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Keywords = mephtetramine

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13 pages, 2268 KB  
Article
Genotoxicity Evaluation of The Novel Psychoactive Substance MTTA
by Monia Lenzi, Sofia Gasperini, Giorgia Corli, Matteo Marti and Patrizia Hrelia
Int. J. Mol. Sci. 2023, 24(13), 10498; https://doi.org/10.3390/ijms241310498 - 22 Jun 2023
Cited by 2 | Viewed by 1883
Abstract
MTTA, also known as mephtetramine, is a stimulant novel psychoactive substance characterized by a simil-cathinonic structure. To date, little has been studied on its pharmaco-toxicological profile, and its genotoxic potential has never been assessed. In order to fill this gap, the aim of [...] Read more.
MTTA, also known as mephtetramine, is a stimulant novel psychoactive substance characterized by a simil-cathinonic structure. To date, little has been studied on its pharmaco-toxicological profile, and its genotoxic potential has never been assessed. In order to fill this gap, the aim of the present work was to evaluate its genotoxicity on TK6 cells in terms of its ability to induce structural and numerical chromosomal aberrations by means of a cytofluorimetric protocol of the “In Vitro Mammalian Cell Micronucleus (MN) test”. To consider the in vitro effects of both the parental compound and the related metabolites, TK6 cells were treated with MTTA in the absence or presence of an exogenous metabolic activation system (S9 mix) for a short-term time (3 h) followed by a recovery period (23 h). No statistically significant increase in the MNi frequency was detected. Specifically, in the presence of S9 mix, only a slight increasing trend was observable at all tested concentrations, whereas, without S9 mix, at 75 µM, almost a doubling of the negative control was reached. For the purposes of comprehensive evaluation, a long-term treatment (26 h) was also included. In this case, a statistically significant enhancement in the MNi frequency was observed at 50 µM. Full article
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22 pages, 2079 KB  
Article
Pharmaco-Toxicological Effects of Atypical Synthetic Cathinone Mephtetramine (MTTA) in Mice: Possible Reasons for Its Brief Appearance over NPSs Scene
by Giorgia Corli, Micaela Tirri, Raffaella Arfè, Beatrice Marchetti, Tatiana Bernardi, Martina Borsari, Sara Odoardi, Serena Mestria, Sabina Strano-Rossi, Margherita Neri, Rosa Maria Gaudio, Sabrine Bilel and Matteo Marti
Brain Sci. 2023, 13(2), 161; https://doi.org/10.3390/brainsci13020161 - 18 Jan 2023
Cited by 4 | Viewed by 2163
Abstract
Over the last year, NPSs have been steadily on the rise in the illicit drug market. Among these, synthetic cathinones seem to become increasingly popular among young adults, mainly because of their ability to replicate the effects of traditional psychostimulant drugs, such as [...] Read more.
Over the last year, NPSs have been steadily on the rise in the illicit drug market. Among these, synthetic cathinones seem to become increasingly popular among young adults, mainly because of their ability to replicate the effects of traditional psychostimulant drugs, such as cocaine, MDMA and amphetamines. However, scarce data are available about the in vivo pharmaco-toxicology of these new substances. To this end, this study focused on evaluation of effects induced by repeated administration of mephtetramine (MTTA 0.1–30 mg/kg i.p.) in mice. This atypical cathinone highlighted a sensorial (inhibition of visual and acoustic reflexes) and transient physiological parameter (decrease in breath rate and temperature) change in mice. Regarding motor activity, both a dose-dependent increase (accelerod test) and biphasic effect (drag and mobility time test) have been shown. In addition, blood and urine samples have been analysed to enrich the experimental featuring of the present study with reference to evaluation of potential toxicity related to consumption of MTTA. The latter analysis has particularly revealed important changes in blood cells count and blood and urine physicochemical profile after repeated treatment with this atypical cathinone. Moreover, MTTA induced histological changes in heart, kidney and liver samples, emphasizing its potential toxicity. Full article
(This article belongs to the Section Behavioral Neuroscience)
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