Search Results (6,979)

Objective: This study explores the associations between parent–child exercise and children’s mental health from the perspective of family physical education. Methods: In total, 527 valid questionnaires were collected from students in grades four to six of three primary schools in Yuhang District, Hangzhou City, including a survey of the status of children’s exercise and family sports and the SCL-90 symptom self-measurement scale. Based on an analysis of practical challenges in family sports engagement and children’s mental health status, the data were analyzed and modeled using structural equation modeling to obtain a model of children’s mental health promotion, with individual children’s exercise as the primary factor and parent–child exercise as the mediator. Results: Both individual children’s exercise and parent–child exercise were significant predictors of children’s mental health promotion. Parent–child activities show a more significant negative correlation with symptoms of anxiety and depression than individual exercise alone. They also partially mediated the relationship between individual exercise and depression/anxiety symptoms. The indirect effects had confidence intervals of [−0.008, −0.001] for depression and [−0.007, −0.001] for anxiety. The direct effects of individual exercise on mental health (depression: β = −0.115; anxiety: β = −0.127) were stronger than the indirect effects and significantly positively correlated with parent–child exercise (β = 0.444, p < 0.05), suggesting that individual exercise may encourage more parent–child exercise. Conclusions: We propose a relational pathways model incorporating parent–child exercise as a mediating variable and individual exercise as the primary activity. This model is more closely aligned with real-life conditions and practical feasibility than approaches lacking such a family-based component. Full article

Background/Objectives: In the age of digitalization, nomophobia has emerged as a relevant issue, especially among university students who utilize smartphones heavily for academic and social purposes. The Stressor–Strain–Outcome (SSO) framework explains the relationship between stressors, strain, and outcomes. Stressors such as nomophobia induce psychological strain. This strain subsequently influences outcomes like mindfulness. Nomophobia has been linked to higher distress, including depression, anxiety, and stress, that can negatively impact students’ focus. However, the mechanisms by which nomophobia impacts mindfulness remain less explored. Hence, this study aims to analyze the mediating effect of distress on the relation between student’s nomophobia and mindfulness. Methods: In this quantitative study, the researcher employed a structured close-ended survey to collect data from 723 students at the University of Ha’il in Saudi Arabia. Nomophobia was measured using the Nomophobia Questionnaire (NMP-Q). The level of distress was measured using the Depression, Anxiety, and Stress scale (DASS-21) Furthermore, the assessment of mindfulness was conducted using the Mindful Attention Awareness Scale (MAAS). Structural equation modeling was utilized to test the hypotheses of this study. Results: The results from PLS-SEM indicate that nomophobia did not directly reduce mindfulness, as its effect was statistically non-significant (β_1 = −0.052, p-value = 0.168). This suggests that nomophobia alone may not weaken focus. However, it significantly increased distress, particularly depression (β_2a = 0.327, p-value < 0.001), anxiety (β_2b = 0.294, p-value < 0.001) and stress (β_2c = 0.259, p-value < 0.001). In plain terms, students with higher nomophobia reported more depression and stress, which in turn reduced mindfulness. Anxiety, however, did not significantly affect mindfulness (β_3b = 0.006, p-value < 0.933), indicating its influence may be negligible or context-specific. Mediation analysis confirmed indirect effects of nomophobia on mindfulness through depression (β_4a = −0.096, p-value < 0.001) and stress (β_4c = −0.045, p-value < 0.020). Together, these mediators explained a substantial portion of the variance in mindfulness. Conclusions: The findings align with the SSO model, indicating that nomophobia acts as a stressor, exacerbating distress, which in turn reduces mindfulness. From a practical perspective, the results highlight the need for comprehensive student support. Universities should integrate digital wellness programs, stress-management resources, and mindfulness training into their services. Limitations and Future Research: The cross-sectional design and convenience sampling restrict causal inference and generalizability. Future studies should employ longitudinal research designs. They should also examine diverse cultural contexts. In addition, researchers should investigate potential mediators such as social support and sleep quality. Full article

Armed conflicts continue to severely impact human populations and essential infrastructure, particularly water supply systems. This study examines the Yechilla area, a high-intensity battle corridor during the Tigray (between 12°15′26″ 14°57′49″ N latitude; and 36°20′57″–39°58′54″ E longitude) war (2020–2022). Using Cochran’s formula, a representative sample of 89 water schemes was selected for onsite assessment. Additional data on damages to water offices, personnel, equipment, and related infrastructure were gathered through face-to-face interviews with local officials and water professionals, onsite visits, and reviews of governmental and non-governmental archives, and previous studies. The findings reveal that 48.3% of water schemes in the study area are non-functional (does not deliver water), which is a significant increase from pre-war non-functionality rates of approximately 7.1% regionally and 21.1% nationally. Despite the Pretoria peace agreement, non-functionality levels remain critically high two years after conflict. Damage includes partial impairments, lack of technical and spare part support, complete destruction, and looting of water scheme components. The widespread destruction of civilian water infrastructure during the Tigray conflict underscores the insufficiency of existing international legal frameworks, such as the International Humanitarian Law and International Water Law, which are inadequately protecting civilians and their property. Understanding the broader consequences of armed conflicts requires examining the indirect effects and the complex interactions within and between social, economic, and environmental systems. These interconnected impacts are essential to fully grasp how conflict affects livelihoods and human security on a wider scale. Full article

Background/Objectives: Aging is characterized by progressive physiological and metabolic decline. Aerobic exercise mitigates age-related impairments, and nicotinamide mononucleotide (NMN), a precursor in the NAD⁺ salvage pathway, has emerged as a nutritional intervention to promote healthy aging. This study investigated whether NMN supplementation combined with aerobic exercise provides synergistic benefits on physical performance and metabolic regulation in aged mice. Methods: Forty male C57BL/6J mice, including eight young (8 weeks) and thirty-two aged (85 weeks) mice, were randomly assigned to five groups: young sedentary (YS), aged sedentary (AS), aged with exercise (AE), aged with NMN (ASNMN; 300 mg/kg/day), and aged with combined NMN and exercise (AENMN). Interventions lasted six weeks. Assessments included grip strength, muscle endurance, aerobic capacity, oral glucose tolerance test (OGTT), and indirect calorimetry, followed by biochemical and molecular analyses of NAMPT and SirT1 expression. Results: The AENMN group demonstrated significant improvements in maximal strength and aerobic endurance compared with the AS group (p < 0.05). Both NMN and exercise interventions increased blood NAMPT concentrations, with the highest levels observed in the AENMN group (p < 0.05). SirT1 expression was elevated in the ASNMN and AENMN groups relative to YS (p < 0.05). Glucose tolerance improved in the ASNMN and AENMN groups (p < 0.05). Enhanced energy metabolism in the AENMN group was indicated by increased oxygen consumption, elevated energy expenditure, and reduced respiratory quotient. Conclusions: NMN supplementation, particularly when combined with aerobic exercise, effectively improved aerobic performance, glucose regulation, and systemic energy metabolism in aged mice. These findings suggest that NMN, in synergy with exercise, may serve as a promising nutritional strategy to counteract age-associated metabolic and functional decline. Full article

Background/Objectives: Substance use disorders (SUD) pose a significant public health challenge, with 47.7 million people nationwide struggling to end their addiction. Individuals in recovery from SUDs are at an elevated risk of relapses, even after an extended period of abstinence from substances. While the importance of social relationships in addiction recovery has been extensively researched, the specific ways addiction recovery differs between sex/gender within Oxford House (OH) settings needs further research. Some evidence suggests males and females experience SUD differently and respond distinctively to recovery. Methods: We recruited 229 participants from 42 OH recovery homes, with 55.5% (n = 127) male participants. Moderated mediation model seven by Andrew F. Hayes was used to determine the relationship between quality of life, length of stay, sense of community, and sex/gender. Results: Length of stay was a significant predictor of sense of community, with longer stays associated with stronger perceived community ties. Additionally, quality of life had a robust direct effect on sense of community. We found that there is a small indirect effect of quality of life on sense of community through length of stay for females. Conclusions: These findings suggest that while quality of life and length of stay both independently contribute to individuals’ sense of community, the mediating role of length of stay appears to be more pronounced among females. Further research is needed to understand and address sex/gender-specific recovery experiences. Full article

The vascular 5-HT sympatho-modulation may involve inhibitory or potentiating pathways: nitric oxide (NO), endothelium-dependent hyperpolarization (EDH)-K⁺ channels, prostanoids, angiotensin II (Ang-II), or endothelin. Compared to males, female rats show differences in the serotonergic sympatho-regulation; therefore, we aimed to study the involvement of indirect pathways via 5-HT_1D-mediated inhibition and 5-HT_2A/3-mediated potentiation of vascular noradrenergic neurotransmission in females. An i.v. bolus of different inhibitors/blockers of modulators/mediators (NO, K⁺ channels, prostanoids, Ang-II, or endothelin) was administered prior to the infusion of the agonists, L-694,247 (5-HT_1D), TCB-2 (5-HT_2A), or 1-PBG (5-HT₃), in female pithed rats. In these conditions, the vascular sympathetic outflow was electrically stimulated to assess the vasopressor responses. The L-694,247 vascular sympatho-inhibition was abolished by a non-selective K⁺ channel blocker, tetraethylammonium. The 1-PBG sympatho-excitatory vascular effect was not modified by any of the inhibitors tested, whereas TCB-2 sympatho-potentiation was blocked solely by losartan (Ang-II type 1 receptor antagonist). Moreover, Ang-II levels were increased after TCB-2 infusion in females. The EDH pathway mediates the 5-HT_1D-induced sympatho-inhibition, while the 5-HT_2A-evoked sympatho-excitatory effect is associated with Ang-II. In contrast, the 5-HT₃ sympatho-potentiation does not involve any indirect pathway. These findings advance current understanding of the complex interactions between 5-HT and vascular homeostasis in female rats. Full article

This study focuses on the challenges of resident mobility in low-density areas. Amid China’s rapid urbanization, rural landscapes and travel patterns are undergoing significant transformation. Using Lanzhou’s rural areas as a representative case study, this research employs questionnaire surveys to collect data. It applies a multi-nominal logit (MNL) model to examine factors influencing travel mode choices and utilizes structural equation modeling (SEM) to assess travel satisfaction—a composite metric derived from residents’ subjective evaluations of convenience, cost, time, and comfort. Findings indicate that private cars and public transportation are the primary travel modes. The MNL model reveals that age and destination accessibility significantly influence travel choices. SEM path analysis further shows that annual household income has a direct positive effect on satisfaction, while age exerts an indirect negative influence through mediating variables. Female satisfaction levels were significantly lower than those of males. Both road density and perceived infrastructure quality significantly enhanced satisfaction, while destination accessibility may exert a slight negative indirect effect by increasing travel expectations. The study theoretically enriches research on rural travel patterns and provides practical insights into rural transportation planning and infrastructure development. Full article

Background/Objectives: Adolescents aged 13–18 are exposed to traumatic content even without direct experience, owing to the increasing media coverage of disasters. Such indirect exposure can result in post-traumatic stress symptoms, including intrusion, avoidance, and hyperarousal, as well as associated emotions such as sadness, anger, and guilt. These effects may persist for months, reflecting the vulnerability of adolescents during cognitive and emotional development. This study examined resilience and social support as protective predictors against indirect trauma. Methods: A cross-sectional correlational design was employed, with middle- and high-school students aged 13–18 years in Seoul, South Korea, as participants. Indirect trauma, resilience, and perceived social support were assessed using validated self-report instruments. Correlation analyses were conducted, followed by stepwise regression. Owing to multicollinearity, resilience was retained as the sole predictor in the final model. Results: The average indirect trauma score was 1.20 out of 4, and 59.2% of participants exhibited partial or full post-traumatic stress disorder. The mean resilience and social support scores were 3.47 and 3.82 out of 5, respectively. Resilience was positively correlated with social support (r = 0.60, p = 0.001). The regression analysis indicated that resilience significantly predicted indirect trauma (β = 0.82, p < 0.001), accounting for 66.4% of the variance, whereas social support showed no direct effect. Conclusions: Resilience emerged as a key predictor of indirect trauma, underscoring its importance in mitigating distress. Although social support did not directly predict trauma, its positive correlation with resilience suggests potential indirect effects. These findings highlight the need to strengthen resilience and expand school-based counseling and support systems to help adolescents deal with indirect trauma. Full article

Gut microbiota has increasingly been shown to exert effects beyond the gastrointestinal tract, some of which are mediated through its metabolites, such as trimethylamine N-oxide (TMAO)—a compound converted by gut bacteria from dietary choline found predominantly in animal products that is associated with cardiovascular disease (CVD). However, a significant gap persists in human clinical trials assessing its potential causal role. This narrative review aims to present the current understanding of the gut microbiome, TMAO, and their relationship with CVD, while proposing future directions that may support the use of TMAO as a biomarker and guide potential interventions to reduce its harmful impact. Both animal and human studies have demonstrated a link between TMAO and CVD, with animal studies also indicating a causal effect—showing increased cardiovascular risk following TMAO administration and reduced risk when TMAO is eliminated. While direct extrapolation from animal models to humans is limited due to biological differences, these findings offer a foundation for the development of well-designed clinical trials in human populations. Although direct approaches to target TMAO—such as trimethylamine (TMA) lyase inhibitors and antisense oligonucleotide (ASO) therapy—have shown promising results in animal studies, they have yet to be investigated in human trials, leaving indirect strategies such as dietary changes and probiotics as the only currently available options. Full article

Minority stress appears to be consistently associated with a heightened risk of developing eating disorders. There is limited data investigating the role of witnessed heterosexist experiences (vicarious trauma), such as discrimination, harassment, or violence happening to other LGBTQ+ people. The present study aims to examine the association between vicarious trauma and eating disorder risk while surveying the mediating role of emotional dysregulation, self-esteem, and shame. An anonymous online survey was conducted involving 376 LGBTQ+ people from Italy. Participants completed self-report questionnaires regarding heterosexist experiences and factors associated with eating behavior. Descriptive, bivariate, and mediation analyses were conducted using the “PROCESS” macro. Statistically significant positive associations were found between all the main variables in bivariate analyses. Mediation analyses highlighted a direct effect of vicarious trauma on eating disorder risk and indirect effects of vicarious trauma on eating disorder risk through low self-esteem and emotion dysregulation. The indirect effect through shame was nonsignificant. Vicarious trauma appears to have a significant direct effect on eating disorder risk and small but significant indirect effects through emotional dysregulation and low self-esteem. Health promotion contexts would benefit from policies at the institutional, organizational, and social levels to prevent minority stress and reduce observed health disparities. Full article

Ship noise not only has an impact on crew comfort, but also causes damage to the marine environment. Longitudinal vibration of propulsion shaft system is one of the most important causes of ship noise, so in order to indirect control the vibration noise, the development of a propulsion shaft system vibration controller is an effective method. In this paper, a Kdamper with a magnetorheological damper (Kdamper-MRD) is proposed to control the longitudinal vibrations transmitted along the propulsion shaft system. The vibration characteristics of the propulsion shaft system are analyzed using the transfer matrix method and the optimal Kdamper-MRD design parameters for controlling the target modes are given. Specific structural design parameters are given as well as material selection. The magnetic field distribution and the magnitude of the output damping force of the MRD are obtained by the simulation method, and the negative stiffness characteristics of the disk spring are also discussed. An on–off current switching control strategy is proposed to further improve the vibration damping performance of the Kdamper-MRD. A comparison with the traditional DVA under simple harmonic excitation and random excitation proves that the Kdamper-MRD has better low-frequency vibration damping performance and is able to attenuate longitudinal vibration of the axle system in the whole frequency domain. Full article

Understanding trait relationships is fundamental in soybean breeding because the goal is to maximize simultaneous gains. Standard multi-trait genome-wide association studies (MT-GWAS) identify variants linked to multiple traits but fail to capture phenotypic structures or interrelations. Structural Equation Models (SEM) account for covariances and recursion, enabling the decomposition of single nucleotide polymorphism (SNP) effects into direct or indirect components and identifying pleiotropic regions. We applied SEM to analyze morphology (pod thickness, PT) and yield traits (number of pods, NP; number of grains, NG; hundred-grain weight, HGW). The dataset comprised 96 soybean individuals genotyped with 4070 SNP markers. The phenotypic network was constructed using the hill-climbing algorithm, a class of score-based methods commonly applied to learn the structure of Bayesian networks, and structural coefficients were estimated with SEM. According to coefficient signs, we identified negative interrelationships between NG and HGW, and positive ones between NP and NG, and HGW and PT. NG, HGW, and PT showed indirect SNP effects. We also found loci jointly controlling traits. In total, 46 candidate genes were identified: 7 associated exclusively with NP and 4 associated with NG. An additional 15 genes were common to NP and NG, 3 were common to NP and HGW, 6 were common to NG and HGW, and 11 were common to NP, NG, and HGW. In summary, SEM-GWAS revealed novel relationships among soybean traits, including PT, supporting breeding programs. Full article

Mathematical performance in early education is influenced by a complex interplay of cognitive and affective factors, including language skills, working memory, and anxiety. This study investigated whether working memory and math anxiety, in both explicit numerical situations (ENS) and general classroom situations (GCS), mediate the relationship between general and math-specific vocabulary and math performance in a sample of 467 second-grade students in Chile. Structural equation modelling was employed to test a dual-pathway model in which both working memory and math anxiety served as mediators between vocabulary knowledge and math performance. Results indicated that both general and math-specific vocabulary positively predicted working memory and negatively predicted math anxiety in ENS. In turn, working memory and ENS significantly predicted math outcomes, whereas GCS was not a significant predictor. Indirect effects supported a dual mediation structure, with vocabulary influencing math performance through both cognitive and affective mechanisms. Math-specific vocabulary exerted a slightly stronger total effect than general vocabulary, consistent with its closer alignment to the semantic demands of mathematical tasks. These findings suggest that vocabulary supports early mathematical learning not only by enhancing cognitive processing capacity but also by reducing anxiety in task-specific contexts. Full article

AmpC β-lactamases are class C enzymes that hydrolyze penicillins, cephalosporins, and monobactams. The WHO recently classified third-generation cephalosporin-resistant and carbapenem-resistant Enterobacterales as critical pathogens. We conducted a systematic review and meta-analysis to evaluate AmpC prevalence in hospital isolates across South America. We searched PubMed/MEDLINE, SciELO, and Google Scholar. We included 69 observational studies that phenotypically or genotypically identified AmpC producers. A random-effects generalized linear mixed model with logit transformation estimated pooled prevalence; heterogeneity and moderators were explored through subgroup analyses and meta-regression. Seventy studies, including 48,801 isolates, were eligible. AmpC β-lactamases were detected in 11.7% of isolates (95% CI 11.4–12.0), with extreme heterogeneity (I² ≈ 97%). Enterobacter species showed the highest prevalence (~46%), whereas Escherichia spp. had the lowest (~4.5%) prevalence of AmpC positivity within each genus. Meta-regression indicated that studies focusing on a single genus reported higher prevalence and that including pediatric patients was associated with a lower prevalence of AmpC-positive microorganisms among isolates. Quality of evidence was rated low due to inconsistency, moderate risk of bias, and indirectness of data. AmpC producers are entrenched in South American hospitals, and species-aware surveillance and harmonized detection are critical to guide empiric therapy and antimicrobial stewardship. Full article

Per- and polyfluoroalkyl substances (PFASs) are highly chemically stable synthetic compounds. They are widely used in industrial and commercial sectors due to their ability to repel water and oil, thermal stability, and surfactant properties. However, this stability results in environmental persistence and bioaccumulation, posing significant health risks as PFASs eventually find their way into environmental media. Key PFAS compounds, including PerFluoroOctanoic Acid (PFOA), PerFluoroOctane Sulfonic acid (PFOS), and PerFluoroHexane Sulfonic acid (PFHxS), have been linked to hepatotoxicity, immunotoxicity, neurotoxicity, and endocrine disruption. In response to the health threats these substances pose, global regulatory measures, such as the Stockholm Convention restrictions and national drinking water standards, have been implemented to reduce PFAS exposure. Despite these efforts, a lack of universally accepted definitions or comprehensive inventories of PFAS compounds hampers the effective management of these substances. As definitions differ across regulatory bodies, research and policy integration have become complicated. PFASs are broadly categorized as either perfluoroalkyl acids (PFAAs), precursors, or other fluorinated substances; however, PFASs encompass over 5000 distinct compounds, many of which are poorly characterized. PFAS contamination arises from direct industrial emissions and indirect environmental formation, these substances have been detected in water, soil, and even air samples from all over the globe, including from remote regions like Antarctica. Analytical methods, such as primarily liquid and gas chromatography coupled with tandem mass spectrometry, have advanced PFAS detection. However, standardized monitoring protocols remain inadequate. Future management requires unified definitions, expanded monitoring efforts, and standardized methodologies to address the persistent environmental and health impacts of PFAS. This review underscores the need for improved regulatory frameworks and further research. Full article