Search Results (19)

The advancement of digital techniques and reduced costs have greatly facilitated their integration into cultural heritage preservation. These technologies are especially valuable in archaeology, where detailed documentation is crucial. However, minimal intervention in restorations often limits public understanding of archaeological spaces, making digital tools essential for enhancing engagement. An example is the study and the virtual hypothesis of the mural decorations in the Sala del Mosaico de los Amores, located in the Castulo Archaeological Site (Linares, Jaén, Spain), dated to the late first and early second centuries AD. The hall originally featured an elaborate wall decoration, now largely lost due to the collapse of its walls, leaving only a few fragments in situ. Using SfM photogrammetry, the hall and the original paintings and cornices—restored in a laboratory—were documented and virtually reassembled. This process employed precise color calibration and dimensional scaling to ensure the faithful recreation of the original appearance. In addition to the anastylosis of the surviving fragments, a virtual reconstruction hypothesis was developed, offering the public an immersive visualization of how the space would have looked in its original state. Full article

This paper addresses the archaeological and archaeochemical study of the fragments of mural painting recovered from the excavation of the baths in Julián Besteiro Square in Carmona. The analysis of the fragments allowed us to associate them with the first phase of the building’s decoration, one of the few examples of urban mural painting currently known in Carmona. It was dated between the first half and the middle of the first century AD. The archaeochemical study identified the composition of the mortar and the pigments of the fragments belonging to the middle and upper zones of the wall, confirming the presence of palmitic and stearic fatty acids, as well as traces of oleic and tetradecanoic acids corresponding to the binders used for the execution of the decoration. This discovery provides specific information on the techniques used in Roman architectural decoration, shedding light on the materials and methods used in first-century-AD urban contexts. Full article

Evaluating the seismic vulnerability of facades of historic masonry buildings is essential not only for their significant historical and heritage value, but also to evaluate the safety of this type of construction. This work applies a simplified methodology to assess the seismic vulnerability of the facade of masonry buildings in the historic center of Morelia, Michoacán, México. The historic center of Morelia was declared a World Cultural Heritage Site by UNESCO in 1991. On the facades, there is ornamentation with sculptural and vegetal decorative elements. The methodology involved conducting visual inspections to identify the location, type of structure, construction materials, doors, windows, balconies, cornices, ironwork, pediments, niches, and sculptures, among other characteristic elements of colonial architecture. The seismic demands were determined specifically for the city’s historic center based on a recent seismic hazard assessment of Morelia. Based on the methodology and the compiled database, characterized vulnerability indices were defined for the different damage scenarios that buildings may present. Results indicate that earthquakes with intensities greater than VIII on the Modified Mercalli scale risk collapsing heritage masonry buildings’ facades. Full article

The tree fern Culcita macrocarpa, a threatened Iberian–Macaronesian endemism, represents the sole European species of the order Cyatheales. Considered a Tertiary relict of European Palaeotropical flora, its evolutionary history and genetic diversity, potentially influenced by presumed high clonal propagation, remain largely unknown. This study elucidates the phylogeographic history of C. macrocarpa, assessing the impact of vegetative reproduction on population dynamics and genetic variability. We provide genetic data from eight newly identified nuclear microsatellite loci and one plastid DNA region for 17 populations spanning the species’ range, together with species distribution modeling data. Microsatellites reveal pervasive clonality in C. macrocarpa, which has varied among populations. We assess the impact of clonality on genetic diversity and evaluate how estimates of intra-population genetic diversity indices and genetic structuring are affected by the chosen definition of “individual” (focusing exclusively on genetically distinct individuals, genets, as opposed to considering all independent clonal replicates, ramets). We identify two main population groups, one in the northern Iberian Peninsula and the other in the Macaronesian archipelagos and southern Iberian Peninsula. Within each group, we found relict populations (in the Azores and the Cantabrian Cornice) as well as recent originated populations. This population structure suggests colonization dynamics in which recent populations originated from one or a few genets of relict populations and became established through intra-gametophytic self-fertilization and vegetative expansion. DAPC analysis facilitated the identification of alleles that most significantly contributed to the observed population structure. The current Andalusian populations appear to have originated from colonization events from the Azores and the Cantabrian Cornice. Our findings suggest that C. macrocarpa persisted through the Last Glacial Maximum in two refugia: the Azores and the Cantabrian Cornice. Colonization into new areas occurred presumably from these refuges, generating two large population groups with structured genetic diversity. This study underscores the significance of clonality in establishing new populations and shaping genetic structure. Full article

Tumor-associated macrophages (TAMs) are the major component of the tumor microenvironment (TME), where they sustain tumor progression and or-tumor immunity. Due to their plasticity, macrophages can exhibit anti- or pro-tumor functions through the expression of different gene sets leading to distinct macrophage phenotypes: M1-like or pro-inflammatory and M2-like or anti-inflammatory. NF-κB transcription factors are central regulators of TAMs in cancers, where they often drive macrophage polarization toward an M2-like phenotype. Therefore, the NF-κB pathway is an attractive therapeutic target for cancer immunotherapy in a wide range of human tumors. Hence, targeting NF-κB pathway in the myeloid compartment is a potential clinical strategy to overcome microenvironment-induced immunosuppression and increase anti-tumor immunity. In this review, we discuss the role of NF-κB as a key driver of macrophage functions in tumors as well as the principal strategies to overcome tumor immunosuppression by targeting the NF-κB pathway. Full article

The effects of various parameters of the solar panel and surrounding structure on wind loads acting on solar panels have been extensively investigated in prior studies. However, the parameter of cornice length has not been considered. With varying lengths of cornices, solar panels can be positioned either near or far away from the roof corner and edge, which are the locations where the largest wind-induced suction forces are likely to occur. To examine the effects of cornices, a wind tunnel test was conducted to measure the wind pressures on a solar module installed on a residential gable roof building. The cornice lengths varied from 0 m to 1.6 m, with an interval of 0.4 m. The results show that when wind blows perpendicular to the roof ridge, cornice can reduce the mean, STD, and peak pressure coefficients on the upper and lower surfaces and resulting net values. However, it should be noted that the most unfavorable area-averaged minimum peaks in the middle and trailing zones exhibit a gradual increase with the growing cornice length. Considering the potential risk of solar module failure resulting from high wind-induced suction forces, more caution is needed when installing solar modules on roofs with larger cornices. Full article

Meandering rivers are among the most dynamic Earth-surface systems, which generally appear in fertile valleys, the most valuable lands for agriculture and human settlement. Landsat time series and morphological parameters are complementary tools for exploring river dynamics. Karun River is the most effluent and largest meandering river in Iran, which keeps the Karun’s basin economy, agriculture, and industrial sections alive; hence, investigating morphological changes in this river is essential. The morphological characteristics of Karun have undergone considerable changes over time due to several tectonic, hydrological, hydraulic, and anthropogenic factors. This study has identified and analyzed morphological changes in Karun River using a time series of Landsat imagery from 1985–2015. On that basis, morphological dynamics, including the river’s active channel width, meander’s neck length, water flow length, sinuosity index, and Cornice central angle, were quantitatively investigated. Additionally, the correlation between the stream power and morphological factors was explored using the data adopted from the hydrometric stations. The results show that the dominant pattern of the Karun River, due to the sinuosity coefficient, is meandering, and the majority of the river falls in the category of developed meander rivers. Moreover, the number of arteries reduced in an anabranch pattern, and the river has been migrating towards the downstream and eastern sides since 1985. This phenomenon disposes a change in the future that can be hazardous to the croplands and demands specific considerations for catchment management. Full article

NF-κB transcription factors are major drivers of tumor initiation and progression. NF-κB signaling is constitutively activated by genetic alterations or environmental signals in many human cancers, where it contributes to almost all hallmarks of malignancy, including sustained proliferation, cell death resistance, tumor-promoting inflammation, metabolic reprogramming, tissue invasion, angiogenesis, and metastasis. As such, the NF-κB pathway is an attractive therapeutic target in a broad range of human cancers, as well as in numerous non-malignant diseases. Currently, however, there is no clinically useful NF-κB inhibitor to treat oncological patients, owing to the preclusive, on-target toxicities of systemic NF-κB blockade. In this review, we discuss the principal and most promising strategies being developed to circumvent the inherent limitations of conventional IκB kinase (IKK)/NF-κB-targeting drugs, focusing on new molecules that target upstream regulators or downstream effectors of oncogenic NF-κB signaling, as well as agents targeting individual NF-κB subunits. Full article

Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy that relies on highly heterogeneous cytogenetic alterations. Although in the last few years new agents have been developed for AML treatment, the overall survival prospects for AML patients are still gloomy and new therapeutic options are still urgently needed. Constitutive NF-κB activation has been reported in around 40% of AML patients, where it sustains AML cell survival and chemoresistance. Given the central role of NF-κB in AML, targeting the NF-κB pathway represents an attractive strategy to treat AML. This review focuses on current knowledge of NF-κB’s roles in AML pathogenesis and summarizes the main therapeutic approaches used to treat NF-κB-driven AML. Full article

Prostate cancer (PCa) is the second most frequent cancer in men worldwide. NF-κB seems to play a key role in cell survival, proliferation and invasion, sustaining the heterogeneous multifocal nature of PCa. In recent years, the Hedgehog (Hh) signaling pathway has attracted attention as a therapeutic target due to its implication in tumorigenesis and metastasis in several types of cancer, including PCa. Although it is well-known that Sonic Hedgehog (SHh) is a transcriptional target of NF-κB(p65), and that GLI1 is the effector of this crosstalk, the precise role played by this axis in PCa is still not completely clear. Here, we set out to explore the correlation between NF-κB activation and SHh pathways in PCa, investigating if the interplay between NF-κB(p65) and SHh-GLI1 in advanced PCa could be a prospective therapeutic target. Our findings demonstrate that a NF-κB-SHh-GLI1 gene signature is enriched in PCa patients featuring a higher Gleason score. Moreover, elevated levels of this signature are associated with worse prognosis, thus suggesting that this axis could provide a route to treat aggressive PCa. Full article

Research on regional residential buildings is an important means of exploring the natural climatic adaptability of buildings and the sustainable development of culture. It is also an important path of sustainable social development. However, current research methods for architectural space find it difficult to clarify the internal and external relations of space, and the function of architectural space to adapt to the regional climate and cultural heritage is difficult to quantitatively analyze and measure. This study constructs a new research method of architectural interiors/exteriors, takes the traditional residential buildings in Wu-style architecture in the Jinhua area as a case study, summarizes the types and characteristics of the interiors/exteriors of Wu-style architecture, and reveals the spatial construction rules of the internal and external types realizing environmental sustainability and traditional residences. The results show that: (1) the architecture of the Wu style has five typical types of interior/exterior, and the regional representation of its interior/exterior is affected by both the human and the natural environment; (2) influenced by traditional Confucian culture, the architecture of the Wu style shows a central axial secondary buckling type and an enclosed type of interior/exterior form, which has the value of the times to coordinate the relationship between people in today’s society; (3) in terms of ventilation, daylighting, and heat dissipation, Wu-style buildings flexibly use the slender gray space form and wide cornice for the internal and external space transition, which effectively improves the ecological efficiency of the buildings’ ventilation, lighting, heat dissipation, etc., and has important reference value for the development and utilization of traditional buildings and the architectural design of new dwellings. At present, this new research method for the internal and external spaces of buildings still has considerable potential and needs to be deepened and improved through further research. Full article

While at first it can be thought that the auxiliary elements of facades are merely ornamental with little practical function, this study shows that these components of the building envelope have a high impact on the envelope’s functioning and performance. This is carried out through the analysis of all relevant lawsuits filed in Spain over a 10 year period, a data set in which a surprisingly high number of 1033 cases of defects was found to affect external windowsills, exterior wainscots or cornices (the three auxiliary elements considered) was found. Considering the total number of lawsuits, this is an objectively unprecedented study. An analysis is carried out regarding the interrelations between elements, defects, causes, and types of buildings, with the aim of obtaining a sorted classification of the data. This constitutes a useful tool to prevent future problems arising from either the design, execution, or maintenance of facades. These include various issues resulting from humidities, one of the most frequent envelope defects, which are found to significantly affect the auxiliary elements of facades. Full article

Fern phylogeographic studies have mostly focused on the influence of the Pleistocene climate on fern distributions and the prevalence of long-distance dispersal. The effect of pre-Pleistocene events on the distributions of fern species is largely unexplored. Here, we elucidate a hypothetical scenario for the evolutionary history of Vandenboschia speciosa, hypothesised to be of Tertiary palaeotropical flora with a peculiar perennial gametophyte. We sequenced 40 populations across the species range in one plastid region and two variants of the nuclear gapCp gene and conducted time-calibrated phylogenetic, phylogeographical, and species distribution modelling analyses. Vandenboschia speciosa is an allopolyploid and had a Tertiary origin. Late Miocene aridification possibly caused the long persistence in independent refugia on the Eurosiberian Atlantic and Mediterranean coasts, with the independent evolution of gene pools resulting in two evolutionary units. The Cantabrian Cornice, a major refugium, could also be a secondary contact zone during Quaternary glacial cycles. Central European populations resulted from multiple post-glacial, long-distance dispersals. Vandenboschia speciosa reached Macaronesia during the Pliocene–Pleistocene, with a phylogeographical link between the Canary Islands, Madeira, and southern Iberia, and between the Azores and northwestern Europe. Our results support the idea that the geological and climate events of the Late Miocene/Early Pliocene shifted Tertiary fern distribution patterns in Europe. Full article

Strong earthquakes could serve as a trigger for glacier detachment and associated ice–rock avalanches. The 1988 Tsambagarav earthquake (M = 6.4) initiated collapse of part of the glacier tongue and a further ice–rock avalanche with an abnormal 5 km long path in Zuslan valley, Tsambagarav ridge (Mongolian Altai). Early documentation of surface effects in 1988, remote sensing and field data gathered 16 and 30 years after this event allowed for the assessment of the seismic impact on a reduction of “damaged” glacier under conditions of global warming as well as estimating topography changes in this arid and seismically active area. Because of the earthquake, the glacier immediately lost 10.4 % of its area (0.1 km² of tongue surface). Additionally, 56% of its area was lost during 1988–2015, shrinking much faster than neighboring glaciers of similar size and exposition. Collapse of snow–ice cornice in the accumulation zone could play a key role in rapid acceleration of the detached ice block and abnormally long path of the ice–rock avalanche. A large amount of debris material provided more than 16 years of ice melting. Downstream, the valley avalanche debris cover repeats the topography of underlying Pleistocene moraines, which should be considered in regional paleogeographical reconstructions. Full article

This paper presents the theoretical assumptions and design praxis concerning colour schemes used in the multi-threaded Moderne, Streamline Moderne and Art Deco styles, which were used in Germany during the interwar period to design commercial facilities. We based our analysis on selected cases of department stores built in the years 1927–1930 in Berlin and Wrocław (Breslau at the time). Streamline Moderne and Art Deco, which was present in Germany alongside Expressionism, operated using a simple spatial structure that followed the precepts formulated by the Bauhaus: it featured rhythmically divided, disciplined facades clad in ceramics, sandstone or travertine, as well as large storefront windows with brass frames. These Modernist compositions were enriched with ceramic or brass cornices and friezes, overhangs and full-figure sculptures that were often gilded. The buildings’ interiors, designed following the principles of efficiency and functionality, had spatially accentuated and colour-marked entrance zones and grand, glazed courtyards that were given an expressive décor via ceramics, stone or exotic wood. The expression of these compositions was underscored by linear illumination and cascade-like chandeliers that formed light sculptures. In our paper, we also presented problems associated with the contemporary revitalisation and reconstruction of such buildings. We specifically focused on research findings that identified original ceramics production technologies and methods that allowed the recreation of the texture and colour of the facade of the A. Wertheim department store in Wrocław. Full article