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Keywords = interrogative mood

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21 pages, 337 KB  
Article
Materially Dispossessing the Troubled Theologian
by John C. McDowell
Religions 2025, 16(8), 1076; https://doi.org/10.3390/rel16081076 - 19 Aug 2025
Viewed by 245
Abstract
Linn Tonstad’s paper, ‘(Un)wise Theologians’, identifies a theological approach that puts pressure on its ability to handle its materiality sufficiently in a number of ways. However, following the trajectory of Tonstad’s discovery of “the deformations to which theology is susceptible in the university” [...] Read more.
Linn Tonstad’s paper, ‘(Un)wise Theologians’, identifies a theological approach that puts pressure on its ability to handle its materiality sufficiently in a number of ways. However, following the trajectory of Tonstad’s discovery of “the deformations to which theology is susceptible in the university” and elsewhere, a supplementation is required to specify where its thesis needs more rigorous development. Firstly, the paper’s argument locates what Tonstad describes as “self-securitization and self-assertion” in a form of a subjectivity characterisable as a docility making possessive form of divine givenness, and it draws the papal encyclical Fides et Ratio into Tonstad’s critique of the theology of John Webster to make this case. Secondly, Tonstad’s appeal to the reparative mode of contextualisation necessitates a differentiation to be made between modes of what is commonly called ‘contextual theology’ since there are forms that shelter under this umbrella term that echo the subjectivity of that which Tonstad uncompromisingly critiques. Thirdly, while ‘(Un)wise Theologians’ only lightly indexes a reparative direction properly “chastened” theology, a kenotically interrogative sensibility may prove to be sufficiently capacious for the critical conduct of “theological therapy”. If so, then it can function to constantly trouble the theological in an appropriate manner without flight into a premature dematerialised fixation point. Full article
(This article belongs to the Special Issue Nature, Functions and Contexts of Christian Doctrine)
12 pages, 556 KB  
Article
Transcription-Driven Repurposing of Cardiotonic Steroids for Lithium Treatment of Severe Depression
by Richard Killick, Claudie Hooper, Cathy Fernandes, Christina Elliott, Dag Aarsland, Svein R. Kjosavik, Ragnhild Østerhus and Gareth Williams
Cells 2025, 14(8), 575; https://doi.org/10.3390/cells14080575 - 11 Apr 2025
Viewed by 707
Abstract
Lithium is prescribed as a mood stabilizer for bipolar disorder and severe depression. However, the mechanism of action of lithium is unknown and there are major side effects associated with prolonged medication. This motivates a search for safer alternative drug repurposing candidates. Given [...] Read more.
Lithium is prescribed as a mood stabilizer for bipolar disorder and severe depression. However, the mechanism of action of lithium is unknown and there are major side effects associated with prolonged medication. This motivates a search for safer alternative drug repurposing candidates. Given that the drug mechanism may be encoded in transcriptional changes, we generated the gene expression profile for acute lithium treatment of cortical neuronal cultures. We found that the lithium-associated transcription response harbors a significant component that is the reverse of that seen in human brain samples from patients with major depression, bipolar disorder, and a mouse model of depression. Interrogating publicly available drug-driven expression data, we found that cardiotonic steroids drive gene expression in a correlated manner to our acute lithium profile. An analysis of the psychiatric medication cohort of the Norwegian Prescription Database showed that cardiotonic prescription is associated with a lower incidence of lithium prescription. Our transcriptional and epidemiological observations point towards cardiotonic steroids as possible repurposing candidates for lithium. These observations motivate a controlled trial to establish a causal connection and genuine therapeutic benefit in the context of depression. Full article
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