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Search Results (351)

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Keywords = artificial intelligence (AI) structure prediction

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23 pages, 717 KB  
Review
AI-Based Optimization Techniques for Hydrodynamic and Structural Design in Ships: A Review
by Nay Min Htein, Panagiotis Louvros, Evangelos Stefanou, Myo Aung, Nabile Hifi and Evangelos Boulougouris
J. Mar. Sci. Eng. 2025, 13(9), 1719; https://doi.org/10.3390/jmse13091719 - 5 Sep 2025
Abstract
Artificial Intelligence (AI) is increasingly integrated into ship design workflows, offering enhanced capabilities for hydrodynamic and structural optimization. This review focuses on AI-based methods applied to key design tasks such as hull resistance prediction, structural weight reduction, and performance-driven form optimization. Techniques examined [...] Read more.
Artificial Intelligence (AI) is increasingly integrated into ship design workflows, offering enhanced capabilities for hydrodynamic and structural optimization. This review focuses on AI-based methods applied to key design tasks such as hull resistance prediction, structural weight reduction, and performance-driven form optimization. Techniques examined include deep neural networks (DNNs), support vector machines (SVMs), tree-based ensemble models, genetic algorithms (GAs), and surrogate modeling approaches. Comparative analyses from the literature indicate that ensemble tree methods, such as XGBoost, have achieved predictive accuracies up to R2 = 0.995 in speed–power modeling, marginally surpassing DNN performance, while GA-based structural optimization studies have reported weight reductions exceeding 10%. The findings confirm that no single method is universally superior; rather, effectiveness depends on the problem definition, data quality, and computational resources available. Hybrid strategies that combine physics-based modeling with data-driven learning have demonstrated improved generalization, reduced data requirements, and enhanced interpretability. Practical challenges remain, including limited access to open high-fidelity datasets, the computational demands of complex models, and balancing predictive accuracy with explainability. The review concludes that AI should be employed as a complementary toolkit to augment human expertise, with method selection guided by design objectives, constraints, and integration within the broader ship design process. Full article
(This article belongs to the Section Ocean Engineering)
24 pages, 4832 KB  
Article
Potential Use of BME Development Kit and Machine Learning Methods for Odor Identification: A Case Study
by José Pereira, Afonso Mota, Pedro Couto, António Valente and Carlos Serôdio
Appl. Sci. 2025, 15(17), 9687; https://doi.org/10.3390/app15179687 - 3 Sep 2025
Viewed by 131
Abstract
Ensuring food quality and safety is a growing challenge in the food industry, where early detection of contamination or spoilage is crucial. Using gas sensors combined with Artificial Intelligence (AI) offers an innovative and effective approach to food identification, improving quality control and [...] Read more.
Ensuring food quality and safety is a growing challenge in the food industry, where early detection of contamination or spoilage is crucial. Using gas sensors combined with Artificial Intelligence (AI) offers an innovative and effective approach to food identification, improving quality control and minimizing health risks. This study aims to evaluate food identification strategies using supervised learning techniques applied to data collected by the BME Development Kit, equipped with the BME688 sensor. The dataset includes measurements of temperature, pressure, humidity, and, particularly, gas composition, ensuring a comprehensive analysis of food characteristics. The methodology explores two strategies: a neural network model trained using Bosch BME AI-Studio software, and a more flexible, customizable approach that applies multiple predictive algorithms, including DT, LR, kNN, NB, and SVM. The experiments were conducted to analyze the effectiveness of both approaches in classifying different food samples based on gas emissions and environmental conditions. The results demonstrate that combining electronic noses (E-Noses) with machine learning (ML) provides high accuracy in food identification. While the neural network model from Bosch follows a structured and optimized learning approach, the second methodology enables a more adaptable exploration of various algorithms, offering greater interpretability and customization. Both approaches yielded high predictive performance, with strong classification accuracy across multiple food samples. However, performance variations depend on the characteristics of the dataset and the algorithm selection. A critical analysis suggests that optimizing sensor calibration, feature selection, and consideration of environmental parameters can further enhance accuracy. This study confirms the relevance of AI-driven gas analysis as a promising tool for food quality assessment. Full article
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20 pages, 2242 KB  
Review
The Use of Computational Approaches to Design Nanodelivery Systems
by Abedalrahman Abughalia, Mairead Flynn, Paul F. A. Clarke, Darren Fayne and Oliviero L. Gobbo
Nanomaterials 2025, 15(17), 1354; https://doi.org/10.3390/nano15171354 - 3 Sep 2025
Viewed by 242
Abstract
Nano-based drug delivery systems present a promising approach to improve the efficacy and safety of therapeutics by enabling targeted drug transport and controlled release. In parallel, computational approaches—particularly Molecular Dynamics (MD) simulations and Artificial Intelligence (AI)—have emerged as transformative tools to accelerate nanocarrier [...] Read more.
Nano-based drug delivery systems present a promising approach to improve the efficacy and safety of therapeutics by enabling targeted drug transport and controlled release. In parallel, computational approaches—particularly Molecular Dynamics (MD) simulations and Artificial Intelligence (AI)—have emerged as transformative tools to accelerate nanocarrier design and optimise their properties. MD simulations provide atomic-to-mesoscale insights into nanoparticle interactions with biological membranes, elucidating how factors such as surface charge density, ligand functionalisation and nanoparticle size affect cellular uptake and stability. Complementing MD simulations, AI-driven models accelerate the discovery of lipid-based nanoparticle formulations by analysing vast chemical datasets and predicting optimal structures for gene delivery and vaccine development. By harnessing these computational approaches, researchers can rapidly refine nanoparticle composition to improve biocompatibility, reduce toxicity and achieve more precise drug targeting. This review synthesises key advances in MD simulations and AI for two leading nanoparticle platforms (gold and lipid nanoparticles) and highlights their role in enhancing therapeutic performance. We evaluate how in silico models guide experimental validation, inform rational design strategies and ultimately streamline the transition from bench to bedside. Finally, we address key challenges such as data scarcity and complex in vivo dynamics and propose future directions for integrating computational insights into next generation nanodelivery systems. Full article
(This article belongs to the Section Theory and Simulation of Nanostructures)
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17 pages, 1447 KB  
Article
A Novel Prediction Model for Multimodal Medical Data Based on Graph Neural Networks
by Lifeng Zhang, Teng Li, Hongyan Cui, Quan Zhang, Zijie Jiang, Jiadong Li, Roy E. Welsch and Zhongwei Jia
Mach. Learn. Knowl. Extr. 2025, 7(3), 92; https://doi.org/10.3390/make7030092 - 2 Sep 2025
Viewed by 524
Abstract
Multimodal medical data provides a wide and real basis for disease diagnosis. Computer-aided diagnosis (CAD) powered by artificial intelligence (AI) is becoming increasingly prominent in disease diagnosis. CAD for multimodal medical data requires addressing the issues of data fusion and prediction. Traditionally, the [...] Read more.
Multimodal medical data provides a wide and real basis for disease diagnosis. Computer-aided diagnosis (CAD) powered by artificial intelligence (AI) is becoming increasingly prominent in disease diagnosis. CAD for multimodal medical data requires addressing the issues of data fusion and prediction. Traditionally, the prediction performance of CAD models has not been good enough due to the complicated dimensionality reduction. Therefore, this paper proposes a fusion and prediction model—EPGC—for multimodal medical data based on graph neural networks. Firstly, we select features from unstructured multimodal medical data and quantify them. Then, we transform the multimodal medical data into a graph data structure by establishing each patient as a node, and establishing edges based on the similarity of features between the patients. Normalization of data is also essential in this process. Finally, we build a node prediction model based on graph neural networks and predict the node classification, which predicts the patients’ diseases. The model is validated on two publicly available datasets of heart diseases. Compared to the existing models that typically involve dimensionality reduction, classification, or the establishment of complex deep learning networks, the proposed model achieves outstanding results with the experimental dataset. This demonstrates that the fusion and diagnosis of multimodal data can be effectively achieved without dimension reduction or intricate deep learning networks. We take pride in exploring unstructured multimodal medical data using deep learning and hope to make breakthroughs in various fields. Full article
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23 pages, 1584 KB  
Article
Image-Based Formalization of Tabular Data for Threshold-Based Prediction of Hospital Stay Using Convolutional Neural Networks: An Intelligent Decision Support System Applied in COPD
by Alberto Pinheira, Manuel Casal-Guisande, Julia López-Canay, Alberto Fernández-García, Rafael Golpe, Cristina Represas-Represas, María Torres-Durán, Jorge Cerqueiro-Pequeño, Alberto Comesaña-Campos and Alberto Fernández-Villar
Appl. Syst. Innov. 2025, 8(5), 128; https://doi.org/10.3390/asi8050128 - 2 Sep 2025
Viewed by 250
Abstract
Background: Chronic Obstructive Pulmonary Disease (COPD) often leads to acute exacerbations requiring hospitalization. While artificial intelligence (AI) has been increasingly used to improve COPD management, predicting whether the length of hospital stay (LOHS) will exceed clinically relevant thresholds remains insufficiently explored. Methods: This [...] Read more.
Background: Chronic Obstructive Pulmonary Disease (COPD) often leads to acute exacerbations requiring hospitalization. While artificial intelligence (AI) has been increasingly used to improve COPD management, predicting whether the length of hospital stay (LOHS) will exceed clinically relevant thresholds remains insufficiently explored. Methods: This study presents a novel clinical decision support system to predict whether LOHS following an acute exacerbation will surpass specific cutoffs (6 or 10 days). The approach involves two stages: (1) clinical, demographic, and social variables are encoded into structured signals and transformed into spectrogram-like images via a pipeline based on sinusoidal encoding and Mel-frequency cepstral coefficients (MFCCs); and (2) these images are fed into a Convolutional Neural Network (CNN) to estimate the probability of extended hospitalization. Feature selection with XGBoost reduced dimensionality to 16 variables. The model was trained and tested on a dataset of over 500 patients. Results: On the test set, the model achieved an AUC of 0.77 for predicting stays longer than 6 days and 0.75 for stays over 10 days. Sensitivity and specificity were 0.79/0.72 and 0.74/0.80, respectively. Conclusions: This system leverages image-based data formalization to predict LOHS in COPD patients, facilitating early risk stratification and more informed clinical planning. Results are promising, but external validation with larger and more diverse datasets remains essential. Full article
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15 pages, 446 KB  
Systematic Review
The Integration of Artificial Intelligence into Robotic Cancer Surgery: A Systematic Review
by Agnieszka Leszczyńska, Rafał Obuchowicz, Michał Strzelecki and Michał Seweryn
J. Clin. Med. 2025, 14(17), 6181; https://doi.org/10.3390/jcm14176181 - 1 Sep 2025
Viewed by 324
Abstract
Background/Objectives: This systematic review aims to synthesize recent studies on the integration of artificial intelligence (AI) into robotic surgery for oncological patients. It focuses on studies using real patient data and AI tools in robotic oncologic surgery. Methods: This systematic review [...] Read more.
Background/Objectives: This systematic review aims to synthesize recent studies on the integration of artificial intelligence (AI) into robotic surgery for oncological patients. It focuses on studies using real patient data and AI tools in robotic oncologic surgery. Methods: This systematic review followed PRISMA guidelines to ensure a robust methodology. A comprehensive search was conducted in June 2025 across Embase, Medline, Web of Science, medRxiv, Google Scholar, and IEEE databases, using MeSH terms, relevant keywords, and Boolean logic. Eligible studies were original research articles published in English between 2024 and 2025, focusing on AI applications in robotic cancer surgery using real patient data. Studies were excluded if they were non-peer-reviewed, used synthetic/preclinical data, addressed non-oncologic indications, or explored non-robotic AI applications. This approach ensured the selection of studies with practical clinical relevance. Results: The search identified 989 articles, with 17 duplicates removed. After screening, 921 were excluded, and 37 others were eliminated for reasons such as misalignment with inclusion criteria or lack of full text. Ultimately, 14 articles were included, with 8 using a retrospective design and 6 based on prospective data. These included articles that varied significantly in terms of the number of participants, ranging from several dozen to several thousand. These studies explored the application of AI across various stages of robotic oncologic surgery, including preoperative planning, intraoperative support, and postoperative predictions. The quality of 11 included studies was very good and good. Conclusions: AI significantly supports robotic oncologic surgery at various stages. In preoperative planning, it helps estimate the risk of conversion from minimally invasive to open colectomy in colon cancer. During surgery, AI enables precise tumor and vascular structure localization, enhancing resection accuracy, preserving healthy tissue, and reducing warm ischemia time. Postoperatively, AI’s flexibility in predicting functional and oncological outcomes through context-specific models demonstrates its value in improving patient care. Due to the relatively small number of cases analyzed, further analysis of the issues presented in this review is necessary. Full article
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23 pages, 881 KB  
Review
Generative AI for the Internet of Vehicles: A Review of Advances in Training, Decision-Making, and Security
by Xiaoming Yuan, Xinling Zhang, Aiwen Wang, Jiaxin Zhou, Yingying Du, Qingxu Deng and Lei Liu
Mathematics 2025, 13(17), 2795; https://doi.org/10.3390/math13172795 - 31 Aug 2025
Viewed by 300
Abstract
Generative artificial intelligence (GAI) has emerged as a transformative force in the Internet of Vehicles (IoV), addressing limitations of traditional AI such as reliance on large labeled datasets and narrow task applicability. This paper aims to systematically review recent advances in applying GAI [...] Read more.
Generative artificial intelligence (GAI) has emerged as a transformative force in the Internet of Vehicles (IoV), addressing limitations of traditional AI such as reliance on large labeled datasets and narrow task applicability. This paper aims to systematically review recent advances in applying GAI to the IoV, with a focus on training, decision-making, and security. We begin by introducing the fundamental concepts of vehicular networks and GAI, laying the groundwork for readers to better understand the subsequent sections. Methodologically, we adopt a structured literature review, covering developments in synthetic data generation, dynamic scene reconstruction, traffic flow prediction, anomaly detection, communication management, and resource allocation. In particular, we integrate multimodal GAI capabilities with 5G/6G-enabled edge computing to support low-latency, reliable, and adaptive vehicular network services. Our synthesis identifies key technical challenges, including lightweight model deployment, privacy preservation, and security assurance, and outlines promising future research directions. This review provides a comprehensive reference for advancing intelligent IoV systems through GAI. Full article
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13 pages, 628 KB  
Article
Artificial Intelligence in Higher Education: Predictive Analysis of Attitudes and Dependency Among Ecuadorian University Students
by Carla Mendoza Arce, Jaime Camacho Gavilanes, Edgar Mendoza Arce, Edgar Mendoza Haro and Diego Bonilla-Jurado
Sustainability 2025, 17(17), 7741; https://doi.org/10.3390/su17177741 - 28 Aug 2025
Viewed by 481
Abstract
This study examines the relationship between attitudes toward artificial intelligence (AI) and AI dependency among Ecuadorian university students. A cross-sectional design was used, applying two validated instruments: the Artificial Intelligence Dependence Scale (DAI) and the General Attitudes Toward Artificial Intelligence Scale (GAAIS), with [...] Read more.
This study examines the relationship between attitudes toward artificial intelligence (AI) and AI dependency among Ecuadorian university students. A cross-sectional design was used, applying two validated instruments: the Artificial Intelligence Dependence Scale (DAI) and the General Attitudes Toward Artificial Intelligence Scale (GAAIS), with a sample of 540 students. Structural equation modeling (SEM) assessed how both positive and negative attitudes predict dependency levels. Results indicate a moderate level of AI dependency and an ambivalent attitudinal profile. Both attitudinal dimensions significantly predicted dependency, suggesting dual-use behaviors shaped by perceived utility and ethical concerns. Urban students reported higher dependency and greater sensitivity to AI-related risks, highlighting digital inequalities. Although the SEM model showed adequate comparative fit (CFI = 0.976; TLI = 0.973), residual indicators (RMSEA = 0.075) suggest further refinement is needed. This study contributes to underexplored Latin American contexts and emphasizes the need for equity-driven digital literacy strategies in higher education. Findings support pedagogical frameworks promoting critical thinking, ethical reasoning, and responsible AI use. The study aligns with Sustainable Development Goals 4 (Quality Education) and 10 (Reduced Inequalities), reinforcing the importance of inclusive, learner-centered approaches to AI integration. Full article
(This article belongs to the Special Issue Technology-Enhanced Education and Sustainable Development)
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34 pages, 9260 KB  
Review
Recent Advances in the Analysis of Functional and Structural Polymer Composites for Wind Turbines
by Francisco Lagos, Brahim Menacer, Alexis Salas, Sunny Narayan, Carlos Medina, Rodrigo Valle, César Garrido, Gonzalo Pincheira, Angelo Oñate, Renato Hunter-Alarcón and Víctor Tuninetti
Polymers 2025, 17(17), 2339; https://doi.org/10.3390/polym17172339 - 28 Aug 2025
Viewed by 637
Abstract
Achieving the full potential of wind energy in the global renewable transition depends critically on enhancing the performance and reliability of polymer composite components. This review synthesizes recent advances from 2022 to 2025, including the development of next-generation hybrid composites and the application [...] Read more.
Achieving the full potential of wind energy in the global renewable transition depends critically on enhancing the performance and reliability of polymer composite components. This review synthesizes recent advances from 2022 to 2025, including the development of next-generation hybrid composites and the application of high-fidelity computational methods—finite element analysis (FEA), computational fluid dynamics (CFD), and fluid–structure interaction (FSI)—to optimize structural integrity and aerodynamic performance. It also explores the transformative role of artificial intelligence (AI) in structural health monitoring (SHM) and the integration of Internet of Things (IoT) systems, which are becoming essential for predictive maintenance and lifecycle management. Special focus is given to harsh offshore environments, where polymer composites must withstand extreme wind and wave conditions. This review further addresses the growing importance of circular economy strategies for managing end-of-life composite blades. While innovations such as the geometric redesign of floating platforms and the aerodynamic refinement of blade components have yielded substantial gains—achieving up to a 30% mass reduction in PLA prototypes—more conservative optimizations of internal geometry configurations in GFRP blades provide only around 7% mass reduction. Nevertheless, persistent challenges related to polymer composite degradation and fatigue under severe weather conditions are driving the adoption of real-time hybrid predictive models. A bibliometric analysis of over 1000 publications confirms more than 25 percent annual growth in research across these interconnected areas. This review serves as a comprehensive reference for engineers and researchers, identifying three strategic frontiers that will shape the future of wind turbine blade technology: advanced composite materials, integrated computational modeling, and scalable recycling solutions. Full article
(This article belongs to the Section Polymer Composites and Nanocomposites)
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23 pages, 5401 KB  
Article
Accelerating Thermally Safe Operating Area Assessment of Ignition Coils for Hydrogen Engines via AI-Driven Power Loss Estimation
by Federico Ricci, Mario Picerno, Massimiliano Avana, Stefano Papi, Federico Tardini and Massimo Dal Re
Vehicles 2025, 7(3), 90; https://doi.org/10.3390/vehicles7030090 - 25 Aug 2025
Viewed by 367
Abstract
In order to determine thermally safe driving parameters of ignition coils for hydrogen internal combustion engines (ICE), a reliable estimation of internal power losses is essential. These losses include resistive winding losses, magnetic core losses due to hysteresis and eddy currents, dielectric losses [...] Read more.
In order to determine thermally safe driving parameters of ignition coils for hydrogen internal combustion engines (ICE), a reliable estimation of internal power losses is essential. These losses include resistive winding losses, magnetic core losses due to hysteresis and eddy currents, dielectric losses in the insulation, and electronic switching losses. Direct experimental assessment is difficult because the components are inaccessible, while conventional computer-aided engineering (CAE) approaches face challenges such as the need for accurate input data, the need for detailed 3D models, long computation times, and uncertainties in loss prediction for complex structures. To address these limitations, we propose an artificial intelligence (AI)-based framework for estimating internal losses from external temperature measurements. The method relies on an artificial neural network (ANN), trained to capture the relationship between external coil temperatures and internal power losses. The trained model is then employed within an optimization process to identify losses corresponding to experimental temperature values. Validation is performed by introducing the identified power losses into a CAE thermal model to compare predicted and experimental temperatures. The results show excellent agreement, with errors below 3% across the −30 °C to 125 °C range. This demonstrates that the proposed hybrid ANN–CAE approach achieves high accuracy while reducing experimental effort and computational demand. Furthermore, the methodology allows for a straightforward determination of the coil safe operating area (SOA). Starting from estimates derived from fitted linear trends, the SOA limits can be efficiently refined through iterative verification with the CAE model. Overall, the ANN–CAE framework provides a robust and practical tool to accelerate thermal analysis and support coil development for hydrogen ICE applications. Full article
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44 pages, 786 KB  
Review
Evolution of Studies on Fracture Behavior of Composite Laminates: A Scoping Review
by C. Bhargavi, K S Sreekeshava and B K Raghu Prasad
Appl. Mech. 2025, 6(3), 63; https://doi.org/10.3390/applmech6030063 - 25 Aug 2025
Viewed by 499
Abstract
This scoping review paper provides an overview of the evolution, the current stage, and the future prospects of fracture studies on composite laminates. A fundamental understanding of composite materials is presented by highlighting the roles of the fiber and matrix, outlining the applications [...] Read more.
This scoping review paper provides an overview of the evolution, the current stage, and the future prospects of fracture studies on composite laminates. A fundamental understanding of composite materials is presented by highlighting the roles of the fiber and matrix, outlining the applications of various synthetic fibers used in current structural sectors. Challenges posed by interlaminar delamination, one of the critical failure modes, are highlighted. This paper systematically discusses the fracture behavior of these laminates under mixed-mode and complex loading conditions. Standardized fracture toughness testing methods, including Mode I Double Cantilever Beam (DCB), Mode II End-Notched Flexure (ENF) and Mixed-Mode Bending (MMB), are initially discussed, which is followed by a decade-wide chronological analysis of fracture mechanics approaches. Key advancements, including toughening mechanisms, Cohesive Zone Modeling (CZM), Virtual Crack Closure Technique (VCCT), Extended Finite Element Method (XFEM) and Digital Image Correlation (DIC), are analyzed. The review also addresses recent trends in fracture studies, such as bio-inspired architecture, self-healing systems, and artificial intelligence in fracture predictions. By mapping the trajectory of past innovations and identifying unresolved challenges, such as scale integration, dataset standardization for AI, and manufacturability of advanced architectures, this review proposes a strategic research roadmap. The major goal is to enable unified multi-scale modeling frameworks that merge physical insights with data learning, paving the way for next-generation composite laminates optimized for resilience, adaptability, and environmental responsibility. Full article
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34 pages, 3670 KB  
Review
Electronic Artificial Intelligence and Digital Twins in Industry 5.0: A Systematic Review and Perspectives
by Alessandro Massaro
Machines 2025, 13(9), 755; https://doi.org/10.3390/machines13090755 - 23 Aug 2025
Viewed by 588
Abstract
This review analyzes the Electronic Digital Twin (EDT) tools characterizing the industrial transformation phase from Industry 4.0 to Industry 5.0. The goal is to provide innovative research EDT solutions to integrate in manufacturing production processes. Specifically, this research is focused on the possibility [...] Read more.
This review analyzes the Electronic Digital Twin (EDT) tools characterizing the industrial transformation phase from Industry 4.0 to Industry 5.0. The goal is to provide innovative research EDT solutions to integrate in manufacturing production processes. Specifically, this research is focused on the possibility of combining the advanced technologies and electronics and mechatronics of industrial machines with Artificial Intelligence (AI) algorithms. Furthermore, this review provides important elements about possible future implementations of AI-EDTs and some circuital examples to support the understanding of the concept of circuit simulation in EDT models. EDTs are useful to comprehend the modeling concepts functional to the AI application using the output of the circuit simulations. The output of the circuit is used to train the AI model, thus strengthening the capability to classify and predict the real behavior of production machines with a good accuracy. This review discusses perspectives, limits, and advantages of EDTs and is useful to define new research patterns integrating structured EDTs in advanced industrial environments. The focus of this paper is the definition of possible perspectives of EDT implementations, including AI, in data-driven processes in specific strategic areas of industrial research by classifying the scientific topics in six main pillars. This paper is also suitable for the researcher to develop innovative topics for projects scaled into different work packages based on EDT facilities. Full article
(This article belongs to the Special Issue Design and Manufacturing: An Industry 4.0 Perspective)
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24 pages, 2123 KB  
Review
Artificial Intelligence for Predicting Insolvency in the Construction Industry—A Systematic Review and Empirical Feature Derivation
by Janappriya Jayawardana, Pabasara Wijeratne, Zora Vrcelj and Malindu Sandanayake
Buildings 2025, 15(17), 2988; https://doi.org/10.3390/buildings15172988 - 22 Aug 2025
Viewed by 453
Abstract
The construction sector is particularly prone to financial instability, with insolvencies occurring more frequently among micro- and small-scale firms. The current study explores the application of artificial intelligence (AI) and machine learning (ML) models for predicting insolvency within this sector. The research combined [...] Read more.
The construction sector is particularly prone to financial instability, with insolvencies occurring more frequently among micro- and small-scale firms. The current study explores the application of artificial intelligence (AI) and machine learning (ML) models for predicting insolvency within this sector. The research combined a structured literature review with empirical analysis of construction sector-level insolvency data spanning the recent decade. A critical review of studies highlighted a clear shift from traditional statistical methods to AI/ML-driven approaches, with ensemble learning, neural networks, and hybrid learning models demonstrating superior predictive accuracy and robustness. While current predictive models mostly rely on financial ratio-based inputs, this research complements this foundation by introducing additional sector-specific variables. Empirical analysis reveals persistent patterns of distress, with micro- and small-sized construction businesses accounting for approximately 92% to 96% of insolvency cases each year in the Australian construction sector. Key risk signals such as firm size, cash flow risks, governance breaches and capital adequacy issues were translated into practical features that may enhance the predictive sensitivity of the existing models. The study also emphasises the need for digital self-assessment tools to support micro- and small-scale contractors in evaluating their financial health. By transforming predictive insights into accessible, real-time evaluations, such tools can facilitate early interventions and reduce the risk of insolvency among vulnerable construction firms. The current study combines insights from the review of AI/ML insolvency prediction models with sector-specific feature derivation, potentially providing a foundation for future research and practical adaptation in the construction context. Full article
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21 pages, 1055 KB  
Review
Advanced Strategies in Phage Research: Innovations, Applications, and Challenges
by Pengfei Wu, Wanwu Li, Wenlu Zhang, Shasha Li, Bo Deng, Shanghui Xu and Zhongjie Li
Microorganisms 2025, 13(8), 1960; https://doi.org/10.3390/microorganisms13081960 - 21 Aug 2025
Viewed by 551
Abstract
The escalating global threat of antimicrobial resistance (AMR) underscores the urgent need for innovative therapeutics. Bacteriophages (phages), natural bacterial predators, offer promising solutions, especially when harnessed through advances in artificial intelligence (AI). This review explores how AI-driven innovations are transforming phage biology, with [...] Read more.
The escalating global threat of antimicrobial resistance (AMR) underscores the urgent need for innovative therapeutics. Bacteriophages (phages), natural bacterial predators, offer promising solutions, especially when harnessed through advances in artificial intelligence (AI). This review explores how AI-driven innovations are transforming phage biology, with an emphasis on three pivotal areas: (1) AI-enhanced structural prediction (e.g., AlphaFold); (2) deep learning functional annotation; (3) bioengineering strategies, including CRISPR-Cas. We further discuss applications extending to medical therapy, biosensing, agricultural biocontrol, and environmental remediation. Despite progress, critical challenges persist—including high false-positive rates, difficulties in modeling disordered protein regions, and biosafety concerns remain. Overcoming these requires experimental validation, robust computational frameworks, and global regulatory oversight. AI integration in phage research is accelerating the development of next-generation therapeutics to combat AMR and advance engineered living therapeutics. Full article
(This article belongs to the Section Antimicrobial Agents and Resistance)
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18 pages, 879 KB  
Systematic Review
Machine Learning in Myasthenia Gravis: A Systematic Review of Prognostic Models and AI-Assisted Clinical Assessments
by Chen-Chih Chung, I-Chieh Wu, Oluwaseun Adebayo Bamodu, Chien-Tai Hong and Hou-Chang Chiu
Diagnostics 2025, 15(16), 2044; https://doi.org/10.3390/diagnostics15162044 - 14 Aug 2025
Viewed by 558
Abstract
Background: Myasthenia gravis (MG), a chronic autoimmune disorder with variable disease trajectories, presents considerable challenges for clinical stratification and acute care management. This systematic review evaluated machine learning models developed for prognostic assessment in patients with MG. Methods: Following PRISMA guidelines, [...] Read more.
Background: Myasthenia gravis (MG), a chronic autoimmune disorder with variable disease trajectories, presents considerable challenges for clinical stratification and acute care management. This systematic review evaluated machine learning models developed for prognostic assessment in patients with MG. Methods: Following PRISMA guidelines, we systematically searched PubMed, Embase, and Scopus for relevant articles published from January 2010 to May 2025. Studies using machine learning techniques to predict MG-related outcomes based on structured or semi-structured clinical variables were included. We extracted data on model targets, algorithmic strategies, input features, validation design, performance metrics, and interpretability methods. The risk of bias was assessed using the Prediction Model Risk of Bias Assessment Tool. Results: Eleven studies were included, targeting ICU admission (n = 2), myasthenic crisis (n = 1), treatment response (n = 2), prolonged mechanical ventilation (n = 1), hospitalization duration (n = 1), symptom subtype clustering (n = 1), and artificial intelligence (AI)-assisted examination scoring (n = 3). Commonly used algorithms included extreme gradient boosting, random forests, decision trees, multivariate adaptive regression splines, and logistic regression. Reported AUC values ranged from 0.765 to 0.944. Only two studies employed external validation using independent cohorts; others relied on internal cross-validation or repeated holdout. Of the seven prognostic modeling studies, four were rated as having high risk of bias, primarily due to participant selection, predictor handling, and analytical design issues. The remaining four studies focused on unsupervised symptom clustering or AI-assisted examination scoring without predictive modeling components. Conclusions: Despite promising performance metrics, constraints in generalizability, validation rigor, and measurement consistency limited their clinical application. Future research should prioritize prospective multicenter studies, dynamic data sharing strategies, standardized outcome definitions, and real-time clinical workflow integration to advance machine learning-based prognostic tools for MG and support improved patient care in acute settings. Full article
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