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Keywords = coordinated development relationship

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28 pages, 3508 KB  
Article
The Digital: A Catalyst for Accelerating the Quality Improvement and Sustainable Development of China’s Marine Industry
by Gang Zhou, Li Zhang, Yao Xu, Lewei Hong and Yi Zhang
Sustainability 2025, 17(21), 9464; https://doi.org/10.3390/su17219464 (registering DOI) - 24 Oct 2025
Abstract
The sustainable development of the marine industry is a vital pillar for achieving global ecological balance and economic prosperity. As a crucial repository of resources and a vital regulator of climate, the ocean plays an irreplaceable role in supporting humanity’s long-term development. Against [...] Read more.
The sustainable development of the marine industry is a vital pillar for achieving global ecological balance and economic prosperity. As a crucial repository of resources and a vital regulator of climate, the ocean plays an irreplaceable role in supporting humanity’s long-term development. Against this backdrop, digital technology drives modern development, supporting decision-making and resource allocation while profoundly transforming industrial models. The resulting digital economy has become one of the core drivers of sustainable global economic growth. Given the close connection between the marine industry and the digital economy, attention has been drawn to whether a correlation exists between their respective growth rates. This study employs a Panel Vector Autoregression (PVAR) model based on panel data from China’s coastal provinces between 2012 and 2023. The empirical analysis reveals: (1) After a certain period, the growth rates of the digital economy and the quality development of the marine industry exhibit a mutually reinforcing trend. Furthermore, the innovation coupling coordination rate and the upgrading rate within the marine industry also strengthen each other, injecting endogenous momentum into the sustainable development of the marine sector. (2) When simulating external shocks through local government expenditure, it was found that while local government spending positively impacts the growth rate of the digital economy, its effect on the quality development rate of marine industries is limited, exhibiting a “single-helix” upward trend. This suggests the need to optimize the precision of policy support to better balance the coordinated sustainable development of the digital economy and marine industries. (3) The growth rate of the digital economy exerts a dual threshold effect on the quality development of marine industries. That is, there are two thresholds: 0.0099 and 0.0725. Initially, the promotion effect is relatively small with a positive and significant coefficient of 0.120. When exceeding the first threshold, the coefficient becomes 0.416, which is positively significant. When exceeding the second threshold, the promotion effect disappears. This necessitates differentiated strategies tailored to distinct developmental stages to propel marine industries toward high-quality, sustainable development empowered by the digital economy. Based on these findings, this study focuses on the relationship between the growth rates of the digital economy and marine industries, offering actionable recommendations for marine nations like China to advance high-level sustainable industrial development. Full article
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15 pages, 913 KB  
Article
The Impact of China’s Targeted Poverty Alleviation Policy on Water Resource Utilization Pressure and Allocation in Arid Regions: A Case Study of Hotan Prefecture, Xinjiang
by Jin-Wei Huo, Fu-Qiang Xia, Rong-Qian Lu, Dan-Ni Lu, De-Gang Yang and Yang Chen
Water 2025, 17(21), 3053; https://doi.org/10.3390/w17213053 (registering DOI) - 24 Oct 2025
Abstract
Targeted poverty alleviation is a major national initiative in China. The Hotan region, located within the four prefectures of Southern Xinjiang, is one of the 14 contiguous poverty-stricken areas in China as well as a quintessential inland arid zone. Water scarcity is the [...] Read more.
Targeted poverty alleviation is a major national initiative in China. The Hotan region, located within the four prefectures of Southern Xinjiang, is one of the 14 contiguous poverty-stricken areas in China as well as a quintessential inland arid zone. Water scarcity is the primary constraint on development in the Hotan region and a major bottleneck for Northwest China as a whole. However, previous assessments of the effectiveness of poverty alleviation measures have primarily focused on industrial growth itself, lacking an analysis of the adaptability between key regional resource elements and industrial poverty alleviation measures. The core of promoting targeted poverty alleviation in arid regions is properly managing the relationships within the “industry–water resources” system and achieving a balance between resource use, environmental capacity, and economic development. Focusing on the coordinated development of industry and water resources, this study evaluates the spatio-temporal evolution of the industry–water resource relationships in the Hotan region after the implementation of the targeted poverty alleviation policy with the aim of measuring the sustainability of industrial poverty alleviation outcomes in this arid region. The results indicate the following: (1) The targeted poverty alleviation policy has reduced industrial water consumption. Following the policy’s implementation, industrial water consumption decreased by 541 million m3, driven by improvements in water use intensity and shifts in the industrial structure. The primary contributor to this reduction was enhanced water use efficiency within the primary sector. (2) The policy exacerbated the misallocation of water resources relative to industrial output across the region. The Gini coefficient for water resources versus GDP across Hotan’s eight counties and cities rose from 0.26 to 0.32, indicating a shift from a ‘relatively balanced’ to a ‘moderately imbalanced’ allocation. Therefore, achieving sustainable poverty alleviation in this arid region necessitates enhanced coordination between industrial development and water resources. Full article
(This article belongs to the Section Water Resources Management, Policy and Governance)
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37 pages, 14970 KB  
Article
Research on Strawberry Visual Recognition and 3D Localization Based on Lightweight RAFS-YOLO and RGB-D Camera
by Kaixuan Li, Xinyuan Wei, Qiang Wang and Wuping Zhang
Agriculture 2025, 15(21), 2212; https://doi.org/10.3390/agriculture15212212 (registering DOI) - 24 Oct 2025
Abstract
Improving the accuracy and real-time performance of strawberry recognition and localization algorithms remains a major challenge in intelligent harvesting. To address this, this study presents an integrated approach for strawberry maturity detection and 3D localization that combines a lightweight deep learning model with [...] Read more.
Improving the accuracy and real-time performance of strawberry recognition and localization algorithms remains a major challenge in intelligent harvesting. To address this, this study presents an integrated approach for strawberry maturity detection and 3D localization that combines a lightweight deep learning model with an RGB-D camera. Built upon the YOLOv11 framework, an enhanced RAFS-YOLO model is developed, incorporating three core modules to strengthen multi-scale feature fusion and spatial modeling capabilities. Specifically, the CRA module enhances spatial relationship perception through cross-layer attention, the HSFPN module performs hierarchical semantic filtering to suppress redundant features, and the DySample module dynamically optimizes the upsampling process to improve computational efficiency. By integrating the trained model with RGB-D depth data, the method achieves precise 3D localization of strawberries through coordinate mapping based on detection box centers. Experimental results indicate that RAFS-YOLO surpasses YOLOv11n, improving precision, recall, and mAP@50 by 4.2%, 3.8%, and 2.0%, respectively, while reducing parameters by 36.8% and computational cost by 23.8%. The 3D localization attains millimeter-level precision, with average RMSE values ranging from 0.21 to 0.31 cm across all axes. Overall, the proposed approach achieves a balance between detection accuracy, model efficiency, and localization precision, providing a reliable perception framework for intelligent strawberry-picking robots. Full article
(This article belongs to the Section Artificial Intelligence and Digital Agriculture)
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20 pages, 1021 KB  
Article
Factors Enabling Data-Based Management in Healthcare: Insights from Case Studies of Eye Hospitals
by Ganesh-Babu Balu Subburaman, Sachin Gupta, Thulasiraj Ravilla, Helen Mertens, Carroll A. B. Webers and Frits van Merode
Hospitals 2025, 2(4), 25; https://doi.org/10.3390/hospitals2040025 - 24 Oct 2025
Abstract
Hospitals are complex systems that function most effectively when operations are coordinated and supported by real-time information and feedback loops. Sustained growth, quality improvement, and financial viability increasingly rely on data-based management (DBM), yet adoption and use vary widely across healthcare institutions. This [...] Read more.
Hospitals are complex systems that function most effectively when operations are coordinated and supported by real-time information and feedback loops. Sustained growth, quality improvement, and financial viability increasingly rely on data-based management (DBM), yet adoption and use vary widely across healthcare institutions. This study examined the enabling and hindering factors influencing DBM, with the aim of generating insights to strengthen data use and improve management of eye hospitals. A qualitative multiple case study design was employed in six purposefully selected eye hospitals in India, varying in size and baseline capacity for DBM. At each site, five to six key personnel were interviewed. Data collection involved audio-recorded interviews, transcripts, and field notes, and analysis followed a grounded theory approach using open and axial coding to identify themes, relationships, and develop a conceptual framework. Findings reaffirmed the core enablers—leadership commitment, data availability, and technology adoption. Additional drivers included operational adaptability, regulatory demands, systematic improvement practices, daily reporting, information policies, and the use of communication platforms such as WhatsApp. Key barriers were incomplete data entry, software limitations, inadequate analytical reporting, and inconsistent adherence to processes. Overall, effective DBM requires both foundational enablers and contextual drivers, while addressing barriers to institutionalizing data use and improving outcomes. Full article
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14 pages, 589 KB  
Article
The Diagnostic and Prognostic Value of Reticulated Platelets in Ischemic Stroke: Is Immature Platelet Fraction a New Biomarker?
by Fatih Cemal Tekin, Osman Lütfi Demirci, Emin Fatih Vişneci, Abdullah Enes Ataş, Hasan Hüseyin Kır, Hasan Basri Yıldırım, Çiğdem Damla Deniz, Demet Acar, Said Sami Erdem and Mehmet Gül
Medicina 2025, 61(10), 1887; https://doi.org/10.3390/medicina61101887 - 21 Oct 2025
Viewed by 126
Abstract
Background and Objectives: Ongoing efforts to develop early diagnostic tools for Acute Ischemic Stroke (AIS) point out the advantages of accessible biomarkers such as Immature Platelet Fraction (IPF). This is particularly important for emergency department (EDs), especially those that are overcrowded and [...] Read more.
Background and Objectives: Ongoing efforts to develop early diagnostic tools for Acute Ischemic Stroke (AIS) point out the advantages of accessible biomarkers such as Immature Platelet Fraction (IPF). This is particularly important for emergency department (EDs), especially those that are overcrowded and have limited resources. The present study aimed to evaluate the diagnostic, prognostic, and therapeutic significance of IPF in patients with AIS presenting to the ED. Materials and Methods: This prospective case–control study was conducted in an ED. Participants aged 18-years and older who presented with complaints of numbness, weakness, diplopia or visual disturbances, speech or comprehension impairment, confusion, imbalance, impaired coordination and gait, or dizziness were included in the study. The diagnostic value of IPF in AIS and its relationship with short-term prognosis (STP) were investigated. Additional variables potentially associated with parameters such as infarct localization, number of lesions, affected hemisphere, main artery status, carotid status and treatment method were also analyzed. Results: The median age of the study participants was 67 years (Q1 = 54, Q3 = 76), with 48.9% (n = 88) being female and 51.1% (n = 92) male. Receiver operating characteristic curve analysis demonstrated that IPF was statistically significantly superior to other complete blood count parameters in the diagnostic evaluation of AIS. The diagnostic cutoff value of IPF for AIS was calculated as 2.45. An increase of 1 unit in IPF was found to raise the likelihood of AIS by 2.599 times. The Ratio of Red Cell Distribution Width (RDW) to IPF and NEU to IPF, mean corpuscular volume, and infarct volume were found to be significant predictors in STP assessment. Conclusions: Although not definitive alone, IPF may aid early stroke recognition, support treatment monitoring, and inform targeted therapies. The use of IPF, a biomarker that can be rapidly obtained, in the diagnosis of AIS is expected to yield beneficial outcomes in patient management, particularly in emergency departments and other clinical settings. Full article
(This article belongs to the Special Issue New Insights into Cerebrovascular Disease)
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28 pages, 1846 KB  
Article
Evaluation of the Coupled Coordination of the Water–Energy–Food System Based on Resource Flow: A Case of Hubei, China
by Yuetong Han, Xiangyang Xu, Jiayi Lu, Xiaoxiao Tan and Ying Long
Agriculture 2025, 15(20), 2177; https://doi.org/10.3390/agriculture15202177 - 21 Oct 2025
Viewed by 208
Abstract
External environmental changes, such as climate, industrial expansion, and population growth, threaten the sustainable development of the water–energy–food (WEF) system. Clarifying the intricate nonlinear relationships within this system and revealing the degree of coupling coordination and evolutionary trends within the WEF system can [...] Read more.
External environmental changes, such as climate, industrial expansion, and population growth, threaten the sustainable development of the water–energy–food (WEF) system. Clarifying the intricate nonlinear relationships within this system and revealing the degree of coupling coordination and evolutionary trends within the WEF system can provide feasible pathways for regional sustainable development. Taking Hubei Province as the study area, this research quantified resource flows between dual systems from a resource consumption perspective. It then analyzed the temporal evolution characteristics of resource interactions within the WEF system from 2003 to 2023. In addition, this WEF system was evaluated by an evaluation index system according to the resource utilization level of the single system and the resource flow level of the dual system, and the CRITIC method was employed to assess the coordinated development of the WEF system in Hubei Province from 2003 to 2023. Finally, the coupling coordination degree for 2025 to 2040 was predicted through the grey GM (1,1) model. The results show that the comprehensive development evaluation index exhibited a trend of initial decline followed by an increase from 2003 to 2023. Among these, the water resources system demonstrated the relatively optimal comprehensive development status, while the energy system performed the worst. The WEF system remained in a high-level coupling stage, with its degree of coupling coordination showing a pattern of initial decline followed by an increase, reaching its peak in 2023 and entering a moderately coordinated stage. Within the dual-coupling systems, the water–food (WF) system achieved the highest level of coordinated development, reaching the good coordination stage. The GM (1,1) model indicates that Hubei Province’s WEF system can gradually achieve a good coordinated stage between 2024 and 2040. Full article
(This article belongs to the Section Agricultural Economics, Policies and Rural Management)
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21 pages, 649 KB  
Article
Research on the Configuration Paths of New Quality Productive Forces Driven by Science and Technology Finance Ecosystem
by Juanmei Zhou and Yaqi Wang
Sustainability 2025, 17(20), 9310; https://doi.org/10.3390/su17209310 - 20 Oct 2025
Viewed by 153
Abstract
The Science and Technology Finance ecosystem plays an increasingly important role in shaping the sustainable development of new quality productive forces (NQPF). This study, based on the perspective of complex systems and using a multi-period fsQCA approach, takes 31 provinces, municipalities, and autonomous [...] Read more.
The Science and Technology Finance ecosystem plays an increasingly important role in shaping the sustainable development of new quality productive forces (NQPF). This study, based on the perspective of complex systems and using a multi-period fsQCA approach, takes 31 provinces, municipalities, and autonomous regions in mainland China as cases to analyze the relationship between the Science and Technology Finance ecosystem and NQPF from 2017 to 2022. The findings are as follows: first, the antecedent configurations of NQPF are multiple, with the variables of the Science and Technology Finance ecosystem jointly matching and working together to drive its development. Second, in 2017–2018, there were three configurations: the “Bank–Enterprise” collaborative-driven type, the Bank-led type, and the Enterprise-led type; in 2019–2020, there were three configurations: the “Bank–Enterprise” collaborative-driven type, the “Bank–Enterprise–Market” collaborative-driven type, and the “Enterprise–Market” collaborative-driven type; in 2021–2022, there was one configuration, namely the Multi-Actor collaborative-driven type. Third, the development of NQPF across the three stages underwent an evolution from being dominated by core financial resources, to coordinated driving by core finance and the market, and finally to multi-stakeholder collaborative promotion. Fourth, in the configurations where high-level NQPF was not achieved, insufficiency of Enterprise Self-owned Funds (ESOF) was identified as a common problem. These findings provide theoretical references and policy implications for optimizing the Science and Technology Finance ecosystem in line with local conditions. Full article
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22 pages, 4745 KB  
Article
The Human–Nature Paradox: Spatiotemporal Coupling and Drivers of Habitat Quality and Human Footprint in China
by Mingxing Zhong and Wanxu Chen
Land 2025, 14(10), 2089; https://doi.org/10.3390/land14102089 - 20 Oct 2025
Viewed by 206
Abstract
Human activities inevitably lead to drastic transformations in land use, thereby significantly impacting natural ecosystems. As a crucial indicator of ecosystem health, habitat quality (HQ) provides appropriate conditions for human survival and development. Elucidating the relationships between human activities and HQ can offer [...] Read more.
Human activities inevitably lead to drastic transformations in land use, thereby significantly impacting natural ecosystems. As a crucial indicator of ecosystem health, habitat quality (HQ) provides appropriate conditions for human survival and development. Elucidating the relationships between human activities and HQ can offer scientific insights into the sustainability of socioeconomic development and ecological environmental protection. Although numerous studies have focused on the correlations between human activities and HQ at various scales, analysis on the interactive coercive relationship between human activities and HQ at the county level in China remains limited. Therefore, we employed the human footprint (HFP) to characterize human activities and the InVEST model to assess HQ, then applied the coupling coordination degree (CCD) model and GeoDetector to identify their interactive coercive relationship and driving factors in China. The results show that the average HQ in China was 0.555, 0.551, 0.547, 0.538, and 0.531 in 2000, 2005, 2010, 2015, and 2020, respectively, showing a declining trend. Furthermore, the average HFP during the same period was 18.3, 18.9, 19.3, 20.1, and 21.6, reflecting an opposite trend. The CCD between HQ and HFP increased continuously from 0.644 in 2000 to 0.659 in 2020 at the county level in China, indicating a highly coupled state with an improving trend. In terms of driving factors, land use intensity was the primary driver of the CCD between HQ and HFP, followed by precipitation, temperature, and night-time light. Notably, the driving force of natural environmental factors showed a declining trend while that of socioeconomic factors increased, and the interaction between natural and socioeconomic factors strengthened. These findings provide important scientific guidance for county-level economic development and ecological environmental protection in China. Full article
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20 pages, 2947 KB  
Article
Research on Spatial Spillover Effects of Comprehensive Carrying Capacity of Water and Soil Resources: Evidence from the Yellow River Basin, China
by Guanghua Dong, Shiya Xiong, Lunyan Wang, Xiaowei An and Xin Li
Sustainability 2025, 17(20), 9299; https://doi.org/10.3390/su17209299 - 20 Oct 2025
Viewed by 212
Abstract
Water and soil resources (WSRs) determine the healthy development of the socio-economic systems. This research seeks to clarify the spatiotemporal evolution characteristics, spatial spillover effects, and key constraint factors influencing the comprehensive carrying capacity (CCC) of WSR in the Yellow River (YR) Basin [...] Read more.
Water and soil resources (WSRs) determine the healthy development of the socio-economic systems. This research seeks to clarify the spatiotemporal evolution characteristics, spatial spillover effects, and key constraint factors influencing the comprehensive carrying capacity (CCC) of WSR in the Yellow River (YR) Basin from 2012 to 2023, thereby supporting the healthy development of the river basin. Based on the structural relationships among the internal elements of this system, the entropy method and an extensible cloud model are employed in this study to evaluate the WSR-CCC. Based on the estimation theory and spatial econometrics methods, the temporal and spatial evolution process of WSR-CCC was explored, and the obstructive factors were analyzed. We made the following discoveries: (1) The WSR-CCC demonstrates a fluctuating upward tendency, gradually moving from critical overload level IV to sustainable level II, but inter-provincial disparities expand. (2) The spatial pattern exhibits a gradient of higher levels in the western region, lower levels in the eastern region, stronger intensity in the northern region, and weaker intensity in the southern region, with weak spatial correlation. However, the spatial spillover effect is significant, with club convergence and the Matthew effect coexisting. (3) The obstacle factors exhibit a drive–influence–state three-stage dominant characteristic. The findings provide actionable insights for coordinating WSR optimization and ecological conservation. Full article
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20 pages, 2427 KB  
Review
Advancing Sustainable Energy Security in Türkiye: Geopolitical and Policy Perspectives
by Mehmet İvgin and Tufan Demirel
Sustainability 2025, 17(20), 9264; https://doi.org/10.3390/su17209264 - 18 Oct 2025
Viewed by 233
Abstract
Energy security remains a central challenge in the context of global sustainability, as geopolitical dynamics, technological advancements, and environmental imperatives converge to reshape energy systems worldwide. This comprehensive review explores the intricate relationship between geopolitics and energy policy, with a particular focus on [...] Read more.
Energy security remains a central challenge in the context of global sustainability, as geopolitical dynamics, technological advancements, and environmental imperatives converge to reshape energy systems worldwide. This comprehensive review explores the intricate relationship between geopolitics and energy policy, with a particular focus on Türkiye’s evolving energy landscape. It examines how diversification of energy sources, investments in renewable technologies, resilient infrastructure development, and international collaborations collectively contribute to securing national and global energy futures. The study highlights the geopolitical significance of strategic energy corridors, resource competition, and the emergent role of renewable energy in redefining power structures. Drawing on comparative case studies, including Germany’s Energiewende, Norway’s resource management, Japan’s post-Fukushima challenges, and the United States’ shale revolution, the review distills lessons applicable to Türkiye and other emerging economies navigating energy transitions. Future trends discussed include the rising importance of energy storage, smart grids, digitalization, cybersecurity, and equitable energy access. Policy recommendations emphasize integrated approaches that balance economic growth, environmental stewardship, and national security, advocating for proactive diversification, innovation, and multilateral cooperation. The article concludes that achieving a resilient, low-carbon, and geopolitically stable energy system requires coordinated global efforts anchored in adaptive governance and inclusive stakeholder engagement. This work provides a valuable framework for policymakers, researchers, and practitioners committed to advancing sustainable and secure energy pathways in Türkiye and beyond. Full article
(This article belongs to the Special Issue Advances in Sustainable Energy Systems)
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24 pages, 6032 KB  
Article
Spatio-Temporal Coupling Coordination and Driving Mechanism of Urban Pseudo and Reality Human Settlements in the Coastal Cities of China
by Xueming Li, Linlin Feng, Meishuo Du and Shenzhen Tian
Land 2025, 14(10), 2081; https://doi.org/10.3390/land14102081 - 17 Oct 2025
Viewed by 226
Abstract
The accelerated development of digital technologies during the 21st century has intensified requirements for Human Settlements (HS) infrastructure advancement in China’s maritime urban centers, driven by national objectives to forge a cohesive, technologically integrated state framework. This transformation has changed people’s work, learning, [...] Read more.
The accelerated development of digital technologies during the 21st century has intensified requirements for Human Settlements (HS) infrastructure advancement in China’s maritime urban centers, driven by national objectives to forge a cohesive, technologically integrated state framework. This transformation has changed people’s work, learning, and entertainment patterns, leading to the rise in complex networks of pseudo human settlements (PHS). Traditional approaches to environmental research are insufficient for understanding the interactions between PHS and reality human settlements (RHS), which are interdependent and shape urban development. This study utilizes advanced methods such as the entropy weight method to determine indicator weights, the coupling coordination degree model to quantify the interaction intensity, the geo-detector to identify driving factors, and ArcGIS for spatial analysis to assess the interaction between PHS and RHS in 53 coastal cities from 2011 to 2022. The results show: (1) The coupling coordination degree rose initially but later declined, reflecting temporal differentiation; (2) The coordination of settlements varies across regions; (3) A migration trend from the northeast to southwest, with faster coordination improvement in the southwest; (4) Socio-economic development drives the coupling coordination, with big data technology enhancing the relationship. The findings guide sustainable urban development in coastal cities. Full article
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20 pages, 4116 KB  
Article
Stability Matters: Revealing Causal Roles of G-Quadruplexes (G4s) in Regulation of Chromatin and Transcription
by Ke Xiao, Rongxin Zhang, Tiantong Tao, Huiling Shu, Hao Huang, Xiao Sun and Jing Tu
Genes 2025, 16(10), 1231; https://doi.org/10.3390/genes16101231 - 17 Oct 2025
Viewed by 314
Abstract
Background: G-quadruplexes (G4s) are non-canonical higher-order nucleic acid structures that form at guanine-rich motifs, with features spanning both secondary and tertiary structural levels. These dynamic structures play pivotal roles in diverse cellular processes. Endogenous G4s (eG4s) function through their dynamically formed structures, prompting [...] Read more.
Background: G-quadruplexes (G4s) are non-canonical higher-order nucleic acid structures that form at guanine-rich motifs, with features spanning both secondary and tertiary structural levels. These dynamic structures play pivotal roles in diverse cellular processes. Endogenous G4s (eG4s) function through their dynamically formed structures, prompting the hypothesis that their thermostability, as a key structural property, may critically influence their functionality. This study investigates the relationship between G4 stability and other functional genomic signals within eG4 regions and examines its broader impact on chromatin organization and transcriptional regulation. Methods: We developed a mapping strategy to associate in vitro-derived thermostability metrics and multi-omics functional signals with eG4 regions. A stability-centric analytical framework combining correlation analysis and causal inference using the Bayesian networks was applied to decipher causal relationships between G4 stability and the other related signals. We further analyzed the association between the stability of transcription start site (TSS)-proximal eG4s and the biological functions of their downstream genes. Results: Our analyses demonstrate that G4 thermostability exerts causal effects on epigenetic states and transcription factor binding, thereby influencing chromatin and transcription regulation. We further show distinct network architectures for G4-binding versus non-binding transcription factors. Additionally, we find that TSS-proximal eG4s are enriched in genes involved in core proliferation and stress-response pathways, suggesting that eG4s may serve as regulatory elements facilitating rapid stress responses through genome-wide coordination. Conclusions: These findings establish thermostability—though measured in vitro—as an intrinsic property that shapes eG4 functionality. Our study not only provides novel insights into the functional relevance of G4 thermostability but also introduces a generalizable framework for high-throughput G4 data interpretation, significantly advancing the functional decoding of eG4s across biological contexts. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
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25 pages, 19035 KB  
Article
Revealing Multiscale Characteristics of Ecosystem Service Flows: Application to the Yangtze River Economic Belt
by Yiyang Li, Hongrui Wang, Li Zhang, Yafeng Yang, Ziyang Zhao and Xin Jiang
Land 2025, 14(10), 2076; https://doi.org/10.3390/land14102076 - 17 Oct 2025
Viewed by 241
Abstract
Assessing ecosystem service (ES) supply–demand relationships and identifying their driving forces are essential for ecological security and sustainable ecosystem development. Using ES supply–demand mismatches as a basis, this study characterized the spatiotemporal evolution of ES supply and demand from 2000 to 2023. Additionally, [...] Read more.
Assessing ecosystem service (ES) supply–demand relationships and identifying their driving forces are essential for ecological security and sustainable ecosystem development. Using ES supply–demand mismatches as a basis, this study characterized the spatiotemporal evolution of ES supply and demand from 2000 to 2023. Additionally, a SHAP-informed Stacking Bayesian optimization model was employed to identify key drivers of supply–demand imbalances. Building on this, threshold-aware spatial optimization of ecosystem service flows was performed using an improved minimum-cost algorithm within an NSGA-II multi-objective framework. The results showed that: (1) The YREB’s supply–demand balance (SDB) exhibited significant spatial heterogeneity. Water SDB declined with fluctuations, decreasing from 5.343 × 1011 m3 to 4.433 × 1011 m3, whereas carbon SDB shifted from a surplus (+1.514 × 109 t) to a deficit (−1.673 × 109 t) during the study period. Crop SDB rose from 1.361 × 108 to 1.450 × 108 t across the study period. (2) Nighttime light intensity (NLI) was the dominant factor for water SDB and carbon SDB, while cropland area was the key driver for crop SDB. (3) Over 2000–2023, water SDB flow increased from 8.5 × 109 m3 to 1.43 × 1010 m3. Carbon SDB flows more than tripled from 9.576 × 107 tons to 2.89 × 108 tons. Crop SDB flow increased nearly twelvefold over 2000–2023, from 3.3 × 105 t to 3.93 × 106 t. The findings provide scientific support for coordinating ecological conservation and high-quality development across the Yangtze River Economic Belt. Full article
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37 pages, 595 KB  
Article
Does R&D Efficiency Hold the Key to Regional Resilience Under Sustainable Urban Development?
by Siyu Li, Tian Xia and Yongrok Choi
Sustainability 2025, 17(20), 9186; https://doi.org/10.3390/su17209186 - 16 Oct 2025
Viewed by 176
Abstract
Amid intensifying geopolitical tensions and global uncertainties, regional economies face mounting pressures that threaten both stability and sustainability. Against this backdrop, building resilient regional systems has become a central issue in sustainable urban development. As a key driver of resilience, innovation has been [...] Read more.
Amid intensifying geopolitical tensions and global uncertainties, regional economies face mounting pressures that threaten both stability and sustainability. Against this backdrop, building resilient regional systems has become a central issue in sustainable urban development. As a key driver of resilience, innovation has been central to China’s development agenda. Continuous and large-scale R&D investment has redirected focus from input expansion to efficiency improvement, positioning R&D efficiency at the heart of resilience-building. Under external shocks and uncertainty, can improvements in R&D efficiency enhance regional economic resilience? If so, which additional factors embedded in sustainable urban development planning can further amplify this effect? To address these questions, this study employs provincial panel data from 2000 to 2021 and integrates the SBM-DEA approach with an entropy-weighted resilience index for regression analysis. The results indicate that (1) R&D efficiency exerts a positive but limited impact on resilience, with an average increase of only 0.188 units, indicating that efficiency alone cannot generate resilient economies without institutional coordination; (2) human capital agglomeration and financial density strengthen this relationship, highlighting the need to integrate talent and financial strategies; (3) the positive effect is observed in eastern provinces but remains insignificant in central and western regions, revealing pronounced structural disparities that risk widening the resilience gap across regions rather than fostering balanced development; and (4) targeted government intervention effectively converts innovation efficiency into resilience gains, fostering coordinated and sustainable development. This study empirically demonstrates that improving R&D efficiency significantly enhances regional resilience in China and based on this evidence introduces the ICT Synergy Framework as a novel analytical lens for understanding how innovation, capital, and talent jointly drive resilience and sustainable development. The findings further suggest that targeted government intervention in R&D resource allocation can reinforce resilience, offering broader lessons for other developing economies. By integrating innovation outcomes with spatial and institutional planning, the study provides actionable insights for advancing sustainable urban development and coordinated regional growth. Full article
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20 pages, 12689 KB  
Article
Assessing the Land Use-Carbon Storage Nexus Along G318: A Coupled SD-PLUS-InVEST Model Approach for Spatiotemporal Coordination Optimization
by Xiaotian Xing, Qi Wang, Fei Meng, Pudong Liu, Li Huang and Wei Zhuo
Land 2025, 14(10), 2067; https://doi.org/10.3390/land14102067 - 16 Oct 2025
Viewed by 190
Abstract
Revealing the coordination relationship between land use/land cover (LULC) and carbon storage (CS) under diverse climate scenarios is crucial for climate change adaptation in topographically complex regions. This study developed an integrated framework combining the System Dynamics (SD) model, Patch-generating Land Use Simulation [...] Read more.
Revealing the coordination relationship between land use/land cover (LULC) and carbon storage (CS) under diverse climate scenarios is crucial for climate change adaptation in topographically complex regions. This study developed an integrated framework combining the System Dynamics (SD) model, Patch-generating Land Use Simulation (PLUS) model, and Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model, enabling a closed-loop analysis of driving forces, spatial simulation, and ecological feedback. This study systematically assessed LULC evolution and ecosystem CS along China’s National Highway 318 (G318) from 2000 to 2020, and projected LULC and CS under three SSP-RCP scenarios (SSP1-1.9, SSP2-4.5, SSP5-8.5) for 2030. Results show the following: (1) Historical LULC change was dominated by rapid urban expansion, cropland loss, and nonlinear grassland fluctuation, exerting strong impacts on ecosystem dynamics. Future scenario simulations revealed distinct thresholds of ecological pressure. (2) Regional CS exhibited a decline–recovery pattern during 2000–2020, with all 2030 scenarios projecting CS reduction, although ecological-priority pathways could mitigate losses. (3) Coordination between land-use intensity and CS improved gradually, with SSP2-4.5 emerging as the optimal strategy for balancing development and ecological sustainability. Overall, the coupled SD-PLUS-InVEST framework provides a practical tool for policymakers to optimize land use patterns and enhance CS in complex terrains. Full article
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