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28 pages, 7371 KB  
Article
Parametric Analysis of a 400-Meter Super-High-Rise Building: Global and Local Structural Behavior
by Jiafeng Chen, Wei Hao, Weihong Cheng, Jie Wang and Haokai Chen
Buildings 2025, 15(17), 3199; https://doi.org/10.3390/buildings15173199 - 4 Sep 2025
Viewed by 174
Abstract
Super high-rise buildings of 400 m and above are currently rare globally, making their design and construction data invaluable. Due to their enormous size, the structural safety, architectural effect, and construction cost are key concerns of all parties. This study employs parametric analysis [...] Read more.
Super high-rise buildings of 400 m and above are currently rare globally, making their design and construction data invaluable. Due to their enormous size, the structural safety, architectural effect, and construction cost are key concerns of all parties. This study employs parametric analysis to research the lateral force-resisting system and key local structural issues of a 400 m under-construction super-high-rise structure. The overall analysis results show that the 8-mega-column scheme can relatively well balance architectural effect and structural performance; the 5-belt truss design minimizes the steel consumption. The local research results indicate that the inward inclination of bottom columns leads to increased axial forces in floor beams significantly, necessitating reinforcement; horizontal braces directly connected to the core tube enhance folded belt truss integrity under rare earthquakes; failure of bottom gravity columns in the folded secondary frame increases beam bending moments and axial forces substantially. Steel consumption sensitivity analysis shows that when the structural first-order period is reduced by 0.1 s, adjusting the section sizes of the members in the belt truss minimizes the increase in steel consumption, while adjusting steel beams maximizes it. These findings provide essential design insights for similar super-high-rise projects. Full article
(This article belongs to the Section Building Structures)
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24 pages, 1524 KB  
Article
A Study of Spiritual Expression in Totemic Art: Based on a Multidimensional Analysis of Sublime Beauty, Humanistic Beauty and Artistic Beauty
by Zhilong Yan and Zhiheng Su
Religions 2025, 16(9), 1148; https://doi.org/10.3390/rel16091148 - 4 Sep 2025
Viewed by 166
Abstract
Totemic art, as the fundamental medium of the spiritual realm of primordial societies, employs its distinctive symbolic system to communicate and articulate humanity’s spiritual understanding and sacred quest for nature, the cosmos, and the essence of existence. This article centers on totemic art, [...] Read more.
Totemic art, as the fundamental medium of the spiritual realm of primordial societies, employs its distinctive symbolic system to communicate and articulate humanity’s spiritual understanding and sacred quest for nature, the cosmos, and the essence of existence. This article centers on totemic art, which, through the three dimensions of sublime beauty, humanistic beauty, and artistic beauty, establishes a spiritual dialogue system between primitive tribes and supernatural forces. The core principle is the aesthetic metamorphosis of the spiritual realm through material carriers. It explores how it functions as a potent medium for articulating both personal and communal spirituality: sublime beauty manifests and materializes the intangible divine force through the “presenting the unpresentable,” thus establishing the spiritual basis of primal reverence; Humanistic beauty, rooted in familial connections, the celebration of life, and community unity, facilitates the awakening and elevation of both individual and collective consciousness, promoting the integration and symbiosis of personal spirituality and communal sanctity; Behind the evolution of styles and the characteristics of anti-aesthetics in the artistic beauty, there remains the fundamental logic of serving spiritual expression. Research indicates that totemic art serves as the fundamental aesthetic practice of primitive societies for comprehending the world, engaging with the divine, and achieving mental tranquility. The three dimensions of its spiritual expression collectively form a spiritual monument of early human civilization. Full article
(This article belongs to the Special Issue Arts, Spirituality, and Religion)
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25 pages, 4822 KB  
Article
Handheld Dual-Point Docking Mechanism for Spacecraft On-Orbit Service of Large-Scale Payloads
by Runqi Han, Weisong Liu, Botao Lin, Bo Wang and Yushu Bian
Machines 2025, 13(9), 782; https://doi.org/10.3390/machines13090782 - 1 Sep 2025
Viewed by 334
Abstract
The rapid development of spacecraft on-orbit services has increased the requirements for docking technology, especially for large-scale payloads that exceed the launch envelope. Docking technology based on astronaut extravehicular activities is one of the most promising directions for on-orbit services. In view of [...] Read more.
The rapid development of spacecraft on-orbit services has increased the requirements for docking technology, especially for large-scale payloads that exceed the launch envelope. Docking technology based on astronaut extravehicular activities is one of the most promising directions for on-orbit services. In view of this, this paper designs and characterizes a handheld double-point docking mechanism for assembling large-scale payloads that is suitable for extravehicular activity (EVA) in dual-astronaut collaborative operations. It achieves the functional decoupling of docking, locking, unlocking, and separation throughout the whole process. The mechanism also has excellent design for human factors engineering, allowing astronauts to change hands, operate with one hand, and apply limited force. The mechanism adopts a dual-point probe–drogue configuration, while the misalignment tolerance design guarantees the docking accuracy and the operating range, and forms a rigid structural connection through a force amplification mechanism. Theoretical analysis and numerical simulations are implemented to estimate the dynamics, statics, and kinematics of the docking process. Corresponding experiments of the prototype are also conducted, including high–low temperature dynamics, docking tests, and kinematic tolerance experiments. The experiments validate the finite element analysis and verify the actual performance of the mechanism. The designed handheld dual-point docking mechanism was successfully applied for the first time by the Shenzhou 15 crew on China’s Space Station in March 2023. This paves a new road for spacecraft on-orbit service of large-scale payloads by EVAs, providing guidance as well as a technical foundation for the on-orbit construction of large spacecraft in the future. Full article
(This article belongs to the Section Machine Design and Theory)
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13 pages, 1805 KB  
Article
Analysis and Optimization for the Sealing Performance of Ultra-High Pressure Solenoid Valves in Low-Temperature Environments
by Tiantian Huang, Yanhao Wu, Changbo Shi and Liang Cai
Appl. Sci. 2025, 15(17), 9608; https://doi.org/10.3390/app15179608 - 31 Aug 2025
Viewed by 273
Abstract
The sealing performance of ultra-high-pressure solenoid valves faces significant challenges, particularly under low-temperature conditions. Due to the difference in thermal expansion coefficients between the valve seat and the sealing tube, combined with material contraction at low temperatures, the bolt preload decreases, and consequently [...] Read more.
The sealing performance of ultra-high-pressure solenoid valves faces significant challenges, particularly under low-temperature conditions. Due to the difference in thermal expansion coefficients between the valve seat and the sealing tube, combined with material contraction at low temperatures, the bolt preload decreases, and consequently the contact force on the sealing surface and the average sealing specific pressure are reduced. This may result in an average sealing specific pressure falling below the required sealing specific pressure, causing leakage and failure of the ultra-high-pressure solenoid valve. To address this problem, this study utilizes theoretical and simulation analysis to examine the preload status in low-temperature environments and the causes of sealing failure in ultra-high-pressure solenoid valves. A corresponding optimization scheme is proposed, which involves increasing the torque from 120 N·m to 130 N·m and applying sealant to the threaded connection to enhance the sealing performance of the ultra-high-pressure solenoid valve. Following the increase in tightening torque and the application of thread sealant, the helium leakage rate at −40 °C is significantly reduced. Specifically, at a test pressure of 87.5 MPa, the helium leakage rate decreases from 1.6×105 mbar·L/s to approximately 1.4×106 mbar·L/s. At test pressures of 1.4 MPa and 10 MPa, the leakage rate is approximately 3.0×107 mbar·L/s. Experimental verification shows that the proposed solution can significantly enhance the sealing reliability of ultra-high-pressure solenoid valves under extreme operating conditions. Full article
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21 pages, 1581 KB  
Review
Research Progress on MET, Tip Link, and Stereocilia Complex with Special Reference to Zebrafish
by Xun Wang, Yuqian Shen and Dong Liu
Int. J. Mol. Sci. 2025, 26(17), 8480; https://doi.org/10.3390/ijms26178480 - 31 Aug 2025
Viewed by 433
Abstract
Hearing is essential for animal survival and social communication, relying on the function of sensory hair cells. These cells possess organized stereocilia bundles enriched with mechano-electrical transduction (MET) channels that convert mechanical stimuli into electrical signals. Tip links, fine extracellular filaments connecting adjacent [...] Read more.
Hearing is essential for animal survival and social communication, relying on the function of sensory hair cells. These cells possess organized stereocilia bundles enriched with mechano-electrical transduction (MET) channels that convert mechanical stimuli into electrical signals. Tip links, fine extracellular filaments connecting adjacent stereocilia, play a critical role in transmitting mechanical forces to MET channels. Over the past three decades, technological advances have significantly enhanced our understanding of the molecular and cellular mechanisms underlying auditory transduction. Zebrafish, with its conserved hair cell structure and function similar to mammals, has become a valuable model in auditory research. The aim of this review is to summarize the research progress on the molecular and cellular mechanisms of MET, tip link, and stereocilia complex, with an emphasis on zebrafish studies, providing an important reference for understanding diseases of the human auditory system. Full article
(This article belongs to the Special Issue Zebrafish Model for Neurological Research)
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34 pages, 6658 KB  
Article
Computational Method for Dynamic Analysis of Multibody Systems with Deformable Elements
by Sorin Dumitru, Nicolae Dumitru, Cristian Copilusi and Adrian Sorin Rosca
Mathematics 2025, 13(17), 2797; https://doi.org/10.3390/math13172797 - 31 Aug 2025
Viewed by 237
Abstract
The dynamics of mechanical systems with fast motions and dynamic loads are strongly influenced by the deformability of kinematic elements. The finite element method and the superposition of rigid body motion with deformable body motion allow us to determine a new structure for [...] Read more.
The dynamics of mechanical systems with fast motions and dynamic loads are strongly influenced by the deformability of kinematic elements. The finite element method and the superposition of rigid body motion with deformable body motion allow us to determine a new structure for the matrices that define the mechanical system equations of motion. Meshing the kinematic elements into finite elements causes the unknowns of the problem to no longer be displacement functions but rather nodal displacements. These displacements are considered as a linear combination of modal shapes and modal coordinates. This method is applied to a drive mechanism of an internal combustion engine with three pistons mounted in line. The system is driven by the pressure exerted by the gas on the piston head, which was experimentally determined. The longitudinal and transversal deformations of the connecting rod are determined, including the nodal displacements. These results were verified through virtual prototyping on the 3D model, using multibody system theory and the finite element method. The recorded differences are mainly explained by the type, size, and shape of the used finite elements. Experimental analysis allows us to determine the connecting rod kinematic and dynamic parameters as functions of time and frequency variation. The developed method is flexible and can be easily adapted to systems with fast motions in which, during operation, impact forces appear in joints for various reasons. Full article
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22 pages, 6408 KB  
Article
Design and Characterization of Negative-Stiffness Lattice Structures for Diabetic Midsoles
by Gianpaolo Savio and Francesca Uccheddu
Appl. Sci. 2025, 15(17), 9544; https://doi.org/10.3390/app15179544 - 30 Aug 2025
Viewed by 263
Abstract
Diabetes mellitus often leads to peripheral neuropathy that compromises protective sensation in the feet and raises ulcer risk through mechanical overload. While prior research has introduced cellular-metamaterial-based shoe midsoles for dynamic plantar pressure redistribution, this study advances the field by delivering a complete, [...] Read more.
Diabetes mellitus often leads to peripheral neuropathy that compromises protective sensation in the feet and raises ulcer risk through mechanical overload. While prior research has introduced cellular-metamaterial-based shoe midsoles for dynamic plantar pressure redistribution, this study advances the field by delivering a complete, application-oriented workflow for physical prototyping and mechanical validation of such structures. Our pipeline integrates analytical synthesis of curved-beam unit cells, process calibration, and fabrication via thermoplastic polyurethane (TPU) fused-filament fabrication, producing customized, test-ready lattices suitable for future gait-simulation studies and in vivo assessment. Printed TPU tests showed a Young’s modulus of 44.5 MPa, ultimate tensile strength of 4.9 MPa, and strain at break ≈ 20% (Shore 84.5 A/37.2 D). The cellular unit’s compressive response was quantified by theoretical force-threshold estimates and controlled compression tests, enabling data-driven selection of unit cell geometry and arrangement for effective offloading. The response is rate-dependent: higher loading speed increases peak force and hysteresis, indicating that loading rate should be treated as a design parameter to tune dynamic behavior for the target application. Although the analytical model overestimates forces by roughly 50% on average relative to experiments, it accurately captures the influence of key geometric parameters on peak force. Accordingly, experimental data can identify cell strategic geometric parameters (i.e., Q), while the achievable maximum force can be predicted from the model by applying an appropriate correction factor. By connecting modeling, calibration, and experimental validation in one coherent path, the proposed workflow enables manufacturable lattices with controllable activation thresholds for plantar pressure redistribution and provides a practical bridge from concept to application. Full article
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24 pages, 1388 KB  
Article
Theory of Functional Connections Applied to Linear Discontinuous Differential Equations
by Trent White and Daniele Mortari
Mathematics 2025, 13(17), 2785; https://doi.org/10.3390/math13172785 - 29 Aug 2025
Viewed by 334
Abstract
This article introduces two numerical methods based on the Theory of Functional Connections (TFC) for solving linear ordinary differential equations that involve step discontinuities in the forcing term. The novelty of the first proposed approach lies in the direct incorporation of discontinuities into [...] Read more.
This article introduces two numerical methods based on the Theory of Functional Connections (TFC) for solving linear ordinary differential equations that involve step discontinuities in the forcing term. The novelty of the first proposed approach lies in the direct incorporation of discontinuities into the free function of the TFC framework, while the second proposed method resolves discontinuities through piecewise constrained expressions comprising particular weighted support functions systematically chosen to enforce continuity conditions. The accuracy of the proposed methods is validated for both a second-order initial value and boundary value problem. As a final demonstration, the methods are applied to a third-order differential equation with non-constant coefficients and multiple discontinuities, for which an analytical solution is known. The methods achieve error levels approaching machine precision, even in the case of equations involving functions whose Laplace transforms are not available. Full article
(This article belongs to the Section E6: Functional Interpolation)
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23 pages, 6161 KB  
Article
Investigation of Screw Layout and Hole Geometry on Cold-Formed Steel Bending Performance Using Finite Element Model and Statistical Methods
by Zeynep Yaman, Mahyar Maali, Ekin Abanoz, Elif Ağcakoca, Mohammad Saber Sadid and Türker Fedai Çavuş
Buildings 2025, 15(17), 3101; https://doi.org/10.3390/buildings15173101 - 29 Aug 2025
Viewed by 440
Abstract
The affordability, ease of manufacturing, and assembly efficiency of cold-formed steel profiles have contributed to their widespread use in structural applications. However, the presence of holes in these profile webs is likely to reduce their mechanical resistance. This study explores the bending behavior [...] Read more.
The affordability, ease of manufacturing, and assembly efficiency of cold-formed steel profiles have contributed to their widespread use in structural applications. However, the presence of holes in these profile webs is likely to reduce their mechanical resistance. This study explores the bending behavior of a built-up box section constructed using lipped and unlipped C-profiles, which are commonly utilized in the construction industry. The investigation focuses on the influence of self-drilling screw layout density and hole distribution within the section. A total of 30 different models were analyzed, considering three primary variables: the spacing of self-drilling screws, hole diameter, and the number of holes. The steel profiles were connected using self-drilling screws with spacing intervals of 100, 200, and 400 mm. Key parameters, such as moment capacity, effects on elastic zones, shear forces on screws, and ductility, were examined in relation to these variables. The findings indicate that reducing screw spacing and increasing the number of holes are crucial design factors for improving joint strength. However, while greater screw spacing enhances ductility, it leads to lower plastic deformation rates. Additionally, optimizing the number of holes in the section proved to be an effective strategy for improving ductility in the analyzed models. Mathematical evaluation confirmed that hole number and screw spacing significantly affect moment capacity and estimation stability, highlighting the need for their joint optimization in structural design. Full article
(This article belongs to the Special Issue Cold-Formed Steel Structures)
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18 pages, 3471 KB  
Article
Research on Combinations of Stator Poles and Rotor Teeth for Conventional Flux-Switching Brushless Machines with Composite Phase Numbers
by Lin Li, Yuexi Liu, Guishu Zhao, Yueheng Ding and Wei Hua
Electronics 2025, 14(17), 3405; https://doi.org/10.3390/electronics14173405 - 27 Aug 2025
Viewed by 299
Abstract
In this paper, a method for determining the optimal stator-rotor combinations of conventional flux-switching permanent magnet (FSPM) machines with composite phase numbers covering symmetrical and asymmetrical topologies is proposed by changing the equivalent number of coils per pole per phase (ENCPP) or the [...] Read more.
In this paper, a method for determining the optimal stator-rotor combinations of conventional flux-switching permanent magnet (FSPM) machines with composite phase numbers covering symmetrical and asymmetrical topologies is proposed by changing the equivalent number of coils per pole per phase (ENCPP) or the number of coil-pairs having complementarity (K) of the optimal stator-rotor combinations of the corresponding machines with prime phases. Taking composite phase machines such as four-phase, six-phase, nine-phase, and twelve-phase machines as examples, a detailed analysis is conducted on how the optimal stator-rotor combinations of four-phase machines are derived from the optimal stator-rotor combinations of the corresponding prime phase machines (i.e., two-phase machines) and how the optimal stator-rotor combinations of six-phase, nine-phase, and twelve-phase machines are derived from the optimal stator-rotor combinations of the corresponding prime phase machines (i.e., three-phase machines). Then, the winding factor of the conventional FSPM machines with composite phase numbers is calculated. Finally, taking a 24-slot/22-tooth (24/22) conventional FSPM topology as an example, the topology is connected into a standard six-phase machine (symmetrical topology) and a dual three-phase machine (asymmetrical topology), and a comparative study between them is conducted in terms of the phase back electromotive force (EMF) waveform, electromagnetic torque, torque ripple, and inductances. The results indicate that both machines have sufficiently large and symmetrical back-EMFs, as well as sufficiently large electromagnetic torque, which validates the correctness of the proposed method for determining the optimal stator-rotor combinations. Full article
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13 pages, 2049 KB  
Article
Negative Mass in the Systems Driven by Entropic Forces
by Edward Bormashenko, Artem Gilevich and Shraga Shoval
Materials 2025, 18(17), 3958; https://doi.org/10.3390/ma18173958 - 24 Aug 2025
Viewed by 467
Abstract
The paper addresses the phenomena of negative effective mass and negative effective density emerging in systems driven by entropic elastic forces. The elasticity of polymers is, at least partially, of entropic origin, and it represents the tendency of a polymer to evolve into [...] Read more.
The paper addresses the phenomena of negative effective mass and negative effective density emerging in systems driven by entropic elastic forces. The elasticity of polymers is, at least partially, of entropic origin, and it represents the tendency of a polymer to evolve into a more probable state, rather than into one of lower potential energy. Entropy forces are temperature-dependent; thus, the temperature dependence of the effective mass and effective density arises. The effect of the negative effective mass is a resonance effect, emerging in core–shell mechanical systems, which takes place when the frequency of the harmonic external force acting on a core–shell system connected by an ideal spring approaches from above to the eigen-frequency of the system. We address the situation when the ideal spring connecting the core to the shell is made from a polymer material, and its elasticity is of an entropic origin. The effective mass is calculated, and it is temperature-dependent. The chain of core–shell units connected with a polymer spring is studied. The effective density of the spring is temperature-dependent. Optical and acoustical branches of vibrations are elucidated. The negative mass and density become attainable under the variation of the temperature of the system. In the situation when only one of the springs demonstrates temperature dependence, entropic behavior is investigated. Exemplifications of the effect are addressed. Full article
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33 pages, 500 KB  
Review
Theoretical Justification, International Comparison, and System Optimization for Comprehensive Supervision of Natural Resource Assets in China
by Wenfei Zhang, Zhihe Jiang and Xianjie Zhou
Sustainability 2025, 17(17), 7620; https://doi.org/10.3390/su17177620 - 23 Aug 2025
Viewed by 576
Abstract
Natural resource assets inherently integrate tripartite synthesis of legal, economic, and ecological attributes. They serve dual critical functions as foundational elements supporting the evolution of new-quality productive forces and pivotal mechanisms safeguarding ecosystemic integrity. It has become a global consensus and direction of [...] Read more.
Natural resource assets inherently integrate tripartite synthesis of legal, economic, and ecological attributes. They serve dual critical functions as foundational elements supporting the evolution of new-quality productive forces and pivotal mechanisms safeguarding ecosystemic integrity. It has become a global consensus and direction of action to advance comprehensive supervision of natural resource assets and practice the concept of “Community of Life for Human and Nature”. Under the background of the super-ministry system restructuring in China, comprehensive supervision of natural resource assets remains challenged by system fragmentation in supervision objectives and multifaceted interest conflicts among stakeholders. In light of this, this research focuses on the theoretical justification and system optimization of the comprehensive supervision of natural resource assets in China. Using comparative analysis and normative analysis methods, we validate the system’s function on the comprehensive supervision of natural resource assets, summarize foreign experiences, and ultimately aim to explore the optimization pathway of the legal system for the comprehensive supervision of natural resource assets. The results show the following: (1) The choice of the legal system for the comprehensive supervision of natural resource assets emerges as the functional product aligning societal objectives, the rational paradigm for achieving efficient resource allocation, and the adaptive response to the external effects of common property. (2) The system supply of comprehensive supervision of natural resource assets in foreign countries is characterized by normative convergence in conceptual elements and typological categorization in objectives and objects. Therefore, this research recommends that, in order to optimize the system of the comprehensive supervision of natural resource assets in China, (1) in terms of protection of source, natural resource assets should be categorized, with operational natural resource assets focusing on management and public welfare natural resource assets focusing on conservation. (2) In terms of valuation, the economic valuation of natural resource assets should be integrated with ecosystem service assessments to enhance fair market equity. (3) In terms of method, the big data center should be established to enable the synergistic integration of technological innovation and system reforms. (4) In terms of subject, requiring the participation of various government departments, non-governmental organizations, the general public, and other parties could realize the connection of different legal bases for the comprehensive supervision of natural resource assets and the balance of multiple rights and interests, which should help to achieve balanced resource efficiency and biodiversity conservation and safeguard national ecological security. Full article
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18 pages, 4550 KB  
Article
Study on the Dynamic Response of a Heaving Buoy with an Accumulator-Integrated Hydraulic Power Take-Off System Under Dam-Break Flow Using a Modified Moving Particle Semi-Implicit Method
by Jun Wang, Zhaode Zhang and Date Li
J. Mar. Sci. Eng. 2025, 13(9), 1613; https://doi.org/10.3390/jmse13091613 - 23 Aug 2025
Viewed by 291
Abstract
The moving particle semi-implicit (MPS) method is employed to investigate the dynamic response of a wave energy converter (WEC) buoy subjected to dam-break flows. The buoy is connected to a hydraulic power take-off (PTO) system equipped with an accumulator, enabling it to capture [...] Read more.
The moving particle semi-implicit (MPS) method is employed to investigate the dynamic response of a wave energy converter (WEC) buoy subjected to dam-break flows. The buoy is connected to a hydraulic power take-off (PTO) system equipped with an accumulator, enabling it to capture wave energy. First, the MPS method is validated by comparison with experimental results, demonstrating its accuracy in simulating violent interactions between dam-break flows and the buoy. Subsequently, numerical simulations are conducted to analyze the influence of different PTO forces and buoy positions on the heave motion, fluid forces and captured power of the buoy. The results indicate that PTO force exerts a significant influence on heave motion, captured power and vertical fluid force while having a relatively minor effect on the horizontal fluid force. In addition, the maximum power that the buoy can capture increases as its distance from the wall decreases. Notably, the maximum average captured power of the buoy located near a wall can be five times higher than that of a buoy far away from the wall, indicating that a vertical wall can significantly increase the efficiency of nearshore WEC devices. These findings could provide valuable insights for the design, optimization and operation of nearshore WEC devices. Full article
(This article belongs to the Section Marine Energy)
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16 pages, 2611 KB  
Article
Influence of Cyclic Loading on the Removal Torque of Unique Subperiosteal Implant Screws
by Ádám Vörös, Klaudia Kulcsár, Dávid Pammer and Ibolya Zsoldos
J. Funct. Biomater. 2025, 16(9), 306; https://doi.org/10.3390/jfb16090306 - 22 Aug 2025
Viewed by 696
Abstract
During the investigation, the effect of screw tightening torque on the potential loosening of screws under load was examined in the case of custom-made subperiosteal implants. The study focused on the connection screws between the implant components, testing the commonly applied tightening torques [...] Read more.
During the investigation, the effect of screw tightening torque on the potential loosening of screws under load was examined in the case of custom-made subperiosteal implants. The study focused on the connection screws between the implant components, testing the commonly applied tightening torques of 15 Ncm and 30 Ncm. Mastication was simulated using a custom-designed, PLC-controlled testing device, which allowed for the reproduction of variable numbers, forces, and speeds of bite cycles. With this device, six different scenarios were tested, including 500, 2000, and 10,000 bite cycles, under both constant and variable bite forces. A caliper was used to record potential length changes of the screws, force sensors measured the bite forces, and calibrated torque screwdrivers were used to verify the loosening torques. Based on the analysis of the measured data, it was concluded that for the M1.8 screws tested, a tightening torque of 15 Ncm does not provide sufficient resistance against loosening, whereas 30 Ncm offers adequate stability. Full article
(This article belongs to the Special Issue Biomechanical Studies and Biomaterials in Dentistry)
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32 pages, 2235 KB  
Hypothesis
Disrupted Biotensegrity in the Fiber Cellular Fascial Network and Neuroma Microenvironment: A Conceptual Framework for “Phantom Limb Pain”
by Shiloh Plaut
Int. J. Mol. Sci. 2025, 26(17), 8161; https://doi.org/10.3390/ijms26178161 - 22 Aug 2025
Viewed by 428
Abstract
Among the leading etiologies of limb amputations are diabetes mellitus, alongside trauma and peripheral vascular disease conditions, whose complications are major indications for surgery, which can subsequently elicit chronic refractory postamputation pain. ‘Phantom limb pain’ (PLP) denotes pain that is perceived as occurring [...] Read more.
Among the leading etiologies of limb amputations are diabetes mellitus, alongside trauma and peripheral vascular disease conditions, whose complications are major indications for surgery, which can subsequently elicit chronic refractory postamputation pain. ‘Phantom limb pain’ (PLP) denotes pain that is perceived as occurring in an absent part of the limb following amputation. Even though it is a relatively common complication among amputees—with an estimated prevalence as high as ~80 percent—the underlying mechanisms of this puzzling condition remain poorly understood. Current theories predominantly emphasize the role of the nervous system and neuropsychopathology in the development of PLP. However, these neurocentric explanations are disputed and have not yet been translated into effective treatments or a definitive cure for the condition, nor have several notable anomalies been settled, which has prompted researchers to call for the exploration of alternative theories. The aim of this paper is to offer an alternative mechanical mechanism for explaining PLP and spontaneous phantom sensations. This work introduces a theoretical model for the mechanism of PLP, drawing on a recent study that proposed this model to explain fibromyalgia-type psychosomatic syndromes as disorders driven by overactive soft tissue myofibroblasts. The manuscript proposes a shift from purely neurocentric models of PLP to a framework where the extracellular matrix and connective tissue, specifically myofascial tissue and inflammatory myofibroblasts—which are often overlooked in research—take part in its pathogenesis. In this suggested model, surgical interventions disrupt the biomechanical stability of the fascio-musculoskeletal biotensegrity-like system, thus acting as a contributing factor in the chronic pain manifestation. The term ‘biotensegrity’ refers to the dynamic biomechanical behavior of a living system that is stabilized by compressive and tensile force elements, a characteristic quality of myofascial tissue. In this framework, abnormal extracellular matrix remodeling, driven by overactive peripheral myofibroblasts, and the concomitant mechanical effects exerted on sensory nerves embedded within the fascia and reaching the neuroma microenvironment contribute to the generation and perception of spontaneous PLP and phantom sensations. The interplay between abnormal extracellular matrix, the neuroma’s intrinsic excitability, as well as peripheral and central neurophysiological mechanisms, collectively provide a biophysical neuropathophysiological basis to help explain PLP. This offers a different unexplored perspective on a condition with poorly understood mechanisms. Full article
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