Search Results (971)

The emergence of antimicrobial resistance (AMR) across the broiler production chain holds significant economic, animal, and public health implications. This study investigated phenotypic resistance to 13 antimicrobials and the presence of 35 antimicrobial resistance genes (ARGs) in Escherichia coli (n = 291) isolated across three broiler production chains (broiler breeder farms, hatcheries, commercial broiler farms, and retail meat shops). An extremely high phenotypic resistance (>70%) to doxycycline, ciprofloxacin, and cefpodoxime, and very high resistance (50–70%) to ampicillin, cefotaxime, gentamicin, and ceftazidime was observed. In addition, 97% of isolates were multidrug-resistant (resistant to ≥1 drug in ≥3 antimicrobial classes), 42% were extended-spectrum beta-lactamase (ESBL) producers, 65% were resistant to third-generation cephalosporins (3GCR), and 21% were resistant to colistin. The Poisson regression model revealed no significant difference in AMR among broiler production stages, except for colistin. Among 35 ARGs tested, 24 (67%) were detected at least once. The most prevalent were tetA, bla_TEM, qnrB, qnrS, and aac(6′)-Ib-cr, while qnrD, sul2, bla_OXA, and bla_CTX-M were detected at lower levels (1–7%). All five tested mcr genes (mcr-1 to mcr-5) were identified in commercial farms and retail shops. No bla_NDM, tetB, tetC, tetD, tetM, qnrC, aac(3)-IIa (aacC2), aph(3)-IIa (aphA2), or aac(6′)-Ib genes were found. A strong correlation was observed between AMR phenotypes and ARGs. High AMR among E. coli in broiler production poses significant One Health risks, with widespread MDR, ESBL production, and resistance to critically important antimicrobials. Prudent antimicrobial use, enhanced surveillance and education, farm biosecurity, and One Health strategies are crucial in mitigating these threats. Full article

In this paper we will be concerned with zeta-symmetry—the functional equation for the (Riemann) zeta-function (equivalents to which are called modular relations)—and reveal the reason why so many results are intrinsic to PFE (Partial Fraction Expansion) for the cotangent function. The hidden reason is that the cotangent function (as a function in the upper half-plane, say) is the polylogarithm function of order 0 (with complex exponential argument), and therefore it shares properties intrinsic to the Lerch zeta-function of order 0. Here we view the Lerch zeta-function defined in the unit circle as a zeta-function in a wider sense, as a function defined in the upper and lower half-planes. As evidence, we give a plausibly most natural proof of Ramanujan’s formula, including the eta transformation formula as a consequence of the modular relation via the cotangent function, speculating the reason why Ramanujan had been led to such a formula. Other evidence includes the pre-Poisson summation formula as the pick-up principle (which in turn is a generalization of the argument principle). Full article

This paper proposes a scheme for enhancing covert communication in cognitive radio networks (CRNs) using a reconfigurable intelligent surface (RIS), which ensures that transmissions by secondary users (SUs) remains statistically undetectable by adversaries (e.g., wardens like Willie). However, there exist stringent challenges in CRNs due to the dual constraints of avoiding detection and preventing harmful interference to primary users (PUs). Leveraging the RIS’s ability to dynamically reconfigure the wireless propagation environment, our scheme jointly optimizes the SU’s transmit power, communication block length, and RIS’s passive beamforming (phase shifts) to maximize the effective covert throughput (ECT) under rigorous covertness constraints quantified by detection error probability or relative entropy while strictly adhering to PU interference limits. Crucially, the RIS configuration is explicitly designed to simultaneously enhance signal quality at the legitimate SU receiver and degrade signal quality at the warden, thereby relaxing the inherent trade-off between covertness and throughput imposed by the fundamental square root law. Furthermore, we analyze the impact of unequal transmit prior probabilities (UTPPs), demonstrating their superiority over equal priors (ETPPs) in flexibly balancing throughput and covertness, and extend the framework to practical scenarios with Poisson packet arrivals typical of IoT networks. Extensive results confirm that RIS assistance significantly boosts ECT compared to non-RIS baselines and establishes the RIS as a key enabler for secure and spectrally efficient next-generation cognitive networks. Full article

The paper examines the association between fertility and female wage employment in Kenya using nationally representative cross-sectional data collected by the Kenya’s National Bureau of Statistics, a government-owned statistical organization. Two findings emerge from our analysis. The first finding is that female wage employment is negatively correlated with the number of births. Incompatibility of childrearing with wage employment is one of the main explanations for this evidence. The other finding is a much larger magnitude of the negative association between wage employment and male births relative to female newborns, but the difference in the estimated gender-specific coefficients is statistically insignificant. However, there is need for further significance tests on the difference between the gendered coefficients because the larger drop in the number of male births relative to female, as female wage employment expands, has strong support in the biomedical literature. The relevance of the second finding in the context of the biomedical literature on the link between a child’s gender at birth and the environment in which the mother works and lives provides a justification for further research on this issue. The tentative findings of the paper point to labor market policies that could be explored in Kenya and elsewhere in Africa to address the problem of excess fertility, and thus enhance women’s health, agency, and socioeconomic empowerment. Full article

The manufacturing industry, in general, and the plastic industry, in particular, have been developing new materials and process methods that need a correct study and optimization. Nowadays, the main approach to optimize these processes is using numerical methods and, in the case of particulate materials, the Discrete Elements Method to estimate the particles interactions. But those mathematical models use some parameters that depend on the material and must be calibrated, thus requiring an important computational and experimental cost. In this study, we integrate different speed-up procedures and present a general calibration method of Low-Density Polyethylene particles, to obtain the calibrated solid density and Poisson’s ratio of the material, the restitution, static and rolling friction factors in the particle-to-particle and particle-to-wall interactions, and the contact model variables (damping factor, stiffness factor, and energy density). For this calibration, four different tests were carried out, both experimentally and with simulations, obtaining the bulk density, the repose and shear angles, and the dropped powder. All these response variables were compared between simulations and experimental tests, and using genetic algorithms, the input parameters (design variables) were calibrated after 85 iterations, obtaining a Mean Absolute Percentage Error of the response variables lower than 2% compared to the experimental results. Full article

We investigate Snyder spacetime and its generalizations, including Yang and Snyder–de Sitter spaces, which constitute manifestly Lorentz-invariant noncommutative geometries. This work initiates a systematic study of gauge theory on such spaces in the semi-classical regime, formulated as Poisson gauge theory. As a first step, we construct the symplectic realizations of the relevant noncommutative spaces, a prerequisite for defining Poisson gauge transformations and field strengths. We present a general method for representing the Snyder algebra and its extensions in terms of canonical phase-space variables, enabling both the reproduction of known representations and the derivation of novel ones. These canonical constructions are employed to obtain explicit symplectic realizations for the Snyder–de Sitter space and to construct the deformed partial derivative which differentiates the underlying Poisson structure. Furthermore, we analyze the motion of freely falling particles in these backgrounds and comment on the geometry of the associated spaces. Full article

This paper considers a heterogeneous queuing system with an unlimited number of servers, where the parameters are determined by a random environment. A distinctive feature is that the parameters of the exponential distribution of the request processing time do not change their values until the end of service. Thus, the devices in the system under consideration are heterogeneous. For the study, a method of asymptotic analysis is proposed under the condition of extremely rare changes in the states of the random environment. We consider the following problem. Cloud node accepts requests of one type that have a similar intensity of arrival and duration of processing. Sometimes an input scheduler switches to accept requests of another type with other intensity and duration of processing. We model the system as an infinite-server queue in a random environment, which influences the arrival intensity and service time of new requests. The random environment is modeled by a Markov chain with a finite number of states. Arrivals are modeled as a Poisson process with intensity dependent on the state of the random environment. Service times are exponentially distributed with rates also dependent on the state of the random environment at the time moment when the request arrived. When the environment changes its state, requests that are already in the system do not change their service times. So, we have requests of different types (serviced with different rates) present in the system at the same time. For the study, we consider a situation where changes of the random environment are made rarely. The method of asymptotic analysis is used for the study. The asymptotic condition of a rarely changing random environment (entries of the generator of the corresponding Markov chain tend to zero) is used. A multi-dimensional joint steady-state probability distribution of the number of requests of different types present in the system is obtained. Several numerical examples illustrate the comparisons of asymptotic results to simulations. Full article

In this paper we present an exact numerical model for the evaluation of a three-echelon supply chain with multiple retailers. Poisson demand, exponentially distributed transportation times and lost sales at the retailers are assumed. The system is modeled as a continuous time Markov chain, and the analysis is based on matrix analytic methods. We analyze the infinitesimal generator matrix of the process and develop an algorithm for its construction. Performance measures for the system are calculated algorithmically from the stationary probabilities vector. The algorithm is used for an extensive numerical investigation of the system so that conclusions of managerial importance may be drawn. Full article

While it is undisputed that Poisson GLMs represent the gold standard for counting COVID-19 deaths, recent studies have analyzed the seasonal growth and decline trends of these deaths in Italy using a simple segmented linear regression. They found that, despite an overall decreasing trend throughout the entire period analyzed (2021–2025), rising mortality trends from COVID-19 emerged in all summers and winters of the period, though they were more pronounced in winter. The technical reasons for the general unsuitability of using linear regression for the precise counting of deaths are well-known. Nevertheless, the question remains whether, under certain circumstances, the use of linear regression can provide a valid and useful tool in a specific context, for example, to highlight the slopes of seasonal growth/decline in deaths more quickly and clearly. Given this background, this paper presents a comparison between the use of linear regression and a Poisson GLM with the aforementioned death data, leading to the following conclusions. Appropriate statistical hypothesis testing procedures have demonstrated that the conditions of a normal distribution of residuals, their homoscedasticity, and the lack of autocorrelation were essentially guaranteed in this particular Italian case (weekly COVID-19 deaths in Italy, from 2021 to 2025) with very rare exceptions, thus ensuring the acceptable performance of linear regression. Furthermore, the development of a Poisson GLM definitively confirmed a strong agreement between the two models in identifying COVID-19 mortality trends. This was supported by a Kolmogorov–Smirnov test, which found no statistically significant difference between the slopes calculated by the two models. Both the Poisson and the linear model also demonstrated a comparably high accuracy in counting COVID-19 deaths, with MAE values of 62.76 and a comparable 88.60, respectively. Based on an average of approximately 6300 deaths per period, this translated to a percentage error of just 1.15% for the Poisson and only a slightly higher 1.48% for the linear model. Full article

Count data are present in many areas of everyday life. Unfortunately, such data are often characterized by over- and under-dispersion. In 1986, Efron introduced the Double Poisson distribution to account for this problem. The aim of this work is to examine the application of this distribution in regression analyses performed in health-related literature by means of a narrative review. The databases Science Direct, PBSC, Pubmed PsycInfo, PsycArticles, CINAHL and Google Scholar were searched for applications. Two independent reviewers extracted data on Double Poisson Regression Models and their applications in the health and life sciences. From a total of 1644 hits, 84 articles were pre-selected and after full-text screening, 13 articles remained. All these articles were published after 2011 and most of them targeted epidemiological research. Both over- and under-dispersion was present and most of the papers used the generalized additive models for location, scale, and shape (GAMLSS) framework. In summary, this narrative review shows that the first steps in applying Efron’s idea of double exponential families for empirical count data have already been successfully taken in a variety of fields in the health and life sciences. Approaches to ease their application in clinical research should be encouraged. Full article

In this article, the mechanism of relaxation polarization currents occurring at a constant temperature (isothermal process) in crystals with ionic-molecular chemical bonds (CIMBs) in an alternating electric field was investigated. Methods of the quasi-classical kinetic theory of dielectric relaxation, based on solutions of the nonlinear system of Fokker–Planck and Poisson equations (for the blocking electrode model) and perturbation theory (by expanding into an infinite series in powers of a dimensionless small parameter) were used. Generalized nonlinear mathematical expressions for calculating the complex amplitudes of relaxation modes of the volume-charge distribution of the main charge carriers (ions, protons, water molecules, etc.) were obtained. On this basis, formulas for the current density of relaxation polarization (for transient processes in a dielectric) in the k-th approximation of perturbation theory were constructed. The isothermal polarization currents are investigated in detail in the first four approximations (k = 1, 2, 3, 4) of perturbation theory. These expressions will be applied in the future to compare the results of theory and experiment, in analytical studies of the kinetics of isothermal ion-relaxation (in crystals with hydrogen bonds (HBC), proton-relaxation) polarization and in calculating the parameters of relaxers (molecular characteristics of charge carriers and crystal lattice parameters) in a wide range of field parameters (0.1–1000 MV/m) and temperatures (1–1550 K). Asymptotic (far from transient processes) recurrent formulas are constructed for complex amplitudes of relaxation modes and for the polarization current density in an arbitrary approximation k of perturbation theory with a multiplicity r by the polarizing field (a multiple of the fundamental frequency of the field). The high degree of reliability of the theoretical results obtained is justified by the complete agreement of the equations of the mathematical model for transient and stationary processes in the system with a harmonic external disturbance. This work is of a theoretical nature and is focused on the construction and analysis of nonlinear properties of a physical and mathematical model of isothermal ion-relaxation polarization in CIMB crystals under various parameters of electrical and temperature effects. The theoretical foundations for research (construction of equations and working formulas, algorithms, and computer programs for numerical calculations) of nonlinear kinetic phenomena during thermally stimulated relaxation polarization have been laid. This allows, with a higher degree of resolution of measuring instruments, to reveal the physical mechanisms of dielectric relaxation and conductivity and to calculate the parameters of a wide class of relaxators in dielectrics in a wide experimental temperature range (25–550 K). Full article

Clostridioides difficile is an obligate anaerobe and is primarily transmitted via the fecal–oral route. Data characterizing the microbiome changes accompanying transitions from non-colonized to C. difficile colonized subjects are currently lacking. In this retrospective cohort study, we examined 16S rRNA gene sequencing data in a total of 481 fecal samples belonging to 107 patients. Based on C. difficile status over time, patients were categorized as Negative-to-Positive, Negative Control, and Positive Control. A linear mixed effects model was fitted to investigate the changes in the Shannon α-diversity index over time. Zero-inflated negative binomial/Poisson mixed effects models or generalized linear mixed models with negative binomial/Poisson distribution were used to investigate the changes in taxon counts over time among different groups. A total of 107 patients were eligible for the study. The median number of stool samples per patient was 3 (IQR 2–4). A total of 42 patients transitioned from C. difficile negative to positive (Negative-to-Positive), 47 patients remained negative throughout their tests (Negative Control) and 18 were always C. difficile positive (Positive Control). A significant difference in microbiome composition between the last negative samples and the first positive samples were shown in Negative-to-Positive patients, ANOSIM p = 0.022. In Negative-to-Positive patients, the phylum Pseudomonadota and family Enterobacteriaceae increased significantly in the first positive samples compared to the last negative samples, p = 0.0075 and p = 0.0094, respectively. Within the first 21 days, Actinomycetota decreased significantly over time in the Positive Control group compared to the other two groups (p < 0.001) while Bacillota decreased in both the Negative-to-Positive group and Positive Control. These results demonstrate that the transition from C. difficile negative to C. difficile positive is associated with alterations in gut microbial communities and their compositional patterns over time. Moreover, these changes play an important role in both the emergence and intensification of the gut microbiome dysbiosis in patients who transitioned from C. difficile negative to positive and those who always tested positive. Full article

Background: General aviation pilots are, anecdotally, referred to as “weekend warriors” due to their flying infrequency. Considering that flight skills erode with irregular practice/reinforcement, we determined whether private pilots (PPLs) fly/train sufficiently to operate safely in the context of slow flight, a skill critical for safe operations and which rapidly atrophies with <~51 h flight time/8 months per prior research. Method: Slow-flight-related aviation accidents (2008–2019) were per the NTSB Access^R database, and fatal mishap rates were calculated using general aviation fleet times. Eight-month flight histories of airplanes in single PPL ownership were captured retrospectively using FlightAware^R. PPL survey responses were collected between January and March 2025. Statistical tests employed proportion/Independent-Samples Median Tests and a Poisson Distribution. Results: The slow-flight-related fatal accident rate (2017–2019) trended downwards (p = 0.077). In-flight tracking of 90 airplanes revealed an 8-month median flight time of 6 h, which is well below the aforementioned 51 h requisite for safe operations. Of the aircraft flown < 51 h, only 9% engaged in slow-flight practice. In the online survey, only the upper quartile of 126 PPLs achieved the aforementioned time requisite for preserving slow-flight skills, but nevertheless, 89% of respondents attested to being flight-proficient. Conclusions: Persistence in slow-flight-related fatal accidents likely partly reflects PPLs’ deficiency in in-flight time/slow-flight practice. Full article

The Mon Valley near Pittsburgh, Pennsylvania, consistently reports some of the poorest air quality in the United States. Recent studies have linked air pollution in this region to poor asthma outcomes but did not examine the impact on other respiratory conditions or vulnerable populations. This retrospective study examined the relationship between the air quality index (AQI) and respiratory exacerbations of asthma, bronchitis, and chronic obstructive pulmonary disease (COPD) in the Mon Valley between January 2018 and February 2020. We linked daily Air Quality Index (AQI) values for ozone, PM_2.5, SO₂ and NO₂, plus temperature and wind speed to healthcare utilization for these conditions. Using a Poisson generalized linear model, we quantified the association between pollutant levels and same-day exacerbation rates, stratified analyses by age, sex, and insurance type to identify vulnerable subgroups. Results indicated that higher AQI scores, driven primarily by PM_2.5 and SO₂, were significantly associated with increased asthma exacerbations on the day of exposure. Children and individuals with public insurance experienced the greatest impact. Bronchitis exacerbations showed a delayed response to SO₂. Our findings affirm PM_2.5 and SO₂ as key drivers of acute asthma events in the Mon Valley and extend this observation to include impacts on bronchitis and vulnerable populations. They also demonstrate the AQI’s value for public health surveillance and underscore the importance of tailored interventions such as issuing timely air quality alerts, strengthening emissions regulations, and improving access to preventive care to protect at-risk populations from adverse air pollution effects. Full article

Coal seams, as critical components of open-pit mine slopes, are subjected to both quasi-static and dynamic loading disturbances during mining operations, with their mechanical properties directly influencing the slope stability. Consequently, to clarify the mechanical properties and failure mechanisms of coal seams affected by the strain rate under the static–dynamic loading conditions, the mineral composition and meso-structural characteristics of lignite were analyzed in this study, and uniaxial compression tests with different quasi-static loading rates and dynamic compression tests with different impact velocities were conducted. The results indicate that there is an obvious horizontal bedding structure in lignite, which leads to differences in mechanical response and failure mechanism at different strain rates. Under the quasi-static loading, lignite exhibits significantly lower strain-rate sensitivity than compared to dynamic impact conditions. The Poisson’s ratio difference between the bedding matrix and the lignite will produce interfacial friction, which gradually decreases with the increase in the distance from the interface, thus promoting the transformation of lignite from multi-crack tensile shear mixed fracture to single-crack splitting failure. Under the dynamic impact conditions, low-impact velocities induce stress wave reflection at bedding interfaces due to wave impedance disparity between the matrix and lignite, generating tensile strains that result in bedding-plane delamination failure; at higher velocities, incomplete energy absorption by the rock specimen leads to fragmentation failure of lignite. These findings are of great significance for the stability analysis of open-pit slopes. Full article