Search Results (78)

The early detection of neurological and psychiatric disorders is critical for optimizing patient outcomes and improving the efficacy of healthcare delivery. This study presents a novel multiclass machine learning (ML) framework designed to classify epilepsy, migraine, and schizophrenia simultaneously using electroencephalography (EEG) signals. Unlike conventional approaches that predominantly rely on binary classification (e.g., healthy vs. diseased cohorts), this work addresses a significant gap in the literature by introducing a unified artificial neural network (ANN) architecture capable of discriminating among three distinct neurological and psychiatric conditions. The proposed methodology involves decomposing raw EEG signals into constituent frequency subbands to facilitate robust feature extraction. These discriminative features were subsequently classified using a multilayer ANN, achieving performance metrics of 95% sensitivity, 96% specificity, and a 95% F1-score. To enhance clinical applicability, the model was optimized for potential integration into real-time diagnostic systems, thereby supporting the development of a rapid, reliable, and scalable decision support tool. The results underscore the viability of EEG-based multiclass models as a promising diagnostic aid for neurological and psychiatric disorders. By consolidating the detection of multiple conditions within a single computational framework, this approach offers a scalable and efficient alternative to traditional binary classification paradigms. Full article

Background: Monitoring and evaluating dynamic changes in brain states during electroencephalography (EEG) neurofeedback training (NFT) for post-traumatic stress disorder (PTSD) patients remains challenging when using traditional methods. Method: This study proposes a novel Process Noise Dynamic Adaptation-Mesoscale Mesonetwork Network (PNDA-MMNet) model, which improves upon conventional techniques by establishing a discrete linear dynamic model of the NFT process. The model utilizes a mesoscale intermediate network architecture to create a brain state observation matrix, computes the brain state transition matrix, and applies fuzzy rules for dynamic adaptive noise processing. This maximizes the separability between brain state transitions during NFT and resting states. Results: The proposed model achieves a brain state identification accuracy of 0.7428 ± 0.12 (area under the curve, AUC = 0.84), significantly outperforming conventional algorithms. Interpretations of the model indicate that continuous NFT reduces functional connectivity within the motor cortex, with stronger suppression in the right hemisphere compared to the left. Additionally, it reveals decreased activity in the occipital cortex, particularly in the left occipital region, where inhibition increases radially from the midline. Notably, the connectivity between the motor and occipital cortices remains stable throughout the training process. These connectivity changes reflect NFT-induced modulation of cortical activity and are consistent with known neurophysiological patterns in PTSD, highlighting their potential relevance to therapeutic mechanisms. Conclusion: This research introduces a more effective approach for real-time monitoring and evaluation of PTSD patients’ brain states during NFT, offering a quantitative method for assessing treatment efficacy and guiding therapeutic interventions. Full article

Electroencephalography (EEG) remains an essential method for monitoring brain activity, but the limitations of conventional systems due to the complexity of installation and lack of portability have led to the introduction and development of in-ear EEG technology. In-ear EEG is an emerging method of recording electrical activity in the brain and is an innovative concept that offers multiple advantages both from the point of view of the device itself, which is easily portable, and from the user’s point of view, who is more comfortable with it, even in long-term use. One of the fundamental components of this type of device is the electrodes used to capture the EEG signal. This innovative method allows bioelectrical signals to be captured through electrodes integrated into an earpiece, offering significant advantages in terms of comfort, portability, and accessibility. Recent studies have demonstrated that in-ear EEG can record signals qualitatively comparable to scalp EEG, with an optimized signal-to-noise ratio and improved electrode stability. Furthermore, this review provides a comparative synthesis of performance parameters such as signal-to-noise ratio (SNR), common-mode rejection ratio (CMRR), signal amplitude, and comfort, highlighting the strengths and limitations of in-ear EEG systems relative to conventional scalp EEG. This study also introduces a visual model outlining the stages of technological development for in-ear EEG, from initial research to clinical and commercial deployment. Particular attention is given to current innovations in electrode materials and design strategies aimed at balancing biocompatibility, signal fidelity, and anatomical adaptability. This article analyzes the evolution of EEG in the ear, briefly presents the comparative aspects of EEG—EEG in the ear from the perspective of the electrodes used, highlighting the advantages and challenges of using this new technology. It also discusses aspects related to the electrodes used in EEG in the ear: types of electrodes used in EEG in the ear, improvement of contact impedance, and adaptability to the anatomical variability of the ear canal. A comparative analysis of electrode performance in terms of signal quality, long-term stability, and compatibility with use in daily life was also performed. The integration of intra-auricular EEG in wearable devices opens new perspectives for clinical applications, including sleep monitoring, epilepsy diagnosis, and brain–computer interfaces. This study highlights the challenges and prospects in the development of in-ear EEG electrodes, with a focus on integration into wearable devices and the use of biocompatible materials to improve durability and enhance user comfort. Despite its considerable potential, the widespread deployment of in-ear EEG faces challenges such as anatomical variability of the ear canal, optimization of ergonomics, and reduction in motion artifacts. Future research aims to improve device design for long-term monitoring, integrate advanced signal processing algorithms, and explore applications in neurorehabilitation and early diagnosis of neurodegenerative diseases. Full article

Emotions play a pivotal role in shaping human decision-making, behavior, and physiological well-being. Electroencephalography (EEG)-based emotion recognition offers promising avenues for real-time self-monitoring and affective computing applications. However, existing commercial solutions are often hindered by high costs, complicated deployment processes, and limited reliability in practical settings. To address these challenges, we propose a low-cost, self-adaptive wearable EEG system for emotion recognition through a hardware–algorithm co-design approach. The proposed system is a four-channel wireless EEG acquisition device supporting both dry and wet electrodes, with a component cost below USD 35. It features over 7 h of continuous operation, plug-and-play functionality, and modular expandability. At the algorithmic level, we introduce a self-supervised feature extraction framework that combines contrastive learning and masked prediction tasks, enabling robust emotional feature learning from a limited number of EEG channels with constrained signal quality. Our approach attains the highest performance of 60.2% accuracy and 59.4% Macro-F1 score on our proposed platform. Compared to conventional feature-based approaches, it demonstrates a maximum accuracy improvement of up to 20.4% using a multilayer perceptron classifier in our experiment. Full article

The electroencephalography (EEG)-based approach provides a promising low-cost and non-invasive approach to the early detection of pathological cognitive decline. However, current studies predominantly utilize EEGs from resting state (rsEEG) or task-state (task EEG), posing challenges to classification performances due to the unconstrainted nature of mind wandering during resting state or the inherent inter-participant variability from task execution. To address these limitations, this study proposes a novel feature extraction framework, working memory task-induced EEG response (WM-TIER), which adjusts task EEG features by rsEEG features and leverages the often-overlooked inter-state changes of EEGs. We recorded EEGs from 21 AD individuals, 24 MCI individuals, and 27 healthy controls (HC) during both resting and working memory task conditions. We then compared the classification performance of WM-TIER to the conventional rsEEG or task EEG framework. For each framework, three feature types were examined: relative power, spectral coherence, and filter-bank phase lag index (FB-PLI). Our results indicated that FB-PLI-based WM-TIER features provide (1) better AD/MCI versus HC classification accuracy than rsEEG and task EEG frameworks and (2) high accuracy for three-class classification of AD vs. MCI vs. HC. These findings suggest that the EEG-based rest-to-task state transition can be an effective neural marker for the early detection of pathological cognitive decline. Full article

Point-of-care electroencephalography (POC-EEG) systems are rapid-access, reduced-montage devices designed to address the limitations of conventional EEG (conv-EEG), enabling faster neurophysiological assessment in acute settings. This review evaluates their clinical impact, diagnostic performance, and feasibility in non-convulsive status epilepticus (NCSE), traumatic brain injury (TBI), stroke, and delirium. A comprehensive search of Medline, Scopus, and Embase identified 69 studies assessing 15 devices. In suspected NCSE, POC-EEG facilitates rapid seizure detection and prompt diagnosis, making it particularly effective in time-sensitive and resource-limited settings. Its after-hours availability and telemedicine integration ensure continuous coverage. AI-assisted tools enhance interpretability and accessibility, enabling use by non-experts. Despite variability in accuracy, it supports triaging, improving management, treatment decisions and outcomes while reducing hospital stays, transfers, and costs. In TBI, POC-EEG-derived quantitative EEG (qEEG) indices reliably detect structural lesions, support triage, and minimize unnecessary CT scans. They also help assess concussion severity and predict recovery. For strokes, POC-EEG aids triage by detecting large vessel occlusions (LVOs) with high feasibility in hospital and prehospital settings. In delirium, spectral analysis and AI-assisted models enhance diagnostic accuracy, broadening its clinical applications. Although POC-EEG is a promising screening tool, challenges remain in diagnostic variability, technical limitations, and AI optimization, requiring further research. Full article

Objective pain measurements are essential in clinical settings for determining effective treatment strategies. This study aims to utilize brain–computer interface technology for reliable pain classification and detection. We developed an electroencephalography-based pain detection system comprising two main components: (1) pain/no-pain detection and (2) pain severity classification across three levels: low, moderate, and high. Deep learning models, including convolutional neural networks and recurrent neural networks, were employed to classify the wavelet features extracted through time–frequency domain analysis. Furthermore, we compared the performance of our system against conventional machine learning models, such as support vector machines and random forest classifiers. Our deep learning approach outperformed the baseline models, achieving accuracies of 91.84% for pain/no-pain detection and 87.94% for pain severity classification, respectively. Full article

Decoding motor imagery electroencephalography (MI-EEG) signals presents significant challenges due to the difficulty in capturing the complex functional connectivity between channels and the temporal dependencies of EEG signals across different periods. These challenges are exacerbated by the low spatial resolution and high signal redundancy inherent in EEG signals, which traditional linear models struggle to address. To overcome these issues, we propose a novel dual-branch framework that integrates an adaptive graph convolutional network (Adaptive GCN) and bidirectional gated recurrent units (Bi-GRUs) to enhance the decoding performance of MI-EEG signals by effectively modeling both channel correlations and temporal dependencies. The Chebyshev Type II filter decomposes the signal into multiple sub-bands giving the model frequency domain insights. The Adaptive GCN, specifically designed for the MI-EEG context, captures functional connectivity between channels more effectively than conventional GCN models, enabling accurate spatial–spectral feature extraction. Furthermore, combining Bi-GRU and Multi-Head Attention (MHA) captures the temporal dependencies across different time segments to extract deep time–spectral features. Finally, feature fusion is performed to generate the final prediction results. Experimental results demonstrate that our method achieves an average classification accuracy of 80.38% on the BCI-IV Dataset 2a and 87.49% on the BCI-I Dataset 3a, outperforming other state-of-the-art decoding approaches. This approach lays the foundation for future exploration of personalized and adaptive brain–computer interface (BCI) systems. Full article

Electroencephalography (EEG) is a non-invasive technique with high temporal resolution and cost-effective, portable, and easy-to-use features. Motor imagery EEG (MI-EEG) data classification is one of the key applications within brain–computer interface (BCI) systems, utilizing EEG signals from motor imagery tasks. BCI is very useful for people with severe mobility issues like quadriplegics, spinal cord injury patients, stroke patients, etc., giving them the freedom to a certain extent to perform activities without the need for a caretaker, like driving a wheelchair. However, motion artifacts can significantly affect the quality of EEG recordings. The conventional EEG enhancement algorithms are effective in removing ocular and muscle artifacts for a stationary subject but not as effective when the subject is in motion, e.g., a wheelchair user. In this research study, we propose an empirical error model-based artifact removal approach for the cross-subject classification of motor imagery (MI) EEG data using a modified CNN-based deep learning algorithm, designed to assist wheelchair users with severe mobility issues. The classification method applies to real tasks with measured EEG data, focusing on accurately interpreting motor imagery signals for practical application. The empirical error model evolved from the inertial sensor-based acceleration data of the subject in motion, the weight of the wheelchair, the weight of the subject, and the surface friction of the terrain under the wheelchair. Three different wheelchairs and five different terrains, including road, brick, concrete, carpet, and marble, are used for artifact data recording. After evaluating and benchmarking the proposed CNN and empirical model, the classification accuracy achieved is 94.04% for distinguishing between four specific classes: left, right, front, and back. This accuracy demonstrates the model’s effectiveness compared to other state-of-the-art techniques. The comparative results show that the proposed approach is a potentially effective way to raise the decoding efficiency of motor imagery BCI. Full article

Increased electrical activity in the brain causes epilepsy, which causes seizures, resulting in various medical complications that can sometimes be fatal. Doctors use electroencephalography (EEG) for the profiling and diagnosis of epilepsy. According to the World Health Organization (WHO), approximately 50 million people worldwide have epilepsy, making it one of the most common neurological disorders globally. This number represents about 0.7% of the global population. The conventional method of EEG analysis employed by medical professionals is a visual investigation that is time-consuming and requires expertise because of the variability in EEG signals. This paper describes a method for detecting epileptic seizures in EEG signals by combining signal processing and machine learning techniques. SVM and other machine learning techniques detect anomalies in the input EEG signal. To extract features, DWT is used for decomposition to sub-bands. The proposed method aims to improve the accuracy of the machine learning model while using as few features as possible. The classification results show an accuracy of 100% with just one feature, mean absolute value, from datasets A and E. With additional features, the overall accuracy remains high at 99%, with specificity and sensitivity values of 97.2% and 99.1%, respectively. These results outperform previous research on the same dataset, demonstrating the effectiveness of our approach. This research contributes to developing more accurate and efficient epilepsy diagnosis systems, potentially improving patient outcomes. Full article

Human–robot collaboration (HRC) has become increasingly prevalent due to innovative advancements in the automation industry, especially in manufacturing setups. Although HRC increases productivity and efficacy, it exposes human workers to psychological stress while interfacing with collaborative robotic systems as robots may not provide visual or auditory cues. It is crucial to comprehend how HRC impacts mental stress in order to enhance occupational safety and well-being. Though academics and industrial interest in HRC is expanding, safety and mental stress problems are still not adequately studied. In particular, human coworkers’ cognitive strain during HRC has not been explored well, although being fundamental to sustaining a secure and constructive workplace environment. This study, therefore, aims to monitor the mental stress of factory workers during HRC using behavioural, physiological and subjective measures. Physiological measures, being objective and more authentic, have the potential to replace conventional measures i.e., behavioural and subjective measures, if they demonstrate a good correlation with traditional measures. Two neuroimaging modalities including electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) have been used as physiological measures to track neuronal and hemodynamic activity of the brain, respectively. Here, the correlation between physiological data and behavioural and subjective measurements has been ascertained through the implementation of seven different machine learning algorithms. The results imply that the EEG and fNIRS features combined produced the best results for most of the targets. For subjective measures being the target, linear regression has outperformed all other models, whereas tree and ensemble performed the best for predicting the behavioural measures. The outcomes indicate that physiological measures have the potential to be more informative and often substitute other skewed metrics. Full article

Background: Mental health issues are increasingly prominent worldwide, posing significant threats to patients and deeply affecting their families and social relationships. Traditional diagnostic methods are subjective and delayed, indicating the need for an objective and effective early diagnosis method. Methods: To this end, this paper proposes a lightweight detection method for multi-mental disorders with fewer data sources, aiming to improve diagnostic procedures and enable early patient detection. First, the proposed method takes Electroencephalography (EEG) signals as sources, acquires brain rhythms through Discrete Wavelet Decomposition (DWT), and extracts their approximate entropy, fuzzy entropy, permutation entropy, and sample entropy to establish the entropy-based matrix. Then, six kinds of conventional machine learning classifiers, including Support Vector Machine (SVM), k-Nearest Neighbors (kNN), Naive Bayes (NB), Generalized Additive Model (GAM), Linear Discriminant Analysis (LDA), and Decision Tree (DT), are adopted for the entropy-based matrix to achieve the detection task. Their performances are assessed by accuracy, sensitivity, specificity, and F1-score. Concerning these experiments, three public datasets of schizophrenia, epilepsy, and depression are utilized for method validation. Results: The analysis of the results from these datasets identifies the representative single-channel signals (schizophrenia: O1, epilepsy: F3, depression: O2), satisfying classification accuracies (88.10%, 75.47%, and 89.92%, respectively) with minimal input. Conclusions: Such performances are impressive when considering fewer data sources as a concern, which also improves the interpretability of the entropy features in EEG, providing a reliable detection approach for multi-mental disorders and advancing insights into their underlying mechanisms and pathological states. Full article

Electroencephalography (EEG) is useful for studying brain activity in major depressive disorder (MDD), particularly focusing on theta and alpha frequency bands via power spectral density (PSD). However, PSD-based analysis has often produced inconsistent results due to difficulties in distinguishing between periodic and aperiodic components of EEG signals. We analyzed EEG data from 114 young adults, including 74 healthy controls (HCs) and 40 MDD patients, assessing periodic and aperiodic components alongside conventional PSD at both source and electrode levels. Machine learning algorithms classified MDD versus HC based on these features. Sensor-level analysis showed stronger Hedge’s g effect sizes for parietal theta and frontal alpha activity than source-level analysis. MDD individuals exhibited reduced theta and alpha activity relative to HC. Logistic regression-based classifications showed that periodic components slightly outperformed PSD, with the best results achieved by combining periodic and aperiodic features (AUC = 0.82). Strong negative correlations were found between reduced periodic parietal theta and frontal alpha activities and higher scores on the Beck Depression Inventory, particularly for the anhedonia subscale. This study emphasizes the superiority of sensor-level over source-level analysis for detecting MDD-related changes and highlights the value of incorporating both periodic and aperiodic components for a more refined understanding of depressive disorders. Full article

Background and Objectives: The relationship between histidine–tryptophan–ketoglutarate (HTK)-induced hyponatremia and brain injury in adult cardiac surgery patients is unclear. This study analyzed postoperative neurological outcomes after intraoperative HTK cardioplegia infusion. Materials and Methods: A prospective cohort study was conducted on 60 adult patients who underwent cardiac surgery with cardiopulmonary bypass. Of these patients, 13 and 47 received HTK infusion and conventional hyperkalemic cardioplegia, respectively. The patients’ baseline characteristics, intraoperative data, brain injury markers, Mini-Mental State Examination (MMSE) scores, and quantitative electroencephalography (qEEG) data were collected. Electrolyte changes during cardiopulmonary bypass, the degree of hyponatremia, and any associated brain insults were evaluated. Results: The HTK group presented with acute hyponatremia during cardiopulmonary bypass, which was intraoperatively corrected through ultrafiltration and normal saline administration. Postoperative sodium levels were higher in the HTK group than in the conventional cardioplegia group. The change in neuron-specific enolase levels after cardiopulmonary bypass was significantly higher in the HTK group (p = 0.043). The changes showed no significant differences using case–control matching. qEEG analysis revealed a significant increase in relative delta power in the HTK group on postoperative day (POD) 7 (p = 0.018); however, no significant changes were noted on POD 60. The MMSE scores were not significantly different between the two groups on POD 7 and POD 60. Conclusions: HTK-induced acute hyponatremia and rapid correction with normal saline during adult cardiac surgeries were associated with a potential short-term but not long-term neurological impact. Further studies are required to determine the necessity of correction for HTK-induced hyponatremia. Full article

Transcranial magnetic stimulation coupled with electroencephalography (TMS-EEG) is a novel technique to investigate cortical physiology in health and disease. The cerebellum has recently gained attention as a possible new hotspot in the field of TMS-EEG, with several reports published recently. However, EEG responses obtained by cerebellar stimulation vary considerably across the literature, possibly due to different experimental methods. Compared to conventional TMS-EEG, which involves stimulation of the cortex, cerebellar TMS-EEG presents some technical difficulties, including strong muscle twitches in the neck area and a loud TMS click when double-cone coils are used, resulting in contamination of responses by electromyographic activity and sensory potentials. Understanding technical difficulties and limitations is essential for the development of cerebellar TMS-EEG research. In this review, we summarize findings of cerebellar TMS-EEG studies, highlighting limitations in experimental design and potential issues that can result in discrepancies between experimental outcomes. Lastly, we propose a possible direction for academic and clinical research with cerebellar TMS-EEG. Full article