Search Results (6,751)

Background/Objectives: Resin 3D printing is widely used to fabricate orthodontic diagnostic models, but the practical performance of commercial desktop workflows compared to dental-certified workflows is still debated. This study compared the dimensional accuracy and 7-day stability of maxillary orthodontic models printed from the same master STL file using a dental-certified workflow versus two commercial desktop workflows. Methods: An ISO 20896-1:2019-based reference cast with four 6 mm calibration spheres was used to generate a master STL file. Fifteen models were printed (n = 5 per workflow) using Primeprint™ (dental-certified workflow) and two commercial desktop printers (Anycubic Photon Mono M5s; Phrozen Sonic Mighty 14K REVO). The models were digitized at baseline (T0, ≤48 h) and after 7 days (T7) using a laboratory scanner. Surface superimposition in CloudCompare^® calculated the RMS (root mean square) surface deviation and mean signed deviation, and two calibrated operators performed independent extractions. Results: The mean RMS deviations were <0.10 mm for all workflows at both time points. No between-workflow differences were detected at T0 (H = 2.000; p = 0.368) or T7 (H = 1.520; p = 0.468), no within-workflow T0–T7 changes were significant (all p > 0.05), and the inter-operator agreement was excellent (ICC 0.991–0.999). Conclusions: Under the tested workflows, dental-certified and commercial desktop resin printing produced orthodontic models with a comparable global surface accuracy and short-term dimensional stability. Full article

Strong light interference severely degrades imaging system performance. This paper presents a novel digital micromirror device (DMD)-based imaging system for robust, strong light suppression and long-distance detection. Our design strategically places the DMD at the primary image plane, utilizing a large F-number objective for extended depth of field. The relay imaging system employs a tilted image plane in a near-symmetric configuration to effectively balance DMD-induced aberrations, which avoids the off-axis layout and overall tilt of the relay system itself and greatly simplifies system alignment. Stray light analysis verifies the rationality of the structural design, and MTF tests confirm that the assembly performance of the prototype meets the design requirements. The system can achieve clear imaging of buildings at 1 km, which demonstrates its long-distance imaging capability. With an entrance pupil power density of 4.68 × 10⁻⁴ W/cm², strong light interference suppression has been successfully achieved via the DMD regional flipping method. This system offers an efficient solution for long-range imaging in strong light environments. Full article

Histopathological evaluation of tissue sections remains the gold standard for the diagnosis, classification, and grading of breast cancer (BC). The widespread adoption of whole-slide imaging (WSI) has enabled the digitization of histological slides and facilitated the development of artificial intelligence (AI) approaches for computational pathology. In recent years, machine learning and deep learning (DL) algorithms have been increasingly investigated for the analysis of hematoxylin and eosin (H&E)-stained images, with potential applications in tumor detection, histological classification, prognostic stratification, and prediction of treatment response. This narrative review summarizes recent developments in AI-driven models applied to BC histopathology and discusses their potential role in supporting diagnostic and prognostic assessment. Several studies have demonstrated the promising performance of DL algorithms in tasks such as the detection of lymph node metastases, assessment of residual tumor after neoadjuvant therapy, and prediction of clinical outcomes from histopathological images. Emerging research has also explored the possibility of inferring molecular and biomarker information from histology images, although these approaches currently identify statistical associations rather than direct molecular measurements. Despite the rapid expansion of this research field, significant barriers remain before routine clinical implementation can be achieved. Key challenges include dataset bias, variability in staining and image acquisition, limited external validation across institutions, and the need for transparent and reproducible model development. In addition, the translation of AI-based systems into clinical practice requires compliance with regulatory frameworks governing software used for medical purposes, such as those established by the U.S. Food and Drug Administration. Overall, AI represents a promising research direction in computational pathology and may contribute to decision-support tools capable of assisting pathologists in the analysis of digital slides. Continued efforts toward methodological rigor, large multicenter datasets, and prospective validation studies will be essential to determine the future role of AI in BC histopathology. Full article

Predictive maintenance plays a key role in digitalization initiatives; however, in real settings, issues related to failure prediction occur when failure instances are rare compared to normal instances, leading to class imbalance. In this study, we systematically compare five machine learning (ML) models—random forest, XGBoost, support vector machine, k-nearest neighbors, and multinomial logistic regression (MLR)—to detect multiclass rare failures using four imbalance-handling approaches (i.e., no handling, manual oversampling, selective manual oversampling, and class weighting), forming 20 configurations. Using the AI4I 2020 predictive maintenance dataset, which contains five failure types, we determined that XGBoost with no handling achieved the highest macro-averaged F1 (macro-F1) score (0.842) but obtained 0% recall for tool wear failure (TWF). MLR with selective manual oversampling achieved approximately 50% TWF recall with lower overall performance (0.636 macro-F1) than top-performing models such as XGBoost. We also found that very rare classes remain difficult to detect. Even high-performing models fail to consistently detect all five failure types. Overall, no single strategy can achieve a high detection rate across all performance measures. Full article

Alcoholic fermentation in winemaking is a complex bioprocess governed by physicochemical parameters such as temperature, density, pH, CO₂ and redox potential, which critically affect yeast metabolism and wine quality. This review provides an integrated analysis of fermentative dynamics and emerging sensorization technologies, highlighting how their combined implementation enables real-time monitoring and advanced control in precision enology. Advances in conventional physicochemical sensors, spectroscopic techniques (NIR/MIR/UV-Vis) and non-conventional devices (e-noses, electronic tongues) integrated into IoT platforms enable continuous data acquisition, overcoming traditional manual sampling limitations. Predictive modeling, including kinetic models, machine learning approaches (e.g., Random Forest, XGBoost) and model predictive control (MPC/NMPC), supports anomaly detection, optimization of enological interventions and energy-efficient thermal management, while virtual sensors based on Kalman filters improve the estimation of non-measurable states (e.g., biomass, ethanol kinetics). Despite current challenges in calibration and interoperability, these innovations foster sustainable and reproducible winemaking under climate variability and pave the way for digital twins and semi-autonomous fermentation systems. Full article

Production greenhouse complexes increasingly require automation and digitalization to address rising labor costs, improve productivity, and support sustainable resource use. However, most existing solutions target isolated tasks and lack a unified framework for continuous monitoring and production-oriented accounting at facility scale. This paper proposes a system-level architecture that integrates robotic monitoring platforms, AI-based perception, and cloud-based data management into a coherent operational framework. The robotic monitoring platforms operate on rails and concrete surfaces and are capable of elevating cameras and sensors up to 5 m to support plant-health assessment, environmental monitoring, and production accounting. Aggregated data are incorporated into a digital twin that supports spatial traceability, historical analysis, and decision support. The proposed approach enables continuous inspection, improves early detection of crop stress, reduces repetitive manual scouting, and supports targeted interventions. The framework provides a scalable foundation for sustainable, data-driven greenhouse management and practical deployment of robotic monitoring systems in industrial production environments. Full article

The high-fidelity 3D digitization of small, detailed cultural heritage objects, such as Oracle Bones, presents significant challenges for which existing reconstruction workflows are often inadequate. Methods based on Structure-from-Motion (SfM) often lack the geometric density required to capture fine inscription details, while Light Detection and Ranging and RGB-Depth approaches may introduce high data overhead and unstable color mapping. Recent specialized studies have utilized multi-shading-based techniques to extract such hidden surface textures, yet integrating these results into a cohesive mesh remains difficult. To address these limitations, we propose a digitization framework specifically designed for object-level archaeological artifacts. Our method combines semi-automatic alignment with ICP-based refinement for robust camera pose estimation, reducing misalignment issues associated with feature-only registration. Furthermore, we employ an efficient mesh-based representation with vertex-level coloring, enabling detailed geometry and consistent texturing while maintaining compact storage requirements. Our contributions include: (1) a high-quality mesh reconstruction framework that preserves fine inscription geometry; (2) a hybrid camera pose estimation strategy that improves alignment robustness; and (3) an integrated hardware-assisted workflow tailored for digitizing small archaeological artifacts under controlled acquisition conditions. Experimental results on physical Oracle Bone artifacts demonstrate that the proposed method achieves a mean geometric reconstruction error of approximately 0.075 mm with a Hausdorff distance of 1 mm. These results demonstrate the effectiveness of the proposed workflow for digitization of oracle bone artifacts. Full article

Major depressive disorder (MDD) is a prevalent mental health condition that inflicts a high burden on individuals and healthcare systems. There is a clinical need to detect MDD relapse practically and effectively to improve treatment outcomes for patients. To address this, we developed a smart monitoring system using an Artificial Intelligence (AI) approach to estimate MDD severity and relapse risk from patients’ smartphone behavioral data (i.e., digital phenotyping). Thirty-five MDD patients were recruited from the Institute of Mental Health in Singapore, who installed the smartphone study app Sallie. Their symptoms were quantified using the Hamilton Depression Rating Scale (HAMD-17) at the start of the trial, and every 30 days after over 3 months. The app collected behavioral data such as activity, activity type, and GPS location used to train AI models such as logistic regression, decision trees, and random forest classifiers. We found that passive data collection continued for most participants (up to 79% retention rate) after 3 months. We also used five-fold cross-validation to predict HAMD-17 severity ranging from two to four classes and the relapse status, achieving 91%, 88%, and 78% accuracies for two to four classes, respectively, and a relapse prediction accuracy of 86% whereby four patients relapsed during the study. Additionally, anxiety factors within the HAMD-17 were significantly predicted (Pearson correlation coefficient = 0.78, p = 1.67 × 10⁻¹⁴). These results demonstrate the promise of using smartphone behavioral data to estimate depressive symptoms and identify early indicators of relapse. Full article

Understanding salmonid spawning dynamics is critical for conserving cold-water river ecosystems amid increasing human and climate pressures. This study developed and validated a species-specific eDNA (Salmo cf. trutta and Thymallus thymallus) and evaluated its performance for seasonal spawning activity monitoring using droplet digital PCR (ddPCR). Species-specific primers and probes targeting mitochondrial nd5 (S. trutta) and cytb (T. thymallus) genes were designed and optimized as a duplex assay. Performance assessments included in vitro validation, cross-amplification testing, and determining the LOB, LOD, and LOQ. Field validation over a year at two spawning sites in the Gradac River, Serbia, involved seasonal eDNA sampling, filtration, extraction, and ddPCR analysis. Fish community composition was also assessed with electrofishing and metabarcoding. The assay showed high specificity and sensitivity, with LODs of 0.14 cp/µL and LOQs of 0.99 and 1.25 cpµL for S. trutta and T. thymallus. S. trutta eDNA peaked in late autumn during spawning, while T. thymallus remained at or below detection limits, reflecting its lower abundance and different spawning season. Filter type affected filtration efficiency but not eDNA yield. These findings confirm ddPCR-based eDNA as a powerful, non-invasive tool for monitoring salmonid spawning and seasonal changes, supporting adaptive fisheries management and conservation amid environmental changes. Full article

The implementation of stringent regulatory policies for foodborne pathogens necessitates ultra-sensitive analytical methods. Digital detection, characterized by absolute quantification and tolerance to complex matrices, serves as a robust approach for food safety monitoring. This review summarizes recent advances in digital detection for foodborne pathogens, including nucleic acid amplification-based platforms such as droplet digital PCR and digital isothermal amplification, as well as emerging preamplification-free approaches based on enzyme-mediated signal conversion, functional nanomaterials, and microfluidic devices. We also profile the applications of digital detection technologies for achieving highly specific and accurate detection of foodborne pathogens and discuss their capabilities in viable bacteria quantification, antimicrobial resistance analysis, and multiplex detection. We finally discuss emerging trends, including partition-free digital detection and artificial intelligence-assisted analysis. These advances are expected to promote the development of intelligent and data-driven food safety surveillance strategies. Full article

Human pose estimation is a crucial task in computer vision with widespread applications in healthcare, rehabilitation, sports, and remote monitoring. In this paper, we propose a deep learning-based method for automatic human pose estimation and joint angle computation, tailored specifically for physiotherapy and telemedicine scenarios. Beyond pose estimation, the proposed method is able to compute angles between joints, enabling analysis of body alignment and posture. The proposed approach is built upon a customized skeleton with 25 anatomical keypoints and a dataset composed of over 150,000 annotated and augmented images derived from multiple open-source datasets. Experimental results demonstrate the effectiveness of the proposed method, achieving a mAP@50 of 0.58 for keypoint localization and 0.98 for object detection. Moreover, we demonstrate several real-world practical use cases in evaluating exercise correctness and identifying postural deviations by exploiting the proposed method, confirming that the proposed method can represent a promising approach for automated motion analysis, with potential impact on digital health, rehabilitation support, and remote patient care. Full article

Enterprise decision making in marketing, finance, and audit remains fragmented, leading to inefficient budget allocation and incomplete risk assessment. This study proposes an integrated, Big Data-driven decision-support framework that unifies Large Language Models (LLMs), attention-based marketing mix modeling, and multi-agent, game-theoretic optimization to coordinate cross-functional decisions. The architecture combines five modules: LLM-enhanced customer segmentation and customer lifetime value prediction, attention-weighted marketing mix modeling, multi-agent LLM systems for hierarchical budget optimization, attention-informed Markov multi-touch attribution, and LLM-augmented audit quality assessment. Empirical validation on a large-scale e-commerce dataset with 2.8 million customers and USD 156 million in marketing expenditure shows that marketing return on investment increases from 4.2 to 6.78 (61.4% relative improvement), financial forecasting error (MAPE) decreases from 12.8% to 4.7% (63.3% reduction), fraud detection accuracy improves by 29.8%, the Audit Quality Index reaches 0.951, and customer lifetime value prediction accuracy improves from 76.4% to 91.3%. By operationalizing the convergence of LLMs, attention mechanisms, and game-theoretic reasoning within a unified and empirically validated framework, the study delivers both theoretical advances and practically deployable tools for integrated business intelligence in digital economies. Full article

Within the Industry 5.0 paradigm, the management of critical assets requires advanced digital architectures capable of ensuring resilience and operational sustainability. The present systematic review analyzes the state of the art in predictive maintenance (PdM) technologies for turbines and turbomachinery, providing a technical examination of anomaly and fault detection frameworks, extended to remaining useful life (RUL) estimation and root cause analysis (RCA). The work addresses inherent sectoral challenges, ranging from the processing of high-dimensional multivariate time series (MTS) from Supervisory Control and Data Acquisition (SCADA) systems to labeled data scarcity and signal non-stationarity in real-world environments. Both purely data-driven frameworks and hybrid physics-informed models, such as Physics-Informed Neural Networks (PINNs), are critically evaluated against performance indicators. A significant contribution of this study lies in the classification of methodologies based on their readiness for real-time inference, emphasizing the role of Explainable AI (XAI) in providing transparent insights to domain experts, who remain central to decision-making processes. The primary objective of this review is to offer an analytical overview of progress to date against current technological gaps, tracing a clear trajectory for future developments. In this regard, the adoption of Generative AI and Large Language Models (LLMs) is identified as a fundamental step toward evolving into interactive, human-centric decision support systems. Full article

Human-centered entrepreneurship considers employee well-being and uses the Sustainable Development Goals as its fundamental pillars. However, existing research predominantly focuses on institutional interventions and fails to provide integrated intelligent solutions for tackling human–machine collaboration issues in the context of digital transformation. Large language models (LLMs) offer potential for affective computing and personalized support, but face critical gaps in ethical governance, privacy protection, and real-time risk intervention in sensitive entrepreneurial contexts. Our proposed Human-Centered Entrepreneurial Intelligent Agent (HCEA) framework achieves the unified optimization of task utility, empathetic expression, and ethical security by integrating a large language model core fine-tuned via a multi-objective hybrid loss function and a cluster of task-specialized intelligent agents. HCEA integrates retrieval-enhanced generation to ensure suggestion accuracy, a hierarchical data governance system for sensitivity-based privacy protection, and an independent risk detection module for real-time intervention and referral. We build the framework by constructing a hybrid entrepreneurial dataset, design the multi-agent architecture of decision support, emotion understanding and ethical risk tracking, and empirically evaluate both comparisons and ablation experiments. The results demonstrate that HCEA outperforms five baseline models across six key metrics, including entrepreneurship guidance relevance, emotion recognition, and high-risk recall. This study contributes to the intersection of digital transformation and sustainable entrepreneurship by providing a technically feasible, ethically grounded intelligent framework that empowers enterprises to reconcile efficiency with human-centric values, advancing SDG 8 (decent work and economic growth) and SDG 9 (industry, innovation, and infrastructure). Full article

The sustainability of higher education systems increasingly depends on the integrity, transparency, and long-term verifiability of academic credentials. Widespread diploma fraud, unauthorized modification of academic records, and fragmented verification mechanisms undermine institutional trust, graduate mobility, and public confidence in educational outcomes. These challenges directly affect the social and governance dimensions of sustainable development, particularly in the context of universities’ digital transformation. This study proposes a blockchain-based approach to support the sustainable governance of academic documents by strengthening transparency, accountability, and auditability. The proposed system employs cryptographic hash anchoring and smart contract–based enforcement to verify academic credentials such as diplomas, transcripts, and certificates. Document contents are processed and stored off-chain, while cryptographic representations and essential metadata are immutably recorded on an EVM-compatible blockchain, ensuring data privacy and resistance to tampering. Any modification to a document results in a mismatch between the original and recomputed hashes, making fraudulent alterations immediately detectable. A web-based application and a role-restricted smart contract were implemented to support document issuance, verification, and immutable audit logging. System evaluation based on blockchain transaction evidence confirms reliable document registration, deterministic verification outcomes, and verifiable linkage between institutional actions and on-chain records. The results indicate that blockchain-based document verification can contribute to the reduction in corruption risks and improve transparency, strengthening institutional trust and supporting sustainable digital governance in higher education systems. Full article