Search Results (12,697)

Brain pathophysiology in Down syndrome (DS), the most common genetic cause of intellectual disability, has traditionally been considered a consequence of neuronal dysfunction. However, although it is well documented that astrocytes play a critical role in brain homeostasis, synaptic regulation, and neuronal support, and their malfunction has been associated with the onset and progression of different neurological disorders, only a few studies have addressed whether astrocyte dysfunction can contribute to the DS pathophysiology. Astrocytes are increased in number and size, and show increased levels of expression of astroglial markers like S100β and GFAP. In this study, we detected a region-specific increase in astrocyte population in CA1 and, to a lesser extent, in the dentate gyrus. Single-nucleus transcriptomic profiling identified markers associated with reactive astroglia, synaptic transmission, and neuroinflammation in trisomic astrocytes. Functional analysis revealed abnormal Ca²⁺ oscillations in trisomic astrocytes and impaired astrocyte-to-neuron communication in CA1, the most affected subregion, leading to astrocyte-mediated excitatory synaptic depression. Our findings demonstrate that astrocytes play an active and critical role in the pathophysiology of DS, not only as reactive responders to neuronal injury but as key contributors to the disease process itself. This astrocytic dysfunction presents a region-specific distribution within the hippocampus, suggesting localized vulnerability and complex glial involvement in DS-related neuropathology. Full article

Immigrant and mixed-status families comprise a growing population in the United States, facing numerous barriers to accessing essential health and social services. This study examines service access barriers within the unique context of New Mexico’s borderlands, where constitutionally protected bilingualism and welcoming local policies contrast sharply with restrictive federal border enforcement. Using a qualitative approach, we conducted five focus groups with 36 immigrant caregivers in Doña Ana County, New Mexico, with the objective of understanding the factors that facilitate and hinder immigrant families’ access to health, behavioral health, and social services in this socio-politically complex border environment. Thematic analysis revealed three overarching themes: (1) structural and organizational limitations, including language barriers and transportation challenges exacerbated by border checkpoints; (2) the persistence of “chilling effects” on service use despite a Democratic presidency and post-pandemic policy shifts; and (3) community-defined recommendations for improving service access. The findings demonstrate how federal immigration enforcement undermines local inclusion efforts, creating enduring barriers to service access even in historically bilingual, immigrant-friendly regions. The participants proposed specific solutions, including mobile service units and integrated service centers, that account for both geographic and socio-political barriers unique to border regions. These community-generated recommendations offer practical strategies for improving immigrant service access in contexts where local welcome and federal enforcement create competing pressures on immigrant families. Full article

Background/Objectives: In Angola, malnutrition contributes each year to the deaths of an estimated 42,000 to 76,000 children under the age of 5. Addressing this issue must stand as a priority and requires providing local residents with access not only to nutritious food but also to adequate and accurate information in order to facilitate informed dietary choices. As part of the “Seigungo—Health, Education and Quality of Maternal and Child Life in Gungo project”, a nutrition-focused study was conducted in Gungo, Angola to evaluate the effectiveness of a training model designed to enhance food literacy among residents. Methods: Data were collected using a 14-item questionnaire developed to assess various key domains of food literacy: information seeking and access; comprehension and thematic knowledge; critical evaluation of information and behaviour; practical application and sound decision-making. Results: Thirty trainees took part in the study, of which 60% were men, with a mean age of 45.6 years. The majority were single (53.3%) and had completed six years of formal education (26.7%). Before attending the training program, 86.7% of the participants demonstrated inadequate or problematic food literacy. Following the intervention, the proportion of participants with adequate food literacy increased significantly from 13.3% to 73.3% (p < 0.001). Conclusions: The training program had a statistically significant impact on improving food literacy. Full article

Farm-to-school (F2S) partnerships connect schools with local producers to enhance student access to healthy, local foods and support regional food systems. Despite widespread implementation, few studies have examined the system-level structures that facilitate effective and sustainable F2S efforts across diverse community contexts. This study utilized a mixed-methods system mapping approach to analyze four F2S systems on California’s Central Coast. Data sources included public data sources, in-person site observations, and local expert resources. The researchers hypothesized that successful F2S systems would share core features that support implementation and long-term sustainability, including aligned values among stakeholders, the presence of identified champions, and multi-directional pathways for food procurement and communication. They constructed system maps and compared them in order to identify both common structural features and context-specific adaptations. Findings support the hypothesis and highlight the critical role of community-based organizations and distributors and/or aggregators in brokering relationships, coordinating resources, and reducing administrative burdens. Institutionalization through wellness policy integration and district-level support further distinguished higher-functioning systems. Identified barriers included inequities in procurement infrastructure, limited funder engagement, and uneven access to local food sources. System mapping offers a valuable tool to understand, strengthen, and scale equitable F2S implementation. Full article

In confronting escalating economic uncertainty, achieving a win–win situation for low-carbon transition and improved employment structure will contribute to economic recovery and sustainable growth but also contribute to building a community with a shared future for mankind. A critical issue for China’s economy and societal welfare, as well as a core component of sustainable development, concerns whether low-carbon economic transition influences employment skill structure. This study utilizes data from 30 provinces (municipalities and autonomous regions) in China from 2006 to 2021. Employing the entropy method, a low-carbon economic development level indicator system was constructed from four aspects: low-carbon output, low-carbon consumption, low-carbon resources, and low-carbon environment to measure the low-carbon economy and explore its direct and indirect effects on employment skill structure and spatial effects. The research findings indicate that low-carbon economies not only directly and significantly promote employment skill structure optimization but also indirectly generate promotional effects through pathways such as industrial structure adjustment, green innovation’s innovative effects, and factor substitution effects of increased pollution control investment. Among these, the indirect impact of industrial structure adjustment contributes most substantially. Low-carbon economies’ influence on employment skill structures exhibits spatial spillover effects, with neighboring regions’ low-carbon economies exerting positive spillover effects on local skill structures. Additionally, significant negative interdependence exists among regional employment skill structures. Based on the aforementioned research conclusions, the following recommendations are proposed: accelerate low-carbon economy development and employment skill structure enhancement in central and western regions to diminish regional disparities; encourage green innovation and promote traditional industry upgrading and transformation; formulate regional coordinated development plans, thereby strengthening the low-carbon economy’s optimizing role upon employment skills structure; and increase educational investment and strengthen labor skill training. Full article

Background: The asymptomatic progression of initial gingival inflammation in children often remains unnoticed or undiagnosed. Although full-mouth periodontal examination is considered the gold standard in diagnosing periodontal diseases, it is usually time-consuming and expensive. Therefore, the aim of this study was to assess gingival status using partial-mouth examination with the Community Periodontal Index of Treatment Needs (CPITN) and full-mouth examination with Bleeding on Probing (BOP) in the periodontal diagnosis of adolescents. Methods: This cross-sectional study was conducted in a sample of 457 Bulgarian children aged 11 to 14 years. Full-mouth examination was performed with the BOP index on all fully erupted permanent teeth, probing four gingival sites—three buccal and one oral. Partial-mouth examination was performed with CPITN, probing six representative teeth at six sites. Statistical analysis was conducted using Pearson’s chi-square test (χ²) and t-tests to compare relative proportions. Results: The BOP index identified significantly more healthy children compared to the CPITN (t = 1.90, p < 0.05). The CPITN has limitations in distinguishing between initial (BOP 10–30%) and advanced (BOP 30–60%) gingival inflammation. The comparative evaluation of the two indices by sextant showed that a healthy periodontium is most commonly observed in the posterior segments of both jaws in children, while gingival inflammation is localized predominantly in frontal areas. Conclusions: The CPITN has the advantage of providing a quick and easy method for recording gingival status in children, but it does not allow for the determination of the severity of gingival inflammation. Clinical Significance: Full-mouth examination using the BOP index is a more appropriate method for periodontal diagnosis in children, as it provides a detailed and comprehensive picture of the condition of the gingival tissues, especially when a clinical diagnosis is required to guide further treatment planning. Full article

The Arctic region, one of the most vulnerable areas globally, faces severe climate change impacts, with rising sea levels and temperatures threatening local communities. Modern geoinformation tools provide a reliable, cost-efficient, and time-saving method for assessing these climate changes in Arctic coastal regions. This study focuses on Finland’s Arctic and sub-Arctic diverse coastline. The Coastal Vulnerability Index (CVI) is used to assess the vulnerability of Finland’s coastlines, using advanced geoinformatics tools. Integrating high-resolution data from EMODnet, the National Land Survey of Finland Digital Elevation Model (DEM), and physical sources, the CVI includes six input parameters: geomorphology, coastal slope, shoreline change rates, mean wave height, tidal range, and relative sea-level change. The CVI results reveal pronounced spatial variability: 37% of the coastline is classified with very low vulnerability, primarily in the southern Gulf of Finland, and some northern segments, specifically part of Lapland, exhibit minimal susceptibility to coastal hazards. Conversely, the central Gulf of Bothnia shows high vulnerability (29%), with low and moderate vulnerability zones comprising 27% and 6%, respectively, and very high vulnerability at 1%. This assessment provides essential insights for sustainable coastal management in Finland by offering a replicable model for Arctic coastal assessments. This study supports policymakers and local communities in developing targeted adaptation strategies to enhance resilience against climate-driven coastal hazards. Full article

Background: The management of older diabetic patients in the Southern Africa Development Community (SADC) has been described by several authors as poor due to several constraints and lack of a team care approach. This systematic review aimed to investigate the facilitators and barriers to the effective implementation of interprofessional care (IPC) of the elderly with type 2 diabetes mellitus (T2D) in the SADC region. Methods: A comprehensive literature search was conducted using the Population–Concept–Context (PCC) framework in the search for relevant articles. Out of a total of 155 relevant articles, only 8 articles matched the set criteria and were selected for the final review. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used in the review. Results: The identified facilitators include providing decision support to healthcare workers, training of healthcare workers, use of local languages during the training sessions, and use of certified guidelines in the management of not only T2D but also all the other disease conditions. Barriers like ill-equipped patients with limited opportunities for education and counseling, enormous workload due to staff shortages, and loss to follow-up, among others, were equally identified. Conclusions: This systematic review identifies key facilitators and barriers to implementing effective interprofessional care for type 2 diabetes management in the elderly population of the SADC. Understanding these factors can help healthcare professionals optimize their collaborative efforts, ultimately enhancing the quality of care and improving health outcomes for elderly patients with T2D in the region. Full article

Community Land Trusts (CLTs) have emerged as alternative housing models mainly taken up by civil society organizations aiming to de-commodify land and ensure long-term affordable housing, while fostering participatory democratic governance and (re)claiming the right to homeownership. Drawing on empirical evidence from the CLT in Leuven (Belgium) and research conducted between November 2022 and February 2025, this study examines state-led CLTs and their potential in providing affordable housing and democratizing housing systems. The leading role of local authorities serves as a catalyst facilitating access to land and resources while setting up democratic and collaborative governance processes towards the creation of housing commons. However, their involvement introduces market mechanisms that undermine long-term affordability. This research mobilizes the literature on commons and commoning, housing affordability debates and governance theories to explore the paradox of state-led CLTs: Can they democratize housing governance, or does state involvement inevitably reinforce the market mechanisms they seek to counteract? The paper argues that states can initiate commons without fully co-opting them, provided governance is polycentric and reflexive. The contribution of state-led housing commons lies not in radical rupture but in incremental decommodification and emergent commoning, showing how commons can evolve within capitalist states. Full article

The breast microbiome remains stable throughout a woman’s life. The breast is not a sterile organ, and its microbiota exhibits a distinct composition compared to other body sites. The breast microbiome is a community characterized by an abundance of Proteobacteria and Firmicutes, which represent the result of host microbial adaptation to the fatty acid environment in the tissue. The breast microbiome demonstrates dynamic adaptability during lactation, responding to maternal physiological changes and infant interactions. This microbial plasticity modulates local immune responses, maintains epithelial integrity, and supports tissue homeostasis, thereby influencing both breast health and milk composition. Disruptions in this balance, the dysbiosis, are closely linked to inflammatory breast conditions such as mastitis. Risk factors for breast cancer (BC) include genetic mutations, late menopause, obesity, estrogen metabolism, and alterations in gut microbial diversity. Gut microbiota can increase estrogen bioavailability by deconjugating estrogen-glucuronide moieties. Perturbations of this set of bacterial genes and metabolites, called the estrobolome, increases circulating estrogens and the risk of BC. Fusobacterium nucleatum has recently been associated with BC. It moves from the oral cavity to other body sites hematogenously. This review deals with the characteristics of the breast microbiome, with a focus on F. nucleatum, highlighting its dual role in promoting tumor growth and modulating immune responses. F. nucleatum acts both on the Wnt/β-catenin pathway by positively regulating MYC expression and on apoptosis by inhibiting caspase 8. Furthermore, F. nucleatum binds to TIGIT and CEACAM1, inhibiting T-cell cytotoxic activity and protecting tumor cells from immune cell attack. F. nucleatum also inhibits T-cell function through the recruitment of myeloid suppressor cells (MDSCs). These cells express PD-L1, which further reduces T-cell activation. A deeper understanding of F. nucleatum biology and its interactions with host cells and co-existing symbiotic microbiota could aid in the development of personalized anticancer therapy. Full article

Obesity is an epidemic that currently impacts many nations. The persistence of this disease is shaped by both genetic and epigenetic factors that extend beyond calorie balance. Research in the past year has revealed that epigenetic and cellular memory within adipose tissue can predispose individuals to weight regain after initial fat loss, as shown by studies indicating persistent transcriptional and chromatin changes even after fat mass reduction. Independent studies also demonstrate long-lasting metabolic shifts, such as those triggered by glucose-dependent insulinotropic polypeptide receptor (GIPR)-induced thermogenesis and sarcolipin (SLN) stabilization that also support a form of “metabolic memory” that is associated with sustained weight loss. At the neural level, rare variants in synaptic genes like BSN (Bassoon presynaptic cytomatrix protein), a presynaptic scaffold protein, and APBA1 (amyloid beta precursor protein binding family A member 1), a neuronal adaptor involved in vesicular trafficking, disrupt communication in feeding circuits, elevating obesity risk and illustrating how synaptic integrity influences food intake regulation. Similarly, the spatial compartmentalization of metabolic signaling within neuronal cilia is emerging as crucial, with cilia-localized receptors G protein-coupled receptor 75 (GPR75) and G protein-coupled receptor 45 (GPR45) exerting opposing effects on energy balance and satiety. Meanwhile, genome-wide association studies (GWAS) have advanced through larger, more diverse cohorts and better integration of environmental and biological data. These studies have identified novel obesity-related loci and demonstrated the value of polygenic risk scores (PRS) in predicting treatment responses. For example, genetic variants in GLP-1R (glucagon-like peptide-1 receptor) and GIPR (glucose-dependent insulinotropic polypeptide receptor) may modulate the effectiveness of incretin-based therapies, while PRS for satiation can help match individuals to the most appropriate anti-obesity medications. This review focuses on studies in the last two years that highlight how advances in obesity genetics are driving a shift toward more personalized and mechanism-based treatment strategies. Full article

A total of 61 specimens of deep-sea chimaeras (Hydrolagus melanophasma = 41; Chimaera sp. = 20) were obtained during September 2017 as by-catch of the local fishery of the Patagonian toothfish (Dissostichus eleginoides, Pisces: Nototheniidae) along the northern Chilean coasts (≈22°20′ S) at depths ranging from 950 to 1500 m using a deep-sea longline. Nine species of metazoan parasites were found in H. melanophasma and seven in Chimaera sp. Four species were shared between both host species. Gyrocotyle sp.1 (Cestodaria) and Multicalyx elegans (Aspidogastrea) showed the higher prevalence H. melanophasma (68.3% and 65.38%, respectively), whereas Plectognathotrema hydrolagi (Digenea), Gyrocotyle sp.1 (Cestodaria), and Chimaericola sp. (Monogenea) showed higher prevalence in Chimaera sp. (90%, 55% and 55%, respectively). Beta diversity analysis reveals that the parasite communities of these two related and sympatric species are strongly differentiated. Our results suggest a strong relationship between the ancient Holocephali, which harbor ancient parasites belonging to Rugogasteridae and Multicalycidae (Aspidogastrea), and two Cestodaria species. Chimaera spp. are also parasitized by some highly specific monogeneans, such as Chimaericola spp. Our results demonstrate the differences in the parasite community structures—both of ecto- and endoparasites—of two related and sympatric hosts. Full article

Malaria remains a significant public health challenge in Angola, particularly in Cuando Cubango province. This study aimed to characterize the local Anopheles mosquito population, evaluate the impact of indoor residual spraying (IRS) on key entomological indicators, and assess the community knowledge, attitudes, and practices (KAP) related to malaria and vector control. Mosquito collections were conducted indoors at three sites over five months using CDC light traps and Prokopack aspirators. Ten Anopheles species were identified, with An. funestus s.s. being the predominant vector, accounting for 91.7% of the Funestus group. The overall Plasmodium falciparum circumsporozoite protein (CSP) infection rate was 9.2%, with Makua exhibiting the highest rate (10.2%). Following IRS, the indoor resting density of the Funestus group decreased significantly in Makua and Agostinho Neto. In Makua, An. funestus s.s. CSP infection rates decreased by 55% following IRS implementation; however, this reduction was not statistically significant. Knockdown resistance mutations were detected in An. arabiensis and An. gambiae s.s. The 2020/2021 IRS campaign achieved 95% spray coverage and reached 421,856 individuals. Complementary KAP surveys with 647 households showed that 87% of respondents correctly identified mosquitoes as malaria vectors, 78% recognized key symptoms, and 89% supported continued IRS. Reported adherence to post-IRS precautions exceeded 70% and preference for IRS over ITN was expressed by most households. These findings highlight both biological and social dimensions of malaria control, demonstrating that vector control, community acceptance, and entomological surveillance are essential for effective and sustainable malaria interventions in Cuando Cubango. Full article

Low-cost ocean monitoring systems are increasingly needed to address data gaps in coastal environments, particularly in regions where traditional research infrastructure is limited. This paper presents the design, development, and field deployment of a biophysical ocean buoy (BOB)—a compact, solar-powered autonomous buoy system capable of measuring sea surface temperature, salinity (via electrical conductivity), total dissolved solids, pH, and GPS position. The system features real-time data transmission via the Iridium satellite, local data logging, and modular sensor integration. The BOB was deployed for three missions in the Seto Inland Sea, Japan, ranging from 26–56 h in duration. The system successfully recorded high-resolution environmental data, revealing coastal gradients, diurnal heating cycles, and tidal current reversals. Over 95% of the measurements were successfully recovered, and the Iridium communications exceeded 90% reliability. The temperature and salinity data captured fine-scale variations consistent with freshwater plume interactions and tidal forcing. With a total system cost under USD 2000 and minimal deployment requirements, the BOB offers a scalable solution for distributed ocean monitoring. Its performance suggests strong potential for use in aquaculture monitoring, coastal hazard detection, and climate change research, especially in data-sparse regions. This work contributes to the growing field of democratized ocean observation, combining affordability with operational reliability. Full article

This study presents a low-cost wearable system for monitoring and classifying paddle strokes in open-water environments. Building upon our previous work in controlled aquatic and dryland settings, the proposed system consists of ESP32-based embedded nodes equipped with MPU6050 accelerometer–gyroscope sensors. These nodes communicate via the ESP-NOW protocol in a master–slave architecture. With minimal hardware modifications, the system implements gesture classification using Dynamic Time Warping (DTW) to distinguish between left and right paddle strokes. The collected data, including stroke type, count, and motion similarity, are transmitted in real time to a local interface for visualization. Field experiments were conducted on a calm lake using a paddleboard, where users performed a series of alternating strokes. In addition to gesture recognition, the study includes empirical testing of ESP-NOW communication range in the open lake environment. The results demonstrate reliable wireless communication over distances exceeding 100 m with minimal packet loss, confirming the suitability of ESP-NOW for low-latency data transfer in open-water conditions. The system achieved over 80% accuracy in stroke classification and sustained more than 3 h of operational battery life. This approach demonstrates the feasibility of real-time, wearable-based motion tracking for water sports in natural environments, with potential applications in kayaking, rowing, and aquatic training systems. Full article