Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition

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Guest Editor
Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
Interests: autonomic nervous system; cardiovascular diseases; neurogenic hypertension; cardiac autonomic modulation; heart rate variability; dysautonomia
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Dear Colleagues,

The autonomic nervous system (ANS) regulates involuntary physiological processes and is essential in controlling most of the body's organ systems through a series of neural reflexes. It is also responsible for modulating and adapting the function of all organs to constantly changing external and internal conditions to maintain the body's homeostasis.

Dysfunctions of the autonomic nervous system are associated with the development of various diseases and underlie major, common internal and neurological conditions (such as diabetes, hypertension, and Parkinson's disease). Recently, neuromodulatory techniques have emerged as potential therapeutic approaches for the complete or partial treatment of autonomic disorders. Additionally, the ANS has been shown to be involved in the co-modulation of body functions, together with the immune system, the neuroendocrine system, and the inflammatory system, thus forming an important interface between the central nervous system, the environment, and the development of chronic non-communicable diseases. 

This Special Issue aims to gather reviews and original research articles that provide up-to-date information and future perspectives on various areas of ANS physiology and clinical medicine that affect all levels of autonomic function. In this second edition, emphasis will also be placed on describing the molecular mechanisms that may underlie autonomic dysfunction.

We invite you to contribute to this Special Issue, covering all aspects of the autonomic nervous system in humans and animals, including functional anatomy; physiology; pharmacology and therapeutics; behavioural aspects; neuromodulation; dysfunction and ageing of autonomic neurons and their circuits; as well as the integrative role and emotional, physical, and motivational aspects of autonomic regulation.

We look forward to receiving your contributions.

Dr. Vera Geraldes
Dr. Isabel Rocha
Guest Editors

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Keywords

  • dysautonomia
  • heart rate variability
  • autonomic function testing
  • cardiovascular autonomic function
  • autonomic neuroscience
  • syncope
  • orthostatic hypotension
  • baroreflex
  • autonomic molecular mechanisms

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Published Papers (1 paper)

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Review

22 pages, 617 KB  
Review
Mapping the Neurophysiological Link Between Voice and Autonomic Function: A Scoping Review
by Carmen Morales-Luque, Laura Carrillo-Franco, Manuel Víctor López-González, Marta González-García and Marc Stefan Dawid-Milner
Biology 2025, 14(10), 1382; https://doi.org/10.3390/biology14101382 - 10 Oct 2025
Viewed by 154
Abstract
Vocal production requires the coordinated control of respiratory, laryngeal, and autonomic systems. In individuals with high vocal demand, this physiological load may influence autonomic regulation, even in the absence of voice disorders. This scoping review systematically mapped current evidence on the relationship between [...] Read more.
Vocal production requires the coordinated control of respiratory, laryngeal, and autonomic systems. In individuals with high vocal demand, this physiological load may influence autonomic regulation, even in the absence of voice disorders. This scoping review systematically mapped current evidence on the relationship between voice production and autonomic nervous system (ANS) activity in adults, focusing exclusively on studies that assessed both systems simultaneously. A systematic search was conducted in PubMed, Scopus, Web of Science, Embase, and CINAHL, following PRISMA-ScR guidelines. Eligible studies included adults performing structured vocal tasks with concurrent autonomic measurements. Data were extracted and synthesized descriptively. Fifteen studies met the inclusion criteria. Most involved healthy adults with high vocal demand, while some included participants with subclinical or functional voice traits. Vocal tasks ranged from singing and sustained phonation to speech under cognitive or emotional load. Autonomic measures included heart rate (HR), heart rate variability (HRV), and electrodermal activity (EDA), among others. Four thematic trends emerged: autonomic synchronization during group vocalization; modulation of autonomic tone by vocal rhythm and structure; voice–ANS interplay under stress; and physiological coupling in hyperfunctional vocal behaviours. This review’s findings suggest that vocal activity can modulate autonomic function, supporting the potential integration of autonomic markers into experimental and clinical voice research. Full article
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