Fermentation Processes: Modeling, Optimization and Control: 3rd Edition

A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Fermentation Process Design".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 2336

Special Issue Editor


E-Mail Website
Guest Editor
Biotechnology and Bioengineering, Center of Research and Advanced Studies, Mexico City, Mexico
Interests: chemical reaction engineering; control theory; kinetics; reaction kinetics; process engineering; kinetic modeling; modeling and simulation; advanced control theory; system modeling; systems dynamics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fermentation plays an important role in food, pharmaceutical, biofuels, metabolite industries, etc. As a result, although the demand for high-quality products with low energy consumption and operational safety is increasing, these products can operate within highly complex biological systems. However, meeting these demands have made processing more challenging, leading to the development of intensive engineering strategies to achieve the desired performance objectives. Therefore, modeling and simulation tasks for optimization and the control purposes of fermentation equipment are incredibly important.

The main goal of this Special Issue is to include the latest developments and advancements in fermentation process technology and bioprocessing to achieve progress in these key industrial sectors. Special attention will be given to certain research topics, such as highly predictive modeling techniques, detailed simulations to characterize realizable operating conditions, the application of multiobjective optimization using the newest mathematical techniques, the design of online estimation procedures for process monitoring purposes and new controller designs, machine learning, artificial intelligence, and improvements to closed-loop operation performance.

Overall, the aim of this Special Issue is to support the development of sustainability assessment tools to measure the socioeconomic and environmental performance of innovative techniques in fermentation processes.

Prof. Dr. Ricardo Aguilar-López
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fermentation technology
  • process modeling
  • simulation analysis
  • process optimization
  • control process
  • sustainability issues
  • artificial intelligence
  • machine learning

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issues

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 1501 KB  
Article
Novel Nonlinear Control in a Chaotic Continuous Flow Enzymatic–Fermentative Bioreactor
by Juan Luis Mata-Machuca, Pablo Antonio López-Pérez and Ricardo Aguilar-López
Fermentation 2025, 11(10), 601; https://doi.org/10.3390/fermentation11100601 - 21 Oct 2025
Viewed by 339
Abstract
Fermentative processes are considered one of the most important technological developments in the modern transforming industry, due to this, the applied research to reach high performance standards with a crucial focus on system intensification, which is the the analysis, optimization, and control issues, [...] Read more.
Fermentative processes are considered one of the most important technological developments in the modern transforming industry, due to this, the applied research to reach high performance standards with a crucial focus on system intensification, which is the the analysis, optimization, and control issues, are a cornerstone. The goal of this proposal is to show a novel nonlinear feedback control structure to assure a stable closed-loop operation in a continuous flow enzymatic–fermentative bioreactor with chaotic dynamic behavior. The proposed structure contains an adaptive-type gain, which, coupled with a proportional term of the named control error, can lead the feedback control trajectories of the bioreactor to the required reference point or trajectory. The Lyapunov method is used to present the stability analysis of the system within a closed loop, where an adequate choice of the controller gains assures asymptotic stability. Moreover, analyzing the dynamic equation of the control error, under some properties of boundedness of the system, shows that the control error can be diminished to close to zero. Numerical experiments are carried out, where a well-tuned standard proportional–integral (PI) controller is also implemented for comparison purposes, the satisfactory performance of the proposed control scheme is observed, including the diminishing offsets, overshoots, and settling times in comparison with the PI controller. Full article
Show Figures

Figure 1

Review

Jump to: Research

22 pages, 558 KB  
Review
Microbial Fermentation Assisted by Pulsed Electric Fields, Magnetic Fields and Cold Atmospheric Plasma: State of the Art
by Nahed Yousfi, Nofel Merbahi, Jalloul Bouajila, Patricia Taillandier and Mohamed Debouba
Fermentation 2025, 11(7), 417; https://doi.org/10.3390/fermentation11070417 - 19 Jul 2025
Cited by 1 | Viewed by 1769
Abstract
Microbial fermentation is a fundamental bioconversion mechanism widely used in diverse industrial sectors, notably in food processing and bioenergy production. Over the years, the wealth of information and scientific and technological advances in the field of fermentation have made considerable progress. Most recent [...] Read more.
Microbial fermentation is a fundamental bioconversion mechanism widely used in diverse industrial sectors, notably in food processing and bioenergy production. Over the years, the wealth of information and scientific and technological advances in the field of fermentation have made considerable progress. Most recent research studies are currently devoted to the implementation of innovative technological processes in order to increase fermentation effectiveness while consuming less energy and processing time. The aim of the present review is to investigate the impact of innovative physical techniques (pulsed electric field, PEFs; cold atmospheric plasma, CAP; and magnetic fields, MFs) on fermentation processes. The bibliographic analysis will mainly focus on recent advances towards non-destructive methods (PEF, CAP, and MF) and their induced changes in fermentation dynamics, fermented product quality, metabolite synthesis, and microbial growth kinetics. Various databases, including PubMed, ScienceDirect, Google Scholar, ResearchGate, Scopus, and Web of Science, were used to collect pertinent scientific literature on the impact of innovative physical techniques on microorganisms and fermentation processes and to investigate the potential applications of these emerging technologies in the food and health sectors. According to the results, all techniques have the potential to optimize fermentation dynamics, boost metabolite synthesis, and enhance product quality. However, each technology displayed its own specific advantages and disadvantages. Full article
Show Figures

Figure 1

Back to TopTop