to delineate Hegel’s appropriation of Aristotle’s concept of soul in post-Kantian European Philosophy. It showcases the way that Hegel fuses central aspects of Aristotle’s theory and Kant’s account of inner purposiveness in order to deliver a hierarchical account of vegetative-, animal-, and human organisms. The article is divided in six parts. The first part offers an introduction to the subject matter. The second part delivers an overall account of the way that Hegel reconstructs Aristotle’s general theory of the soul and fuses it with Kant’s theory of inner purposiveness. The third part highlights Hegel’s distinctive argumentative strategy for delivering a unified, atemporal account of the connection between the various natural realms, both inorganic and organic. Parts four, five and six proceed to his theory of vegetative-, animal- and human life respectively, while showcasing the underlying logic and the upshot of Hegel’s developmental account of these three kinds of life qua soul. Full article
(This article belongs to the Special Issue Ancient and Medieval Theories of Soul)
13 pages, 493 KB  
Entry
Archard’s Law: Foundations, Extensions, and Critiques
by Brian Delaney and Q. Jane Wang
Encyclopedia 2025, 5(3), 124; https://doi.org/10.3390/encyclopedia5030124 - 15 Aug 2025
Viewed by 354
Definition
Archard’s wear law is among the first and foremost wear models derived from contact mechanics that relates key operating conditions and material hardness to sliding wear through a multifaceted wear coefficient. This entry explores the development, generalization, and critique of the Archard model—a [...] Read more.
Archard’s wear law is among the first and foremost wear models derived from contact mechanics that relates key operating conditions and material hardness to sliding wear through a multifaceted wear coefficient. This entry explores the development, generalization, and critique of the Archard model—a foundational model in wear prediction. It outlines the historical origins of the model, its basis in contact plasticity, and its use of a constant wear coefficient. The discussion highlights modern efforts to extend the model through variable exponents and empirical calibration. Key limitations such as the oversimplification of wear behavior, exclusion of factors like sliding velocity, and scale sensitivity are examined through both theoretical arguments and experimental evidence. The critiques reflect the model’s constrained applicability in diverse wear conditions across varied operating conditions and material phenomena. Full article
(This article belongs to the Section Engineering)
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14 pages, 287 KB  
Article
Global Boundedness of Weak Solutions to Fractional Nonlocal Equations
by Zhenjie Li, Lihe Wang and Chunqin Zhou
Mathematics 2025, 13(16), 2612; https://doi.org/10.3390/math13162612 - 14 Aug 2025
Viewed by 221
Abstract
In this paper, we establish the global boundedness of weak solutions to fractional nonlocal equations using the fractional Moser iteration argument and some other ideas. Our results not only extend the boundedness result of Ros-Oton-Serra to general fractional nonlocal equations under a weaker [...] Read more.
In this paper, we establish the global boundedness of weak solutions to fractional nonlocal equations using the fractional Moser iteration argument and some other ideas. Our results not only extend the boundedness result of Ros-Oton-Serra to general fractional nonlocal equations under a weaker assumption can but also be viewed as a generalization of the boundedness of weak solutions of second-order elliptic equations to nonlocal equations. Full article
22 pages, 378 KB  
Article
On the Cauchy Problem for a Simplified Compressible Oldroyd–B Model Without Stress Diffusion
by Yuanyuan Dan, Feng Li, Haitao Ma and Yajuan Zhao
Mathematics 2025, 13(16), 2589; https://doi.org/10.3390/math13162589 - 13 Aug 2025
Viewed by 165
Abstract
In this paper, we are concerned with the Cauchy problem of the compressible Oldroyd-B model without stress diffusion in Rn(n=2,3). The absence of stress diffusion introduces significant challenges in the analysis of this system. [...] Read more.
In this paper, we are concerned with the Cauchy problem of the compressible Oldroyd-B model without stress diffusion in Rn(n=2,3). The absence of stress diffusion introduces significant challenges in the analysis of this system. By employing tools from harmonic analysis, particularly the Littlewood–Paley decomposition theory, we establish the global well-posedness of solutions with initial data in Lp critical spaces, which accommodates the case of large, highly oscillating initial velocity. Furthermore, we derive the optimal time decay rates of the solutions by a suitable energy argument. Full article
(This article belongs to the Section C: Mathematical Analysis)
24 pages, 653 KB  
Article
Yul2Vec: Yul Code Embeddings
by Krzysztof Fonał
Appl. Sci. 2025, 15(16), 8915; https://doi.org/10.3390/app15168915 - 13 Aug 2025
Viewed by 237
Abstract
In this paper, I propose Yul2Vec, a novel method for representing Yul programs as distributed embeddings in continuous space. Yul serves as an intermediate language between Solidity and Ethereum Virtual Machine (EVM) bytecode, designed to enable more efficient optimization of smart contract execution [...] Read more.
In this paper, I propose Yul2Vec, a novel method for representing Yul programs as distributed embeddings in continuous space. Yul serves as an intermediate language between Solidity and Ethereum Virtual Machine (EVM) bytecode, designed to enable more efficient optimization of smart contract execution compared to direct Solidity-to-bytecode compilation. The vectorization of a program is achieved by aggregating the embeddings of its constituent code elements from the bottom to the top of the program structure. The representation of the smallest construction units, known as opcodes (operation codes), along with their types and arguments, is generated using knowledge graph relationships to construct a seed vocabulary, which forms the foundation for this approach. This research is important for enabling future enhancements to the Solidity compiler, paving the way for advanced optimizations of Yul and, consequently, EVM code. Optimizing the EVM bytecode is essential not only for improving performance but also for minimizing the operational costs of smart contracts—a key concern for decentralized applications. By introducing Yul2Vec, this paper aims to provide a foundation for further research into compiler optimization techniques and cost-efficient smart contract execution on Ethereum. The proposed method is not only fast in learning embeddings but also efficient in calculating the final vector representation of Yul code, making it feasible to integrate this step into the future compilation process of Solidity-based smart contracts. Full article
(This article belongs to the Section Computing and Artificial Intelligence)
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18 pages, 3018 KB  
Article
Organizing Relational Complexity—Design of Interactive Complex Systems
by Linus de Petris and Siamak Khatibi
Multimodal Technol. Interact. 2025, 9(8), 81; https://doi.org/10.3390/mti9080081 - 12 Aug 2025
Viewed by 177
Abstract
With the advent of AI- and robot-systems, the current Human–Computer Interaction (HCI) paradigm, which treats interaction as a transactional exchange, is increasingly insufficient for complex socio-technical systems. This paper argues for a shift toward an agential realist perspective, which understands interaction not as [...] Read more.
With the advent of AI- and robot-systems, the current Human–Computer Interaction (HCI) paradigm, which treats interaction as a transactional exchange, is increasingly insufficient for complex socio-technical systems. This paper argues for a shift toward an agential realist perspective, which understands interaction not as an exchange between separate entities, but as a phenomenon continuously enacted through dynamic, material-discursive practices known as ‘intra-actions’. Through a diffractive reading of agential realism, HCI, complex systems theory, and an empirical case study of a touring exhibition on skateboarding culture, this paper explores an alternative approach. A key finding emerged from a sound-recording workshop when a participant described the recordings not as “how it sounds,” but as “how it feels” to skate. The finding reveals the limits of traditional HCI and it illustrates how interacting parts are co-constituted through the intra-actions of entangled agencies. An argument is made that design for interactive complex systems should change from focusing on causal transactional interaction towards organizing relational complexity, which is staging the conditions for a rich scope of emergent encounters to unfold. The paper concludes by suggesting further research into non-causal explanation and computation. Full article
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