Search Results (19,741)

The Lunayyir Volcanic Field (Harrat Lunayyir), located on the western boundary of the Arabian Microplate, comprises a Quaternary volcanic region featuring approximately 150 volcanoes formed from around 700 vents. In 2009, a significant volcano-seismic event occurred, resulting in the formation of a nearly 20 km long fissure. Geophysical modeling has demonstrated that this area lies above an eruptible magma system, unequivocally confirming ongoing volcanic activity. Recent geological mapping and age determinations have further established the field as a young Quaternary volcanic landscape. Notably, the 2009 event provided critical evidence of the region’s volcanic activity and underscored the potential to connect its volcanic geoheritage with hazard mitigation strategies. The volcanic field displays diverse features, including effusive eruptions—primarily pāhoehoe and ‘a‘ā lava flows—and explosive structures such as spatter ramparts and multi-crater scoria cones. While effusive eruptions are most common and exert long-term impacts, explosive eruptions tend to be less intense; however, some events have reached a Volcanic Explosivity Index (VEI) of 4, distributing ash up to 250 km. Recognizing the geoheritage and geodiversity of the area may enhance resilience to volcanic hazards through geoconservation, educational initiatives, managed visitation, and establishment of a geoheritage reserve to preserve site conditions. Hazards associated with this dispersed monogenetic volcanic field manifest with recurrence intervals ranging from centuries to millennia, presenting challenges for effective communication. Although eruptions are infrequent, they have the potential to impact regional infrastructure. Documentation of volcanic geoheritage supports hazard communication efforts. Within the northern development sector, 26 geosites have been identified, 22 of which pertain to the Quaternary basaltic volcanic field, each representing a specific hazard and contributing vital information for resilience planning. Full article

Many intrinsically disordered proteins (IDPs) are known to undergo liquid–liquid phase separation (LLPS), which is a physical process that drives the formation of biomolecular condensates and membraneless organelles in biological cells. Molecular dynamics (MD) simulations provide valuable tools to explore both the molecular mechanisms of LLPS and the physical properties of biomolecular condensates. However, a direct comparison of MD simulation results with phase diagrams obtained experimentally is normally prevented not only by the high computational costs of simulating large biomacromolecular systems on sufficient timescales but also by conceptual challenges. Specifically, there currently seems to be no standard or unambiguous method of defining and determining volumes occupied by coexisting phases at the nanoscale, with typically no more than a few hundred biomacromolecules in the simulation box. The goal of this work is to fill in this gap in the methodology. Focusing on $\alpha$-synuclein as a model IDP, we test and compare three methods for determining the molecular density of protein nanodroplets, or clusters, generated in MD simulations or using other molecular modeling approaches. Two of the methods are based on approximating nanodroplets with homogeneous spheres and ellipsoids, respectively. The third method, which is expected to yield the most physically accurate results, is based on the SPACEBALL algorithm, with optimized, cluster-specific radii for volume probes. Our results contribute to the construction of accurate phase diagrams on the basis of MD simulations of IDP systems. Full article

Background/Objectives: Effective clinical handover is a critical component of nursing care, particularly in mental health settings, where the transfer of clinical and behavioral information is essential for both patients’ and health personnel’s safety. Gamification has emerged as a promising strategy to enhance clinical education, yet few interventions have focused specifically on mental health care contexts. This study aimed to evaluate the effectiveness of a serious game designed to teach the SBAR (Situation, Background, Assessment, Recommendation) handover framework to undergraduate nursing students through a psychiatric care unit scenario. Methods: A quasi-experimental pre–post design was employed with a convenience sample of 48 nursing students from a Northern Italian university. Participants completed a test assessing their ability to organize clinical information according to the SBAR model before and after the game intervention. Students’ experience was assessed using the Player Experience Inventory. Results: A statistically significant improvement in SBAR application was observed post-intervention. The majority of students reported a positive experience across PXI domains such as Meaning, Challenge, Progress Feedback, and Enjoyment. Comparisons with a previously validated video-based nursing serious game showed a consistent overall pattern in response trends. Conclusions: The SG was an effective and engaging educational tool for improving structured handover skills in nursing students. Gamification may represent a valuable complement to traditional instruction in nursing education, especially in high-communication clinical areas such as mental health. Further research is needed to assess long-term retention and to explore more immersive formats. Full article

Compared with conventional RC frame buildings, staggered-story frame buildings are prone to the formation of short columns due to the vertical staggering of beam members, which exerts an adverse impact on the seismic performance of the building. Therefore, steel tube-reinforced concrete (ST-RC) columns are usually adopted to address the issue of the insufficient ductility of short columns. For this purpose, to investigate the seismic performance of partial staggered-story RC frame buildings, an elastic–plastic model is established based on a specific practical building, with ST-RC columns installed in the staggered-story area. By varying the confinement coefficients of the ST-RC columns (1.087, 1.152, 1.224, and 1.307) and classifying the member-level performance states, the seismic performance of ST-RC columns in staggered-story buildings under different confinement coefficients is evaluated. The research results indicate the following: in the statistical analysis of the performance states of the positive sections of the ST-RC columns, the degree of damage of the ST-RC columns first decreases and then increases sharply with an increase in the confinement coefficient, and the member damage is minimized when the confinement coefficient is 1.224. In the statistical analysis of the performance states of the inclined sections of the ST-RC columns, the damage state of the ST-RC columns shows a decreasing trend as the confinement coefficient increases; when the confinement coefficients are 1.224 and 1.307, the ST-RC columns are completely in the elastic state. With an increase in the confinement coefficient, the shear force borne by the ST-RC columns first increases and then decreases, while the tensile strain and compressive strain generally show a decreasing trend. When the confinement coefficient is 1.224, the tensile strain and compressive strain of the ST-RC columns are the smallest. Therefore, when arranging ST-RC columns in staggered-story buildings, it is necessary to select an appropriate confinement coefficient according to the actual project conditions to maximize the ductility of the short columns. Full article

In the process of heat contact sealing of thin, flexible polymer films, the choice of the film material, the layer structure, the sealing tools, and the process parameters influence the melt flow. A pronounced melt flow dynamic, which is to be expected in industrial applications due to the high temperatures and pressures, favors the formation of sealing edges that negatively affect the user-friendliness when opening the packaging. In this study, the influence of seal seam formation on the opening behavior was systematically investigated by numerical simulation. A detailed model was developed that simulates the seam opening process, accounting for the composite structure, the detailed geometry of the seal seam, and the separation process. The numerical results of the force-offset behavior showed good agreement with experimental data. Parameter studies revealed that the thicker and more pronounced seal seams lead to higher tear-off forces, while thinner and less pronounced seams result in lower forces. These findings provide valuable insights into the interactions between seam formation and the mechanical behavior of flexible films, enabling the optimization of sealing processes for improved package performance. Full article

Increasing the frequency and duration of extreme heat events significantly compromises asphalt pavement performance, particularly in critical urban infrastructure such as heavily trafficked pavements, BRT lanes, and intersections subjected to slow-moving heavy traffic under extreme temperatures. This study systematically investigates rutting formation mechanisms through integrated theoretical and numerical approaches, addressing significant knowledge gaps regarding rutting evolution under coupled extreme-temperature (70 °C), heavy-load (100 kN–225 kN), and braking conditions (1 m/s²–7 m/s²). A three-dimensional thermo-mechanical finite element model integrating solar radiation heat transfer with the Bailey–Norton creep law was developed to quantify synergistic effects of axle loads, travel speeds, and braking accelerations. Results demonstrate that when the pavement surface temperature rises from 34 °C to 70 °C, the rutting depth is increased by 4.83 times. When the axle load is increased from 100 kN to 225 kN, the rutting of conventional asphalt pavements under 70 °C is increased by 56.4%. Rutting is exacerbated by braking acceleration; due to prolonged loading duration under low acceleration, the rutting depth is increased by 30–40% compared with that under emergency braking. These findings establish theoretical foundations for optimizing pavement design and material selection in slow-moving heavy-load environments, delivering significant engineering value for transportation infrastructure. Full article

In the context of circular economy, waste generated by fruit processing can be used to produce new materials with a wide range of uses. This study presents a method to synthesize biochar from peach kernel or grape pit waste. The adsorbents were tested in the removal of hexavalent chromium from synthetic wastewater with Cr⁶⁺ concentrations specific to plating processes. Characterization by BET, SEM, FTIR, and TG-DTG confirmed the formation of porous structures, and a well-functionalized surface. The effects of contact time, initial Cr⁶⁺ concentration, and adsorbent dose were investigated in static conditions. Both materials are efficient in hexavalent chromium removal, with sorption equilibrium achieved within 180 min. Kinetic studies indicated that the removal process follows a pseudo-second-order model. Equilibrium studies showed that optimal sorption occurred at pH = 6, with sorption capacities of 78.54 mg/g for biochar from peach kernels and 67.57 mg/g for biochar from grape pits. Hexavalent chromium followed a Sips adsorption isotherm for both biochars. Following the reusability study, it can be concluded that biochar from peach kernels maintains removal efficiency higher than 75% after four cycles. Full article

In extended-reach wells, cuttings bed formation in high-deviation sections presents a major challenge for hole cleaning and borehole stability. This study analyzes the morphological and mechanical behavior of cuttings beds, focusing on particle size distribution and repose angle as key indicators of accumulation behavior. The modeling approach considers dominant interparticle forces, including buoyancy and cohesion, while neglecting secondary microscale forces for clarity. A theoretical model is developed to predict repose angles under both rolling and sliding regimes and is calibrated through laboratory-scale experiments using simulated drilling fluid with field-representative rheological properties. Results show that cohesive effects are negligible when cuttings are of similar size but exhibit higher densities. Laboratory measurements reveal that the repose angle of cuttings beds varies between 23.9° and 31.7°, with increasing polyacrylamide (PAM) concentration and particle size contributing to steeper repose angles. Additionally, the rolling repose angle is found to be relatively stable, ranging from 25° to 30°, regardless of fluid or particle property variations. These findings provide a predictive framework and practical guidelines for optimizing hole cleaning strategies and designing more effective models in extended-reach drilling. Full article

With the increasing deployment of unmanned aerial vehicle (UAV) swarms in scenarios such as disaster response, environmental monitoring, and military reconnaissance, the need for secure and scalable formation control has become critical. Traditional centralized architectures face challenges such as limited scalability, communication bottlenecks, and single points of failure in large-scale swarm coordination. To address these issues, this paper proposes a blockchain-based decentralized formation control framework that integrates smart contracts to manage UAV registration, identity authentication, formation assignment, and positional coordination. The system follows a leader–follower structure, where the leader broadcasts formation tasks via on-chain events, while followers respond in real-time through event-driven mechanisms. A parameterized control model based on dynamic angle and distance adjustments is employed to support various formations, including V-shape, line, and circular configurations. The transformation from relative to geographic positions is achieved using Haversine and Euclidean methods. Experimental validation in a simulated environment demonstrates that the proposed method achieves lower communication latency and better responsiveness compared to polling-based schemes, while offering enhanced scalability and robustness. This work provides a feasible and secure decentralized control solution for future UAV swarm systems. Full article

Tubular aggregate myopathy (TAM) is an inherited skeletal muscle disease associated with progressive muscle weakness, cramps, and myalgia. Tubular aggregates (TAs) are regular arrays of highly ordered and densely packed straight-tubules observed in muscle biopsies; the extensive presence of TAs represent a key histopathological hallmark of this disease in TAM patients. TAM is caused by gain-of-function mutations in proteins that coordinate store-operated Ca²⁺ entry (SOCE): STIM1 Ca²⁺ sensor proteins in the sarcoplasmic reticulum (SR) and Ca²⁺-permeable ORAI1 channels in the surface membrane. Here, we assessed the therapeutic potential of endurance exercise in the form of voluntary wheel running (VWR) in mitigating TAs and muscle weakness in Orai1^G100S/+ (GS) mice harboring a gain-of-function mutation in the ORAI1 pore. Six months of VWR exercise significantly increased specific force production, upregulated biosynthetic and protein translation pathways, and normalized both mitochondrial protein expression and morphology in the soleus of GS mice. VWR also restored Ca²⁺ store content, reduced the incidence of TAs, and normalized pathways involving the formation of supramolecular complexes in fast twitch muscles of GS mice. In summary, sustained voluntary endurance exercise improved multiple skeletal muscle phenotypes observed in the GS mouse model of TAM. Full article

Complete dentures (CD) are prone to biofilm formation, particularly by Candida species, which may lead to denture stomatitis (DS). As edentulism remains highly prevalent among the global ageing population, denture-related infections represent a significant public health concern. The novelty of this study lies in integrating the clinical severity of DS with the prevalence, microbial load, and antifungal susceptibility profile of Candida spp., providing new insights into the pathogenesis and therapeutic management of this condition. Biofilm from the CD and palate was seeded for prevalence and microbial load. The identification of strains was confirmed molecularly, and susceptibility to micafungin, nystatin, fluconazole, and miconazole was assessed by the broth microdilution method. Prevalence was shown in percentage, microbial load was analyzed using a generalized linear model test, and susceptibility was assessed using Pearson’s Chi-square test (p < 0.05). Candida albicans was the most prevalent regardless of DS. However, a higher microbial load of C. albicans was observed with increased severity of DS (p = 0.038). Except for Candida tropicalis, the microbial load of the CD was higher than that of the palate. C. tropicalis showed resistance to fluconazole with increased severity of DS (p = 0.004). All strains were susceptible to nystatin and miconazole, and three were resistant to micafungin. The findings suggest that the prevalence of Candida spp. is not a determining factor in the variation in DS severity. Nevertheless, patients with severe inflammation harbor an increased load of C. albicans on both sites. Nystatin and miconazole appear to be effective treatments for DS. Full article

By modulating the mass ratio of hydrothermal agents to cobalt/iron precursors, Co₃O₄ nanowires were successfully integrated into spinel-type Co/Fe@NF, forming a heterojunction anode for alkaline water electrolysis (AWE) hydrogen production. This Co₃O₄ nanowire-assembled CoFe₂O₄ nanosheet anode (Co/Fe(5:1)@NF) exhibits exceptional electrochemical oxygen evolution reaction (OER) performance, requiring only 221 mV overpotential to achieve 10 mA cm⁻². Sulfamethoxazole (SMX) was employed as a model pollutant to investigate the anode sacrificial material; it achieved approximately 95% SMX degradation efficiency, reducing the OER potential of 50 mV/10 mA cm⁻². SMX oxidation coupled with Co/Fe heterojunction structure partially substitutes the OER. Co/Fe heterojunction generates an internal magnetic field, which induces the formation of novel active species within the system. ·O₂⁻ is the newly formed active oxygen species, which enhanced the proportion of indirect SMX oxidation. Quantitative analysis reveals that superoxide radical-mediated indirect oxidation of SMX accounts for approximately 38.5%, Fe(VI) for 9.4%, other active species for 6.1%, and direct oxidation for 46.0%. The nanowire–nanosheet assembly stabilizes a high-spin configuration on the catalyst surface, redirecting oxygen intermediate pathways toward triplet oxygen (³O₂) generation. Subsequent electron transfer from nanowire tips facilitates rapid ³O₂ reduction, forming superoxide radicals (·O₂⁻). This study effectively driven by indirect oxidation, with cathodic hydrogen production, providing a novel strategy for utilizing renewable electricity and reducing OER while offering insights into the design of Co/Fe-based catalyst. Full article

The effectiveness of industrial heritage conservation relies on the collaborative efforts of multiple stakeholders. However, existing research lacks systematic exploration of stakeholders’ perception of heritage value and the pathways through which such perception translates into conservation behaviors. This study takes the Shaanxi section of the Baocheng Railway, a typical linear industrial heritage, as a case study. Based on the “Cognitive Appraisal Theory of Emotions” (CATE) theory, it examines the mechanism between heritage value perception, place identity, and heritage responsibility behavior. Through structural equation modeling (SEM) analysis of 414 questionnaire responses, the study finds that heritage value perception of the Baocheng Railway’s Shaanxi section not only significantly positively influences stakeholders’ place identity but also directly promotes the formation of heritage responsibility behavior. Among these, the perception of social value has the most pronounced impact on place identity and responsibility behavior. Furthermore, place identity plays a key mediating role between value perception and responsibility behavior. This study introduces the CATE theory into industrial heritage research, revealing the mechanism of behavior generation from the path of “cognition → emotion → behavior”. By focusing on linear industrial heritage sites, it broadens the scope of heritage research and highlights the central role of social value perception in driving conservation intentions and behaviors. The study further enriches research on heritage responsibility behavior, and the proposed theoretical model and findings can provide theoretical references for the management and conservation of industrial heritage. Full article

Intestinal disorders such as inflammatory bowel diseases (IBDs), Crohn’s disease, malabsorption syndromes, and gastrointestinal fistulae (GIFs) are often characterized by chronic inflammation, epithelial barrier disruption, impaired stromal remodeling, and defective angiogenesis. These multifactorial alterations hinder tissue repair and contribute to poor clinical outcomes, with limited efficacy from current therapeutic options. Despite recent advances in surgical and endoscopic techniques, current treatment options remain limited and are frequently accompanied by high morbidity and costs. In this context, regenerative medicine offers a promising avenue to support tissue repair and improve patient care Regenerative medicine offers a promising avenue to restore intestinal homeostasis using advanced biomaterials and cell-based therapies. In this study, we developed a 3D-bioprinted model based on patient-derived stromal vascular fraction (SVF) embedded in a GelMA hydrogel, designed to promote intestinal tissue regeneration. To identify the most suitable hydrogel for bioprinting, we initially evaluated the mechanical properties and biocompatibility of four distinct matrices using bone marrow-derived mesenchymal stromal cells (BM-MSCs). Among the tested formulations, GelMA demonstrated optimal support for cell viability, low oxidative stress, and structural stability in physiologically relevant conditions. Based on these results, GelMA was selected for subsequent bioprinting of freshly isolated SVF. The resulting bioprinted constructs enhanced key regenerative processes across multiple compartments. The SVF-laden constructs significantly enhanced intestinal epithelial cell viability and tight junction formation, as shown by increased trans-epithelial electrical resistance (TEER). Co-culture with fibroblasts accelerated wound closure, while endothelial cells exhibited increased tube formation in the presence of SVF. Together with VEGF secretion, indicating strong paracrine and angiogenic effects. By supporting epithelial, stromal, and vascular regeneration, this approach provides a versatile and translational platform for treating a broad spectrum of intestinal pathologies. Full article

Malignant bone and soft tissue tumors are often resistant to conventional treatment, and treatment options for unresectable and metastatic cases are limited. L-type amino acid transporter 1 (LAT1) is overexpressed in several malignancies, including sarcomas, making it an attractive target for targeted alpha therapy. In this study, we investigated the therapeutic efficacy of LAT1-targeted alpha therapy using a novel modified 3-astatin-211 Astato-α-methyl-L-tyrosine (²¹¹At-AAMT) for bone and soft tissue sarcomas. LAT1 expression and the specificity of LAT1-mediated uptake of ²¹¹At-AAMT were evaluated in bone and soft tissue sarcoma cell lines. Antiproliferative effects were assessed using cell viability and colony formation assays. DNA damage was assessed using immunostaining with phosphorylated histone γH2AX. In vivo efficacy of ²¹¹At-AAMT, determined using xenograft mouse models, was compared with that of doxorubicin. LAT1 was highly expressed in all cell lines, especially MP-CCS-SY and MG-63 cells. ²¹¹At-AAMT uptake was LAT1-dependent and significant in all cell lines. It inhibited cell proliferation in a dose-dependent manner, comparable to that of doxorubicin. In xenograft models, a single administration of ²¹¹At-AAMT significantly inhibited tumor growth without systemic toxicity, whereas doxorubicin caused weight loss. Histopathological analysis showed reduced cell density, inhibited proliferation, and extensive DNA damage in tumors treated with ²¹¹At-AAMT, whereas LAT1 expression was maintained in residual tumor tissues. LAT1-targeted alpha therapy with ²¹¹At-AAMT demonstrated antitumor efficacy comparable to that of first-line chemotherapy for osteosarcoma and soft tissue sarcoma. Sustained LAT1 expression suggests the potential for repeated or combination treatments, highlighting its promise as a novel therapy for advanced, treatment-resistant sarcomas. Full article