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21 pages, 8000 KB  
Article
Benchmark Problems for the One-Dimensional Wave Equation Under Mixed Boundary Conditions: Initial-Value and Two-Time Specifications
by Zsolt Vadai and Csaba Kézi
Appl. Sci. 2026, 16(8), 3755; https://doi.org/10.3390/app16083755 - 11 Apr 2026
Viewed by 207
Abstract
This paper presents two complementary classes of analytical benchmark problems for the one-dimensional wave equation governing longitudinal vibration of a prismatic rod with mixed (clamped–free) boundary conditions. The first benchmark class consists of classical initial-value problems and includes both compatible and incompatible initial [...] Read more.
This paper presents two complementary classes of analytical benchmark problems for the one-dimensional wave equation governing longitudinal vibration of a prismatic rod with mixed (clamped–free) boundary conditions. The first benchmark class consists of classical initial-value problems and includes both compatible and incompatible initial data at the space–time corners, highlighting their influence on convergence, regularity, and termwise differentiation of displacement, velocity, and axial force series representations. The second benchmark class prescribes the displacement at two time instants (initial and final time), leading to a fundamentally different modal structure and revealing spectral conditioning effects governed by the ratio L/(cte). The derived closed-form solutions provide reference configurations for verification of transient numerical solvers, particularly in scenarios where classical smooth compatibility assumptions are not satisfied. Full article
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17 pages, 3276 KB  
Article
An Improved Compression-After-Low-Velocity-Impact Test Setup and Its Application to Thin Angle-Ply CFRP Laminates
by Marius Nicolae Baba
J. Compos. Sci. 2026, 10(3), 165; https://doi.org/10.3390/jcs10030165 - 18 Mar 2026
Viewed by 468
Abstract
Low-velocity impacts can cause barely visible impact damage (BVID) in carbon-fiber-reinforced polymer (CFRP) laminates, leading to significant reductions in residual compressive strength. Compression-after-impact (CAI) tests are therefore essential for damage-tolerance design, but existing fixtures often allow global buckling or edge crushing, which can [...] Read more.
Low-velocity impacts can cause barely visible impact damage (BVID) in carbon-fiber-reinforced polymer (CFRP) laminates, leading to significant reductions in residual compressive strength. Compression-after-impact (CAI) tests are therefore essential for damage-tolerance design, but existing fixtures often allow global buckling or edge crushing, which can compromise test accuracy. This study experimentally investigates the CAI response of two symmetric angle-ply CFRP laminates with reversed stacking sequences, [0/−45/45/90]s and [90/45/−45/0]s, using a modified CAI fixture. Compared to standard CAI rigs, the modified fixture combines the lateral guidance with anti-buckling plates that clamp the upper and lower specimen edges using a bolt–nut assembly, thereby reducing the active gauge length and stabilizing the panel during compression. Rectangular plate specimens were first impacted at low velocity with a hemispherical projectile; the BVID threshold was defined by a permanent indentation depth of 0.8 mm for [0/−45/45/90]s and 0.7 mm for [90/45/−45/0]s, measured 24 h after impact. Subsequent CAI tests showed about a 22% reduction in maximum compressive load at the BVID level for both layups, while the post-impact compressive stiffness decreased by 17% for [0/−45/45/90]s and 6% for [90/45/−45/0]s. These results demonstrate that reversing the symmetric layup significantly affects stiffness degradation and that the proposed CAI setup suppresses global buckling and edge-dominated failures in all testson the investigated thin CFRP laminates, enabling repeatable residual-strength and stiffness measurements. Full article
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18 pages, 7585 KB  
Article
Design and Characterization of a Bench-Top Ludwieg Tube for Aerodynamic Measurements via Simultaneous Quantification of Mach Number and Velocity
by Boris S. Leonov, Richard Q. Binzley, Nathan G. Phillips, Roman Rosser, Farhan Siddiqui, Arthur Dogariu and Richard B. Miles
Fluids 2026, 11(3), 80; https://doi.org/10.3390/fluids11030080 - 15 Mar 2026
Viewed by 494
Abstract
This article presents the design and detailed characterization of a new supersonic wind tunnel at the Aerospace Laboratory for Lasers, ElectroMagnetics, and Optics of Texas A&M University, tailored for optical diagnostic development and sub-scale fundamental compressible fluid dynamics research. A Ludwieg tube tunnel [...] Read more.
This article presents the design and detailed characterization of a new supersonic wind tunnel at the Aerospace Laboratory for Lasers, ElectroMagnetics, and Optics of Texas A&M University, tailored for optical diagnostic development and sub-scale fundamental compressible fluid dynamics research. A Ludwieg tube tunnel architecture was selected due to its robustness, versatility, and low operational costs. The tunnel consists of a 50-foot-long driver tube constructed from modular Tri-Clamp spools, a Mach 4 nozzle with 3 in. exit diameter configured as a free jet, and a fast-acting valve with 14 ms opening time for high-duty-cycle operation. Such construction proved to be a robust, compact, and affordable solution for academic applications. Characterization methods consisted of simultaneous high-speed dot-schlieren, total and static pressure measurements, and femtosecond laser electronic excitation tagging. Average flow velocity for the first steady-state test time was measured via FLEET at (668.0 ± 5.7) m/s. The Mach number was calculated based on the angles of the attached oblique shocks formed near the 30° cone model. Calculated Mach number was repeatable from run to run and had small oscillations near the average value of 3.96 ± 0.03. Based on the simultaneously measured velocity and Mach number, the static temperature was calculated to be between (68.6 ± 0.3) K and (66.3 ± 0.3) K throughout the 400 ms test time, completely defining the thermodynamic state of the generated freestream flow. Full article
(This article belongs to the Special Issue High-Speed Processes in Continuous Media)
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17 pages, 1938 KB  
Article
Optimal Scheduling of a Park-Scale Virtual Power Plant Based on Thermoelectric Coupling and PV–EV Coordination
by Ruiguang Ma, Tiannan Ma, Yanqiu Hou, Hao Luo, Jieying Liu, Luoyi Li, Yueping Xiang, Liqing Liao and Dan Tang
Eng 2026, 7(1), 54; https://doi.org/10.3390/eng7010054 - 21 Jan 2026
Viewed by 292
Abstract
This paper presents a closed-loop price–dispatch framework for park-scale virtual power plants (VPPs) with coupled electric–thermal processes under high penetrations of photovoltaics (PVs) and electric vehicles (EVs). The outer layer clears time-varying prices for operator electricity, operator heat, and user feed-in using an [...] Read more.
This paper presents a closed-loop price–dispatch framework for park-scale virtual power plants (VPPs) with coupled electric–thermal processes under high penetrations of photovoltaics (PVs) and electric vehicles (EVs). The outer layer clears time-varying prices for operator electricity, operator heat, and user feed-in using an improved particle swarm optimizer with adaptive coefficients and velocity clamping. Given these prices, the inner layer executes a lightweight linear source decomposition with feasibility projection that enforces transformer limits, combined heat-and-power (CHP) and boiler constraints, ramping, energy balances, and EV state-of-charge requirements. PV uncertainty is represented by a small set of scenarios and a conditional value-at-risk (CVaR) term augments the welfare objective to control tail risk. On a typical winter day case, the coordinated setting aligns EV charging with solar hours, reduces evening grid imports, and improves a social welfare proxy while maintaining interpretable price signals. Measured outcomes include 99.17% PV utilization (95.14% self-consumption and 4.03% routed to EV charging) and a reduction in EV charging cost from CNY 304.18 to CNY 249.87 (−17.9%) compared with an all-from-operator benchmark; all transformer, CHP/boiler, and EV constraints are satisfied. The price loop converges within several dozen iterations without oscillation. Sensitivity studies show that increasing risk weight lowers CVaR with modest welfare trade-offs, while wider price bounds and higher EV availability raise welfare until physical limits bind. The results demonstrate an effective, interpretable, and reproducible pathway to integrate market signals with engineering constraints in park VPP operations. Full article
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23 pages, 5241 KB  
Article
BAARTR: Boundary-Aware Adaptive Regression for Kinematically Consistent Vessel Trajectory Reconstruction from Sparse AIS
by Hee-jong Choi, Joo-sung Kim and Dae-han Lee
J. Mar. Sci. Eng. 2026, 14(2), 116; https://doi.org/10.3390/jmse14020116 - 7 Jan 2026
Viewed by 463
Abstract
The Automatic Identification System (AIS) frequently suffers from data loss and irregular report intervals in real maritime environments, compromising the reliability of downstream navigation, monitoring, and trajectory reconstruction tasks. To address these challenges, we propose BAARTR (Boundary-Aware Adaptive Regression for Kinematically Consistent Vessel [...] Read more.
The Automatic Identification System (AIS) frequently suffers from data loss and irregular report intervals in real maritime environments, compromising the reliability of downstream navigation, monitoring, and trajectory reconstruction tasks. To address these challenges, we propose BAARTR (Boundary-Aware Adaptive Regression for Kinematically Consistent Vessel Trajectory Reconstruction), a novel kinematically consistent interpolation framework. Operating solely on time, latitude, and longitude inputs, BAARTR explicitly enforces boundary velocities derived from raw AIS data. The framework adaptively selects a velocity-estimation strategy based on the AIS reporting gap: central differencing is applied for short intervals, while a hierarchical cubic velocity regression with a quadratic acceleration constraint is employed for long or irregular gaps to iteratively refine endpoint slopes. These boundary slopes are subsequently incorporated into a clamped quartic interpolation at a 1 s resolution, effectively suppressing overshoots and ensuring velocity continuity across segments. We evaluated BAARTR against Linear, Spline, Hermite, Bezier, Piecewise cubic hermite interpolating polynomial (PCHIP) and Modified akima (Makima) methods using real-world AIS data collected from the Mokpo Port channel, Republic of Korea (2023–2024), across three representative vessels. The experimental results demonstrate that BAARTR achieves superior reconstruction accuracy while maintaining strictly linear time complexity (O(N)). BAARTR consistently achieved the lowest median Root Mean Square Error (RMSE) and the narrowest Interquartile Ranges (IQR), producing visibly smoother and more kinematically plausible paths-especially in high-curvature turns where standard geometric interpolations tend to oscillate. Furthermore, sensitivity analysis shows stable performance with a modest training window (n ≈ 16) and minimal regression iterations (m = 2–3). By reducing reliance on large training datasets, BAARTR offers a lightweight, extensible foundation for post-processing in Maritime Autonomous Surface Ship (MASS) and Vessel Traffic Service (VTS), as well as for accident reconstruction and multi-sensor fusion. Full article
(This article belongs to the Special Issue Advanced Research on Path Planning for Intelligent Ships)
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28 pages, 1849 KB  
Article
A Robot Welding Clamp Force Control Method Based on Dual-Loop Adaptive RBF Neural Network
by Yanhong Wang, Qiu Tang, Xincheng Tian and Yan Liu
Appl. Sci. 2026, 16(1), 478; https://doi.org/10.3390/app16010478 - 2 Jan 2026
Viewed by 550
Abstract
As the core component in intelligent manufacturing systems, the precise control of the welding clamp’s electrode pressure plays a decisive role in ensuring the quality of spot welding. This paper proposes a novel pressure control strategy for robotic welding clamp based on partitioned [...] Read more.
As the core component in intelligent manufacturing systems, the precise control of the welding clamp’s electrode pressure plays a decisive role in ensuring the quality of spot welding. This paper proposes a novel pressure control strategy for robotic welding clamp based on partitioned adaptive RBF neural networks: (1) Deformation of the clamp body can lead to deviations in workpiece positioning. To address this issue, a deflection compensation method for robot welding clamp based on the PSO-RBF neural network is proposed. By leveraging pre-calibrated empirical data, the intrinsic mapping relationships are identified, and the derived deflection compensation value is integrated into the real-time position command of the robot end-effector. (2) During electrode motion, the system is subjected to external disturbances such as friction and gravitational forces. So, a sliding mode control strategy incorporating adaptive RBF disturbance compensation is proposed to achieve robust speed regulation. Furthermore, the electrode’s reference velocity is dynamically adjusted based on the welding force error and improved admittance control algorithm, enabling indirect regulation of the welding force to reach the desired set value. The results demonstrate that the proposed composite control strategy reduces electrode pressure overshoot to less than 5% and enhances steady-state control accuracy to ±1.5%. Full article
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15 pages, 579 KB  
Article
Pericardial Closure Preserves Early Right Ventricular Function After Cardiac Surgery: A Retrospective Cohort Study
by Hannah Breuer, Marjolijn C. Sales, Natasja W. M. Ramnath, Yusuf Shieba, Alish Kolashov, Ajay Moza, Lachmandath Tewarie, Rashad Zayat and Nima Hatam
J. Cardiovasc. Dev. Dis. 2025, 12(11), 431; https://doi.org/10.3390/jcdd12110431 - 31 Oct 2025
Cited by 1 | Viewed by 681
Abstract
Background: Perioperative right ventricular (RV) dysfunction is a frequent complication of cardiac surgery linked to poor outcomes and may result from the loss of pericardial support. We investigated whether pericardial closure preserves early postoperative RV function. Methods: We compared patients with pericardial closure [...] Read more.
Background: Perioperative right ventricular (RV) dysfunction is a frequent complication of cardiac surgery linked to poor outcomes and may result from the loss of pericardial support. We investigated whether pericardial closure preserves early postoperative RV function. Methods: We compared patients with pericardial closure versus open pericardium. Co-primary endpoints were early postoperative RV longitudinal function by tricuspid annular plane systolic excursion (TAPSE) and tricuspid annular systolic velocity (TASV). Adjusted comparisons used analysis-of-covariance (postoperative value adjusted for baseline) with prespecified covariates (baseline outcome, LV global longitudinal strain, left-ventricular ejection fraction, LVEDVI, sex, procedure; cardiopulmonary bypass and cross-clamp times when available). Holm correction-controlled multiplicity across the co-primary endpoints. Sensitivity linear mixed-effects models (time × group) were performed. Results: Pericardial closure was associated with better early RV longitudinal function after multivariable adjustment. TAPSE: adjusted mean difference (AMD, Closed–Open) 1.531 mm (95% CI 0.130–2.931; p = 0.033). TASV: AMD 1.694 cm/s (95% CI 0.437–2.951; p = 0.009; Holm-adjusted p = 0.018). Sensitivity analyses yielded consistent estimates. Conclusions: Pericardial closure was independently associated with improved early RV longitudinal function. These adjusted findings address baseline LV imbalances and support considering closure to preserve RV performance; confirmation in prospective trials is warranted. Full article
(This article belongs to the Section Cardiac Surgery)
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22 pages, 9740 KB  
Article
Design and Performance Analysis of a High-Temperature Forging Deformation Simulation Device for Dual Manipulators
by Xiaonan Wang, Fugang Zhai, Ziyuan Wang, Zhuofan Yang, Runyuan Zhao and Zunzheng Gu
Machines 2025, 13(11), 999; https://doi.org/10.3390/machines13110999 - 30 Oct 2025
Viewed by 591
Abstract
To address the difficulty of directly detecting internal stresses in high-temperature forgings during dual-manipulator control experiments and the significant safety risks associated with high-temperature environments, this study developed an experimental device to simulate the deformation behavior of such forgings. First, numerical simulations of [...] Read more.
To address the difficulty of directly detecting internal stresses in high-temperature forgings during dual-manipulator control experiments and the significant safety risks associated with high-temperature environments, this study developed an experimental device to simulate the deformation behavior of such forgings. First, numerical simulations of the elongation process were conducted using DEFORM V11 software to examine the deformation mechanisms of high-temperature forgings. Quantitative results for axial deformation, maximum deformation velocity, and deformation force ranges were obtained, which defined the operational specifications and functional requirements of the device. Second, the mechanical structure and hydraulic system were designed based on engineering principles. The dynamic response characteristics of the simulation device under conventional PID and fuzzy PID control were compared through simulations, and the feasibility of the fuzzy PID control strategy was experimentally verified. Finally, a joint simulation model of the high-temperature forging deformation simulation device and the dual forging manipulator clamping system was established. This model was used to analyze the dynamic response of the simulated workpiece under typical cooperative conditions of dual manipulators and to assess the accuracy of the simulation process during clamping. The results confirmed the practical applicability of the device. Overall, the developed simulation device can effectively reproduce the deformation behavior of high-temperature forgings under ambient conditions, providing a safe and reliable platform for studying coordinated control strategies of dual forging manipulators. Full article
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25 pages, 66105 KB  
Article
Toward Real-Time Scalable Rigid-Body Simulation Using GPU-Optimized Collision Detection and Response
by Nak-Jun Sung and Min Hong
Mathematics 2025, 13(19), 3230; https://doi.org/10.3390/math13193230 - 9 Oct 2025
Viewed by 2949
Abstract
We propose a GPU-parallelized collision-detection and response framework for rigid-body dynamics, designed to efficiently handle densely populated 3D simulations in real time. The method combines explicit Euler time integration with a hierarchical Octree–AABB collision-detection scheme, enabling early pruning and localized refinement of contact [...] Read more.
We propose a GPU-parallelized collision-detection and response framework for rigid-body dynamics, designed to efficiently handle densely populated 3D simulations in real time. The method combines explicit Euler time integration with a hierarchical Octree–AABB collision-detection scheme, enabling early pruning and localized refinement of contact checks. To resolve collisions, we employ a two-step response algorithm that integrates non-penetration correction and impulse-based velocity updates, stabilized through smoothing, clamping, and bias mechanisms. The framework is fully implemented within Unity3D using compute shaders and optimized GPU kernels. Experiments across multiple mesh models and increasing object counts demonstrate that the proposed hierarchical configuration significantly improves scalability and frame stability compared to conventional flat AABB methods. In particular, a two-level hierarchy achieves the best trade-off between spatial resolution and computational cost, maintaining interactive frame rates (≥30 fps) under high-density scenarios. These results suggest the practical applicability of our method to real-time simulation systems involving complex collision dynamics. Full article
(This article belongs to the Topic Extended Reality: Models and Applications)
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26 pages, 4900 KB  
Article
Design and Experiment of Bare Seedling Planting Mechanism Based on EDEM-ADAMS Coupling
by Huaye Zhang, Xianliang Wang, Hui Li, Yupeng Shi and Xiangcai Zhang
Agriculture 2025, 15(19), 2063; https://doi.org/10.3390/agriculture15192063 - 30 Sep 2025
Viewed by 819
Abstract
In traditional scallion cultivation, the bare-root transplanting method—which involves direct seeding, seedling raising in the field, and lifting—is commonly adopted to minimize seedling production costs. However, during the mechanized transplanting of bare-root scallion seedlings, practical problems such as severe seedling damage and poor [...] Read more.
In traditional scallion cultivation, the bare-root transplanting method—which involves direct seeding, seedling raising in the field, and lifting—is commonly adopted to minimize seedling production costs. However, during the mechanized transplanting of bare-root scallion seedlings, practical problems such as severe seedling damage and poor planting uprightness exist. In this paper, the Hertz–Mindlin with Bonding contact model was used to establish the scallion seedling model. Combined with the Plackett–Burman experiment, steepest ascent experiment, and Box–Behnken experiment, the bonding parameters of scallion seedlings were calibrated. Furthermore, the accuracy of the scallion seedling model parameters was verified through the stress–strain characteristics observed during the actual loading and compression process of the scallion seedlings. The results indicate that the scallion seedling normal/tangential contact stiffness, scallion seedling normal/tangential ultimate stress, and scallion Poisson’s ratio significantly influence the mechanical properties of scallion seedlings. Through optimization experiments, the optimal combination of the above parameters was determined to be 4.84 × 109 N/m, 5.64 × 107 Pa, and 0.38. In this paper, the flexible planting components of scallion seedlings were taken as the research object. Flexible protrusions were added to the planting disc to reduce the damage rate of scallion seedlings, and an EDEM-ADAMS coupling interaction model between the planting components and scallion seedlings was established. Based on this model, optimization and verification were carried out on the key components of the planting components. Orthogonal experiments were conducted with the contact area between scallion seedlings and the disc, rotational speed of the flexible disc, furrow depth, and clamping force on scallion seedlings as experimental factors, and with the uprightness and damage status of scallion seedlings as evaluation criteria. The experimental results showed that when the contact area between scallion seedlings and the disc was 255 mm2, the angular velocity was 0.278 rad/s, and the furrow depth was 102.15 mm, the performance of the scallion planting mechanism was optimal. At this point, the uprightness of the scallion seedlings was 94.80% and the damage rate was 3%. Field experiments were carried out based on the above parameters. The results indicated that the average uprightness of transplanted scallion seedlings was 93.86% and the damage rate was 2.76%, with an error of less than 2% compared with the simulation prediction values. Therefore, the parameter model constructed in this paper is reliable and effective, and the designed and improved transplanting mechanism can realize the upright and low-damage planting of scallion seedlings, providing a reference for the low-damage and high-uprightness transplanting operation of scallions. Full article
(This article belongs to the Section Agricultural Technology)
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20 pages, 1819 KB  
Article
Reynolds-Dependent Velocity Profile Correction and Its Uncertainty Demonstrated on an Ultrasonic Clamp-On Meter
by Martin Straka, Christian Höhne, Christian Koglin, Bernhard Funck and Thomas Eichler
Metrology 2025, 5(3), 57; https://doi.org/10.3390/metrology5030057 - 22 Sep 2025
Viewed by 1358
Abstract
Most flow metering methods used in industrial applications produce results sensitive to the local velocity profile. In response, manufacturers often implement correction algorithms; however, these are rarely supported by rigorous uncertainty evaluations. This paper presents a Reynolds number-dependent velocity profile correction, applicable under [...] Read more.
Most flow metering methods used in industrial applications produce results sensitive to the local velocity profile. In response, manufacturers often implement correction algorithms; however, these are rarely supported by rigorous uncertainty evaluations. This paper presents a Reynolds number-dependent velocity profile correction, applicable under fully developed flow conditions and for the Reynolds-dependent part of the correction in disturbed flows, demonstrated on the example of an ultrasonic clamp-on flow meter. Measurement uncertainties are evaluated and propagated through a regression model using Monte Carlo simulation, in compliance with the Guide to the Expression of Uncertainty in Measurement (GUM). Special care is taken to assess the validity range and impact of assuming fully developed flow conditions at the test rig. A validation case demonstrates the reliability of the correction algorithm and its associated uncertainty within the tested conditions. The proposed approach is applicable to other meter types and can be extended to corrections for specific flow disturbances. Full article
(This article belongs to the Collection Measurement Uncertainty)
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23 pages, 7920 KB  
Article
Dynamic Behavior of a Rotationally Restrained Pipe Conveying Gas-Liquid Two-Phase Flow
by Guangming Fu, Huilin Jiao, Aixia Zhang, Xiao Wang, Boying Wang, Baojiang Sun and Jian Su
J. Mar. Sci. Eng. 2025, 13(8), 1524; https://doi.org/10.3390/jmse13081524 - 8 Aug 2025
Viewed by 774
Abstract
This study explores the dynamic behavior of a vertical pipe conveying gas-liquid two-phase flow with rotationally restrained boundaries, employing the generalized integral transform technique (GITT). The rotationally restrained boundary conditions are more realistic for practical engineering applications in comparison to the classical simply-supported [...] Read more.
This study explores the dynamic behavior of a vertical pipe conveying gas-liquid two-phase flow with rotationally restrained boundaries, employing the generalized integral transform technique (GITT). The rotationally restrained boundary conditions are more realistic for practical engineering applications in comparison to the classical simply-supported and clamped boundary conditions, which can be viewed as limiting scenarios of the rotationally restrained boundary conditions when rotational stiffness approaches zero and infinity, respectively. Utilizing the small-deflection Euler-Bernoulli beam theory, the governing equation of motion for the deflection of the pipe is transformed into an infinite set of coupled ordinary differential equations, which is then numerically solved following truncation at a finite order NW. The proposed integral transform solution was initially validated against extant literature results. Numerical findings demonstrate that as the gas volume fraction increases, there is a reduction in both the first-order critical flow velocity and the vibration frequency of the pipe conveying two-phase flow. Conversely, as the rotational stiffness factor enhances, both the first-order critical velocity and vibration frequency increase, resulting in improved stability of the pipe. The impact of the bottom-end rotational stiffness factor r2 on the dynamic stability of the pipe is more pronounced compared to the top-end rotational factor r1. The variation in two-phase flow parameters is closely associated with the damping and stiffness matrices. Modifying the gas volume fraction in the two-phase flow alters the distribution of centrifugal and Coriolis forces within the pipeline system, thereby affecting the pipeline’s natural frequency. The results illustrate that an increase in the gas volume fraction leads to a decrease in both the pipeline’s critical velocity and vibration frequency, culminating in reduced stability. The findings suggest that both the gas volume fraction and boundary rotational stiffness exert a significant influence on the dynamic behavior and stability of the pipe conveying gas-liquid two-phase flow. Full article
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20 pages, 3689 KB  
Article
Active Colitis-Induced Atrial Electrophysiological Remodeling
by Hiroki Kittaka, Edward J. Ouille V, Carlos H. Pereira, Andrès F. Pélaez, Ali Keshavarzian and Kathrin Banach
Biomolecules 2025, 15(7), 982; https://doi.org/10.3390/biom15070982 - 10 Jul 2025
Cited by 1 | Viewed by 1187
Abstract
Patients with ulcerative colitis exhibit an increased risk for supraventricular arrhythmia during the active disease phase of the disease and show signs of atrial electrophysiological remodeling in remission. The goal of this study was to determine the basis for colitis-induced changes in atrial [...] Read more.
Patients with ulcerative colitis exhibit an increased risk for supraventricular arrhythmia during the active disease phase of the disease and show signs of atrial electrophysiological remodeling in remission. The goal of this study was to determine the basis for colitis-induced changes in atrial excitability. In a mouse model (C57BL/6; 3 months) of dextran sulfate sodium (DSS)-induced active colitis (3.5% weight/volume, 7 days), electrocardiograms (ECG) revealed altered atrial electrophysiological properties with a prolonged P-wave duration and PR interval. ECG changes coincided with a decreased atrial conduction velocity in Langendorff perfused hearts. Action potentials (AP) recorded from isolated atrial myocytes displayed an attenuated maximal upstroke velocity and amplitude during active colitis, as well as a prolonged AP duration (APD). Voltage clamp analysis revealed a colitis-induced shift in the voltage-dependent activation of the Na-current (INa) to more depolarizing voltages. In addition, protein levels of Nav1.5 protein and connexin isoform Cx43 were reduced. APD prolongation depended on a reduction in the transient outward K-current (Ito) mostly generated by Kv4.2 channels. The changes in ECG, atrial conductance, and APD were reversible upon remission. The change in conduction velocity predominantly depended on the reversibility of the reduced Cx43 and Nav1.5 expression. Treatment of mice with inhibitors of Angiotensin-converting enzyme (ACE) or Angiotensin II (AngII) receptor type 1 (AT1R) prevented the colitis-induced atrial electrophysiological remodeling. Our data support a colitis-induced increase in AngII signaling that promotes atrial electrophysiological remodeling and puts colitis patients at an increased risk for atrial arrhythmia. Full article
(This article belongs to the Special Issue Molecular Advances in Inflammatory Bowel Disease)
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11 pages, 1065 KB  
Article
Short-Term Outcomes of Partial Upper Ministernotomy for Aortic Valve Replacement Within the Learning Curve Context
by Tomáš Toporcer, Marián Homola, Anton Bereš, Michal Trebišovský, Tomáš Lopuchovský, Štefánia Mižáková, Lukáš Vajda, Štefan Lukačín and Adrián Kolesár
J. Cardiovasc. Dev. Dis. 2025, 12(7), 254; https://doi.org/10.3390/jcdd12070254 - 1 Jul 2025
Viewed by 1332
Abstract
Background: In recent decades, aortic valve surgery has transitioned from conventional median sternotomy (MS) to minimally invasive techniques, including partial upper mini-sternotomy (PUMS) and right anterolateral mini-thoracotomy (RAMT). This study retrospectively compares the outcomes of aortic valve replacement (AVR) using PUMS during the [...] Read more.
Background: In recent decades, aortic valve surgery has transitioned from conventional median sternotomy (MS) to minimally invasive techniques, including partial upper mini-sternotomy (PUMS) and right anterolateral mini-thoracotomy (RAMT). This study retrospectively compares the outcomes of aortic valve replacement (AVR) using PUMS during the learning phase with those of standard MS. Methods: A retrospective analysis was conducted on patients (n = 211) who underwent AVR for aortic stenosis. They were divided into MS (n = 119) and PUMS (n = 92) groups. Various preoperative, surgical and postoperative parameters, including survival, were examined. Results: Preoperatively, the main difference was age, with PUMS patients being older (67.5 ± 7 vs. 66.5 ± 9.6; p = 0.010). PUMS patients also had longer cardiopulmonary bypass (CPB) and cross-clamping times (99 ± 25 vs. 80 ± 16 min; p < 0.002; 79 ± 18 vs. 65 ± 13 min; p < 0.024). There were no significant differences in body mass index, prosthesis size, indexed effective orifice area, hospitalisation duration or any other monitored parameter. Echocardiographic follow-up found no differences in prosthetic pressure gradients, flow velocity or paravalvular leak between the PUMS and MS groups. Survival rates were similar over 1000 days. Conclusions: The data suggest that PUMS offers comparable surgical outcomes to MS for AVR with additional cosmetic benefits, undeterred by a learning curve. Full article
(This article belongs to the Section Cardiac Surgery)
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20 pages, 3828 KB  
Article
Research on Measurement Error Distribution and Optimization Measurement Method of Clamp-On Ultrasonic Flowmeter in Downstream Pipeline Disturbance
by Zhongzhi Yang, Wei Wang, Xianjie Liu, Xin Chen, Xia Li and Xiaofeng Lu
Sensors 2025, 25(13), 4011; https://doi.org/10.3390/s25134011 - 27 Jun 2025
Cited by 1 | Viewed by 1587
Abstract
Clamp-on ultrasonic flowmeters serve as an important tool for on-site testing of gas flow meters. However, its accuracy is significantly affected by the actual flow field, thus limiting its application scenarios. To address this issue, this study focuses on typical industrial disturbance structures [...] Read more.
Clamp-on ultrasonic flowmeters serve as an important tool for on-site testing of gas flow meters. However, its accuracy is significantly affected by the actual flow field, thus limiting its application scenarios. To address this issue, this study focuses on typical industrial disturbance structures and obtains the evolution and distribution of non-ideal flow fields downstream of disturbances through experiments and numerical simulations, as well as their effects on velocity and flow measurement errors. The results indicate that when traditional reflection or diagonal measurements were used in the downstream of disturbances, the flow deviation was largely dependent on the installation position and angle of the clamp-on ultrasonic flowmeter. This introduced significant uncertainty and bias, rendering it impossible to correct measurement results through quantitative coefficients. Utilizing a dual-channel measurement method can enhance measurement accuracy. When two sets of sensors perpendicular to each other were used to combine the reflection measurement path, the deviation fluctuation downstream of disturbances can be effectively controlled within the range of ±2%, irrespective of the installation angle. This measurement approach significantly reduced the distance limitations on the distance of the straight pipe section during the use of clamp-on ultrasonic flowmeters. Full article
(This article belongs to the Section Physical Sensors)
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