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Keywords = damage evolution

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19 pages, 5379 KB  
Article
Geometric Coupling Effects of Multiple Cracks on Fracture Behavior: Insights from Discrete Element Simulations
by Shuangping Li, Bin Zhang, Hang Zheng, Zuqiang Liu, Xin Zhang, Linjie Guan and Han Tang
Intell. Infrastruct. Constr. 2025, 1(2), 6; https://doi.org/10.3390/iic1020006 (registering DOI) - 25 Aug 2025
Abstract
Understanding the multi-crack coupling fracture behavior in brittle materials is particularly critical for aging dam infrastructure, where 78% of structural failures originate from crack network coalescence. In this study, we introduce the concepts of crack distance ratio (DR) and size ratio (SR) to [...] Read more.
Understanding the multi-crack coupling fracture behavior in brittle materials is particularly critical for aging dam infrastructure, where 78% of structural failures originate from crack network coalescence. In this study, we introduce the concepts of crack distance ratio (DR) and size ratio (SR) to describe the relationship between crack position and length and employ the discrete element method (DEM) for extensive numerical simulations. Specifically, a crack density function is introduced to assess microscale damage evolution, and the study systematically examines the macroscopic mechanical properties, failure modes, and microscale damage evolution of rock-like materials under varying DR and SR conditions. The results show that increasing the crack distance ratio and crack angle can inhibit the crack formation at the same tip of the prefabricated crack. The increase in the size ratio will promote the formation of prefabricated cracks on the same side. The increase in the distance ratio and size ratio significantly accelerate the rapid increase in crack density in the second stage. The crack angle provides the opposite effect. In the middle stage of loading, the growth rate of crack density decreases with the increase in crack angle. Overall, the size ratio has a greater influence on the evolution of microscopic damage. This research provides new insights into understanding and predicting the behavior of materials under complex stress conditions, thus contributing to the optimization of structural design and the improvement of engineering safety. Full article
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19 pages, 1954 KB  
Article
Analyzing Possible Shifts in the Climatic Niche of Pomacea canaliculata Between Native and Chinese Ranges
by Ran Zhang, Yue Gao, Rui Wang, Shigang Liu, Qianqian Yang, Yuan Li and Longshan Lin
Biology 2025, 14(9), 1127; https://doi.org/10.3390/biology14091127 (registering DOI) - 25 Aug 2025
Abstract
The impact of invasive alien species (IAS) is one of the direct factors causing global biodiversity decline and economic losses, and predicting the potential invasion risks of invasive species is crucial for developing prevention and control strategies. In recent years, an increasing number [...] Read more.
The impact of invasive alien species (IAS) is one of the direct factors causing global biodiversity decline and economic losses, and predicting the potential invasion risks of invasive species is crucial for developing prevention and control strategies. In recent years, an increasing number of studies have shown that invasive species undergo rapid shifts in climate niche in invaded areas. Accurately quantifying the dynamic shifts in the climate niche of invasive species in invaded areas is crucial for developing a more accurate framework for early warning of invasive species risks. Pomacea canaliculata is a freshwater snail found in South America and has become one of the most aggressive aquatic species in the world. Since its introduction to China in 1981, it has rapidly spread and caused multiple serious damages to agriculture, ecology, and public health. Therefore, based on multi-source distribution data of P. canaliculata, this study calculated the climate niche overlap by Schoener’ s D, quantified the niche shifts between the P. canaliculata in native and invaded areas (China) via the COUE scheme (a unified terminology representing niche centroid shift, overlap, unfilling, and expansion), and analyzed their changes on a time scale. The results revealed that there have been significant climate niche shifts (Schoener’s D < 0.2, niche similarity tests p > 0.01, niche equivalence tests p < 0.01) between the native and invaded areas (China) of P. canaliculata, which does not support the climate niche conservation hypothesis. The minimum temperature of the coldest month (Bio 6) and precipitation seasonality (Bio 15) were the key climate variables driving the climatic niche shift, and P. canaliculata can survive in colder and more arid regions than their native counterparts. The changes in the niche shifts in P. canaliculata on a time scale show significant temporal heterogeneity, and its invasion behavior in China presents a discontinuous and phased expansion pattern, with strong adaptability to new environments. The results are of great significance for the future development of more accurate ecological niche model (ENM), the formulation of more targeted prevention and control strategies, and the study of adaptive evolution mechanisms of invasive species. Full article
(This article belongs to the Section Ecology)
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13 pages, 2075 KB  
Article
A Multi-Level Nonlinear Cumulative Fatigue Damage Life Prediction Model Considering Load Loading Effects
by Bowen Yang and Junzhou Huo
Materials 2025, 18(17), 3973; https://doi.org/10.3390/ma18173973 (registering DOI) - 25 Aug 2025
Abstract
Fatigue damage failure is a process where the mechanical properties of different materials continuously degrade under the action of cyclic loads. The cumulative analysis of fatigue damage has a significant impact on the service structure of major equipment. This paper starts from the [...] Read more.
Fatigue damage failure is a process where the mechanical properties of different materials continuously degrade under the action of cyclic loads. The cumulative analysis of fatigue damage has a significant impact on the service structure of major equipment. This paper starts from the mechanism of fatigue damage evolution, comprehensively considers the influence of the order of high-low cycle load mixed cyclic loading on the fatigue life performance, and based on the Manson-Halford nonlinear fatigue damage accumulation theory and the mechanism of relative cumulative damage, a new nonlinear damage accumulation fatigue life model is established, and a fatigue damage accumulation influencing factor Dcr is introduced to improve the prediction accuracy of the model. The new model proposed in this paper is verified through multi-level fatigue load data. By comparing the prediction results with other models under the same experimental conditions, the fatigue life prediction error precision of the new model is the best in similar cases, generally with an error precision between 10% and 20%, which proves the effectiveness and accuracy of the nonlinear damage accumulation model proposed in this paper. At the same time, the improved method in this paper has better stability while ensuring prediction accuracy. Full article
(This article belongs to the Section Mechanics of Materials)
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14 pages, 1425 KB  
Article
Design-Informed Evaluation and Fretting Damage Mapping of Additive-Manufactured Ti-6Al-4V Components
by Ahmad Sadeghian and Saeed Adibnazari
Designs 2025, 9(5), 100; https://doi.org/10.3390/designs9050100 - 25 Aug 2025
Abstract
This paper experimentally investigates the fretting fatigue behavior of metal additive-manufactured Ti-6Al-4V alloy specimens fabricated using the selective laser melting (SLM) method, focusing on damage characterization and fatigue life assessment. Based on the ASTM E466 standard, the test components were manufactured using metal [...] Read more.
This paper experimentally investigates the fretting fatigue behavior of metal additive-manufactured Ti-6Al-4V alloy specimens fabricated using the selective laser melting (SLM) method, focusing on damage characterization and fatigue life assessment. Based on the ASTM E466 standard, the test components were manufactured using metal 3D printing technology. Fretting fatigue tests were conducted under varying axial stress levels and contact loads, followed by microscopic examinations using scanning electron microscopy (SEM) to analyze damage mechanisms. A fretting map was developed based on SEM observations, providing insights into damage evolution under different loading conditions. These findings contribute to a better understanding of the relationship between fretting fatigue parameters and failure mechanisms. The developed fretting map and experimental observations provide a foundation for further studies aimed at enhancing the fretting fatigue life assessment of standard specimens for different test parameters. Finally, this paper includes design-oriented evaluation frameworks that can guide engineers in integrating AM components into safety-critical systems under fretting fatigue conditions. Full article
(This article belongs to the Section Mechanical Engineering Design)
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22 pages, 8222 KB  
Article
Structural Health Monitoring of Defective Carbon Fiber Reinforced Polymer Composites Based on Multi-Sensor Technology
by Wuyi Li, Heng Huang, Boli Wan, Xiwen Pang and Guang Yan
Sensors 2025, 25(17), 5259; https://doi.org/10.3390/s25175259 - 24 Aug 2025
Abstract
Carbon fiber reinforced polymer (CFRP) composites are prone to developing localized material loss defects during long-term service, which can severely degrade their mechanical properties and structural reliability. To address this issue, this study proposes a multi-sensor synchronous monitoring method combining embedded fiber Bragg [...] Read more.
Carbon fiber reinforced polymer (CFRP) composites are prone to developing localized material loss defects during long-term service, which can severely degrade their mechanical properties and structural reliability. To address this issue, this study proposes a multi-sensor synchronous monitoring method combining embedded fiber Bragg grating (FBG) sensors and surface-mounted electrical resistance strain gauges. First, finite element simulations based on the three-dimensional Hashin damage criterion were performed to simulate the damage initiation and propagation processes in CFRP laminates, revealing the complete damage evolution mechanism from initial defect formation to progressive failure. The simulations were also used to determine the optimal sensor placement strategy. Subsequently, tensile test specimens with prefabricated defects were prepared in accordance with ASTM D3039, and multi-sensor monitoring techniques were employed to capture multi-parameter, dynamic data throughout the damage evolution process. The experimental results indicate that embedded FBG sensors and surface-mounted strain gauges can effectively monitor localized material loss defects within composite laminate structures. Strain gauge measurements showed uniform strain distribution at all measuring points in intact specimens (with deviations less than 5%). In contrast, in defective specimens, strain values at measurement points near the notch edge were significantly higher than those in regions farther from the notch, indicating that the prefabricated defect disrupted fiber continuity and induced stress redistribution. The combined use of surface-mounted strain gauges and embedded FBG sensors was demonstrated to accurately and reliably track the damage evolution behavior of defective CFRP laminates. Full article
(This article belongs to the Section Sensor Materials)
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21 pages, 7107 KB  
Article
Study on Mesoscopic Evolution Mechanism and Influencing Factors of Concrete Blasting Damage Based on PFC
by Xueying Hu, Shuyang Yu, Yifei Li, Yihan Tang, Ying Sun and Pingping Gu
Buildings 2025, 15(17), 3000; https://doi.org/10.3390/buildings15173000 - 23 Aug 2025
Viewed by 113
Abstract
In urban construction, the efficient demolition of concrete structures imposes high-precision requirements on blasting technology. The mesoscopic evolution mechanism of concrete blasting damage is the key to optimizing blasting parameters. In this study, a numerical model of concrete blasting is established using Particle [...] Read more.
In urban construction, the efficient demolition of concrete structures imposes high-precision requirements on blasting technology. The mesoscopic evolution mechanism of concrete blasting damage is the key to optimizing blasting parameters. In this study, a numerical model of concrete blasting is established using Particle Flow Code (PFC). By comparing it with an experimental model containing a blast hole and a horizontal single fissure, the rationality and reliability of the model in simulating blasting damage evolution are verified. On this basis, four groups of control variable schemes are designed (concrete particle size distribution, aggregate content, prefabricated fissure inclination angle, and fissure length) to systematically explore the effects of mesoscopic structures and macroscopic defects on blasting damage. The results show that larger concrete particles make it easier for damage cracks to avoid large particles, forming sparse and irregular crack networks. A higher aggregate content enhances the “obstruction-guidance” effect of aggregate distribution on damage. When the aggregate content is 40%, the vertical damage expansion is the most prominent, reaching up to 3.05 cm. Fissure inclination angle affects the damage direction by guiding the propagation path of stress waves. Fissures inclined at 30°~60° serve as preferential damage channels, while 90° vertical fissures make vertical damage more significant. An increased fissure length expands the damage range, and the damage degree is the highest for a 40 mm long fissure, being 1.29 times that of a 30 mm fissure. The research results reveal the mesoscopic evolution laws of concrete blasting damage, providing a theoretical basis for the optimization of engineering blasting parameters and safety control. Full article
(This article belongs to the Section Building Structures)
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23 pages, 5608 KB  
Review
Development of Self-Healing Polyurethane and Applications in Flexible Electronic Devices: A Review
by Jie Du, Xinlan Zhao, Yang Li, Wanqing Lei and Xing Zhou
Polymers 2025, 17(17), 2274; https://doi.org/10.3390/polym17172274 - 22 Aug 2025
Viewed by 205
Abstract
Traditional polyurethanes have gained widespread application due to their excellent mechanical properties, wear resistance, and processability. However, these materials are susceptible to cracking or fracture under environmental stresses. In recent years, self-healing polyurethanes have garnered significant attention as a critical research field owing [...] Read more.
Traditional polyurethanes have gained widespread application due to their excellent mechanical properties, wear resistance, and processability. However, these materials are susceptible to cracking or fracture under environmental stresses. In recent years, self-healing polyurethanes have garnered significant attention as a critical research field owing to their key capabilities, such as repairing physical damage, restoring mechanical strength, structural adaptability, and cost-effective manufacturing. This review systematically examines the healing mechanisms, structural characteristics, and performance metrics of self-healing polyurethanes, with in-depth analysis of their repair efficacy across various applications—particularly in flexible electronic devices. It demonstrates that self-healing polyurethanes overcome traditional failure modes in flexible electronics through self-repair-function integration mechanisms. Their stimuli-responsive healing behavior is driving the evolution of this field toward an intelligent regenerative electronics paradigm. Full article
(This article belongs to the Special Issue Polymer Modification for Soft Matter and Flexible Devices)
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20 pages, 4092 KB  
Article
Origin of Bilinear Low Cycle Fatigue in Ti-6Al-4V Alloy: A Crystal Plasticity Study
by Haifeng Xu, Dianxi Yang, Wei Li, Zhengxiao Guo and Yinghonglin Liu
Materials 2025, 18(17), 3931; https://doi.org/10.3390/ma18173931 - 22 Aug 2025
Viewed by 150
Abstract
This study resolves the long-standing question of the origin of bilinear Low Cycle Fatigue (LCF) behavior in Ti-6Al-4V using a high-fidelity CPFEM-XFEM framework. We identify that the fundamental origin lies in a fundamental shift in the efficiency of converting macroscopic energy dissipation into [...] Read more.
This study resolves the long-standing question of the origin of bilinear Low Cycle Fatigue (LCF) behavior in Ti-6Al-4V using a high-fidelity CPFEM-XFEM framework. We identify that the fundamental origin lies in a fundamental shift in the efficiency of converting macroscopic energy dissipation into microscopic damage. This energetic efficiency is directly governed by the evolution of plastic strain heterogeneity (quantified by the Coefficient of Variation, CV). At low strain amplitudes, high strain localization (high CV) creates a highly efficient “energy funnel,” concentrating dissipated energy into a few critical grains. This manifests physically as a single-crack failure mode, where the crack initiation phase is prolonged, consuming ~80% of the total fatigue life. Conversely, at high strain amplitudes, deformation homogenization (low CV) leads to inefficient, diffuse energy dissipation across many grains. The material must therefore activate a more drastic failure mechanism—multi-site crack initiation and coalescence—to accumulate sufficient damage, reducing the initiation phase to just ~45% of the total life. Therefore, the bilinear C-M curve is the macroscopic signature of this transition from an energetically efficient, localized damage mode to an inefficient, distributed one. This work provides a quantitative, mechanism-based framework for understanding and predicting the complex fatigue behavior of advanced metallic materials. Full article
(This article belongs to the Section Mechanics of Materials)
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22 pages, 7050 KB  
Article
Fractal-Based Modeling and Quantitative Analysis of Hydraulic Fracture Complexity in Digital Cores
by Xin Liu, Yuepeng Wang, Tianjiao Li, Zhengzhao Liang, Siwei Meng, Licai Zheng and Na Wu
Mathematics 2025, 13(17), 2700; https://doi.org/10.3390/math13172700 - 22 Aug 2025
Viewed by 142
Abstract
Hydraulic fracturing in shale reservoirs is affected by microscale structural and material heterogeneity. However, studies on fracture responses to the injection rate across different microstructural types remain limited. To examine the coupled effects of microstructure and flow rate on fracture propagation and mineral [...] Read more.
Hydraulic fracturing in shale reservoirs is affected by microscale structural and material heterogeneity. However, studies on fracture responses to the injection rate across different microstructural types remain limited. To examine the coupled effects of microstructure and flow rate on fracture propagation and mineral damage, high-fidelity digital rock models were constructed from SEM images of shale cores, representing quartz grains and ostracod laminae. Coupled hydro-mechanical damage simulations were conducted under varying injection rates. Fracture evolution and complexity were evaluated using three quantitative parameters: stimulated reservoir area, fracture ratio, and fractal dimension. The results show that fracture morphology and mineral failure are strongly dependent on both the structure and injection rate. All three parameters increase with the flow rate, with the ostracod model showing abrupt complexity jumps at higher rates. In quartz-dominated models, fractures tend to deflect and bypass weak cement, forming branches. In ostracod-lamina models, higher injection rates promote direct penetration and multi-point propagation, resulting in a radial–branched–nested fracture structure. Mineral analysis shows that quartz exhibits brittle failure under high stress, while organic matter fails more readily in tension. These findings provide mechanistic insights into the coupled influence of microstructure and flow rate on hydraulic fracture complexity, with implications for optimizing hydraulic fracturing strategies in heterogeneous shale formations. Full article
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25 pages, 7725 KB  
Article
Effects of Scale Parameters and Counting Origins on Box-Counting Fractal Dimension and Engineering Application in Concrete Beam Crack Analysis
by Junfeng Wang, Gan Yang, Yangguang Yuan, Jianpeng Sun and Guangning Pu
Fractal Fract. 2025, 9(8), 549; https://doi.org/10.3390/fractalfract9080549 - 21 Aug 2025
Viewed by 118
Abstract
Fractal theory provides a powerful tool for quantifying complex geometric patterns such as concrete cracks. The box-counting method is widely employed for fractal dimension (FD) calculation due to its intuitive principles and compatibility with image data. However, two critical limitations persist [...] Read more.
Fractal theory provides a powerful tool for quantifying complex geometric patterns such as concrete cracks. The box-counting method is widely employed for fractal dimension (FD) calculation due to its intuitive principles and compatibility with image data. However, two critical limitations persist in existing studies: (1) the selection of scale parameters (including minimum measurement scale and cutoff scale) lacks systematization and exhibits significant arbitrariness; (2) insufficient attention to the sensitivity of counting origins compromises the stability and comparability of FDs, severely limiting reliable engineering application. To address these limitations, this study first employs classical fractal images and crack samples to systematically analyze the impact of four minimum measurement scales (2, 2, 3, 3) and three cutoff scale coefficients (cutoff-to-minimum image side ratios: 1, 1/2, 1/3) on computational accuracy. Subsequently, the farthest point sampling (FPS) method is adopted to select counting origins, comparing two optimization strategies—Count-FD-Mean (mean of fits from multiple origins) and Count-Min-FD (fit using minimal box counts across scales). Finally, the optimized approach is validated through static loading tests on concrete beams. Key findings demonstrate that: the optimal scale combination (minimum scale: 2; cutoff coefficient: 1) yields a mere 0.5% average error from theoretical FDs; the Count-Min-FD strategy delivers the highest stability and closest alignment with theoretical values; FDs of beam cracks increase continuously with loading, exhibiting an exponential correlation with midspan deflection that effectively captures crack evolution; uncalibrated scale parameters and counting strategies may induce >40% errors in inferred mechanical parameters; results stabilize with 40–45 counting origins across three tested fractal patterns. This work advances standardization in fractal analysis, enhances reliability in concrete crack assessment, and provides critical support for the practical application of fractal theory in structural health monitoring and damage evaluation. Full article
(This article belongs to the Special Issue Fractal and Fractional in Construction Materials)
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23 pages, 5651 KB  
Article
Creep Tests and Fractional Creep Damage Model of Saturated Frozen Sandstone
by Yao Wei and Hui Peng
Water 2025, 17(16), 2492; https://doi.org/10.3390/w17162492 - 21 Aug 2025
Viewed by 146
Abstract
The rock strata traversed by frozen shafts in coal mines located in western regions are predominantly composed of weakly cemented, water-rich sandstones of the Cretaceous system. Investigating the rheological damage behavior of saturated sandstone under frozen conditions is essential for evaluating the safety [...] Read more.
The rock strata traversed by frozen shafts in coal mines located in western regions are predominantly composed of weakly cemented, water-rich sandstones of the Cretaceous system. Investigating the rheological damage behavior of saturated sandstone under frozen conditions is essential for evaluating the safety and stability of these frozen shafts. To explore the damage evolution and creep characteristics of Cretaceous sandstone under the coupled influence of low temperature and in situ stress, a series of triaxial creep tests were conducted at a constant temperature of −10 °C, under varying confining pressures (0, 2, 4, and 6 MPa). Simultaneously, acoustic emission (AE) energy monitoring was employed to characterize the damage behavior of saturated frozen sandstone under stepwise loading conditions. Based on the experimental findings, a fractional-order creep constitutive model incorporating damage evolution was developed to capture the time-dependent deformation behavior. The sensitivity of model parameters to temperature and confining pressure was also analyzed. The main findings are as follows: (1) Creep deformation progressively increases with higher confining pressure, and nonlinear accelerated creep is observed during the final loading stage. (2) A fractional-order nonlinear creep model accounting for the coupled effects of low temperature, stress, and damage was successfully established based on the test data. (3) Model parameters were identified using the least squares fitting method across different temperature and pressure conditions. The predicted curves closely match the experimental results, validating the accuracy and applicability of the proposed model. These findings provide a theoretical foundation for understanding deformation mechanisms and ensuring the structural integrity of frozen shafts in Cretaceous sandstone formations of western coal mines. Full article
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23 pages, 5187 KB  
Article
Bond–Slip Properties and Acoustic Emission Characterization Between Steel Rebar and Manufactured Sand Concrete
by Lei Han, Hua Yang, Qifan Wu and Yubo Jiao
Buildings 2025, 15(16), 2959; https://doi.org/10.3390/buildings15162959 - 20 Aug 2025
Viewed by 218
Abstract
Natural sand (NS) is facing the problem of resource scarcity, while manufactured sand (MS) has become a favorable alternative resource due to its wide range of sources, superior performance, as well as economic and environmental protection. This study adopted MS to replace NS [...] Read more.
Natural sand (NS) is facing the problem of resource scarcity, while manufactured sand (MS) has become a favorable alternative resource due to its wide range of sources, superior performance, as well as economic and environmental protection. This study adopted MS to replace NS to prepare manufactured sand concrete (MSC). The water–cement ratio, replacement rate of MS, and stone powder content were systematically investigated for the damage evolution of rebar during bond–slip with MSC. Seven groups of specimens were tested using the center pull-out test to analyze the effects of different factors on the bond–slip characteristics (bond stress–slip curve, bond fracture energy, peak stress, and peak slip). Acoustic emission (AE) monitoring was also adopted to synchronously characterize the slip damage process of reinforced MSC. The results indicate that the water–cement ratio and replacement ratio of MS present significant influences on the bond strength of reinforced MSC, in which the smaller the water–cement ratio is, the stronger the bond strength of reinforced concrete. Further, the larger the replacement rate of MS is, the stronger the bond strength of reinforced concrete. The higher the stone powder content, the higher the bond strength, but the effect is small compared to the two variables mentioned above. In terms of AE, count and energy remain at low values in the first and middle stages, followed by larger values, proving that cracks were beginning to develop within the specimen, and then a very large signal and then splitting occurred. The information entropy is relatively stable in the first and middle stages of the test, then fluctuates with the generation of cracks, and finally fluctuates violently and then the specimen splits. The AE parameters are more active with an increasing water–cement ratio, while they are smoother with increases in the replacement rate of MS and stone powder content. Full article
(This article belongs to the Section Building Materials, and Repair & Renovation)
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26 pages, 4388 KB  
Article
Deciphering Common Genetic Pathways to Antibiotic Resistance in Escherichia coli Using a MEGA-Plate Evolution System
by Nami Morales-Durán, Angel León-Buitimea, Roberto Álvarez Martínez and José Rubén Morones-Ramírez
Antibiotics 2025, 14(8), 841; https://doi.org/10.3390/antibiotics14080841 - 20 Aug 2025
Viewed by 564
Abstract
Background. Antimicrobial resistance (AMR) poses a significant global health threat, necessitating a deeper understanding of bacterial adaptation mechanisms. Introduction. This study investigates the genotypic and phenotypic evolutionary trajectories of Escherichia coli under meropenem and gentamicin selection, and it benchmarks these findings against florfenicol-evolved [...] Read more.
Background. Antimicrobial resistance (AMR) poses a significant global health threat, necessitating a deeper understanding of bacterial adaptation mechanisms. Introduction. This study investigates the genotypic and phenotypic evolutionary trajectories of Escherichia coli under meropenem and gentamicin selection, and it benchmarks these findings against florfenicol-evolved strains. Methodology. Utilizing a downsized, three-layer acrylic modified “Microbial Evolution and Growth Arena (MEGA-plate) system”—scaled to 40 × 50 cm for sterile handling and uniform 37 °C incubation—we tracked adaptation over 9–13 days, enabling real-time visualization of movement across antibiotic gradients. Results. Meropenem exposure elicited pronounced genetic heterogeneity and morphological remodeling (filamentous and circular forms), characteristic of SOS-mediated division arrest and DNA-damage response. In contrast, gentamicin exposure produced a uniform resistance gene profile and minimal shape changes, suggesting reliance on conserved defenses without major morphological adaptation. Comprehensive genomic analysis revealed a core resistome of 22 chromosomal loci shared across all three antibiotics, highlighting potential cross-resistance and the central roles of baeR, gadX, and marA in coordinating adaptive responses. Gene ontology enrichment underscored the positive regulation of gene expression and intracellular signaling as key themes in resistance evolution. Discussion. Our findings illustrate the multifaceted strategies E. coli employs—combining metabolic flexibility with sophisticated regulatory networks—to withstand diverse antibiotic pressures. This study underscores the utility of the MEGA-plate system in dissecting spatiotemporal AMR dynamics in a controlled yet ecologically relevant context. Conclusions. The divergent responses to meropenem and gentamicin highlight the complexity of resistance development and reinforce the need for integrated, One Health strategies. Targeting shared regulatory hubs may open new avenues for antimicrobial intervention and help preserve the efficacy of existing drugs. Full article
(This article belongs to the Section Mechanism and Evolution of Antibiotic Resistance)
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23 pages, 2990 KB  
Article
Self-Healing Asphalt Mixtures Meso-Modelling: Impact of Capsule Content on Stiffness and Tensile Strength
by Gustavo Câmara, Nuno Monteiro Azevedo and Rui Micaelo
Sustainability 2025, 17(16), 7502; https://doi.org/10.3390/su17167502 - 19 Aug 2025
Viewed by 257
Abstract
Capsule-based self-healing technologies offer a promising solution to extend pavement service life without requiring external activation. The effect of the capsule content on the mechanical behaviour of self-healing asphalt mixtures still needs to be understood. This study presents a numerical evaluation of the [...] Read more.
Capsule-based self-healing technologies offer a promising solution to extend pavement service life without requiring external activation. The effect of the capsule content on the mechanical behaviour of self-healing asphalt mixtures still needs to be understood. This study presents a numerical evaluation of the isolated effect of incorporating capsules containing encapsulated rejuvenators, at different volume contents, on the stiffness and strength of asphalt mixtures through a three-dimensional discrete-based programme (VirtualPM3DLab), which has been shown to predict well the experimental behaviour of asphalt mixtures. Uniaxial tension–compression cyclic and monotonic tensile tests on notched specimens are carried out for three capsule contents commonly adopted in experimental investigations (0.30, 0.75, and 1.25 wt.%). The results show that the effect on the stiffness modulus progressively increases as the capsule content grows in the asphalt mixture, with a reduction ranging from 4.3% to 12.3%. At the same time, the phase angle is marginally affected. The capsule continuum equivalent Young’s modulus has minimum influence on the overall rheological response, suggesting that the most critical parameter affecting asphalt mixture stiffness is the capsule content. Finally, while the peak tensile strength shows a maximum reduction of 12.4% at the highest capsule content, the stress–strain behaviour and damage evolution of the specimens remain largely unaffected. Most damaged contacts, which mainly include aggregate–mastic and mastic–mastic contacts, are highly localised around the notch tips. Contacts involving capsules remained intact during early and intermediate loading stages and only fractured during the final damage stage, suggesting a delayed activation consistent with the design of healing systems. The findings suggest that capsules within the studied contents may have a moderate impact on the mechanical properties of asphalt mixtures, especially for high-volume contents. For this reason, contents higher than 0.75 wt.% should be applied with caution. Full article
(This article belongs to the Section Sustainable Materials)
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13 pages, 9838 KB  
Article
Molecular Dynamics Simulation of Nano-Defects on Fused Silica Surface Induced by Low-Temperature Plasma Cleaning
by Yuhai Li, Yilan Jiang, Laixi Sun, Qiang Yuan, Peng Zhang, Qingshun Bai and Xiaodong Yuan
Molecules 2025, 30(16), 3418; https://doi.org/10.3390/molecules30163418 - 19 Aug 2025
Viewed by 274
Abstract
Low-temperature plasma cleaning technology has been widely used to clean various optical components precisely. After the complete removal of organic contaminants from fused silica surfaces through plasma cleaning, continuous plasma irradiation can lead to nano-defects on the fused silica surface, resulting in the [...] Read more.
Low-temperature plasma cleaning technology has been widely used to clean various optical components precisely. After the complete removal of organic contaminants from fused silica surfaces through plasma cleaning, continuous plasma irradiation can lead to nano-defects on the fused silica surface, resulting in the degradation of optical performance. Thus, the microscale processes underlying plasma-induced surface damage on fused silica were investigated through molecular dynamics simulations, aiming to analyze the mechanisms of surface damage on optical components during plasma cleaning. Oxygen plasma bombardment disrupted fused silica bonds, leading to the successive sputtering of silicon–oxygen atoms. The quantity of sputtered silicon atoms demonstrated a linear correlation with irradiation time. The emergence of pit defects and distinctive interface damage patterns elucidated the impact of neutral oxygen atoms. Critical findings underscore the onset of significant damage beyond 33 eV, underlining plasma’s role in thinning fused silica. Temperature is a crucial factor affecting surface damage during plasma cleaning. Ultimately, investigating the surface damage mechanism of fused silica during plasma cleaning establishes a groundwork for achieving non-destructive optics cleaning. Full article
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