Search Results (1,037)

Polycystic ovary syndrome (PCOS) represents one of the most prevalent endocrine–metabolic disorder in women of reproductive age, which includes but not restricted to reproductive disruptions, insulin resistance (IR), hyperandrogenism, and chronic low-grade inflammation. Its heterogeneous pathophysiology arises from the interplay of metabolic, endocrine, and immune factors, including dysregulated adipokine secretion, cytokine-mediated inflammation, oxidative stress (OS), and mitochondrial dysfunction. Current pharmacological therapies, such as metformin, clomiphene, and oral contraceptives, often provide partial benefits and are limited by side effects, necessitating the exploration of safer, multi-target strategies. Flavonoids, a structurally diverse class of plant-derived polyphenols, have gained attention as promising therapeutic candidates in PCOS due to their antioxidant, anti-inflammatory, insulin-sensitizing, and hormone-modulating properties. Preclinical studies in rodent PCOS models consistently demonstrate improvements in insulin sensitivity, normalization of ovarian morphology, restoration of ovulation, and reduction in hyperandrogenism. Human clinical studies, though limited in scale and heterogeneity, report favorable effects of flavonoids such as quercetin, isoflavones, and catechins on glucose metabolism, adipokine balance, inflammatory markers, and reproductive functions. This evidence-based study critically synthesizes mechanistic insights into how flavonoids modulate insulin signaling, adipokine–cytokine crosstalk, OS, and androgen excess, while highlighting translational evidence and emerging delivery systems aimed at overcoming bioavailability barriers. Collectively, flavonoids represent a promising class of nutraceuticals and adjuncts to conventional therapies, offering an integrative strategy for the management of PCOS. Full article

Cardiovascular diseases pose a major global health threat, making early automated detection through heart sound analysis crucial for their prevention. However, existing deep learning-based heart sound detection methods have shortcomings in feature extraction, and current attention mechanisms perform inadequately in capturing key heart sound features. To address this, we first introduce a Multi-Scale Feature Extraction Network composed of Multi-Scale Inverted Residual (MIR) modules and Dynamically Gated Convolution (DGC) modules to extract heart sound features effectively. The MIR module can efficiently extract multi-scale heart sound features, and the DGC module enhances the network’s representation ability by capturing feature interrelationships and dynamically adjusting information flow. Subsequently, a Multi-Scale Attention Prediction Network is designed for heart sound feature classification, which includes a multi-scale attention (MSA) module. The MSA module effectively captures subtle pathological features of heart sound signals through multi-scale feature extraction and cross-scale feature interaction. Additionally, pitch-shifting techniques are applied in the preprocessing stage to enhance the model’s generalization ability, and multiple feature extraction techniques are used for initial feature extraction of heart sounds. Evaluated via five-fold cross-validation, the model achieved accuracies of 98.89% and 98.86% on the PhysioNet/CinC 2016 and 2022 datasets, respectively, demonstrating superior performance and strong potential for clinical application. Full article

Current drone navigation systems primarily rely on Global Navigation Satellite Systems (GNSSs), but their signals are susceptible to interference, spoofing, or suppression in complex environments, leading to degraded positioning performance or even failure. To enhance the positioning accuracy and robustness of low-altitude drones in satellite-denied environments, this paper investigates an absolute visual localization solution. This method achieves precise localization by matching real-time images with reference images that have absolute position information. To address the issue of insufficient feature generalization capability due to the complex and variable nature of ground scenes, a visual-based image retrieval algorithm is proposed, which utilizes a fusion of shallow spatial features and deep semantic features, combined with generalized average pooling to enhance feature representation capabilities. To tackle the registration errors caused by differences in perspective and scale between images, an image registration algorithm based on cyclic consistency matching is designed, incorporating a reprojection error loss function, a multi-scale feature fusion mechanism, and a structural reparameterization strategy to improve matching accuracy and inference efficiency. Based on the above methods, a hierarchical absolute visual localization system is constructed, achieving coarse localization through image retrieval and fine localization through image registration, while also integrating IMU prior correction and a sliding window update strategy to mitigate the effects of scale and rotation differences. The system is implemented on the ROS platform and experimentally validated in a real-world environment. The results show that the localization success rates for the h, s, v, and w trajectories are 95.02%, 64.50%, 64.84%, and 91.09%, respectively. Compared to similar algorithms, it demonstrates higher accuracy and better adaptability to complex scenarios. These results indicate that the proposed technology can achieve high-precision and robust absolute visual localization without the need for initial conditions, highlighting its potential for application in GNSS-denied environments. Full article

Wheat blast, caused by Magnaporthe oryzae pathotype Triticum (MoT), poses a major threat to wheat (Triticum aestivum) cultivation, particularly in South America and Bangladesh. The rapid evolution and spread of the pathogen necessitate the development of durable and broad-spectrum resistance in wheat cultivars. This review summarizes current insights into the multi-layered defense mechanisms of wheat, encompassing resistance (R) genes, pattern-triggered immunity (PTI), and effector-triggered immunity (ETI) against MoT. The R-genes provide race-specific resistance through ETI, while both ETI and PTI are required to form integral layers of the plant immune system that synergistically reinforce host defense network. Recent advances in genomics, transcriptomics, and molecular breeding have facilitated the discovery and deployment of key R-genes and signaling components involved in PTI and ETI pathways. Integrating these immune strategies through gene pyramiding, marker-assisted selection (MAS), and genome editing offers a promising route towards enhanced and durable resistance in hosts. Harnessing and optimizing these multilayered immune systems will be pivotal to securing wheat productivity amid the growing threat of wheat blast. Full article

Obtaining accurate information on stratigraphic conditions and drilling status is necessary to ensure the safety of the drilling process and to guarantee the production of oil and gas. Sensing while drilling and intelligent monitoring technology, which employ multiple sensors and involve the use of intelligent algorithms, can be used to collect downhole information in situ to ensure safe, reliable, and efficient drilling and mining operations. These approaches are characterized by effective sensing and comprehensive utilization of drilling information through the integration of multi-sensor signals and intelligent algorithms, a core component of machine learning. The article summarizes the current research status of domestic and international sensing while drilling and intelligent monitoring technology using systematically collected relevant information. Specifically, first, the drilling-sensing methods used for in situ acquisition of downhole information, including fiber-optic sensing, electronic-nose sensing, drilling engineering-parameter sensing, drilling mud-parameter sensing, drilling acoustic logging, drilling electromagnetic wave logging, and drilling seismic logging, are described. Next, the basic composition and development direction of each sensing technology are analyzed. Subsequently, the application of intelligent monitoring technology based on machine learning in various aspects of drilling- and mining-status identification, including bit wear monitoring, stuck drill real-time monitoring, well surge real-time monitoring, and real-time monitoring of oil and gas output, is introduced. Finally, the potential applications of sensing while drilling and intelligent monitoring technology in deep-earth, deep-sea, and deep-space contexts are discussed, and the challenges, constraints, and development trends are summarized. Full article

Gut microbiota changes have emerged as central players in the pathogenesis of both metabolic dysfunction-associated steatohepatitis (MASH) and inflammatory bowel disease (IBD). Although these diseases affect distinct primary organs, they share converging mechanisms driven by dysbiosis, including loss of beneficial short-chain fatty acid-producing taxa such as Faecalibacterium prausnitzii and Roseburia, enrichment of pro-inflammatory Enterobacteriaceae, and disruption of bile acid and tryptophan metabolism. These shifts compromise epithelial barrier integrity, promote the translocation of microbial products such as lipopolysaccharide, and trigger toll-like receptor 4-mediated activation of inflammatory cascades dominated by tumor necrosis factor-alpha, interleukin-6, and transforming growth factor-beta. In MASH, this dysbiotic environment fuels hepatic inflammation, insulin resistance, and fibrogenesis, while in IBD it sustains chronic mucosal immune activation. Shared features include impaired butyrate availability, altered bile acid pools affecting farnesoid X receptor and Takeda G protein-coupled Receptor 5 signaling, and defective aryl hydrocarbon receptor activation, all of which link microbial dysfunction to host metabolic and immune dysregulation. Understanding these overlapping pathways provides a deeper understanding of the role of the gut-liver and gut-immune axes as unifying frameworks in disease progression. This narrative review synthesizes current evidence on gut microbiota in MASH and IBD, underscoring the need for longitudinal, multi-omics studies and microbiome-targeted strategies to guide personalized therapeutic approaches. Full article

The prediction of Remaining Useful Life (RUL) constitutes a vital aspect of Prognostics and Health Management (PHM), providing capabilities for the assessment of mechanical component health status and prediction of failure instances. Recent studies on feature extraction, time-series modeling, and multi-task learning have shown remarkable advancements. However, most deep learning (DL) techniques predominantly focus on unimodal data or static feature extraction techniques, resulting in a lack of RUL prediction methods that can effectively capture the individual differences among heterogeneous sensors and failure modes under complex operational conditions. To overcome these limitations, an adaptive RUL prediction framework named ADAPT-RULNet is proposed for mechanical components, integrating the feature extraction capabilities of attention-enhanced deep learning (DL) and the decision-making abilities of deep reinforcement learning (DRL) to achieve end-to-end optimization from raw data to accurate RUL prediction. Initially, Functional Alignment Resampling (FAR) is employed to generate high-quality functional signals; then, attention-enhanced Dynamic Time Warping (DTW) is leveraged to obtain individual degradation stages. Subsequently, an attention-enhanced of hybrid multi-scale RUL prediction network is constructed to extract both local and global features from multi-format data. Furthermore, the network achieves optimal feature representation by adaptively fusing multi-source features through Bayesian methods. Finally, we innovatively introduce a Deep Deterministic Policy Gradient (DDPG) strategy from DRL to adaptively optimize key parameters in the construction of individual degradation stages and achieve a global balance between model complexity and prediction accuracy. The proposed model was evaluated on aircraft engines and railway freight car wheels. The results indicate that it achieves a lower average Root Mean Square Error (RMSE) and higher accuracy in comparison with current approaches. Moreover, the method shows strong potential for improving prediction accuracy and robustness in varied industrial applications. Full article

Autoimmune diseases are chronic inflammatory conditions characterized by the breakdown of immune tolerance to self-antigens. While genetic and environmental factors play key roles, growing evidence highlights chronic stress as a significant contributor to immune dysregulation through its impact on the hypothalamic–pituitary–adrenal (HPA) axis. The HPA axis, primarily via cortisol secretion, serves as the major neuroendocrine mediator of stress responses, influencing both immune regulation and systemic homeostasis. This review synthesizes current literature on HPA axis physiology, the mechanisms of cortisol signaling, and the maladaptive effects of chronic stress. Emphasis is placed on clinical and experimental findings linking HPA dysfunction to immune imbalance and autoimmunity, as well as organ-specific consequences across neuroimmune, endocrine, cardiovascular, gastrointestinal, integumentary, and musculoskeletal systems. Chronic stress leads to impaired HPA axis feedback, glucocorticoid receptor resistance, and paradoxical cortisol dysregulation, fostering a pro-inflammatory state. This dysregulation promotes cytokine imbalance, weakens protective immune mechanisms, and shifts the immune response toward autoimmunity. Evidence from both human and animal studies associates persistent HPA dysfunction with diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis. HPA axis dysregulation under chronic stress constitutes a critical mechanistic link between psychological stress and autoimmune disease. Understanding these pathways provides opportunities for therapeutic interventions, including stress management, lifestyle modification, and neuroendocrine-targeted treatments. Future research should focus on multi-omics and longitudinal approaches to clarify the reversibility of HPA alterations and identify resilience factors. Full article

To alleviate the communication burden of wide-area protection and enhance the fault tolerance of multi-source criteria, this paper introduces an improved wide-area backup protection method based on multi-source information fusion. Initially, the variation characteristics of bus sequence voltages after a fault are utilized to screen suspected fault lines, thereby reducing communication traffic. Subsequently, four basic probability assignment functions are constructed using the polarity of zero-sequence current charge, the polarity of phase-difference current charge, and the starting signals of Zone II/III distance protection from the local and adjacent lines. The confidence of each probability function is evaluated using normalized information entropy, while consistency is analyzed via Gaussian similarity, enabling dynamic allocation of fusion weights. Additionally, a conflict adaptation factor is designed to adjust the fusion strategy dynamically, improving fault tolerance in high-conflict scenarios and mitigating the impact of abnormal single criteria on decision results. Finally, the fused fault probability is used to identify the fault line. Simulation results based on the IEEE 39-bus model demonstrate that the proposed algorithm can accurately identify fault lines under different fault types and locations and remains robust under conditions such as information loss and protection maloperation or failure. Full article

At present, traditional X-ray inspection is used to inspect the welds of the bottom, barrel section and short shell parts of the launch vehicle, which has the disadvantages of low automation, complicated process and low efficiency, and cannot meet the fast-paced development needs of multiple models at present. Moreover, the degree of digitization is low, the test results are recorded in the form of negatives, data statistics, storage and access are difficult, and the circulation efficiency is low, which is not conducive to product quality control and traceability; At the same time, it cannot adapt to and meet the needs of digital and intelligent transformation and development. In this paper, a dual-robot collaborative digital radiographic inspection system for rocket tank welds is developed by combining dual-robot control technology and digital radiographic inspection technology. The system can be directly applied to digital radiographic inspection of tank bottom, barrel section and short shell welds of multiple types of launch vehicles; meanwhile, the dual-robot path planning technology based on the dual-mode is studied. Finally, the imaging software platform based on VS and Twincat3.0 VS2015 software combined with QT upper computer is designed. Experiments show that compared with the existing traditional ray detection methods, the detection efficiency of the system is improved by 5 times, the image sensitivity reaches W14, the resolution reaches D10, and the standardized signal-to-noise ratio reaches 128, which far exceeds the requirements of process technology A, and meets the current non-destructive detection work of multi-model rocket tank welds. Full article

Cardiovascular disease (CVD) remains the leading cause of global mortality, highlighting the need for continuous vital sign monitoring. Photoplethysmography (PPG) is well suited for wearable devices. Smart rings, benefiting from dense capillary distribution and minimal tissue interference, can capture high-quality PPG signals with comfort, making them a promising next-generation wearable. However, ring rotation relative to the finger alters the optical path, especially for multi-wavelength light, thus reducing accuracy. This paper proposes a rotation-robust PPG sensor for smart rings. Monte Carlo simulations analyze photon transmission under different LED–photodiode (PD) angles, showing that at ±60°, green, red, and infrared light achieve optimal penetration into the microcirculation layer. Considering non-ideal conditions, the green-light angle is adjusted to ±30°, and a symmetrical sensor design is adopted. A prototype smart ring is developed, capable of recording 4-channel PPG, 3-axis acceleration, and 4-channel temperature signals at 100, 25, and 0.2 Hz, respectively. The system achieves reliable PPG acquisition with only 0.59 mA average current consumption. In continuous testing, heart rate estimation reached mean absolute errors of 0.82, 0.79, and 0.78 bpm for green, red, and IR light. The results provide a reference for future smart ring development. Full article

Background: This narrative review examines the role of artificial intelligence (AI) in bowel sound analysis for the diagnosis and management of inflammatory bowel disease (IBD). Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, presents a significant clinical burden due to its unpredictable course, variable symptomatology, and reliance on invasive procedures for diagnosis and disease monitoring. Despite advances in imaging and biomarkers, tools such as colonoscopy and fecal calprotectin remain costly, uncomfortable, and impractical for frequent or real-time assessment. Meanwhile, bowel sounds—an overlooked physiologic signal—reflect underlying gastrointestinal motility and inflammation but have historically lacked objective quantification. With recent advances in artificial intelligence (AI) and acoustic signal processing, there is growing interest in leveraging bowel sound analysis as a novel, non-invasive biomarker for detecting IBD, monitoring disease activity, and predicting disease flares. This approach holds the promise of continuous, low-cost, and patient-friendly monitoring, which could transform IBD management. Objectives: This narrative review assesses the clinical utility, methodological rigor, and potential future integration of artificial intelligence (AI)-driven bowel sound analysis in inflammatory bowel disease (IBD), with a focus on its potential as a non-invasive biomarker for disease activity, flare prediction, and differential diagnosis. Methods: This manuscript reviews the potential of AI-powered bowel sound analysis as a non-invasive tool for diagnosing, monitoring, and managing inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis. Traditional diagnostic methods, such as colonoscopy and biomarkers, are often invasive, costly, and impractical for real-time monitoring. The manuscript explores bowel sounds, which reflect gastrointestinal motility and inflammation, as an alternative biomarker by utilizing AI techniques like convolutional neural networks (CNNs), transformers, and gradient boosting. We analyze data on acoustic signal acquisition (e.g., smart T-shirts, smartphones), signal processing methodologies (e.g., MFCCs, spectrograms, empirical mode decomposition), and validation metrics (e.g., accuracy, F1 scores, AUC). Studies were assessed for clinical relevance, methodological rigor, and translational potential. Results: Across studies enrolling 16–100 participants, AI models achieved diagnostic accuracies of 88–96%, with AUCs ≥ 0.83 and F1 scores ranging from 0.71 to 0.85 for differentiating IBD from healthy controls and IBS. Transformer-based approaches (e.g., HuBERT, Wav2Vec 2.0) consistently outperformed CNNs and tabular models, yielding F1 scores of 80–85%, while gradient boosting on wearable multi-microphone recordings demonstrated robustness to background noise. Distinct acoustic signatures were identified, including prolonged sound-to-sound intervals in Crohn’s disease (mean 1232 ms vs. 511 ms in IBS) and high-pitched tinkling in stricturing phenotypes. Despite promising performance, current models remain below established biomarkers such as fecal calprotectin (~90% sensitivity for active disease), and generalizability is limited by small, heterogeneous cohorts and the absence of prospective validation. Conclusions: AI-powered bowel sound analysis represents a promising, non-invasive tool for IBD monitoring. However, widespread clinical integration requires standardized data acquisition protocols, large multi-center datasets with clinical correlates, explainable AI frameworks, and ethical data governance. Future directions include wearable-enabled remote monitoring platforms and multi-modal decision support systems integrating bowel sounds with biomarker and symptom data. This manuscript emphasizes the need for large-scale, multi-center studies, the development of explainable AI frameworks, and the integration of these tools within clinical workflows. Future directions include remote monitoring using wearables and multi-modal systems that combine bowel sounds with biomarkers and patient symptoms, aiming to transform IBD care into a more personalized and proactive model. Full article

Background: Artificial Intelligence (AI) is increasingly applied in endurance sports to optimize performance, enhance recovery, and personalize nutrition and supplementation. This review synthesizes current knowledge on AI applications in endurance sports, emphasizing implications for metabolic health, nutritional strategies, and recovery optimization, while also addressing ethical considerations and future directions. Methods: A narrative review was conducted using targeted searches of PubMed, Scopus, and Web of Science with cross-referencing. Extracted items included sport/context, data sources, AI methods including machine learning (ML), validation type (internal vs. external/field), performance metrics, comparators, and key limitations to support a structured synthesis; no formal risk-of-bias assessment or meta-analysis was undertaken due to heterogeneity. Results: AI systems effectively integrate multimodal physiological, environmental, and behavioral data to enhance metabolic health monitoring, predict recovery states, and personalize nutrition. Continuous glucose monitoring combined with AI algorithms allows precise carbohydrate management during prolonged events, improving performance outcomes. AI-driven supplementation strategies, informed by genetic polymorphisms and individual metabolic responses, have demonstrated enhanced ergogenic effectiveness. However, significant challenges persist, including measurement validity and reliability of sensor-derived signals and overall dataset quality (e.g., noise, missingness, labeling error), model performance and generalizability, algorithmic transparency, and equitable access. Furthermore, limited generalizability due to homogenous training datasets restricts widespread applicability across diverse athletic populations. Conclusions: The integration of AI in endurance sports offers substantial promise for improving performance, recovery, and nutritional strategies through personalized approaches. Realizing this potential requires addressing existing limitations in model performance and generalizability, ethical transparency, and equitable accessibility. Future research should prioritize diverse, representative, multi-site data collection across sex/gender, age, and race/ethnicity. Coverage should include performance level (elite to recreational), sport discipline, environmental conditions (e.g., heat, altitude), and device platforms (multi-vendor/multi-sensor). Equally important are rigorous external and field validation, transparent and explainable deployment with appropriate governance, and equitable access to ensure scientifically robust, ethically sound, and practically relevant AI solutions. Full article

Partial Discharge (PD) measurement is one of the effective methods for assessing the internal insulation condition of power transformers in factories and substations. The pulse current signals generated by PD within transformer windings are significantly influenced by the winding structure during their propagation from the discharge source to the external measurement system. This influence may lead to misinterpretation of the insulation status, particularly in the analysis of PD measurement results. Such effects are closely related to the signal transmission path and distance and exhibit a strong correlation with the winding transfer function, manifesting as attenuation, distortion, or delay of the measured signals compared to the original PD waveforms. Therefore, it is essential to investigate the impact of the discharge path on the propagation characteristics of transformer windings and its effect on PD waveforms. This paper establishes a simplified distributed parameter model of a 180-turn single-winding multi-conductor transmission line using the finite element method and mathematical modeling, deriving the transfer functions between the winding head or winding end and various internal discharge positions. By injecting different types of PD waveforms collected in the laboratory at various discharge locations within the winding, the alterations of PD signals propagated to the winding head and winding end are simulated, and clustering analysis is performed on the propagated PD signals of different types. Full article

Visible Light Positioning (VLP) has emerged as a pivotal technology for industrial Internet of Things (IoT) and smart logistics, offering high accuracy, immunity to electromagnetic interference, and cost-effectiveness. However, fluctuations in signal gain caused by target motion significantly degrade the positioning accuracy of current VLP systems. Conventional approaches face intrinsic limitations: propagation-model-based techniques rely on static assumptions, fingerprint-based approaches are highly sensitive to dynamic parameter variations, and although CNN/LSTM-based models achieve high accuracy under static conditions, their inability to capture long-term temporal dependencies leads to unstable performance in dynamic scenarios. To overcome these challenges, we propose a novel dynamic VLP algorithm that incorporates a Spatio-Temporal Feature Information Network (STFI-Net) for joint localization and orientation estimation of moving targets. The proposed method integrates a two-layer convolutional block for spatial feature extraction and employs modern Temporal Convolutional Networks (TCNs) with dilated convolutions to capture multi-scale temporal dependencies in dynamic environments. Experimental results demonstrate that the STFI-Net-based system enhances positioning accuracy by over 26% compared to state-of-the-art methods while maintaining robustness in the face of complex motion patterns and environmental variations. This work introduces a novel framework for deep learning-enabled dynamic VLP systems, providing more efficient, accurate, and scalable solutions for indoor positioning. Full article