Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (4)

Search Parameters:
Keywords = complex coacervate core micelle

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
12 pages, 1640 KiB  
Article
Sequence of Polyurethane Ionomers Determinative for Core Structure of Surfactant–Copolymer Complexes
by Elizabeth M. Timmers, Jose Rodrigo Magana, Sandra M. C. Schoenmakers, P. Michel Fransen, Henk M. Janssen and Ilja K. Voets
Int. J. Mol. Sci. 2021, 22(1), 337; https://doi.org/10.3390/ijms22010337 - 30 Dec 2020
Cited by 4 | Viewed by 3393
Abstract
The core of micelles self-assembled from amphiphiles is hydrophobic and contains little water, whereas complex coacervate core micelles co-assembled from oppositely charged hydrophilic polymers have a hydrophilic core with a high water content. Co-assembly of ionic surfactants with ionic-neutral copolymers yields surfactant–copolymer complexes [...] Read more.
The core of micelles self-assembled from amphiphiles is hydrophobic and contains little water, whereas complex coacervate core micelles co-assembled from oppositely charged hydrophilic polymers have a hydrophilic core with a high water content. Co-assembly of ionic surfactants with ionic-neutral copolymers yields surfactant–copolymer complexes known to be capable of solubilizing both hydrophilic and hydrophobic cargo within the mixed core composed of a coacervate phase with polyelectrolyte-decorated surfactant micelles. Here we formed such complexes from asymmetric (PUI-A2) and symmetric (PUI-S2), sequence-controlled polyurethane ionomers and poly(N-methyl-2-vinylpyridinium iodide)29-b-poly(ethylene oxide)204 copolymers. The complexes with PUI-S2 were 1.3-fold larger in mass and 1.8-fold larger in radius of gyration than the PUI-A2 complexes. Small-angle X-ray scattering revealed differences in the packing of the similarly sized PUI micelles within the core of the complexes. The PUI-A2 micelles were arranged in a more ordered fashion and were spaced further apart from each other (10 nm vs. 6 nm) than the PUI-S2 micelles. Hence, this work shows that the monomer sequence of amphiphiles can be varied to alter the internal structure of surfactant–copolymer complexes. Since the structure of the micellar core may affect both the cargo loading and release, our findings suggest that these properties may be tuned through control of the monomer sequence of the micellar constituents. Full article
(This article belongs to the Special Issue Assembly Superstructures in Chemistry)
Show Figures

Figure 1

35 pages, 7748 KiB  
Review
On Complex Coacervate Core Micelles: Structure-Function Perspectives
by Jose Rodrigo Magana, Christian C. M. Sproncken and Ilja K. Voets
Polymers 2020, 12(9), 1953; https://doi.org/10.3390/polym12091953 - 28 Aug 2020
Cited by 51 | Viewed by 8318
Abstract
The co-assembly of ionic-neutral block copolymers with oppositely charged species produces nanometric colloidal complexes, known, among other names, as complex coacervates core micelles (C3Ms). C3Ms are of widespread interest in nanomedicine for controlled delivery and release, whilst research activity into other application areas, [...] Read more.
The co-assembly of ionic-neutral block copolymers with oppositely charged species produces nanometric colloidal complexes, known, among other names, as complex coacervates core micelles (C3Ms). C3Ms are of widespread interest in nanomedicine for controlled delivery and release, whilst research activity into other application areas, such as gelation, catalysis, nanoparticle synthesis, and sensing, is increasing. In this review, we discuss recent studies on the functional roles that C3Ms can fulfil in these and other fields, focusing on emerging structure–function relations and remaining knowledge gaps. Full article
(This article belongs to the Collection The Next Generation in Polymer Research)
Show Figures

Graphical abstract

16 pages, 3080 KiB  
Article
Effect of Ionic Group on the Complex Coacervate Core Micelle Structure
by Tae-Young Heo, Inhye Kim, Liwen Chen, Eunji Lee, Sangwoo Lee and Soo-Hyung Choi
Polymers 2019, 11(3), 455; https://doi.org/10.3390/polym11030455 - 10 Mar 2019
Cited by 22 | Viewed by 4859
Abstract
Pairs of ionic group dependence of the structure of a complex coacervate core micelle (C3M) in an aqueous solution was investigated using DLS, cryo-TEM, and SANS with a contrast matching technique and a detailed model analysis. Block copolyelectrolytes were prepared by introducing an [...] Read more.
Pairs of ionic group dependence of the structure of a complex coacervate core micelle (C3M) in an aqueous solution was investigated using DLS, cryo-TEM, and SANS with a contrast matching technique and a detailed model analysis. Block copolyelectrolytes were prepared by introducing an ionic group (i.e., ammonium, guanidinium, carboxylate, and sulfonate) to poly(ethylene oxide-b-allyl glycidyl ether) (NPEO = 227 and NPAGE = 52), and C3Ms were formed by simple mixing of two oppositely-charged block copolyelectrolyte solutions with the exactly same degree of polymerization. All four C3Ms are spherical with narrow distribution of micelle dimension, and the cores are significantly swollen by water, resulting in relatively low brush density of PEO chains on the core surface. With the pair of strong polyelectrolytes, core radius and aggregation number increases, which reflects that the formation of complex coacervates are significantly sensitive to the pairs of ionic groups rather than simple charge pairing. Full article
Show Figures

Graphical abstract

6819 KiB  
Article
Colorful Packages: Encapsulation of Fluorescent Proteins in Complex Coacervate Core Micelles
by Antsje Nolles, Adrie H. Westphal, J. Mieke Kleijn, Willem J. H. Van Berkel and Jan Willem Borst
Int. J. Mol. Sci. 2017, 18(7), 1557; https://doi.org/10.3390/ijms18071557 - 19 Jul 2017
Cited by 12 | Viewed by 8104
Abstract
Encapsulation of proteins can be beneficial for food and biomedical applications. To study their biophysical properties in complex coacervate core micelles (C3Ms), we previously encapsulated enhanced green fluorescent protein (EGFP) and its monomeric variant, mEGFP, with the cationic-neutral diblock copolymer poly(2-methyl-vinyl-pyridinium)n- [...] Read more.
Encapsulation of proteins can be beneficial for food and biomedical applications. To study their biophysical properties in complex coacervate core micelles (C3Ms), we previously encapsulated enhanced green fluorescent protein (EGFP) and its monomeric variant, mEGFP, with the cationic-neutral diblock copolymer poly(2-methyl-vinyl-pyridinium)n-b-poly(ethylene-oxide)m (P2MVPn-b-PEOm) as enveloping material. C3Ms with high packaging densities of fluorescent proteins (FPs) were obtained, resulting in a restricted orientational freedom of the protein molecules, influencing their structural and spectral properties. To address the generality of this behavior, we encapsulated seven FPs with P2MVP41-b-PEO205 and P2MVP128-b-PEO477. Dynamic light scattering and fluorescence correlation spectroscopy showed lower encapsulation efficiencies for members of the Anthozoa class (anFPs) than for Hydrozoa FPs derived from Aequorea victoria (avFPs). Far-UV CD spectra of the free FPs showed remarkable differences between avFPs and anFPs, caused by rounder barrel structures for avFPs and more elliptic ones for anFPs. These structural differences, along with the differences in charge distribution, might explain the variations in encapsulation efficiency between avFPs and anFPs. Furthermore, the avFPs remain monomeric in C3Ms with minor spectral and structural changes. In contrast, the encapsulation of anFPs gives rise to decreased quantum yields (monomeric Kusabira Orange 2 (mKO2) and Tag red fluorescent protein (TagRFP)) or to a pKa shift of the chromophore (FP variant mCherry). Full article
(This article belongs to the Special Issue Fluorescent Proteins)
Show Figures

Graphical abstract

Back to TopTop