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22 pages, 17966 KiB  
Article
CTIFERK: A Thermal Infrared Facial Expression Recognition Model with Kolmogorov–Arnold Networks for Smart Classrooms
by Zhaoyu Shou, Yongsheng Tang, Dongxu Li, Jianwen Mo and Cheng Feng
Symmetry 2025, 17(6), 864; https://doi.org/10.3390/sym17060864 (registering DOI) - 2 Jun 2025
Abstract
Accurate recognition of student emotions in smart classrooms is vital for understanding learning states. Visible light-based facial expression recognition is often affected by illumination changes, making thermal infrared imaging a promising alternative due to its robust temperature distribution symmetry. This paper proposes CTIFERK, [...] Read more.
Accurate recognition of student emotions in smart classrooms is vital for understanding learning states. Visible light-based facial expression recognition is often affected by illumination changes, making thermal infrared imaging a promising alternative due to its robust temperature distribution symmetry. This paper proposes CTIFERK, a thermal infrared facial expression recognition model integrating Kolmogorov–Arnold Networks (KANs). By incorporating multiple KAN layers, CTIFERK enhances feature extraction and fitting capabilities. It also balances pooling layer information from the MobileViT backbone to preserve symmetrical facial features, improving recognition accuracy. Experiments on the Tufts Face Database, the IRIS Database, and the self-constructed GUET thermalface dataset show that CTIFERK achieves accuracies of 81.82%, 82.19%, and 65.22%, respectively, outperforming baseline models. These results validate CTIFERK’s effectiveness and superiority for thermal infrared expression recognition in smart classrooms, enabling reliable emotion monitoring. Full article
(This article belongs to the Section Computer)
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24 pages, 583 KiB  
Review
Hear, See, Do (Nothing)? An Integrative Framework of Co-Workers’ Reactions to Interpersonal Workplace Mistreatment
by Caroline Veronique Marijke Bastiaensen, Elfi Baillien and Lieven Brebels
Behav. Sci. 2025, 15(6), 764; https://doi.org/10.3390/bs15060764 (registering DOI) - 2 Jun 2025
Abstract
Interpersonal workplace mistreatment (IWM) is a pervasive issue with varied co-worker reactions. Despite significant growth in IWM research, understanding co-workers’ responses remains challenging due to scattered research streams and a focus on isolated components. Therefore, this integrative review synthesizes the existing literature to [...] Read more.
Interpersonal workplace mistreatment (IWM) is a pervasive issue with varied co-worker reactions. Despite significant growth in IWM research, understanding co-workers’ responses remains challenging due to scattered research streams and a focus on isolated components. Therefore, this integrative review synthesizes the existing literature to examine when and how co-workers respond to IWM. We identify key factors influencing both the intention and actual behavior of co-workers when initially witnessing IWM. These factors are categorized into eight overarching individual (perceived responsibility, emotion and affect, personal characteristics) and contextual themes (social relationships, risks and costs considerations, workplace characteristics, target characteristics, characteristics of the perpetrator and the act of IWM). By integrating these factors into a comprehensive framework drawing on dual processing accounts, we highlight the complex interplay between cognitive and affective processes in shaping co-worker responses. Understanding these dynamics is crucial for designing effective intervention programs that encourage co-workers to counteract IWM. Our findings offer valuable theoretical insights and practical implications for fostering a more supportive and just workplace environment. Full article
(This article belongs to the Special Issue Preventing and Addressing Negative Behaviors in the Workplace)
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16 pages, 262 KiB  
Article
Cultural Codes of Marriage Rituals in Anatolia: From Ritual to Word in the Context of Oral Culture
by Atila Kartal
Religions 2025, 16(6), 716; https://doi.org/10.3390/rel16060716 (registering DOI) - 2 Jun 2025
Abstract
Marriage is a social contract that carries a number of qualities recognized as having fundamental values. These qualities include a spiritual bond between spouses, mutual love, affection, and responsibility, the continuation of the generation, and the existence of social order. The social definition [...] Read more.
Marriage is a social contract that carries a number of qualities recognized as having fundamental values. These qualities include a spiritual bond between spouses, mutual love, affection, and responsibility, the continuation of the generation, and the existence of social order. The social definition of marriage implies that it is a phenomenon that occurs not only between two individuals in the context of cultural continuity but also in other social structures. It evolves into a structure that encompasses not only the initial two families but also the broader societal context. In Islamic marriage, a contract is formalized between a man and a woman who meet the religious requirements for marriage. The contract is executed with their consent and in the presence of witnesses. However, from a cultural perspective, marriage embodies a multifaceted structure, influenced by religion, ritual practices, symbols, and traditions. In this study, topics such as oral culture, wedding traditions, and rituals are discussed, and cultural practices are interpreted. This study sheds light on the manner in which marriage rites influence the discourse and actions within the social structure. Such studies are of paramount importance in demonstrating the continuity and vitality of culture, as well as the transformative nature of ritual meanings over time. They underscore the notion that culture is an ever-evolving process of interpretation, a characteristic that is intrinsic to its very essence. These actions, inextricably linked to societal structures, have the potential to give rise to novel symbolic meanings and values at any given juncture. However, it is imperative to recognize that the mere analysis of texts representing oral culture products is insufficient for comprehending their ritual functions, social messages, and emotional dimensions. Consequently, an interdisciplinary approach that incorporates the study of transitional rituals and oral culture is necessary to achieve a more comprehensive understanding. By examining cultural elements from diverse perspectives, we can develop a more comprehensive and nuanced understanding of cultural diversity in Anatolia. Full article
22 pages, 945 KiB  
Article
Beyond the Classroom: The Role of Social Connections and Family in Adolescent Mental Health in the Transylvanian Population of Romania
by Alexandra-Ioana Roșioară, Bogdana Adriana Năsui, Nina Ciuciuc, Dana Manuela Sîrbu, Daniela Curșeu, Ștefan Cristian Vesa, Codruța Alina Popescu and Monica Popa
Medicina 2025, 61(6), 1031; https://doi.org/10.3390/medicina61061031 - 2 Jun 2025
Abstract
Background and Objectives: This study explores gender variations in the associations between lifestyle choices, mental health, and social behaviors among adolescents in the Transylvania region of Romania. The analysis is based on data obtained through the Global School-Based Student Health Survey (GSHS). [...] Read more.
Background and Objectives: This study explores gender variations in the associations between lifestyle choices, mental health, and social behaviors among adolescents in the Transylvania region of Romania. The analysis is based on data obtained through the Global School-Based Student Health Survey (GSHS). Materials and Methods: Data on 900 Romanian adolescents aged 11–18 years were obtained via the GSHS. This study evaluated nutritional statuses through BMI Z-scores, employing World Health Organization (WHO) cut-offs applied to self-reported height and weight; furthermore, it assessed well-being and perceived health; worries and sleep anxiety; social connections through having friends, loneliness, peer support, and emotional support; parental bonding relations; experiences of being bullied; safety and protection factors, including distance learning during the COVID-19 pandemic and testing or vaccinations for COVID-19; and social behaviors, including the use of social networks. A multiple logistic regression was used to predict sleep disturbance anxiety, depending on sex, bullying, cyberbullying, loneliness, social network use, and peer support. Results: Results showed that the majority of the adolescents reported having one or more friends (96.8%), with no significant difference between girls and boys (p = 0.071). There were no statistically significant differences in bullying and cyberbullying experiences between sexes (p = 0.063). Notably, gender disparities exist in both health perceptions and risk behaviors, with girls experiencing higher rates of negative health perceptions, sleep anxiety (p < 0.001), and loneliness (p = 0.011) and boys exhibiting more overweight/obesity (p < 0.001) and school truancy (p = 0.027). According to the results, loneliness is significantly associated with a higher likelihood of sleep-disturbing anxiety (p < 0.001). Students who have experienced cyberbullying are more likely to also experience traditional bullying. Students who feel lonely are more likely to be victims of bullying. Conclusions: This study reveals significant gender disparities in adolescent health, particularly in mental health, risk behaviors, and social support. It highlights the need for gender-specific interventions to address these challenges and promote healthy development. Furthermore, this study emphasizes the importance of social connections, family support, and parental involvement in adolescent well-being. Addressing bullying, promoting mental health awareness, and providing accessible support services are crucial for improving adolescent health in Romania. Full article
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15 pages, 952 KiB  
Systematic Review
The Impact of ICT on Primary School Students’ Natural Science Learning in Support of Diversity: A Meta-Analysis
by José Gabriel Soriano-Sánchez
Educ. Sci. 2025, 15(6), 690; https://doi.org/10.3390/educsci15060690 (registering DOI) - 2 Jun 2025
Abstract
In recent years, studies analyzing how information and communication technologies (ICTs) contribute to the development of students with special educational needs (SENs) have gained interest. The proliferation of studies in this field has driven the creation of numerous digital resources that can be [...] Read more.
In recent years, studies analyzing how information and communication technologies (ICTs) contribute to the development of students with special educational needs (SENs) have gained interest. The proliferation of studies in this field has driven the creation of numerous digital resources that can be applied in science teaching. Therefore, this study aims to conduct a systematic review of the literature on the usefulness of ICT in teaching Natural Sciences in Primary Education to address diversity. The methodology used for this systematic review and meta-analysis followed PRISMA guidelines, drawing data from the Scopus and Web of Science databases. A total of three documents were analyzed. The results indicated a favorable effect for the experimental groups (I2 = 84; p = 0.002). These findings show that the use of ICT enhances participation and motivation among Primary School students with SENs in Natural Sciences. In conclusion, ICT positively influences learning in Natural Sciences by increasing motivation among Primary School students with SENs. This meta-analysis highlights the importance and positive impact of ICT on Natural Sciences learning in Primary Education, especially in support of student diversity. The reviewed evidence confirms that personalizing learning through adaptive systems, using methodologies based on individual learning styles, and employing innovative technologies significantly enhance academic performance, motivation, and student engagement. The effective use of ICTs for inclusion in primary school science relies on the design of instructional methods that link technology, emotions, and diversity. Full article
(This article belongs to the Section Special and Inclusive Education)
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13 pages, 218 KiB  
Article
A Diagnosis or a Trap: Exploring the Psychosocial and Ethical Impacts of Autosomal Dominant Polycystic Kidney Disease Diagnosis
by Mert Türk and Cuma Bülent Gül
Healthcare 2025, 13(11), 1316; https://doi.org/10.3390/healthcare13111316 - 2 Jun 2025
Abstract
Objective: This study aimed to explore the emotional, social, and ethical dimensions of early or presymptomatic diagnosis in individuals with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Methods: A total of 118 participants diagnosed with ADPKD were recruited from a tertiary nephrology [...] Read more.
Objective: This study aimed to explore the emotional, social, and ethical dimensions of early or presymptomatic diagnosis in individuals with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Methods: A total of 118 participants diagnosed with ADPKD were recruited from a tertiary nephrology center in Türkiye. Data were collected via a 22-item structured and open-ended questionnaire. Chi-square and non-parametric statistical tests were used to assess associations between awareness, attitudes, and demographic variables. Results: Although only 10% of participants reported direct disadvantages from their diagnosis, such as difficulties in employment, insurance, or relationships, many voiced concerns about stigma and long-term uncertainties. Genetic awareness was significantly associated with increased likelihood of recommending family screening (p = 0.022), and higher educational attainment correlated with greater disease knowledge (p < 0.01). Despite emotional burden, 71.2% of participants reported adopting lifestyle modifications, and 79.6% expressed willingness to screen their children, though often with ethical hesitation. Conclusions: While early diagnosis of ADPKD may offer clinical benefits, it also introduces complex psychosocial and ethical dilemmas. These findings highlight the importance of integrating patient-centered counseling, clear communication strategies, and supportive policies to ensure informed decision making and mitigate potential harms. Full article
(This article belongs to the Section Health Assessments)
18 pages, 2855 KiB  
Article
Visual Environment Effects on Wayfinding in Underground Spaces
by Jupeng Wu and Soobeen Park
Buildings 2025, 15(11), 1918; https://doi.org/10.3390/buildings15111918 - 2 Jun 2025
Abstract
This study investigates how visual environmental factors influence wayfinding behavior in underground spaces, with a particular focus on cultural differences between Korean and Chinese college students. A virtual reality (VR) environment was developed using Unity3D to simulate an underground space, incorporating five key [...] Read more.
This study investigates how visual environmental factors influence wayfinding behavior in underground spaces, with a particular focus on cultural differences between Korean and Chinese college students. A virtual reality (VR) environment was developed using Unity3D to simulate an underground space, incorporating five key visual variables: passage width, brightness, color temperature (warm vs. cool), the presence or absence of obstacles, and the configuration of sign systems. Participants were divided into two groups—Korean (Group K) and Chinese (Group C)—and engaged in a VR-based wayfinding experiment followed by an emotional vocabulary evaluation. The results indicate significant cultural differences in spatial perception and navigation preferences. Chinese participants preferred narrower, brighter, and cool-colored passages, associating them with an improved sense of direction, lower stress, and enhanced attention. In contrast, Korean participants favored wider, darker, and warm-colored passages, valuing accessibility, stability, and distance perception. Both groups showed a strong preference for environments with floor signage and combined sign systems, though Korean participants were more tolerant of obstacles. These findings provide practical insights for designing more inclusive and navigable underground public spaces across different cultural contexts. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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19 pages, 757 KiB  
Systematic Review
Social Cognition in Suicidal Behavior in Psychosis: A Systematic Review
by María Carcedo Herrero, Aina Sastre-Buades and Maria Luisa Barrigón
Behav. Sci. 2025, 15(6), 759; https://doi.org/10.3390/bs15060759 (registering DOI) - 1 Jun 2025
Abstract
Suicide is a major concern worldwide, especially in psychotic disorders that have an increased risk for suicidal behavior (SB). There are many well-established risk factors for SB in psychosis. Still, others, such as the domains of social cognition (SC)—the theory of mind, social [...] Read more.
Suicide is a major concern worldwide, especially in psychotic disorders that have an increased risk for suicidal behavior (SB). There are many well-established risk factors for SB in psychosis. Still, others, such as the domains of social cognition (SC)—the theory of mind, social perception, emotional processing, and attributional style—are unclarified. We aim to review evidence on SC and SB in psychosis and clarify their relationship, examining the differences between SC domains and the potential mediating variables in this relationship and proposing that worse performance in regard to SC is related to a higher risk of suicide. We searched databases for papers on SC and SB published between 2009 and 2024, resulting in the 18 articles included in this systematic review. Individuals with psychotic disorders and SB showed better emotional processing for basic emotional recognition—although they performed poorly on more complex tasks—and exhibited greater empathy within the affective theory of mind. Cognitive biases associated with attributional style and increased distrust as part of social perception were also found. Our findings cannot establish a relationship with the cognitive theory of mind. So, further studies are needed to integrate all domains of SC in longitudinal studies and examine the mediating variables of these relationships. Full article
(This article belongs to the Special Issue Suicidal Behaviors: Prevention, Intervention and Postvention)
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12 pages, 268 KiB  
Article
Orthorexic Tendencies Are Associated with Autistic Traits in Patients with Borderline Personality Disorder
by Liliana Dell’Osso, Benedetta Nardi, Federico Giovannoni, Chiara Bonelli, Gabriele Massimetti, Ivan Mirko Cremone, Stefano Pini and Barbara Carpita
J. Clin. Med. 2025, 14(11), 3891; https://doi.org/10.3390/jcm14113891 (registering DOI) - 1 Jun 2025
Abstract
Background/Objectives: Orthorexia Nervosa (ON), a condition marked by an obsessive focus on eating healthily, has drawn increasing clinical attention due to its rigid dietary patterns and social impairment. Borderline Personality Disorder (BPD), characterized by emotional dysregulation, impulsivity, and unstable interpersonal relationships, frequently [...] Read more.
Background/Objectives: Orthorexia Nervosa (ON), a condition marked by an obsessive focus on eating healthily, has drawn increasing clinical attention due to its rigid dietary patterns and social impairment. Borderline Personality Disorder (BPD), characterized by emotional dysregulation, impulsivity, and unstable interpersonal relationships, frequently co-occurs with eating disorders. Recent research suggests that autistic traits—such as cognitive rigidity and restricted interests—may underlie both ON and BPD, especially in female populations. This study aimed to assess the prevalence of orthorexic tendencies in patients with BPD compared to healthy controls (HCs) and to explore their associations with autistic traits and disordered eating behaviors. Methods: This study involved 73 BPD patients and 52 HCs. Participants completed the Adult Autism Subthreshold (AdAS) Spectrum, Eating Disorder Inventory-2 (EDI-2), and the ORTO-15 questionnaire. Results: BPD patients scored significantly higher than HCs on AdAS Spectrum and EDI-2, and significantly lower on ORTO-15, indicating more pronounced autistic traits, disordered eating behavior, and orthorexic tendencies. A greater proportion of BPD individuals reported clinically relevant ON symptoms according to the ORTO-15 threshold. Orthorexic symptoms were significantly correlated with most EDI-2 and all AdAS Spectrum domains. Regression analysis revealed that autistic traits, but not feeding and eating disorder symptoms, significantly predicted orthorexic tendencies. Conclusions: Orthorexic tendencies are more prevalent in individuals with BPD and are significantly associated with autistic traits. These findings suggest that ON may represent a manifestation of the autism spectrum, particularly in individuals with BPD, and support a reconceptualization of ON within a neurodevelopmental framework. Recommendation: Future research is needed in order to clarify the temporal and causal relationships among autistic traits, BPD symptomatology, and the emergence of orthorexic behaviors. Full article
(This article belongs to the Section Mental Health)
13 pages, 513 KiB  
Article
“We Report to Traditional Leaders, but Patriarchy Means We Rarely Win the Case”: Gender-Based Violence and Women’s Wellness in Rural South Africa
by Casey Joyce Mabasa, Gudani Goodman Mukoma and Bumani Solomon Manganye
Int. J. Environ. Res. Public Health 2025, 22(6), 887; https://doi.org/10.3390/ijerph22060887 (registering DOI) - 31 May 2025
Abstract
Background: Gender-based violence has serious health impacts on survivors and is perpetuated by cultural norms, patriarchy, and traditional values. This study explored women’s (survivors) views, attitudes and the impact of gender-based violence on their health in a selected rural village within the Collins [...] Read more.
Background: Gender-based violence has serious health impacts on survivors and is perpetuated by cultural norms, patriarchy, and traditional values. This study explored women’s (survivors) views, attitudes and the impact of gender-based violence on their health in a selected rural village within the Collins Chabane Municipality, Vhembe District, Limpopo Province. Methods: A qualitative descriptive design was used, involving 20 women aged 18 to 59. Semi-structured in-depth interviews were conducted, and data were analysed thematically using ATLAS.ti 8, based on Braun and Clarke’s six-step framework. Ethical considerations were prioritised due to the sensitive nature of the research. Results: The results revealed that women in the Collins Chabane Municipality experience multiple forms of GBV, including physical, sexual, emotional, and financial abuse, which severely impacts their mental and physical health. Additionally, socioeconomic factors like unemployment and financial dependence exacerbate their vulnerability, making it difficult to escape abusive relationships. Conclusions: Cultural norms, patriarchal beliefs, and limited community support intersect to shape women’s experiences and responses to abuse. Full article
18 pages, 623 KiB  
Article
The Mediating Role of Mental Toughness in the Relationship Between Burnout and Perceived Stress Among Hungarian Coaches
by Eszter Bíró and László Balogh
Sports 2025, 13(6), 174; https://doi.org/10.3390/sports13060174 - 31 May 2025
Viewed by 45
Abstract
This study aimed to explore the relationship between perceived stress, burnout, and mental toughness, and investigate how mental toughness mediates the relationship between perceived stress and burnout among Hungarian coaches. Three hundred and thirty-three active coaches completed anonymous self-report questionnaires assessing burnout (CBQ), [...] Read more.
This study aimed to explore the relationship between perceived stress, burnout, and mental toughness, and investigate how mental toughness mediates the relationship between perceived stress and burnout among Hungarian coaches. Three hundred and thirty-three active coaches completed anonymous self-report questionnaires assessing burnout (CBQ), mental toughness (SMTQ), and perceived stress (PSS). In the international comparison, Hungarian coaches indicated significantly higher burnout levels than those investigated in previous international research. PLS-SEM results showed that coaches with higher stress levels are less likely to experience burnout. Furthermore, mental toughness serves as a buffer between stress and burnout; however, the buffering effects of its various subfactors on different dimensions of coaching burnout vary. Consequently, further research is necessary to fully understand the mitigating effects of mental toughness, particularly by analyzing coping strategies, motivation, and success. Our research unequivocally indicates that the integration of targeted stress management training into coaching education is crucial for effectively addressing the emotional challenges inherent in the profession. By incorporating workshops that focus on self-awareness and emotion regulation strategies, coaching programs can substantially reduce the risk of burnout and promote the well-being of coaches. These findings underscore the vital importance of embedding practical stress management interventions within coach development initiatives to cultivate more resilient and effective coaching professionals. Full article
12 pages, 246 KiB  
Article
Soil Eating as a Psychological Coping Strategy for Women in Rural African Patriarchal Contexts
by Libopuoa Notsi and Mamochana Anacletta Ramatea
Int. J. Environ. Res. Public Health 2025, 22(6), 876; https://doi.org/10.3390/ijerph22060876 (registering DOI) - 31 May 2025
Viewed by 55
Abstract
In African patriarchal contexts, women have borne the dual responsibilities of mental and physical caregiving for their households and communities. These responsibilities often contribute to significant emotional, social, and economic burdens imposed by deeply entrenched gender and power structures. Alternative psychological coping mechanisms [...] Read more.
In African patriarchal contexts, women have borne the dual responsibilities of mental and physical caregiving for their households and communities. These responsibilities often contribute to significant emotional, social, and economic burdens imposed by deeply entrenched gender and power structures. Alternative psychological coping mechanisms emerge to navigate these challenges, some deeply rooted in cultural and historical practices. One such practice is soil eating, which has been observed in various African communities. Historically linked to cultural and spiritual beliefs, soil eating has been largely unexplored from a psychological perspective. This paper examined soil eating as a coping strategy among women in Africa, investigating its role as a means of emotional relief, resistance, or a symbolic reclamation of agency in the face of oppression. Drawing on the indigenous knowledge systems (IKS) of eZiko siPheka siSophula as a psychological framework, this study engaged sixteen women aged 20 to 89 in Ha Makintane Lesotho to participate in focus group discussions and reveal their personal narratives, cultural traditions, and the intersections of gender, race, and class to understand how this practice helps them manage their mental and emotional toll of patriarchal dominance. This research contributes to discussions on resilience, survival, and the psychological strategies developed by marginalized communities, shedding light on the complex interplay between cultural practices, mental health, and gendered experiences of power. Full article
24 pages, 1131 KiB  
Article
Impact of a Brief Family Skills Training Programme “Strong Families” in a Low–Middle-Income-Country: Cambodia
by Aala El-Khani, Dina Idriss-Wheeler, Santana Chea, Shatha Darwish and Wadih Maalouf
Children 2025, 12(6), 728; https://doi.org/10.3390/children12060728 (registering DOI) - 31 May 2025
Viewed by 69
Abstract
Introduction: Children living in low- and middle-income countries (LMICs) are at increased risk of emotional and behavioural challenges, often linked to caregiver stress and harsh parenting practices. Strengthening family functioning through parenting interventions is a critical strategy for improving child mental health in [...] Read more.
Introduction: Children living in low- and middle-income countries (LMICs) are at increased risk of emotional and behavioural challenges, often linked to caregiver stress and harsh parenting practices. Strengthening family functioning through parenting interventions is a critical strategy for improving child mental health in these settings. The Strong Families programme was developed as a light-touch family skills intervention for high-stress, low-resource environments. Methods: A multisite pilot feasibility and acceptability study was conducted in Cambodia with 40 families. Caregivers and children (aged 8–15) participated in a 3-week intervention, with one session per week. Data were collected using the Parenting and Family Adjustment Scales (PAFAS), the Strengths and Difficulties Questionnaire (SDQ), and the Child and Youth Resilience Measure (CYRM-R) at baseline, two weeks, and six weeks post-intervention. Repeated measures ANOVA and Friedman’s ANOVA were used to assess changes over time. Results: Caregivers showed statistically significant improvements across all PAFAS subscales. For example, coercive parenting scores decreased from 8.13 at baseline to 4.00 post-intervention and 2.33 at follow-up (F(2,78) = 59.76, p < 0.001). Positive encouragement improved from 2.60 to 1.00 and 0.33, respectively (F(2,78) = 27.05, p < 0.001). In terms of child outcomes, SDQ total difficulty scores declined from 20.68 to 16.55 over time (F(2,78) = 7.58, p = 0.001). Emotional problems dropped from 5.60 to 2.38 (χ2(2) = 21.17, p < 0.001), and conduct problems from 4.33 to 2.68 (F(2,78) = 11.35, p < 0.001). Prosocial behaviours increased from 5.60 to 9.45 (F(2,78) = 69.93, p < 0.001). Personal resilience scores rose from 32.70 at baseline to 47.48 at follow-up (χ2(2) = 62.42, p < 0.001), while caregiver resilience improved from 23.63 to 33.63 (χ2(2) = 61.83, p < 0.001). Improvements were particularly pronounced among families with the highest baseline challenges. Conclusions: Findings indicate that the Strong Families programme is feasible and effective in improving parenting skills, family adjustment, child mental health, and resilience in a Cambodian LMIC context. These results reinforce the programme’s potential for integration into broader national strategies to improve psychosocial outcomes for families in high-stress, low-resource environments. Full article
(This article belongs to the Special Issue Advances in Child–Parent Attachment and Children's Peer Relations)
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23 pages, 1687 KiB  
Article
Cannabinoid Modulation of Excitability and Short-Term Neuronal Dynamics in the Dorsal and Ventral Hippocampus
by Giota Tsotsokou, Ioanna-Maria Sotiropoulou, Klearchos Stampolitis, George D. Oikonomou, Aikaterini-Paraskevi Avdi and Costas Papatheodoropoulos
Biology 2025, 14(6), 642; https://doi.org/10.3390/biology14060642 (registering DOI) - 31 May 2025
Viewed by 57
Abstract
Endocannabinoids, acting primarily through CB1 receptors, are critical modulators of neuronal activity, influencing cognitive functions and emotional processing. CB1 receptors are highly expressed in the hippocampus, primarily on GABAergic interneurons, modulating the excitation/inhibition balance. Previous evidence suggests the functional heterogeneity of CB1 receptors [...] Read more.
Endocannabinoids, acting primarily through CB1 receptors, are critical modulators of neuronal activity, influencing cognitive functions and emotional processing. CB1 receptors are highly expressed in the hippocampus, primarily on GABAergic interneurons, modulating the excitation/inhibition balance. Previous evidence suggests the functional heterogeneity of CB1 receptors along the dorsoventral axis of the hippocampus. However, it is not known whether CB1 receptors differentially modulate basic aspects of the local neuronal network along the hippocampus. This study investigated how CB1 receptor activation modulates excitability, paired-pulse inhibition (PPI), and short-term neuronal dynamics (STND) in the dorsal and ventral CA1 hippocampus under physiologically relevant conditions. Using extracellular recordings from hippocampal slices of male Wistar rats, we compared the effects of two CB1 receptor agonists, ACEA and WIN55,212-2, on network activity in the dorsal and ventral hippocampus. We found that both agonists significantly increased excitability and reduced PPI in the dorsal, but not the ventral, hippocampus. Similarly, CB1 receptor activation modulated STND more prominently in the dorsal hippocampus, reducing facilitation at low frequencies and reversing depression at high frequencies, whereas effects on the ventral region were minimal. These dorsoventral differences in the actions of cannabinoid receptor agonists occurred despite similar CB1 receptor expression levels in both regions, suggesting that functional differences arise from downstream mechanisms rather than receptor density. Pre-application of the GIRK channel blocker Tertiapin-Q occluded the effects of WIN55,212-2 on STND, indicating a significant role of GIRK channel-mediated signaling in CB1 receptor actions. These findings demonstrate that CB1 receptors modulate hippocampal circuitry in a region-specific manner, with the dorsal hippocampus being more sensitive to cannabinoid signaling, likely through differential engagement of intracellular signaling pathways such as GIRK channel activation. These results provide novel insights into how endocannabinoid signaling differentially regulates neuronal dynamics along the dorsoventral axis of the hippocampus. They also have important implications for understanding the role of cannabinoids in hippocampus-dependent behaviors. Full article
(This article belongs to the Section Neuroscience)
19 pages, 5895 KiB  
Article
Brain Structural Correlates of EEG Network Hyperexcitability, Symptom Severity, Attention, and Memory in Borderline Personality Disorder
by Andrea Schlump, Bernd Feige, Swantje Matthies, Katharina von Zedtwitz, Isabelle Matteit, Thomas Lange, Kathrin Nickel, Katharina Domschke, Marco Reisert, Alexander Rau, Markus Heinrichs, Dominique Endres, Ludger Tebartz van Elst and Simon Maier
Brain Sci. 2025, 15(6), 592; https://doi.org/10.3390/brainsci15060592 (registering DOI) - 31 May 2025
Viewed by 52
Abstract
Introduction: Previous neuroimaging studies have reported structural brain alterations and local network hyperexcitability in terms of increased slow-wave electroencephalography (EEG) activity in patients with borderline personality disorder (BPD). In particular, intermittent rhythmic delta and theta activity (IRDA/IRTA) has drawn attention in mental [...] Read more.
Introduction: Previous neuroimaging studies have reported structural brain alterations and local network hyperexcitability in terms of increased slow-wave electroencephalography (EEG) activity in patients with borderline personality disorder (BPD). In particular, intermittent rhythmic delta and theta activity (IRDA/IRTA) has drawn attention in mental health contexts due to its links with metabolic imbalances, neuronal stress, and emotional dysregulation—processes that are highly pertinent to BPD. These functional disturbances may be reflected in corresponding structural brain changes. The current study investigated cortical thickness and subcortical volumes in BPD and examined their associations with IRDA/IRTA events per minute, symptom severity, and neuropsychological measures. Methods: Seventy female BPD patients and 36 age-matched female healthy controls (HC) were included (for clinical EEG comparisons even 72 patients were available). IRDA/IRTA rates were assessed using an automatic independent component analyses (ICA) approach. T1-weighted MRI data were obtained using a MAGNETOM Prisma 3T system and analyzed with FreeSurfer (version 7.2) for subcortical structures and CAT12 for cortical thickness and global volume measurements. Psychometric assessments included questionnaires such as Borderline Symptom List (BSL-23) and Inventory of Personality Organization (IPO). Neuropsychological performance was evaluated with the Test for Attentional Performance (TAP), Culture Fair Intelligence Test (CFT-20-R), and Verbal Learning and Memory Test (VLMT). Results: Between-group comparisons exhibited no significant increase in IRDA/IRTA rates or structural abnormalities between the BPD and HC group. However, within the BPD group, cortical thickness of the right isthmus of the cingulate gyrus negatively correlated with the IRDA/IRTA difference (after minus before hyperventilation, HV; p < 0.001). Furthermore, BPD symptom severity (BSL-23) and IPO scores positively correlated with the thickness of the right rostral anterior cingulate cortex (p < 0.001), and IPO scores were associated with the thickness of the right temporal pole (p < 0.001). Intrinsic alertness (TAP) significantly correlated with relative cerebellar volume (p = 0.01). Discussion: While no group-level structural abnormalities were observed, correlations between EEG slowing, BPD symptom severity, and alertness with cortical thickness and/or subcortical volumes suggest a potential role of the anterior cingulate cortex, temporal pole, and cerebellum in emotion regulation and cognitive functioning in BPD. Future research employing multimodal EEG-MRI approaches may provide deeper insights into the neural mechanisms underlying BPD and guide personalized therapeutic strategies. Full article
(This article belongs to the Special Issue Application of MRI in Brain Diseases)
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