Search Results (3,410)

As the core refrigeration equipment in cooling systems, the operational state of chiller units is crucial for ship support, equipment cooling, and mission stability. However, because of their sensitivity and the complexity of operating environments, obtaining large volumes of complete, fault-labeled data is difficult in practical engineering appli-cations. This limitation makes it challenging for traditional data-driven approaches to deliver accurate fault diagnoses. Furthermore, data collected from different devices or under varying operating conditions often differ significantly in both feature dimensions and distributions, i.e., data heterogeneity, which further complicates model transfer. To address these challenges, this study proposes a deep transfer learning–based fault di-agnosis method designed to leverage abundant knowledge from the source domain while adaptively learning features of the target domain. Given the persistent difficulties in collecting sufficient high-quality labeled fault data, traditional data-driven models continue to face restricted diagnostic performance on target equipment. At the same time, data heterogeneity across devices or operating conditions intensifies the challenge of cross-domain knowledge transfer. To overcome these issues, this study develops a heterogeneous transfer learning method that integrates a dual-channel autoencoder, domain adversarial training, and pseudo-label self-training. This combination enables precise small-sample knowledge transfer from the source to the target domain. Specifi-cally, the dual-channel autoencoder is first applied to align heterogeneous feature di-mensions. Then, a Gradient Reversal Layer (GRL) and a domain discriminator are in-troduced to extract domain-invariant features. In parallel, high-confidence pseu-do-labeled samples from the target domain are incorporated into joint training to im-prove generalization and robustness. Experimental results confirm that the method achieves high fault diagnosis accuracy in typical industrial application scenarios, ena-bling effective identification of common faults in various types of chiller units under conventional operating conditions, the proposed method achieves higher accuracy and F1-scores in multi-class fault diagnosis tasks compared with both traditional approaches and existing transfer learning methods. These findings provide a novel perspective for advancing the intelligent operation and maintenance of chiller units. Full article

The temperature of the thermal energy storage unit is a critical parameter for the stable operation of seasonal borehole thermal energy storage (BTES) systems. However, existing temperature prediction models predominantly focus on estimating single-point temperatures or borehole wall temperatures, while lacking effective methods for calculating the average temperature of the storage unit. This limitation hinders accurate assessment of the thermal charging and discharging states. Furthermore, some models involve complex computations and exhibit low operational efficiency, failing to meet the practical engineering demands for rapid prediction and response. To address these challenges, this study first develops a thermal response model for the average temperature of the storage unit based on the finite line source theory and further proposes a simplified engineering algorithm for predicting the storage unit temperature. Subsequently, two-dimensional discrete convolution and Fast Fourier Transform (FFT) techniques are introduced to accelerate the solution of the storage unit temperature distribution. Finally, the model’s accuracy is validated against practical engineering cases. The results indicate that the single-point temperature engineering algorithm yields a maximum relative error of only 0.3%, while the average temperature exhibits a maximum relative error of 1.2%. After employing FFT, the computation time of both single-point and average temperature engineering algorithms over a 10-year simulation period is reduced by more than 90%. When using two-dimensional discrete convolution to calculate the temperature distribution of the storage unit, expanding the input layer from 200 × 200 to 400 × 400 and the convolution kernel from 25 × 25 to 51 × 51 reduces the time required for temperature superposition calculations to approximately 0.14–0.82% of the original time. This substantial improvement in computational efficiency is achieved without compromising accuracy. Full article

Background/Objectives: Appendiceal cancer (AC) is a rare and understudied malignancy with limited genomic data available to guide clinical interventions. Historically treated as a subtype of colorectal cancer, AC is now recognized as a distinct disease with unique histologic subtypes and molecular features. This review aims to consolidate current genomic data across AC subtypes and explore the clinical relevance of recurrent mutations. Methods: A systematic literature review was performed in accordance with general Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines. Using search engines such as PubMed and Web of Science, we selected studies based on relevance to AC genomics using search terms such as “appendix cancer”, “appendiceal cancer”, “pseudomyxoma peritonei”, “sequencing”, “mutation”, and “genotype”. Results: AC comprises five major histologic subtypes—appendiceal neuroendocrine neoplasms (ANENs), mucinous appendiceal neoplasms (MANs), goblet cell adenocarcinomas (GCAs), colonic-type adenocarcinomas (CTAs) and signet ring cell adenocarcinomas (SRCs)—each with unique clinical behaviors and mutational profiles. Low-grade tumors, such as ANENs and MANs, frequently harbor KRAS and GNAS mutations, while high-grade subtypes, such as CTAs and SRCs, are enriched for TP53, APC, and SMAD gene alterations. GCA tumors exhibit a distinct mutational spectrum involving chromatin remodeling genes such as ARID1A and KMT2D. Compared to colorectal cancer, AC demonstrates lower frequencies of APC and TP53 mutations and a higher prevalence of GNAS mutations, consistent with a pathological divergence from CRC. Conclusions: The genomic heterogeneity of AC is commensurate with its histological complexity and has important implications for diagnosis, prognosis and treatment. While certain actionable mutations are present in a subset of tumors, large-scale genomic characterization efforts and development of subtype-specific models will be essential for advancing precision medicine in AC. Full article

Security is crucial, especially as software systems become increasingly complex. Both practitioners and researchers advocate for the early integration of security requirements (SR) into the Software Development Life Cycle (SDLC). However, ensuring the validation and assurance of security requirements is still a major challenge in developing secure systems. To investigate this issue, a two-phase study was carried out. First phase: a literature review was conducted on 45 relevant studies related to Security Requirements Engineering (SRE) and Security Requirements Assurance (SRA). Nine SRE techniques were examined across multiple parameters, including major categories, requirements engineering stages, project scale, and the integration of standards involving 17 distinct activities. Second phase: An empirical survey of 58 industry professionals revealed a clear disparity between the understanding of Security Requirements Engineering (SRE) and the implementation of Security Requirements Assurance (SRA). While statistical analyses (ANOVA, regression, correlation, Kruskal–Wallis) confirmed a moderate grasp of SRE practices, SRA remains poorly understood and underapplied. Unlike prior studies focused on isolated models, this research combines practical insights with comparative analysis, highlighting the systemic neglect of SRA in current practices. The findings indicate the need for stronger security assurance in early development phases, offering targeted, data-driven recommendations for bridging this gap. Full article

This study investigates the utilisation of AI tools, including Grammarly Free, QuillBot Free, Canva Free Individual, and others, to enhance learning outcomes for 180 s-year telecommunications engineering students at Universidad Politécnica de Madrid. This research incorporates teaching methods like problem-based learning, experiential learning, task-based learning, and content–language integrated learning, with English as the medium of instruction. These tools were strategically used to enhance language skills, foster computational thinking, and promote critical problem-solving. A control group comprising 120 students who did not receive AI support was included in the study for comparative analysis. The control group’s role was essential in evaluating the impact of AI tools on learning outcomes by providing a baseline for comparison. The results indicated that the pilot group, utilising AI tools, demonstrated superior performance compared to the control group in listening comprehension (98.79% vs. 90.22%) and conceptual understanding (95.82% vs. 84.23%). These findings underscore the significance of these skills in enhancing communication and problem-solving abilities within the field of engineering. The assessment of the pilot course’s forum revealed a progression from initially error-prone and brief responses to refined, evidence-based reflections in participants. This evolution in responses significantly contributed to the high success rate of 87% in conducting complex contextual analyses by pilot course participants. Subsequent to these results, a project for educational innovation aims to implement the AI-PBL-CLIL model at Universidad Politécnica de Madrid from 2025 to 2026. Future research should look into adaptive AI systems for personalised learning and study the long-term effects of AI integration in higher education. Furthermore, collaborating with industry partners can significantly enhance the practical application of AI-based methods in engineering education. These strategies facilitate benchmarking against international standards, provide structured support for skill development, and ensure the sustained retention of professional competencies, ultimately elevating the international recognition of Spain’s engineering education. Full article

Offshore reservoirs in the high water-cut stage present significant development challenges, including declining production, complex remaining oil distribution, and the inadequacy of conventional evaluation methods to capture intricate flow dynamics. To overcome these limitations, this study introduces a novel approach based on flow diagnostics for performance evaluation and potential adjustment. The method integrates key metrics such as time-of-flight (TOF) and the dynamic Lorenz coefficient, supported by reservoir engineering principles and numerical simulation, to construct a multi-parameter evaluation system. This system, which also incorporates injection–production communication volume and inter-well fluid allocation factors, precisely quantifies and visualizes waterflood displacement processes and sweep efficiency. Applied to the QHD32 oilfield, this framework was used to establish specific thresholds for operational adjustments. These include criteria for infill drilling (waterflooded ratio < 45%, remaining oil thickness > 6 m, TOF > 200 days), conformance control (TOF < 50 days, dynamic Lorenz coefficient > 0.5), and artificial lift optimization (remaining oil thickness ratio > 2/3, TOF > 200 days). Field validation confirmed the efficacy of this approach: an additional cumulative oil production of 165,600 m³ was achieved from infill drilling in the C29 well group, while displacement adjustments in the B03 well group increased oil production by 2.2–3.8 tons/day, demonstrating a significant enhancement in waterflooding performance. This research provides a theoretical foundation and a technical pathway for the refined development of offshore heavy oil reservoirs at the ultra-high water-cut stage, offering a robust framework for the sustainable management of analogous reservoirs worldwide. Full article

Harvesting winter jujubes is a key step in production, yet traditional manual approaches are labor-intensive and inefficient. To overcome these challenges, we propose SCC-YOLO, a lightweight method for winter jujube detection, 3D localization, and cross-platform deployment, aiming to support intelligent harvesting. In this study, RGB-D cameras were integrated with an improved YOLOv11 network optimized by ShuffleNetV2, CBAM, and a redesigned C2f_WTConv module, which enables joint spatial–frequency feature modeling and enhances small-object detection in complex orchard conditions. The model was trained on a diversified dataset with extensive augmentation to ensure robustness. In addition, the original localization loss was replaced with DIoU to improve bounding box regression accuracy. A robotic harvesting system was developed, and an Eye-to-Hand calibration-based 3D localization pipeline was implemented to map fruit coordinates to the robot workspace for accurate picking. To validate engineering applicability, the SCC-YOLO model was deployed on both desktop (PyTorch and ONNX Runtime) and mobile (NCNN with Vulkan+FP16) platforms, and FPS, latency, and stability were comparatively analyzed. Experimental results showed that SCC-YOLO improved mAP by 5.6% over YOLOv11, significantly enhanced detection precision and robustness, and achieved real-time performance on mobile devices while maintaining peak throughput on high-performance desktops. Field and laboratory tests confirmed the system’s effectiveness for detection, localization, and harvesting efficiency, demonstrating its adaptability to diverse deployment environments and its potential for broader agricultural applications. Full article

General-purpose graphics computing on processing units (GPGPUs) face significant performance limitations due to memory access latencies, particularly when traditional memory hierarchies and thread-switching mechanisms prove insufficient for complex access patterns in data-intensive applications such as machine learning (ML) and scientific computing. This paper presents a novel hardware design for a memory prefetching subsystem targeted at DDR (Double Data Rate) memory in GPGPU architectures. The proposed prefetching subsystem features a modular architecture comprising multiple parallel prefetching engines, each handling distinct memory address ranges with dedicated data buffers and adaptive stride detection algorithms that dynamically identify recurring memory access patterns. The design incorporates robust system integration features, including context flushing, watchdog timers, and flexible configuration interfaces, for runtime optimization. Comprehensive experimental validation using real-world workloads examined critical design parameters, including block sizes, prefetch outstanding limits, and throttling rates, across diverse memory access patterns. Results demonstrate significant performance improvements with average memory access latency reductions of up to 82% compared to no-prefetch baselines, and speedups in the range of 1.240–1.794. The proposed prefetching subsystem successfully enhances memory hierarchy efficiency and provides practical design guidelines for deployment in production GPGPU systems, establishing clear parameter optimization strategies for different workload characteristics. Full article

Copper ions play essential roles in biological systems, but they can cause toxicity following dysregulation or excessive accumulation. In addition, environmental overexposure to Cu²⁺ can lead to serious agricultural and ecological issues. Accurate detection of Cu²⁺ is therefore critical in both medical diagnostics and environmental monitoring. Fluorescent proteins (FPs), which are widely used in molecular and cell biology, have been suggested as attractive modalities for metal ion detection owing to their biocompatibility and specific responsiveness to metal ions. The fluorescence emission of FPs is efficiently quenched by Cu²⁺ in a reversible manner, suggesting the potential to develop Cu²⁺-responsive biosensors. To develop highly sensitive and selective Cu²⁺ biosensors based on FPs, an understanding of Cu²⁺ binding to FPs is crucial, along with FP engineering guided by structural analysis. In this study, the molecular properties of FPs and their fluorescence responses to metal ions were reviewed. The crystal structures of FPs complexed with Cu²⁺ were analyzed, revealing both specific and nonspecific Cu²⁺ binding modes. This structural analysis provides insights into the potential of engineering FPs to enhance sensitivity and selectivity for Cu²⁺ detection. Full article

Nano- and micro-indentation have become essential tools for quantifying the micromechanical behavior of rocks beyond traditional macroscopic tests. This review summarizes the historical evolution, experimental methodologies, and interpretation models (e.g., Oliver–Pharr, Doerner–Nix, energy-based methods, Hertz/ECM/Lawn), with a particular focus on rock-specific challenges such as heterogeneity, anisotropy, and surface roughness. A structured literature survey (1980–August 2025) covers representative studies on shale, limestone, marble, sandstone, claystone, and granite. The transition from classical hardness measurements to advanced instrumented indentation has enabled more reliable determination of localized properties, including hardness, elastic modulus, fracture toughness, and creep. Special attention is given to the applicability and limitations of different interpretation models when applied to heterogeneous and anisotropic rocks. Current challenges include high sensitivity to surface conditions and difficulties in capturing the full complexity of natural rock behavior. Looking forward, promising directions involve intelligent systems that integrate AI-driven data analytics, robotic automation, and multiscale modeling (from molecular dynamics to continuum FEM) to enable predictive material design. This review aims to provide geoscientists and engineers with a comprehensive foundation for the effective application and further development of indentation-based testing in rock mechanics and geotechnical engineering. Full article

Computer-Aided Design (CAD) software has long served as a foundation for planning and modeling in Architecture, Engineering, and Construction (AEC). In recent years, the introduction of Augmented Reality (AR) and Virtual Reality (VR) has significantly reshaped the CAD landscape, offering novel interaction paradigms that bridge the gap between digital prototypes and real-world spatial understanding. These technologies have enabled users to engage with 3D architectural content in more immersive and intuitive ways, facilitating improved decision making and communication throughout design workflows. As digital design services grow more complex and span multiple media platforms—from desktop-based modeling to immersive AR/VR environments—evaluating usability and User Experience (UX) becomes increasingly challenging. This paper presents a longitudinal usability and UX study of a multiplatform house design pipeline (i.e., structured workflow for creating, adapting, and delivering house designs so they can be used seamlessly across multiple platforms) comprising a web-based application for initial house creation, a mobile AR tool for contextual exterior visualization, and VR applications that allow full-scale interior exploration and configuration. Together, these components form a unified yet heterogeneous service experience across different devices and modalities. We describe the iterative design and development of this system over three distinct phases (lasting two years), each followed by user studies which evaluated UX and usability and targeted different participant profiles and design maturity levels. The paper outlines our approach to cross-platform UX evaluation, including methods such as the Think-Aloud Protocol (TAP), standardized usability metrics, and structured interviews. The results from the studies provide insight into user preferences, interaction patterns, and system coherence across platforms. From both participant and evaluator perspectives, the iterative methodology contributed to improvements in system usability and a clearer mental model of the design process. The main research question we address is how iterative design and development affects the UX of the heterogeneous service. Our findings highlight important considerations for future research and practice in the design of integrated, multiplatform XR services for AEC, with potential relevance to other domains. Full article

Fungi play a crucial yet often unnoticed role in our lives and the health of our planet by breaking down organic matter through their diverse enzymes or eliminating environmental contamination, enhancing biomass pretreatment, and facilitating biofuel production. They offer transformative possibilities not only for improving the production of materials they naturally produce, but also for the production of non-native and even new-to-nature materials. However, despite these promising applications, the full potential of fungi remains untapped mainly due to limitations in our ability to control and optimize their complex biological systems. This review focuses on developments that address these challenges, with specific emphasis on fungal-derived rigid and flexible materials. To achieve this goal, the application of synthetic biology tools—such as programmable regulators, CRISPR-based genome editing, and combinatorial pathway optimization—in engineering fungal strains is highlighted, and how external environmental parameters can be tuned to influence material properties is discussed. This review positions filamentous fungi as promising platforms for sustainable bio-based technologies, contributing to a more sustainable future across various sectors. Full article

Selecting an appropriate Multi-Criteria Decision-Making (MCDM) algorithm for optimizing marine diesel engine operation presents a complex challenge due to the diversity in mathematical formulations, normalization schemes, and trade-off resolutions across methods. This study systematically evaluates fourteen MCDM algorithms, which are grouped into five primary methodological categories: Scoring-Based, Distance-Based, Pairwise Comparison, Outranking, and Hybrid/Intelligent System-Based methods. The goal is to identify the most suitable algorithm for real-time performance optimization of two stroke marine diesel engines. Using Diesel-RK software, calibrated for marine diesel applications, simulations were performed on a variant of the MAN-B&W-S60-MC-C8-8 engine. A refined five-dimensional parameter space was constructed by systematically varying five key control variables: Start of Injection (SOI), Dwell Time, Fuel Mass Fraction, Fuel Rail Pressure, and Exhaust Valve Timing. A subset of 4454 high-potential alternatives was systematically evaluated according to three equally important criteria: Specific Fuel Consumption (SFC), Nitrogen Oxides (NO_x), and Particulate Matter (PM). The MCDM algorithms were evaluated based on ranking consistency and stability. Among them, Proximity Indexed Value (PIV), Integrated Simple Weighted Sum Product (WISP), and TriMetric Fusion (TMF) emerged as the most stable and consistently aligned with the overall consensus. These methods reliably identified optimal engine control strategies with minimal sensitivity to normalization, making them the most suitable candidates for integration into automated marine engine decision-support systems. The results underscore the importance of algorithm selection and provide a rigorous basis for establishing MCDM in emission-constrained maritime environments. This study is the first comprehensive, simulation-based evaluation of fourteen MCDM algorithms applied specifically to the optimization of two stroke marine diesel engines using Diesel-RK software. Full article

The actomyosin complex—nature’s dynamic engine composed of actin filaments and myosin motors—is emerging as a versatile tool for bio-integrated nanotechnology. This review explores the growing potential of actomyosin-powered systems in biosensing and actuation applications, highlighting their compatibility with physiological conditions, responsiveness to biochemical and physical cues and modular adaptability. We begin with a comparative overview of natural and synthetic nanomachines, positioning actomyosin as a uniquely scalable and biocompatible platform. We then discuss experimental advances in controlling actomyosin activity through ATP, calcium, heat, light and electric fields, as well as their integration into in vitro motility assays, soft robotics and neural interface systems. Emphasis is placed on longstanding efforts to harness actomyosin as a biosensing element—capable of converting chemical or environmental signals into measurable mechanical or electrical outputs that can be used to provide valuable clinical and basic science information such as functional consequences of disease-associated genetic variants in cardiovascular genes. We also highlight engineering challenges such as stability, spatial control and upscaling, and examine speculative future directions, including emotion-responsive nanodevices. By bridging cell biology and bioengineering, actomyosin-based systems offer promising avenues for real-time sensing, diagnostics and therapeutic feedback in next-generation biosensors. Full article

Antibiotic resistance remains one of the most formidable challenges to modern medicine, threatening to outpace therapeutic innovation and undermine decades of clinical progress. While resistance was once viewed narrowly as a clinical phenomenon, it is now understood as the outcome of complex ecological and molecular interactions that span soil, water, agriculture, animals, and humans. Environmental reservoirs act as silent incubators of resistance genes, with horizontal gene transfer and stress-induced mutagenesis fueling their evolution and dissemination. At the molecular level, advances in genomics, structural biology, and systems microbiology have revealed intricate networks involving plasmid-mediated resistance, efflux pump regulation, integron dynamics, and CRISPR-Cas interactions, providing new insights into the adaptability of pathogens. Simultaneously, the environmental dimensions of resistance, from wastewater treatment plants and aquaculture to airborne dissemination, highlight the urgency of adopting a One Health framework. Yet, alongside this growing threat, novel therapeutic avenues are emerging. Innovative β-lactamase inhibitors, bacteriophage-based therapies, engineered lysins, antimicrobial peptides, and CRISPR-driven antimicrobials are redefining what constitutes an “antibiotic” in the twenty-first century. Furthermore, artificial intelligence and machine learning now accelerate drug discovery and resistance prediction, raising the possibility of precision-guided antimicrobial stewardship. This review synthesizes molecular insights, environmental drivers, and therapeutic innovations to present a comprehensive landscape of antibiotic resistance. By bridging ecological microbiology, molecular biology, and translational medicine, it outlines a roadmap for surveillance, prevention, and drug development while emphasizing the need for integrative policies to safeguard global health. Full article