Search Results (34)

Although the existence of highly prevalent pain, disability, and work time lost associated with discogenic low back pain is well known, the recognition of the culpability of universally present disc degradation and mechanical insufficiency in the first three decades of life is often overlooked. There is a corresponding “treatment gap” and no current interventions with demonstrated capabilities to address the pain and resist the usual progression of increasing structural failure of spinal tissues with increasing levels of pain and disability. This narrative review summarizes more than forty years of the literature describing the pathomechanics of progressive degradation of lumbar discs, with a focus on studies that implicate an increasing mechanical insufficiency in the etiology of early-stage chronic and recurrent discogenic low back pain. Topics highlighted in this review include the deleterious biological changes that begin soon after birth, stress intensification due to the loss of fluid phase load support, fatigue weakening and damage accumulation in non-regenerative tissue, disc tears, segmental instability, and the timeline for first incidence of chronic low back pain. The review concludes with preferred treatment characteristics and a brief summary of emerging treatment approaches. Full article

Euphemisms, anthropomorphisms, and equivocation are established characteristics of traditional equestrian language. ‘Evasion’, ‘resistance’, and ‘disobedience’ are common labels assigned to unwelcome equine behaviours, implying that the horse is at fault for not complying with the human’s cues and expectations. These terms appear to overlook multiple motivations that may directly result in the horse offering unwelcome responses, which may then inadvertently be reinforced. This article revisits some of the anthropocentric inferences in these terms and explores the harmful consequences of such convenient but incorrect labels before proposing a redefinition of ‘conflict behaviour’ in human–horse interactions: Responses reflective of competing motivations for the horse that may exist on a continuum from subtle to overt, with frequencies that range from a singular momentary behavioural response to repetitive displays when motivational conflict is prolonged. Addressing how inadequate terms may mask pain, obscure the horse’s motivation, and deflect human culpability, this commentary highlights the merits of a multidisciplinary approach to terminology across equine research. Acknowledging that variables contributing to behaviour can be biological, environmental and anthropogenic, it emphasises the need for more investigation into the relationships between equicentric motivations reflecting equine telos and problematic horse behaviours. Full article

Wisteria vein mosaic virus (WVMV, Potyvirus wisteriae), a virus belonging to the genus Potyvirus, is responsible for Wisteria vein mosaic disease (WMD), a severe disease that affects Wisteria, a genus of garden plants acclaimed worldwide. Although probably originating in the Far East, WVMV infection was first reported in the US, and subsequently in numerous countries. Following the first molecular detection of an Italian isolate, WVMV Bari, its full-length genome was achieved using NGS barcoding technology. A PhyML phylogenetic analysis, supported by clustering algorithm validation, identified a clear separation between two phylogroups. One major clade comprised WVMV strains isolated from Wisteria spp. A second clade grouped three highly divergent strains, at the borderline species threshold, all found in non-wisteria hosts. Relying on a Relative Time Dated Tips (RTDT) molecular clock, the first emergence of WVMV clades has been traced back to around the 17th century. A network inference analysis confirmed the sharp separation between the two host-related phylogroups, also highlighting the presence of potential intermediate variants. Inter-population genetic parameters revealed a very high genetic differentiation in both populations, which was made reliable by statistically significant permutation tests. The migrant number (Nm) and fixation index (F_ST) evidenced a restricted gene flow and strong population structures. According to the dN/dS ratio and negative neutrality tests, it was derived that purifying selection at the expense of non-silent variants is underway within WVMV populations. Targeting WVMV evolutionary traits, the present effort raised interesting questions about the underestimated potential of this culpably neglected species to spread in economically relevant crops. The main intention of our study is, therefore, to propose an evolution-based analysis approach that serves as a case study to investigate how other potyviruses or newly emerging viruses may spread. Full article

In a quest to vet UNS S32205 as a potential structural material to serve moderate-to-high temperature operations of NPP auxiliary components, the DL-EPR test was exploited. A bifronted scheme comprised of 650 and 850 °C discrete treatments intended to explore progressive eutectoid decomposition and degree-of-sensitization (DoS) scenarios was adopted. The nuance witnessed with yet another dual approach—the Cihal- and image processing (IP)-normalized signal landscape—was rationalized through its attribution to culprit microstructures. This was sought, inter alia, in the vicinity of grain boundaries and σ-phase inclusions by virtue of postmortem FESEM, STEM-EDX, HRTEM SAED and XRD ascertainment. Discernable reactivation-kinetics resurgence was believed to mark the onset of deleterious σ-phase dissolution. This only came into fruition with longer ageing times (8–17 h) at 650 °C and succumbed to prematurely (1 h), and at DC biases more cathodic than −0.25 VAg/AgCl with the 850 °C counterpart. Opportune corroboration was offered in i_r/i_a breakaway for the respective conditions, which was unveiled to be particularly pre-emptive (5 h) with IP- vs. Cihal-normalized peers (8 h) related to the 650 °C condition. Meanwhile, the 850 °C condition endured a similar surge after as little as 1 h of ageing across the board, which hints at concomitant sigma-phase culpability. Full article

This study examined whether public opinion on drug addiction, perceived culpability/responsibility, and punishment were impacted by statements from medical associations that drug addiction is a disease and not a choice. We utilized an experimental information provision survey distributed via Qualtrics to heads of household in South Carolina with an associated email address. The randomized treatment variable had two conditions. The first condition presented participants with a statement from several noteworthy medical associations/institutions noting that drug addiction is a disease. The second condition provided no statement (control condition). Results from our sample of over 5000 indicated that a large majority of respondents felt that individuals who have been diagnosed with a drug addiction should be fully responsible for any crimes that they commit. The presentation of official statements that addiction was a disease did not produce meaningful differences from the control group. Additionally, a large majority of respondents did not agree that addiction should relieve a defendant from punishment for drug crimes, theft crimes, or violent crimes. Here again, the presentation of official statements that addiction was a disease did not produce meaningful differences from the control groups. Finally, our results indicated that a majority of respondents viewed addiction as both a choice and disease, and the presentation of official statements that addiction was a disease did not meaningfully alter any responses. Full article

South African criminal law has no separate, distinct, or novel cultural defence. Such a defence could negate or mitigate an accused’s criminal liability for a culturally motivated crime. Whether South Africa’s criminal law could adopt such a defence requires understanding its influence on the requirements for criminal liability. This article evaluates the influence of the cultural defence on the elements of conduct and culpability. The first part deals with the cultural defence and voluntary conduct. The discussion then turns to culpability, which consists of criminal capacity and fault (mens rea). The third part considers the cultural defence’s influence on criminal capacity, while the fourth considers its influence on fault. More specifically, the article evaluates how the existing types of defence that can negate conduct and culpability in South Africa’s criminal law can accommodate arguments of an accused’s cultural background, values, and beliefs to determine whether there is a gap that only a separate, distinct, or novel cultural defence can fill. The article concludes that South Africa’s principles of conduct and culpability are already flexible enough to accommodate such arguments, obviating the need for introducing a separate, distinct, or novel cultural defence. Full article

Repeated regulatory incident investigations demonstrate the insufficiency of company risk assessments and the vulnerabilities that this exposes to the business and its duty holders who are, ultimately, culpable for the subsequent legislative breaches. While the epistemology and taxonomy of the traditional risk assessment are well established, there is a paucity of information that allows the verification and validation of the risk assessment content. Using evidence-based methodologies such as Content Analysis, Thematic Analysis, and validating the outputs using a survey, it became possible to “reverse engineer” the risk assessment content. This analysis of the published risk assessments, kindly supplied by six different Renewable Energy businesses, established that deterministic and behavioristic risk management methodologies had been adopted. These methodologies permitted and guided the use of vague and imprecise terminology and phraseology, numerical inconsistencies resulting in data ossification, and flawed assumptions. This analysis enables the duty holders to make informed and rational judgements about the adequacy of the risk assessment documents, and the process that permitted and guided their creation. Full article

At the beginning of 2023, the Italian former prime minister, the former health minister and 17 others including the current president of the Lombardy region were placed under investigation on suspicion of aggravated culpable epidemic in connection with the government’s response at the start of the COVID-19 pandemic. The charges revolve around the failure by authorities to take adequate measures to prevent the spread of the virus in the Bergamo area, which experienced a significant excess of deaths during the initial outbreak. The aim of this paper is to analyse the pandemic data of Italy and the Lombardy region in the first 10 days of the pandemic, spanning from the 24th of February 2020 to the 4th of March 2020. The objective is to determine whether the use of early warning indicators could have facilitated the identification of a critical increase in infections. This identification, in turn, would have enabled the timely formulation of strategies for pandemic containment, thereby reducing the number of deaths. In conclusion, to translate our findings into practical guidelines, we propose a low-cost early warning method for infectious respiratory diseases with asymptomatic carriers. Full article

Synthesized by the secondary metabolic pathway in Aspergilli, aflatoxins (AFs) cause economic and health issues and are culpable for serious harmful health and economic matters affecting consumers and global farmers. Consequently, the detection and quantification of AFs in foods/feeds are paramount from food safety and security angles. Nowadays, incessant attempts to develop sensitive and rapid approaches for AFs identification and quantification have been investigated, worldwide regulations have been established, and the safety of degrading enzymes and reaction products formed in the AF degradation process has been explored. Here, occurrences in feed commodities, innovative methods advanced for AFs detection, regulations, preventive strategies, biological detoxification, removal, and degradation methods were deeply reviewed and presented. This paper showed a state-of-the-art and comprehensive review of the recent progress on AF contamination in feed matrices with the intention of inspiring interests in both academia and industry. Full article

We have always had and will always have “disruptive” or “dysfunctional” doctors behaving unprofessionally within healthcare institutions. Disruptive physician behaviour (also called “unprofessional behaviour”) was described almost 150 years ago, but remains a persistent, wicked problem in healthcare, largely fuelled by systemic inaction. In this Commentary, we aim to explore the following aspects from a systemic lens: (i) the gaps in understanding systemic resistance and difficulty in addressing this issue; and (ii) pragmatic approaches to its management in the healthcare system. In doing so, we hope to shift the systemic effect from nihilism and despair, to one of hopeful realism about disruptive or unprofessional behaviour. We suggest that solutions lie in cultural change to ensure systemic awareness, responsiveness and early intervention, and an understanding of what systemic failure looks like in this context. Staff education, policies and procedures that outline a consistent reporting and review process including triaging the problem, its source, its effects, and the attempted solutions, are also crucial. Finally, assessment and intervention from appropriately mental-health-trained personnel are required, recognising that this is a complex mental health problem. We are not doing anyone any favours by ignoring, acting as bystanders, or otherwise turning a blind eye to disruptive or unprofessional behaviour; otherwise, we share culpability. Full article

Criminal trials and claims against physicians for malpractice-related damages have increased dramatically in recent years, and, with Obstetrics and Gynecology being one of the medical specialties that is at the highest risk, we carried out a retrospective analysis aimed at examining all Obstetrics- and Gynecology-related medical professional liability prosecutions within the General Register of Criminal Records of the Rome Public Prosecutor’s Office between the years 2000 and 2014. The number of prosecutions increased steadily in the years 2000–2005, with varying trends in the following years. A total of 727 healthcare professionals were involved in criminal charges, and most prosecuted crimes were related to Articles 590 and 589 of the Italian Penal Code, followed by violations of Article 17 of Law 194/78. In most cases, filing was requested and granted without opposition. In 95 cases, an expert witness was appointed by the Court, and in 68 cases, the technical consultants of the State Prosecutor found culpable conduct. Public hospitals, private nursing homes and outpatient clinics, or private practices were mostly involved; in 45% of the cases, the physicians were hospital employees. In this setting, Italy is prepared to introduce new measures and regulations to address the issues posed by defensive medicine and charges of professional liability for healthcare providers. Full article

Falls are the most frequent adverse events recorded in healthcare facilities. By employing a multifaceted strategy to ensure prevention interventions that are specific to the patient type and environmental risk management, risk factor evaluation may help to reduce falls in the hospital setting. Patient falls are one of the main causes of lawsuits against hospitals, which has led to the development of validated instruments that are beneficial in treating the patient after the incident and effective in minimizing the frequency of falls. The aim of our study is to evaluate compensation claims asserting healthcare culpability in situations where a patient fell in a hospital setting. The collected data relate to judgments issued in Italy until December 2022 regarding 30 episodes of falls that occurred between 2003 and 2018. Our research revealed that approximately 50% of Italian healthcare organizations lose the case in court when a patient falls in a hospital setting and dies or is injured. In half of these cases, the failure of the medical staff to use protective equipment against falls is what led to the court’s acceptance of the compensation claim. In order to improve the quality of healthcare services, fall prevention techniques must continue to be implemented. Full article

Attitudes and perceptions about climate change (CC) are crucial to public engagement and support in the promotion of mitigating actions and sustainable lifestyles embracing the United Nations’ sustainable development goals. This study aimed to investigate how worried are European citizens about CC, and what is their willingness to assume self-responsibility in its mitigation. We used the European Social Survey, namely the answers to the questions “How worried are you about climate change?” and “To what extent do you feel a personal responsibility to try to CC?” and have related them with demography and individual perception of the society and its policies. We fit two statistical models to each of the questions studied and found the following: Model 1—people that trust in scientists are more worried about CC, people satisfied with the national government are more worried about CC, women are more worried about CC than men, and older and more educated people are also more worried about CC; Model 2—Women have higher levels of self-responsibility, people that trust in scientists feel more responsibility when satisfied with the economy and the health system of the country, and older people that trust in scientists also have more responsibility. Full article

Pharmacovigilance databases are showing evidence of injury in the context of the modified COVID-19 mRNA products. According to recent publications, adverse event reports linked to the mRNA COVID-19 injections largely point to the spike protein as an aetiological agent of adverse events, but we propose that the platform itself may be culpable. To assess the safety of current and future mRNA vaccines, further analysis is needed on the risks due to the platform itself, and not specifically the expressed antigen. If harm can be exclusively and conclusively attributed to the spike protein, then it is possible that future mRNA vaccines expressing other antigens will be safe. If harms are attributable to the platform itself, then regardless of the toxicity, or lack thereof, of the antigen to be expressed, the platform may be inherently unsafe, pending modification. In this work, we examine previous studies of RNA-based delivery by a lipid nanoparticle (LNP) and break down the possible aetiological elements of harm. Full article

The Mawgridge’s case in 1707 set the precedent where adultery was recognised as a justified trigger for the husband’s killing of his wife’s lover; this crystallised a partial defence for provocation. However, in an 1810 case, the killing of the unfaithful wife followed a manslaughter conviction rather than murder for the first time. This study aims to investigate the shaping of a legally permissible violence, that is, the mitigation of the husband’s culpability in killing his adulterous wife. This provides the opportunity to question the (ir)rationality behind the judiciary’s discourse in the case of R v Clinton 2012; here, despite infidelity being abolished in 2009 in England and Wales as a defence for murder, the judges still insisted on its relevance in our culture and hence on legal culpability. The theoretical framework in this paper draws upon the scholarship of masculinity, the family, and the law. This paper discusses the contribution of the hegemonic male identity in creating this legal violence and fortifying social-hierarchical structure. Full article