Search Results (1,048)

Glazed components in ancient Chinese architecture hold profound historical and cultural value. However, over time, environmental erosion, physical impacts, and human disturbances gradually lead to various forms of damage, severely impacting the durability and stability of the buildings. Therefore, preventive protection of glazed components is crucial. The key to preventive protection lies in the early detection and repair of damage, thereby extending the component’s service life and preventing significant structural damage. To address this challenge, this study proposes a Restoration-Scale Identification (RSI) method that integrates depth information. By combining RGB-D images acquired from a depth camera with intrinsic camera parameters, and embedding a Convolutional Block Attention Module (CBAM) into the backbone network, the method dynamically enhances critical feature regions. It then employs a scale restoration strategy to accurately identify damage areas and recover the physical dimensions of glazed components from a global perspective. In addition, we constructed a dedicated semantic segmentation dataset for glazed tile damage, focusing on cracks and spalling. Both qualitative and quantitative evaluation results demonstrate that, compared with various high-performance semantic segmentation methods, our approach significantly improves the accuracy and robustness of damage detection in glazed components. The achieved accuracy deviates by only ±10 mm from high-precision laser scanning, a level of precision that is essential for reliably identifying and assessing subtle damages in complex glazed architectural elements. By integrating depth information, real scale information can be effectively obtained during the intelligent recognition process, thereby efficiently and accurately identifying the type of damage and size information of glazed components, and realizing the conversion from two-dimensional (2D) pixel coordinates to local three-dimensional (3D) coordinates, providing a scientific basis for the protection and restoration of ancient buildings, and ensuring the long-term stability of cultural heritage and the inheritance of historical value. Full article

Background: Most immunologically “cold” tumors do not respond durably to checkpoint blockade because tumor antigen (TA) release and presentation are insufficient to prime effective T-cell immunity. While prior work demonstrated synergy between cisplatin and a TLR7/8/9 agonist (CR108) in 4T1 tumors, the underlying mechanism—particularly whether chemotherapy functions as a broad antigen-releasing agent enabling TLR-driven immune amplification—remained undefined. Methods: Using murine models of breast (4T1), melanoma (B16-F10), and colorectal cancer (CT26), we tested multiple chemotherapeutic classes combined with CR108. We quantified intratumoral and systemic soluble TAs, antigen presentation and cross-priming by antigen-presenting cells, tumor-infiltrating lymphocytes, and cytokine production by flow cytometry/ICS. T-cell receptor β (TCRβ) repertoire dynamics in tumor-draining lymph nodes were profiled to assess amplitude and breadth. Tumor microenvironment remodeling was analyzed, and public datasets (e.g., TCGA basal-like breast cancer) were interrogated for expression of genes linked to TA generation/processing and peptide loading. Results: Using cisplatin + CR108 in 4T1 as a benchmark, we demonstrate that diverse chemotherapies—especially platinum agents—broadly increase the repertoire of soluble tumor antigens available for immune recognition. Across regimens, chemotherapy combined with CR108 increased T-cell recognition of candidate TAs and enhanced IFN-γ⁺ CD8⁺ responses, with platinum agents producing the largest expansions in soluble TAs. TCRβ sequencing revealed increased clonal amplitude without loss of repertoire breadth, indicating focused yet diverse antitumor T-cell expansion. Notably, therapeutic efficacy was not predicted by canonical damage-associated molecular pattern (DAMP) signatures but instead correlated with antigen availability and processing capacity. In human basal-like breast cancer, higher expression of genes involved in TA generation and antigen processing/presentation correlated with improved survival. Conclusions: Our findings establish an antigen-centric mechanism underlying chemo–TLR agonist synergy: chemotherapy liberates a broadened repertoire of tumor antigens, which CR108 then leverages via innate immune activation to drive potent, T-cell-mediated antitumor immunity. This framework for rational selection of chemotherapy partners for TLR7/8/9 agonism and support clinical evaluation to convert “cold” tumors into immunologically responsive disease. Full article

Self-healing hydrogels, a novel class of “smart” hydrogels, possess the ability to autonomously restore their network structure and mechanical properties following damage through the reconnection of a fractured three-dimensional network via reversible interactions. This characteristic enhances their safety and durability, exhibiting significant potential in biomedicine. The key determinants of self-healing hydrogels are their mechanical strength and healing efficiency. Ideally, these hydrogels exhibit both high mechanical strength and good healing efficiency. Nevertheless, an inverse relationship between the mechanical strength and self-healing efficiency of self-healing hydrogels typically exists. Thus, research is currently focused on the development of self-healing hydrogels that combine good biocompatibility, high mechanical strength, and good self-healing efficiency. This review focuses on the research progress that is being made regarding the mechanical properties and self-healing capabilities of self-healing hydrogels, where we aim to achieve a balance between self-healing performance and mechanical strength. We outline the evaluation methods for assessing self-healing performance, followed by providing a summary of recent advancements in the mechanical strength and self-healing efficiency of external-stimulus-triggered self-healing hydrogels and autonomous self-healing hydrogels. Finally, we address the challenges and prospects for the future development of self-healing hydrogels. Full article

Chrysanthemum morifolium Ramat. is a major ornamental crop that suffers from diverse fungal, bacterial, viral, and insect pests, causing significant yield and quality losses. Between 2015 and 2025, rapid progress in molecular biology, genomics, and ecological regulation has advanced both fundamental research and applied control strategies. Multi-locus sequencing, multiplex PCR, and next-generation sequencing refined the identification of fungal and bacterial pathogens, while functional studies of WRKY, MYB, and NAC transcription factors revealed key resistance modules. Hormone-mediated signaling pathways, particularly those of salicylic acid, jasmonic acid, and abscisic acid, were shown to play central roles in host defense. Despite these advances, durable genetic resistance against bacterial pathogens and broad-spectrum defense against viruses remains limited. Novel technologies, including virus-free propagation, RNA interference, and spray-induced gene silencing, have shown promising outcomes. For insect pests, studies clarified the damage and virus-vectoring roles of aphids and thrips, and resistance traits linked to trichomes, terpenoids, and lignin have been identified. Biocontrol agents such as Trichoderma spp., Bacillus spp., predatory mites, and entomopathogenic fungi have also demonstrated efficacy. Future efforts should integrate molecular breeding, genome editing, RNA-based tools, and microbiome management to achieve sustainable chrysanthemum protection. Full article

Background: Cryopreservation of hematopoietic stem cells (HSCs) at −80 °C using uncontrolled-rate freezing is frequently employed in resource-constrained settings, yet concerns remain regarding long-term viability and clinical efficacy. Reliable post-thaw assessment is essential to ensure graft quality and engraftment success. Methods: This single-center, retrospective study evaluated 72 cryopreserved stem cell products from 25 patients stored at −80 °C for a median of 868 days. Viability was assessed using both acridine orange (AO) staining and 7-AAD (7-aminoactinomycin D) flow cytometry at three time points: collection (T0), pre-infusion (T1), and delayed post-thaw evaluation (T2). Associations between viability loss, storage duration, and clinical engraftment outcomes were analyzed. Results: Median post-thaw viability remained high (94.8%) despite a moderate time-dependent decline (~1.02% per 100 days; R² = 0.283, p < 0.001). Mean viability loss at T2 was 9.2% (AO) and 6.6% (flow cytometry). AO demonstrated greater sensitivity to delayed degradation, with a significant difference between methods (p < 0.001). Engraftment kinetics were preserved in most patients, with neutrophil and platelet recovery primarily influenced by disease type rather than product integrity. Notably, storage duration and donor age were not significantly associated with engraftment outcomes or CD34⁺ cell dose. Conclusions: Long-term cryopreservation at −80 °C maintains HSC viability sufficient for durable engraftment, despite gradual decline. While transplant outcomes are primarily dictated by disease biology and remission status, AO staining provides enhanced sensitivity for detecting delayed cellular damage. Notably, our viability-loss model offers a practical framework for predicting product quality, potentially supporting graft selection and clinical decision-making in real-world, resource-constrained transplant settings. Full article

The construction of large-scale infrastructure, such as power facilities, requires extensive use of reinforced concrete. The durability degradation of reinforced concrete structures in chloride environments involves multi-physics coupling effects, chloride ion diffusion, rebar corrosion, and concrete damage. Existing models neglect the coupling mechanisms among these processes and the influence of mesoscale structural characteristics. Therefore, this study proposes a diffusive–mechanical coupled phase field by integrating the phase field, chloride ion diffusion, and mechanical equivalence for rebar corrosion, establishing a multi-physics coupling analysis framework at the mesoscale. The model incorporates heterogeneous meso-structure of concrete and constructs a dynamic coupling function between the phase field damage variable and chloride diffusion coefficient, enabling full-process simulation of corrosion-induced cracking under chloride erosion. Numerical results demonstrate that mesoscale heterogeneity significantly affects crack propagation paths, with increased aggregate content delaying the initiation of rebar corrosion. Moreover, the case with corner-positioned rebar exhibits earlier cracking compared to the case with centrally located rebar. Furthermore, larger clear spacing delays delamination failure. Comparisons with the damage mechanics model and experimental data confirm that the proposed model more accurately captures tortuous crack propagation behavior, especially suitable for evaluating the durability of reinforced concrete components in facilities such as transmission tower foundations, substation structures, and marine power facilities. This research provides a highly accurate numerical tool for predicting the service life of reinforced concrete power infrastructure in chloride environments. Full article

The durability of asphalt concrete is highly dependent on the geometry and mineralogy of coarse aggregates, yet their combined influence on mechanical and moisture resistance properties is still not fully understood. This study evaluates the effects of coarse aggregate geometry, specifically flat and elongated particle ratios and angularity, as well as mineral composition (quartz versus calcite), on asphalt mixture durability. The durability of mixtures was evaluated through Marshall properties as well as moisture susceptibility indicators, including the tensile strength ratio (TSR) and index of retained strength (IRS). Statistical analyses (ANOVA and t-tests) were also conducted to confirm the significance of the observed effects. Results showed that mixtures containing higher proportions of flat and elongated particles exhibited greater void content, reduced stability, and weaker moisture resistance, with the 1:5 flat-to-elongated ratio showing the most adverse impact (TSR 73.9%, IRS 69.2%). Conversely, increasing coarse aggregate angularity (CAA) enhanced mixture performance, with TSR values rising from 63.5% at 0% angularity to 81.2% at 100% angularity, accompanied by corresponding improvements in IRS. Mineral composition analysis further demonstrated that calcite-based aggregates achieved stronger bonding with asphalt binder and superior resistance to stripping compared to quartz-based ones. These findings confirm that aggregate geometry and mineralogy exert a decisive influence on asphalt mixture durability. They also highlight the need to revise current specifications that permit the use of uncrushed coarse aggregate in asphalt base courses, particularly when such layers may serve as surface courses in suburban or low-volume roads, where long-term resistance to moisture damage is critical. Full article

Thermal cycling test is one of the reliability tests, which are important for metal-ceramic layered composites (metallized ceramic substrates), a part in power modules. Since thermal cycles are within a large range of temperature, the test has only been performed using a thermal chamber. It limited the understanding of degradation mechanism in metallized ceramics substrates. Among NDE techniques, Digital Image Correlation (DIC) is a simple and effective method, enhanced by modern digital imaging technologies, enabling precise measurements of displacement, strain, deformation, and defects with a simple setup. In this paper, we combined some of our previous work to make a review to present a full analysis of a silicon metallized substrate under thermal cycling test (from beginning to fail) using DIC method. The main content is the application of DIC in evaluating the reliability of metallized silicon nitride (AMB-SN) substrates under thermal cycling with temperatures from −40 °C to 250 °C. Three key aspects of the AMB-SN substrate are presented, including (i) thermal strain characteristics before and after delamination, (ii) warpage and dynamic bending behavior across damage states, and (iii) stress–strain behavior of constituent materials. The review provides insights into degradation progress of the substrate and the role of Cu in substrate failure, and highlights DIC’s potential in ceramic composites, offering a promising approach for improving reliability test simulations and advancing digital transformation in substrate evaluation, ultimately contributing to enhanced durability in high-power applications. Full article

Wet–dry cycles are a key factor aggravating the durability degradation of foam concrete. To address this issue, this study prepared bentonite slurry–steel slag foam concrete (with steel slag and cement as main raw materials, and bentonite slurry as admixture) using the physical foaming method. Based on 7-day unconfined compressive strength tests with different mix proportions, the optimal mix proportion was determined as follows: mass ratio of bentonite to water 1:15, steel slag content 10%, and mass fraction of bentonite slurry 5%. Based on this optimal mix proportion, dry–wet cycle tests were carried out in both water and salt solution environments to systematically analyze the improvement effect of steel slag and bentonite slurry on the durability of foam concrete. The results show the following: steel slag can act as fine aggregate to play a skeleton role; after fully mixing with cement paste, it wraps the outer wall of foam, which not only reduces foam breakage but also inhibits the formation of large pores inside the specimen; bentonite slurry can densify the interface transition zone, improve the toughness of foam concrete, and inhibit the initiation and propagation of matrix cracks during the dry–wet cycle process; the composite addition of the two can significantly enhance the water erosion resistance and salt solution erosion resistance of foam concrete. The dry–wet cycle in the salt solution environment causes more severe erosion damage to foam concrete. The main reason is that, after chloride ions invade the cement matrix, they erode hydration products and generate expansive substances, thereby aggravating the matrix damage. Scanning Electron Microscopy (SEM) analysis shows that, whether in water environment or salt solution environment, the fractal dimension of foam concrete decreased slightly with an increasing number of wet–dry cycle times. Based on fractal theory, this study established a compressive strength–porosity prediction model and a dense concrete compressive strength–dry–wet cycle times prediction model, and both models were validated against experimental data from other researchers. The research results can provide technical support for the development of durable foam concrete in harsh environments and the high-value utilization of steel slag solid waste, and are applicable to civil engineering lightweight porous material application scenarios requiring resistance to dry–wet cycle erosion, such as wall bodies and subgrade filling. Full article

The pore structure of SCC and of all cement-based materials plays a crucial role on the mechanical and durability characteristics of the material. The pore structure is affected by mix design, water–binder ratio and the incorporation of SCM and/or nanomaterials, all of which can improve mechanical and durability characteristics by decreasing porosity. Computed tomography (CT) is a powerful, non-destructive imaging technique to investigate the internal pore structure of concrete. The main advantage compared to other investigation techniques used to assess the pore structure is in terms of sample size. More specifically, industrial CT can be used to scan large concrete samples and be able to assess the internal pore structure without damaging the specimen. CT provides accurate measurements of pore diameters, volumes and shapes and enables the assessment of the total porosity. The paper presents the results of an experimental program on the characterization of self-compacting concrete (SCC) at a very long age (7 years) in terms of static and dynamic elastic properties and compressive and splitting tensile strength, all of which are correlated with the internal pore structure assessed via the use of an industrial Nikon XTH 450 CT. The results highlight the influence of pore volume, maximum pore diameter and sphericity on the strength and elastic properties of SCC at the age of 7 years. Both the compressive strength and the static modulus of elasticity values tend to decrease with the increase in the internal total porosity, with stronger influence on the former. Full article

Microplastics have become a significant concern for human health, primarily because aquatic animals can ingest these particles, which then enter the human food chain. Crabs (Portunus pelagicus) were collected along the coastline of Rayong Province in January, April, and August 2024. Crabs were then examined for MP contamination. Our results revealed that MPs were present at all sampling sites, with a detection rate of 62.5% in external body parts and 72.2% in internal body parts. The gut was the most contaminated tissue, followed by the gills, while no MPs were found in the hepatopancreas or muscle tissues. Although overall MP detection and contamination levels were similar across sites, significant differences in abundance were observed between seasons (p < 0.05), with August showing the highest contamination levels. Polyethylene terephthalate glycol was the most common polymer detected, followed by nylon, polypropylene, polyethylene, polystyrene, and polyester. Anthropogenic and fishing activities contribute significantly to MP pollution in these crabs. Fibers from household laundry, followed by damaged fishing gear, are major sources of MP pollution. Enhancing the quality and durability of fishing equipment is crucial to reducing the amount of abandoned fishing gear that may be ingested by marine organisms, while the proper collection and management of discarded gear in the ocean should also be emphasized. Full article

To elucidate the fatigue damage evolution of solar road panels under long-term loading and enhance their structural durability, this study develops a particle-based discrete element model and simulates fatigue responses under different structural configurations and loading rates. A strength degradation index was established by introducing peak stress and terminal stress, enabling quantitative evaluation of strength deterioration. Combined with fracture evolution, the dominant mesoscopic damage mechanisms were revealed. The results indicate that structural configuration strongly influences fatigue performance, with square panels showing the best resistance due to geometric symmetry and stable boundary constraints. Loading rate regulates damage evolution: lower rates promote structural coordination but may delay cumulative failure, while higher rates suppress overall deformation yet increase localized fracture risk. Based on these findings, a nonlinear predictive model of the strength degradation rate was constructed (R² = 0.935), offering reliable support for structural life prediction and design optimization. Finally, fatigue-resistant design strategies are proposed, including optimal structural configuration, controlled loading rates, bonding enhancement, and integration of online monitoring—providing both theoretical and technical guidance for high-performance, long-lifespan solar road systems. Full article

The ridged cutter, a highly representative non-planar PDC cutter known for its strong impact resistance and wear durability, has demonstrated significant effectiveness in enhancing the rate of penetration (ROP) in hard, highly abrasive, and interbedded soft–hard formations. Understanding the crack evolution is fundamental to revealing the rock-breaking mechanism of ridged PDC cutters. To date, studies on rock breaking with ridged cutters have largely focused on macroscopic experimental observations, lacking an in-depth understanding of the crack evolution characteristics during the rock fragmentation process. This study employs the Finite–Discrete Element Method (FDEM) to establish a three-dimensional numerical model for simulating the interaction between the ridged cutter and the rock. By analyzing crack propagation paths, stress distribution, and the stiffness degradation factor (SDEG), the initiation, propagation patterns, and sequence of cracks around the cutter are investigated. The results indicate the following outcomes: (1) The ridged cutter breaks rock mainly by tensioning and shearing, while the conventional planar cutter breaks the rock by shearing. (2) The rock-breaking process proceeds in three stages: compaction, micro-failure, and volumetric fragmentation. (3) Crack evolution around the cutter follows the rule of “tension-initiated and shear-propagation”; that is, tensile damage first generates at the front of the crack due to tensile stress concentration, whereas shear damage subsequently occurs at the rear under high shear stress. Finally, mixed tensile–shear macro-cracks are generated. (4) The spatial distribution of cracks exhibits strong regional heterogeneity. The zone ahead of the cutter contains mixed tensile–shear cracks, forming upward-concave cracks, horizontal cracks, and oblique cracks at 45°. The sub-cutter zone is dominated by tensile cracks; the zone on the flank side of the cutter consists of a radial stress field, accompanied by oblique 45° cracks. The synergistic evolution mechanism and distribution law of tensile–shear cracks revealed in this study elucidate the rock-breaking advantages of ridged cutters from a micro-crack perspective and provide a theoretical basis for optimizing non-planar cutter structures to achieve more efficient volumetric fracture. Full article

Natural sand extraction for concrete manufacturing is a global issue for ecological balance and environmental concerns. This study introduced three mixes with three newly developed sand types to replace natural sand in concrete manufacturing. Additionally, three more mixes were made by incorporating optimized 10% silica fume. The durability of the prepared mixes was evaluated at high temperatures of (150–750 °C) at the interval of 150 °C and against immersion in a 5% sulfuric acid solution for 28, 56, 91, and 182 days, respectively. The study’s results reported the stability of the samples up to 300 °C, and then the fall of the samples started at 450 °C. Severe damage in the samples was formed at about 600 °C, and finally, a total collapse was seen at 750 °C. From (150 to 750 °C), the mix TYPE-3SSFC with a sustainable sand combination (50% recycled sand + 45% desert sand + 5% crumb rubber) and 10% silica fume showed better resistance than the other mixes. The compressive strength in the mix TYPE-3SSFC was 20.6%, 16.3%, 14.7%, 21.3%, 26.5%, and 43.2% higher than the mix TYPE-3SC with 10% silica fume. The mix TYPE-3SSFC with optimized 10% silica fume content showed better resistance against 5% sulfuric acid solution than those without silica fume. By morphological analysis, the mix TYPE-3SSFC showed that the interface improved due to the dense interconnectivity of the concrete mix between the crumb rubber paste and silica fume content. A dense calcite crystal was also seen in the mixture, which confirmed the study’s results. The mix with TYPE 2-Sand (100% recycled sand) revealed inferior results, low stability, and high damage. Thus, 100% recycled sand is not recommended for structural concrete. Full article

Ensuring the long-term integrity of structural materials in extreme environments is a critical challenge in the design of equipment for nuclear fuel cycle operations. In particular, the durability of materials exposed to high temperatures and chemically aggressive environments during the processing of irradiated reactor components remains a key concern. This study investigates the high-temperature corrosion behavior of 12Cr18Ni10Ti austenitic stainless steel in the reaction chamber of a beryllium chlorination plant developed for recycling irradiated beryllium reflectors from the JMTR (Japan Materials Testing Reactor). The chlorination process was conducted at temperatures ranging from 500 °C to 1000 °C in a chlorine-rich atmosphere. Post-operation analysis of steel samples extracted from the chamber revealed that uniform wall thinning was the predominant degradation mechanism. However, in high-temperature regions near the heating element, localized forms of damage, specifically pitting and intergranular corrosion, were detected, indicating that thermal stresses exacerbated localized attack. These findings contribute to the assessment of the service life of structural components under extreme conditions and offer practical guidance for material selection and design optimization in high-temperature chlorination systems used in nuclear applications. Full article