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13 pages, 1060 KB  
Article
Reaction Mechanisms of Aqueous Methane Reforming by Continuous Flow Two-Phase Plasma Discharge
by Ekow Agyekum-Oduro, Md. Mokter Hossain, Ahmad Mukhtar and Sarah Wu
Catalysts 2025, 15(10), 980; https://doi.org/10.3390/catal15100980 (registering DOI) - 14 Oct 2025
Abstract
This study explores nonthermal plasma reactions of methane and water in a two-phase system to produce methanol, examining reaction pathways, kinetics, and product distribution over time. The results show that methanol is the dominant liquid phase product among other oxygenates, including ethanol and [...] Read more.
This study explores nonthermal plasma reactions of methane and water in a two-phase system to produce methanol, examining reaction pathways, kinetics, and product distribution over time. The results show that methanol is the dominant liquid phase product among other oxygenates, including ethanol and acetic acid, with hydrogen as the largest fraction among gas-phase products comprising carbon monoxide, carbon dioxide, ethylene, and acetylene. Conductivity and pH trends of reactant water and their influence on reaction products were also analyzed. Methanol was found to be formed principally from the reactive coupling of methyl and hydroxyl radicals, as well as from methoxy and hydrogen radical combinations. Hydrogen was produced from three pathways: stepwise dehydrogenation of methane through electron-mediated hydrogen abstraction, sequential hydrogenation of ethane to acetylene, and water splitting. The methanol-yielding reactions proceeded at different rates in the liquid and gas phases, with gas-phase reactions occurring approximately nine times faster than the liquid-phase reactions. This work provides valuable insights into reaction pathways for direct methane conversion to oxygenates and value-added gas products under mild conditions using water as an environmentally friendly oxidant. Full article
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13 pages, 2101 KB  
Proceeding Paper
Emotion Recognition and Soft Skills Prediction: A Bibliometric Exploration
by Nouhaila Farajy, Ahmed Remaida, Benyoussef Abdellaoui and Aniss Moumen
Eng. Proc. 2025, 112(1), 8; https://doi.org/10.3390/engproc2025112008 - 14 Oct 2025
Abstract
This study, based on a 25-year dataset (2000–2025) collected from the Scopus database, provides a comprehensive bibliometric analysis of the intellectual structure of research on emotion recognition, prediction, and skills. Using bibliographic coupling as the primary method, the analysis examines the titles, abstracts, [...] Read more.
This study, based on a 25-year dataset (2000–2025) collected from the Scopus database, provides a comprehensive bibliometric analysis of the intellectual structure of research on emotion recognition, prediction, and skills. Using bibliographic coupling as the primary method, the analysis examines the titles, abstracts, keywords, frameworks, and review literature, presenting the most significant articles in this area, along with the headings of 202 relevant papers. The study investigates the temporal distribution of research outputs, focusing particularly on trends from the last decade. To visualize the scientific landscape, the study uses VOSviewer to map co-authorship, keyword co-occurrence, and citation networks. The analysis highlights the most prolific journals, influential authors, dominant subject areas, and frequently used keywords. Additionally, it identifies the algorithms used for emotion recognition in predicting soft skills, along with the objectives of the studies, as well as the data and results involved. The study also identifies the leading countries and educational institutions contributing to this research domain. The findings offer a detailed overview of the field’s development and intellectual trends, providing insights and recommendations for future research directions. This research also helps to understand how emotion recognition can contribute to human development across various domains, as discussed in this article. Full article
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31 pages, 1671 KB  
Review
Neuromuscular Performance of High-Level Football Goalkeepers by Age Category and Sex: A Systematic Review
by Pablo González-Jarrín, Jaime Fernández-Fernández, José Vicente García-Tormo and Carlos Gutiérrez García
J. Funct. Morphol. Kinesiol. 2025, 10(4), 398; https://doi.org/10.3390/jfmk10040398 (registering DOI) - 13 Oct 2025
Abstract
Background: Goalkeeper actions directly influence match outcomes and overall team performance. Neuromuscular determinants (e.g., perception–action coupling, reaction speed, rate of force development (RFD), balance, etc.) translate into higher save probability, faster second actions, and more accurate distribution. Objectives: This systematic review analysed neuromuscular [...] Read more.
Background: Goalkeeper actions directly influence match outcomes and overall team performance. Neuromuscular determinants (e.g., perception–action coupling, reaction speed, rate of force development (RFD), balance, etc.) translate into higher save probability, faster second actions, and more accurate distribution. Objectives: This systematic review analysed neuromuscular performance factors in 11-a-side football goalkeepers and examined how these factors evolve across age and sex groups. Methods: The review adhered to the PRISMA 2020 Statement guidelines. A systematic search was conducted using the PubMed, Web of Science, SPORTDiscus, PsycINFO, Dialnet, LILACS, and Scopus databases. Studies that assessed any aspect of goalkeepers’ neuromuscular performance except for aerobic endurance and VO2 max (due to the short duration of goalkeeping actions) were included, regardless of the type of observational design. Results: Thirty-five studies were finally included in the synthesis, encompassing neuromuscular performance factors such as agility, speed, anaerobic power, strength, flexibility, and dynamic balance and coordination. The findings underscore the need for neuromuscular training for goalkeepers, particularly agility training. Neuromuscular performance improves with age, especially in linear speed, agility, change-of-direction speed, strength, and power; however, flexibility shows no significant progression. This review identifies key tests for evaluating goalkeepers’ neuromuscular capacities across major performance domains. Conclusions: Although sex differences are apparent, the main limitation is the lack of research on neuromuscular performance in male and female goalkeepers, making it difficult to define indicators for different age and sex categories. Full article
(This article belongs to the Special Issue Sport-Specific Movement Analysis)
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18 pages, 2662 KB  
Article
NVH Optimization of Motor Based on Distributed Mathematical Model Under PWM Control
by Kai Zhao, Zhihui Jin and Jian Luo
Energies 2025, 18(20), 5395; https://doi.org/10.3390/en18205395 (registering DOI) - 13 Oct 2025
Abstract
For the combination of finite elements and control circuits, the calculation is complex and time-consuming, making direct optimization impractical. In this paper, a new distributed node and magnetic circuit model is proposed to simulate the spatial and temporal variation of the distributed air-gap [...] Read more.
For the combination of finite elements and control circuits, the calculation is complex and time-consuming, making direct optimization impractical. In this paper, a new distributed node and magnetic circuit model is proposed to simulate the spatial and temporal variation of the distributed air-gap magnetic density with the current and rotor angle and solve the electromagnetic force wave variation. Compared to other distributed flux-linkage models, the proposed model not only considers the radial magnetic path but also connects adjacent magnetic paths tangentially. The inclusion of this tangential path enhances the mutual interaction between magnetic circuits, leading to a more accurate model. Based on the control circuit model, the electromagnetic force wave changes caused by the harmonic currents under various circuits and operating conditions are calculated, the topology is analyzed and optimized to mitigate critical harmonics, the electromagnetic force wave is reduced, and finally, the model accuracy is verified experimentally. While most distributed flux-linkage models are applied to the optimization of motor performance metrics such as the magnetomotive force (MMF), power, and torque, this paper applies the model to the optimization of the magnetic field strength, the harmonic content, and the corresponding noise, vibration, and harshness (NVH), demonstrating a broader range of applications. This method can be coupled with the control circuit to analyze the changes in electromagnetic force waves and quickly optimize them, improving the accuracy and efficiency of research and development. Full article
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19 pages, 3065 KB  
Article
Coordinated Control of Trajectory Tracking and Lateral Stability for Distributed Electric-Driven Buses
by Yuanjie Huang, Xian Zheng, Tongqun Han and Wenhao Tan
World Electr. Veh. J. 2025, 16(10), 576; https://doi.org/10.3390/wevj16100576 (registering DOI) - 13 Oct 2025
Abstract
To resolve the inherent coupling conflict between trajectory tracking and lateral stability in distributed electric drive buses, this paper proposes a hierarchical cooperative control framework. A simplified two-degree-of-freedom (2-DOF) vehicle model is first established, and kinematically derived reference states for stable motion are [...] Read more.
To resolve the inherent coupling conflict between trajectory tracking and lateral stability in distributed electric drive buses, this paper proposes a hierarchical cooperative control framework. A simplified two-degree-of-freedom (2-DOF) vehicle model is first established, and kinematically derived reference states for stable motion are computed. At the upper level, a model predictive controller (MPC) generates real-time steering commands while explicitly minimizing lateral tracking error. At the lower level, a proportional integral derivative (PID)-based roll moment controller and a linear quadratic regulator (LQR)-based direct yaw moment controller are designed, with four-wheel torque distribution achieved via quadratic programming subject to friction circle and vertical load constraints. Co-simulation results using TruckSim and MATLAB/Simulink demonstrate that, during high-speed single-lane-change maneuvers, peak lateral error is reduced by 11.59–18.09%, and root-mean-square (RMS) error by 8.67–14.77%. Under medium-speed double-lane-change conditions, corresponding reductions of 3.85–12.16% and 4.48–11.33% are achieved, respectively. These results fully validate the effectiveness of the proposed strategy. Compared with the existing MPC–direct yaw moment control (DYC) decoupled control framework, the coordinated control strategy proposed in this paper achieves the optimal trade-off between trajectory tracking and lateral stability while maintaining the quadratic programming solution delay below 0.5 milliseconds. Full article
(This article belongs to the Section Propulsion Systems and Components)
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23 pages, 8455 KB  
Article
Monitoring River–Lake Dynamics in the Mid-Lower Reaches of the Yangtze River Using Sentinel-2 Imagery and X-Means Clustering
by Zhanshuo Qi, Shiming Yao, Xiaoguang Liu, Bing Ding, Hongyang Wang, Yuqi Jiang and Jinpeng Hu
Remote Sens. 2025, 17(20), 3421; https://doi.org/10.3390/rs17203421 (registering DOI) - 13 Oct 2025
Abstract
River–lake systems are essential for sustaining ecosystems and human livelihoods. However, the complexity and variability of large river–lake systems, coupled with characteristic differences in water bodies across regions, have made quantifying their extent and changes inherently challenging. This study implements a robust water [...] Read more.
River–lake systems are essential for sustaining ecosystems and human livelihoods. However, the complexity and variability of large river–lake systems, coupled with characteristic differences in water bodies across regions, have made quantifying their extent and changes inherently challenging. This study implements a robust water extraction method based on the multidimensional X-means clustering algorithm. This method leverages the advantages of Sentinel-2 imagery for water detection. Utilizing the X-means algorithm, it generates a new seasonal surface water area (SWA) product for the mid-lower reaches of the Yangtze River (MLRYR). The implemented method achieved an overall accuracy of 97.98%, a producer’s accuracy of 98.02%, a user’s accuracy of 96.01%, a Matthews correlation coefficient of 0.954, and a Kappa coefficient of 0.954. Analysis of water body dynamics reveals that over the past six years, the overall trend of SWA in the MLRYR has remained stable. However, within a broad range including multiple sub-basins, a decline in SWA has been observed on an inter-annual scale. Among the large lakes and reservoirs in the MLRYR, the water areas of Poyang Lake, Dongting Lake and Shijiu Lake all showed a marked decline. Among all water bodies with a significant increase in area, the Danjiangkou Reservoir is the largest. Further correlation analysis indicates that SWA exhibited the strongest correlations with precipitation and drought index in most sub-basins. In sub-basins where large lakes and reservoirs exist, the presence of river networks played a buffering role by regulating and storing water, thereby reducing the direct influence of climatic factors on lake and reservoir water extent. These findings highlight the complex interplay of climatic and hydrological factors. By integrating satellite imagery and Earth observation, this study advances understanding of MLRYR surface water dynamics, providing a robust framework for monitoring in other regions. It offers critical insights into drought impacts and informs effective water resource management and conservation strategies. Full article
(This article belongs to the Section Remote Sensing in Geology, Geomorphology and Hydrology)
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39 pages, 19794 KB  
Article
Cylindrical Coordinate Analytical Solution for Axisymmetric Consolidation of Unsaturated Soils: Dual Bessel–Trigonometric Orthogonal Expansion Approach to Radial–Vertical Composite Seepage Systems
by Yiru Hu and Lei Ouyang
Symmetry 2025, 17(10), 1714; https://doi.org/10.3390/sym17101714 - 13 Oct 2025
Abstract
This study develops a novel analytical solution for three-dimensional axisymmetric consolidation of unsaturated soils incorporating radial–vertical composite seepage mechanisms and anisotropic permeability characteristics. A groundbreaking dual orthogonal expansion framework is established, utilizing innovative Bessel–trigonometric function coupling to solve the inherently complex spatiotemporal coupled [...] Read more.
This study develops a novel analytical solution for three-dimensional axisymmetric consolidation of unsaturated soils incorporating radial–vertical composite seepage mechanisms and anisotropic permeability characteristics. A groundbreaking dual orthogonal expansion framework is established, utilizing innovative Bessel–trigonometric function coupling to solve the inherently complex spatiotemporal coupled partial differential equations in cylindrical coordinate systems. The mathematical approach synergistically combines modal expansion theory with Laplace transform methodology, achieving simultaneous spatial expansion of gas–liquid two-phase pressure fields through orthogonal function series, thereby transforming the three-dimensional problem into solvable ordinary differential equations. Rigorous validation demonstrates exceptional accuracy with coefficient of determination R2 exceeding 0.999 and relative errors below 2% compared to numerical simulations, confirming theoretical correctness and practical applicability. The analytical solutions reveal four critical findings with quantitative engineering implications: (1) dual-directional drainage achieves 28% higher pressure dissipation efficiency than unidirectional drainage, providing design optimization criteria for vertical drainage systems; (2) normalized matric suction variation exhibits characteristic three-stage evolution featuring rapid decline, plateau stabilization, and slow recovery phases, while water phase follows bidirectional inverted S-curve patterns, enabling accurate consolidation behavior prediction under varying saturation conditions; (3) gas-water permeability ratio ka/kw spanning 0.1 to 1000 produces two orders of magnitude time compression effect from 10−2 s to 10−4 s, offering parametric design methods for construction sequence control; (4) initial pressure gradient parameters λa and λw demonstrate opposite regulatory mechanisms, where increasing λa retards consolidation while λw promotes the process, providing differentiated treatment strategies for various geological conditions. The unified framework accommodates both uniform and gradient initial pore pressure distributions, delivering theoretical support for refined embankment engineering design and construction control. Full article
(This article belongs to the Section Engineering and Materials)
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16 pages, 5856 KB  
Article
Characteristics of Lower Limb Dominant and Nondominant Joint Load Changes After Long-Distance Running in Young Male Runners Under OpenSim Environment
by Xiaocan Li and Lijuan Mao
Sensors 2025, 25(20), 6301; https://doi.org/10.3390/s25206301 (registering DOI) - 11 Oct 2025
Viewed by 191
Abstract
This study aims to investigate the characteristics of load changes in the hip, knee, and ankle joints of the dominant and non-dominant lower limbs of young male runners after long-distance running. Using the OpenSim public dataset (containing bilateral biomechanical data before and after [...] Read more.
This study aims to investigate the characteristics of load changes in the hip, knee, and ankle joints of the dominant and non-dominant lower limbs of young male runners after long-distance running. Using the OpenSim public dataset (containing bilateral biomechanical data before and after long-distance running from 20 young male runners), personalized musculoskeletal models were established. Contact forces in three directions at lower limb joints during the running stance phase were calculated. Statistical analysis employed one-dimensional statistical parameter mapping (SPM1d) and two-factor repeated measures ANOVA (time × side). Results revealed significant time × side interaction effects (p < 0.05) for contact forces in the medial–lateral direction at the hip, the anterior–posterior direction at the knee, and all three directions at the ankle. Simple effects analysis showed that post-run medial–lateral hip forces significantly increased during the push-off phase, while anterior–posterior ankle forces significantly increased during the mid-to-late stance phase on both sides (d = 0.718–1.002). For the superior–inferior direction at the hip and knee, only main effects of time or side were present. Post-run joint contact forces significantly increased, with the dominant side consistently exceeding the non-dominant side across multiple stance and push-off phases (d = 0.58–1.6), indicating stable side-to-side differences. These findings indicate that long-distance running not only increases multi-joint loading in the lower limbs but also exacerbates asymmetry between the dominant and non-dominant sides during the initial stance and push-off phases. This redistribution of load, coupled with bilateral control imbalance, may further elevate the risk of injury. Full article
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27 pages, 4080 KB  
Review
A Review of Recent Development of Geosynchronous Synthetic Aperture Radar Technique
by Jinwei Li, Caipin Li, Xiaomin Tan, Dong You, Chongdi Duan, Sheng Zhang, Hongxing Dang, Guangting Li and Qingjun Zhang
Remote Sens. 2025, 17(20), 3405; https://doi.org/10.3390/rs17203405 - 11 Oct 2025
Viewed by 243
Abstract
As the world’s first geosynchronous (GEO) orbit synthetic aperture radar (SAR) satellite, LuTan-4 was successfully launched on 13 August 2023. It was developed by the China Academy of Space Technology, with which the authors are affiliated. This study presents a comprehensive review of [...] Read more.
As the world’s first geosynchronous (GEO) orbit synthetic aperture radar (SAR) satellite, LuTan-4 was successfully launched on 13 August 2023. It was developed by the China Academy of Space Technology, with which the authors are affiliated. This study presents a comprehensive review of the recent advancements in GEO SAR technology. The review first begins by summarizing key considerations in GEO SAR system design, including orbital parameters and synthetic aperture time, transmit power and antenna aperture, two-dimensional beam-steering, imaging parameters and non-ideal factors. In terms of GEO SAR signal processing, the article focuses on two fundamental models, i.e., the high-order slant-range model and the coupled space-variant signal model. It also introduces the current GEO SAR imaging algorithms. Furthermore, the study presents an analysis between GEO SAR and low-Earth orbit SAR systems, highlighting the superior capability of GEO SAR for large-scale surface dynamic processes. Finally, the paper outlines the future development directions and potential applications of GEO SAR technology. Full article
(This article belongs to the Section Satellite Missions for Earth and Planetary Exploration)
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19 pages, 9150 KB  
Article
Design and Parameter Optimization of a Vertical Rotary Fixed-Angle Straw Cleaning Device
by Naiyu Shi, He Li, Bailin Jiang, Yan Chen, Jiaxing Cui, Wenyi Ji and Huaiyu Zhang
Agriculture 2025, 15(20), 2113; https://doi.org/10.3390/agriculture15202113 - 11 Oct 2025
Viewed by 81
Abstract
This study addresses the challenges encountered in mechanized agricultural fields, particularly the soil disruption associated with conventional horizontal rotary straw cleaning equipment. To mitigate the inefficiency of straw cleaning observed in the current vertical rotary apparatus, this study introduces a vertical rotary fixed-angle [...] Read more.
This study addresses the challenges encountered in mechanized agricultural fields, particularly the soil disruption associated with conventional horizontal rotary straw cleaning equipment. To mitigate the inefficiency of straw cleaning observed in the current vertical rotary apparatus, this study introduces a vertical rotary fixed-angle straw cleaning device. The essential conditions for establishing the cutter tooth angle were identified through theoretical analysis. Analyzing the kinematics of the cutter tooth to direct the movement of the straw, we determined that the deflection angle of the cutter tooth group (DA) is a critical parameter for enhancing the effectiveness of straw cleaning. A multiphase interaction model encompassing soil, straw, and machinery components was developed utilizing a coupled simulation approach with RecurDyn and EDEM software. The Box–Behnken response surface methodology was employed to systematically investigate the interaction effects of three critical parameters on both the straw cleaning rate and the soil disturbance rate: operation speed (OS), rotation speed of the straw cleaning rotary table (RS), and the DA. For optimization experiments where the OS is set to 2.4 m/s, RS is 400 r/min, and DA is 48°, the straw cleaning rate reaches 94.1% and the soil disturbance rate is 27.2%. This device can efficiently create a localized clean seeding belt for no-till planters without significantly damaging the soil structure, providing an innovative solution for the development of low-disturbance, high-efficiency conservation tillage equipment. Full article
(This article belongs to the Section Agricultural Technology)
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20 pages, 41724 KB  
Article
TRIC-A Facilitates Sarcoplasmic Reticulum–Mitochondrial Ca2+ Signaling Crosstalk in Cardiomyocytes
by Ang Li, Xinyu Zhou, Ki Ho Park, Jianxun Yi, Xuejun Li, Jae-Kyun Ko, Yuchen Chen, Miyuki Nishi, Daiju Yamazaki, Hiroshi Takeshima, Jingsong Zhou and Jianjie Ma
Cells 2025, 14(20), 1579; https://doi.org/10.3390/cells14201579 - 11 Oct 2025
Viewed by 157
Abstract
TRIC-A is an intracellular cation channel enriched in excitable tissues that is recently identified as a key modulator of sarcoplasmic reticulum (SR) Ca2+ homeostasis through direct interaction with type 2 ryanodine receptors (RyR2). Given the intimate anatomical and functional coupling [...] Read more.
TRIC-A is an intracellular cation channel enriched in excitable tissues that is recently identified as a key modulator of sarcoplasmic reticulum (SR) Ca2+ homeostasis through direct interaction with type 2 ryanodine receptors (RyR2). Given the intimate anatomical and functional coupling between the SR and mitochondria, we investigated whether TRIC-A contributes to SR–mitochondrial crosstalk under cardiac stress conditions. Using a transverse aortic constriction (TAC) model, we found that TRIC-A−/− mice developed more severe cardiac hypertrophy, underwent maladaptive remodeling, and activated apoptotic pathways compared with wild-type littermates. At the cellular level, TRIC-A-deficient cardiomyocytes were more susceptible to H2O2-induced mitochondrial injury and displayed abnormal mitochondrial morphology. Live-cell imaging revealed exaggerated mitochondrial Ca2+ uptake during caffeine stimulation and increased propensity for store-overload-induced Ca2+ release (SOICR). Complementary studies in HEK293 cells expressing RyR2 demonstrated that exogenous TRIC-A expression attenuates RyR2-mediated mitochondrial Ca2+ overload, preserves respiratory function, and suppresses superoxide generation. Together, these findings identify TRIC-A as a critical regulator of SR–mitochondrial Ca2+ signaling. By constraining mitochondrial Ca2+ influx and limiting oxidative stress, TRIC-A safeguards cardiomyocytes against SOICR-driven injury and confers protection against pressure overload-induced cardiac dysfunction. Full article
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16 pages, 12939 KB  
Article
Strategic Carbon Source Selection Enhances Biomass and Paramylon Yields in Mixotrophic Euglena gracilis Cultivation
by Xue Xiao, Rui He, Xinyue Guo, Xinxin Zhao, Zhengfei Yang, Yongqi Yin, Minato Wakisaka and Jiangyu Zhu
Microorganisms 2025, 13(10), 2339; https://doi.org/10.3390/microorganisms13102339 - 11 Oct 2025
Viewed by 179
Abstract
Euglena gracilis’s mixotrophic metabolism offers biotechnological potential. This study investigated how glucose, sodium acetate, ethanol, and propanetriol regulate its growth, photosynthesis, and paramylon production. All carbon sources boosted paramylon yield versus photoautotrophic controls. Ethanol and glucose were both highly effective, supporting the [...] Read more.
Euglena gracilis’s mixotrophic metabolism offers biotechnological potential. This study investigated how glucose, sodium acetate, ethanol, and propanetriol regulate its growth, photosynthesis, and paramylon production. All carbon sources boosted paramylon yield versus photoautotrophic controls. Ethanol and glucose were both highly effective, supporting the highest biomass accumulation (5.71 and 4.42-fold increases, respectively) and paramylon content without a significant difference between them. Ethanol supplementation enhanced chlorophyll b via coupled TCA cycle/glyoxylate shunt activity, while glucose showed the strongest tendency for high paramylon and the highest carotenoid content (13.36-fold higher). Sodium acetate triggered alkaline stress (pH 8.5), suppressing pigments and inducing spherical cells. Propanetriol reduced biomass but enhanced PSII efficiency (Fv/Fm). These results demonstrate carbon source-driven metabolic partitioning: ethanol and glucose both excel in promoting growth and storage, while additionally directing carbon toward chlorophyll b or carotenoids, respectively. These findings enable targeted bioprocess optimization: selection between ethanol or glucose can be based on the value of co-products, advancing E. gracilis as a sustainable cell factory. Full article
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18 pages, 577 KB  
Article
Impact of Xenobiotic Detoxification Gene Polymorphisms on Steady-State Plasma Concentrations of Apixaban and the Development of Hemorrhagic Complications in Older Patients with Non-Valvular Atrial Fibrillation
by Andrey P. Kondrakhin, Sherzod P. Abdullaev, Ivan V. Sychev, Pavel O. Bochkov, Svetlana N. Tuchkova, Karin B. Mirzaev, Maksim L. Maksimov and Dmitry A. Sychev
Genes 2025, 16(10), 1179; https://doi.org/10.3390/genes16101179 - 10 Oct 2025
Viewed by 210
Abstract
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with a fivefold increase in stroke risk. Direct oral anticoagulants (DOACs), including apixaban, are now the preferred therapy for stroke prevention in patients with non-valvular AF (NVAF). However, interindividual [...] Read more.
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with a fivefold increase in stroke risk. Direct oral anticoagulants (DOACs), including apixaban, are now the preferred therapy for stroke prevention in patients with non-valvular AF (NVAF). However, interindividual variability in drug response and safety remains a major challenge, particularly in elderly patients with comorbidities and polypharmacy. Genetic polymorphisms in drug-metabolizing enzymes and transporters may contribute to variability in apixaban exposure and bleeding risk. This study aimed to evaluate the association of polymorphisms in ABCB1, CYP3A4, and CYP3A5 with steady-state plasma concentrations of apixaban (Cssmin) and hemorrhagic complications in elderly patients with NVAF. Methods: This cross-sectional study included 197 patients (mean age 83 ± 8 years; 67% women) with NVAF treated with apixaban (5 mg twice daily). Genotyping of ABCB1 (rs1045642, rs2032582, rs1128503), CYP3A4*22 (rs35599367), and CYP3A5*3 (rs776746) was performed using allele-specific real-time PCR. Cssmin of apixaban was determined by high-performance liquid chromatography coupled with tandem mass spectrometry. Associations with bleeding events were evaluated. Results: Bleeding events were recorded in 40 patients (20.3%). An association signal was observed for ABCB1 rs1045642, where carriers of the CC genotype had a higher risk of bleeding compared with alternative alleles (OR = 2.805; 95% CI: 1.326–5.935; p = 0.006). After correction for multiple testing, the association remained significant only under the log-additive model (OR = 1.93 per C allele; 95% CI: 1.17–3.20; q = 0.0275; p_adj = 0.044), while recessive and codominant effects did not withstand Bonferroni adjustment. No significant associations were observed for rs2032582, rs1128503, CYP3A4*22, or CYP3A5*3. None of the studied polymorphisms, including rs1045642, significantly affected Cssmin. Concomitant therapy, particularly with antiarrhythmic drugs and statins (rosuvastatin), also increased bleeding risk. Conclusions: The findings highlight the potential contribution of ABCB1 rs1045642 and specific drug–drug interactions to the risk of hemorrhagic complications in elderly NVAF patients receiving apixaban. Full article
(This article belongs to the Special Issue Pharmacogenomics and Personalized Treatment)
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21 pages, 19022 KB  
Article
Analysis on the “History–Space” Inter-Construction Mechanism of Traditional Villages Based on Multi-Historical Elements: A Case Study of Nankou Town, Northwest Beijing
by Yi You, Hongjie Wu and Lingyu Xu
Land 2025, 14(10), 2026; https://doi.org/10.3390/land14102026 - 10 Oct 2025
Viewed by 204
Abstract
Traditional villages are widely recognized as vast cultural treasure troves, characterized by diverse historical elements and distinctive spatial forms. Within this context, historical factors exert varying degrees of influence on spatial configurations, and each type of space preserves a distinct facet of historical [...] Read more.
Traditional villages are widely recognized as vast cultural treasure troves, characterized by diverse historical elements and distinctive spatial forms. Within this context, historical factors exert varying degrees of influence on spatial configurations, and each type of space preserves a distinct facet of historical memory. Taking Nankou Village in Beijing as a case study, this paper selects three distinct periods as entry points to explore how historical elements affect the spatial morphology of villages through Multiscale Geographically Weighted Regression analysis and standard deviation ellipse methods. Under the theories of Halbwachs and Nora, this research analyzes the role of village spaces in the bearing and reshaping of historical memory. It further employs qualitative materials to inversely verify the quantitative results, thereby cross-validating the findings through both quantitative and qualitative perspectives in exploring the interactions between “historical elements” and “spatial morphology”. This integrated approach culminates in the innovative proposal of a “history–space” inter-construction mechanism. The findings reveal that different types of historical elements have significant influences on guiding and reshaping spatial features, exhibiting strong spatial heterogeneity. When multiple historical elements are coupled, the evolution of village morphology shows distinct phases, directions, and expansive characteristics. As these spaces undergo continuous practice, they drive the reconstruction of memory and reinterpretation of historical significance. Ultimately, Nankou Village has developed a unique “history–space” inter-construction mechanism, which uncovers the inherent logic of their ongoing evolution. This mechanism further holds theoretical extrapolative value for other historically and culturally significant villages. This study underscores the importance of integrating research and preservation of intangible cultural elements and physical spaces, providing critical insights into understanding spatial evolution patterns of traditional villages and their influencing factors. Full article
(This article belongs to the Section Land Planning and Landscape Architecture)
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15 pages, 2538 KB  
Article
Active Damped PI Speed Loop Design for Motor Direct-Drive Operating Mechanism for High-Voltage Circuit Breakers
by Xiao Wang, Xusheng Wu and Xi Xiao
Electronics 2025, 14(19), 3969; https://doi.org/10.3390/electronics14193969 - 9 Oct 2025
Viewed by 244
Abstract
To address the prevalent issues of oscillation and overshoot in high-voltage circuit breaker motor direct-drive mechanisms under classical PI control, this paper proposes an optimized PI speed loop with active damping characteristics. By first establishing a detailed kinematic and dynamic model of the [...] Read more.
To address the prevalent issues of oscillation and overshoot in high-voltage circuit breaker motor direct-drive mechanisms under classical PI control, this paper proposes an optimized PI speed loop with active damping characteristics. By first establishing a detailed kinematic and dynamic model of the mechanism, we reveal the inherent coupling between tracking performance, disturbance immunity, and the damping ratio within the classical PI speed loop. Our novel method introduces a speed feedback channel at the output of the PI controller to synthesize equivalent viscous damping, thereby enhancing system stability without compromising responsiveness. Through rigorous simulation and experimental validation, the proposed controller’s effectiveness is demonstrated. Compared with the traditional PI controller, the ADPI method reduces the velocity overshoot to only 5.76% in the startup phase, and the maximum velocity tracking error of the velocity is only 18.62% and the cumulative position tracking error is only 0.632 rad under the actual working condition, which is a reduction of 42.7% in the positional error relative to the traditional PI method. The controller also exhibits low sensitivity to changes in the system’s equivalent rotational inertia. This work provides a low-complexity and easy-to-implement speed loop performance enhancement scheme, ideally suited for the short-duration, high-dynamic-load conditions of high-voltage circuit breaker applications. Full article
(This article belongs to the Section Electronic Materials, Devices and Applications)
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