Search Results (955)

This study investigates the air filtration capabilities of fibrous membranes fabricated via electrospinning, with a focus on optimizing processing parameters. Specifically, Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a well-characterized biodegradable polyester, was electrospun to produce membranes exhibiting precisely controlled surface microstructures. The optimal fiber morphology was attained under conditions of a 20 kV applied electric field, a solution flow rate of 0.5 mL·h⁻¹, a polymer concentration of 13 wt.%, and a needle inner diameter of 0.21 mm. The microstructural features of the electrospun PHBV membranes were characterized using scanning electron microscopy (SEM). Complementary analysis via ¹³C nuclear magnetic resonance (NMR) spectroscopy confirmed that the membranes comprised pure 3-hydroxyvalerate (3HV) copolymerized with 3-hydroxybutyrate (3HB) terminal units, with 3HV mole fractions ranging from 17% to 50%. The incorporation of different molar percentages of 3HV in PHBV membrane significantly enhances its durability, as evidenced by Ball Burst Strength (BBS) measurements, with an elongation at burst that is 65–86% greater than that of ASTM F2100 level 3 mask. The nanofibrous membranes exhibited a controlled pore size distribution, indicating their potential suitability for air filtration applications. Particle filtration efficiency (PFE) assessments under standard atmospheric pressure conditions showed that the optimized electrospun PHBV membranes achieved filtration efficiencies exceeding 98%. Additionally, the influence of 3HV content on biodegradation behavior was evaluated through soil burial tests conducted over 90 days. Results indicated that membranes with lower 3HV content (17 mol.%) experienced the greatest weight loss, suggesting accelerated degradation in natural soil environments. Full article

Background/Objectives: The design of scaffolds that mimic the extracellular matrix has gained increasing attention in regenerative medicine. This study aims to develop and characterize electrospun nanofibrous scaffolds based on pullulan blended with either gelatin or gliadin and doped with selenium nanoparticles (Se NPs), to assess the influence of protein type and Se NP doping on scaffold performance and regenerative potential. Methods: Se NPs were synthesized via redox reaction and stabilized using pullulan. Electrospun scaffolds were then prepared by blending pullulan-stabilized Se NPs with either gelatin or gliadin. The resulting fibers were characterized using a multidisciplinary approach, including physicochemical (morphology, fiber dimension, swelling capacity, surface zeta potential, mechanical properties) and preclinical properties (antioxidant properties, fibroblast adhesion and proliferation, collagen expression). Results: Protein type influenced fiber morphology and dimensions, as well as mechanical behavior, with gelatin-based scaffolds demonstrating smaller fiber diameters and higher mechanical properties. The doping with Se NPs enhanced scaffold antioxidant properties without affecting fiber formation. Moreover, all scaffolds supported fibroblast proliferation, but those containing Se NPs showed enhanced modulation of ECM gene expression. Conclusions: The results show that scaffolds doped with Se NPs exhibited superior performance compared to the undoped counterparts, offering promising platforms for chronic wound reparation. Full article

Neural tissue injuries, including spinal cord damage and neurodegenerative diseases, pose a major clinical challenge due to the central nervous system’s limited regenerative capacity. Current treatments focus on stabilization and symptom management rather than functional restoration. Tissue engineering offers new therapeutic perspectives, particularly through the combination of electrospun nanofibrous scaffolds and mesenchymal stem cells (MSCs). Electrospun fibers mimic the neural extracellular matrix, providing topographical and mechanical cues that enhance MSC adhesion, viability, and neural differentiation. MSCs are multipotent stem cells with robust paracrine and immunomodulatory activity, capable of supporting regeneration and, under proper stimuli, acquiring neural-like phenotypes. This systematic review, following the PRISMA 2020 method, analyzes 77 selected articles from the last ten years to assess the potential of electrospun biopolymer scaffolds for MSC-mediated neural repair. We critically examine the scaffold’s composition (synthetic and natural polymers), fiber architecture (alignment and diameter), structural and mechanical properties (porosity and stiffness), and biofunctionalization strategies. The influence of MSC tissue sources (bone marrow, adipose, and dental pulp) on neural differentiation outcomes is also discussed. The results of a literature search show both in vitro and in vivo enhanced neural marker expression, neurite extension, and functional recovery when MSCs are seeded onto optimized electrospun scaffolds. Therefore, integrating stem cell therapy with advanced biomaterials offers a promising route to bridge the gap between neural injury and functional regeneration. Full article

Biocompatible nanofibrous dressings integrating bioactive compounds with antioxidative and antimicrobial properties offer a promising solution for effective wound healing. In the presented study, we developed a novel dual-delivery system by combining forcespun nanofibres with poly(3-hydroxybutyrate) (PHB)-liposomes to enhance bioavailability and enable targeted release of bioactive agents (eugenol, thymol, curcumin, ampicillin, streptomycin, gentamicin). These agents exhibited notable antioxidant activity (2.27–2.33 mmol TE/g) and synergistic or partially synergistic antimicrobial effects against E. coli, M. luteus, S. epidermidis, and P. aeruginosa ( Fractional Inhibitory Concentration index 0.09–0.73). The most potent combinations, particularly thymol, eugenol, and ampicillin, were encapsulated in the nanofibre–liposomal matrix. The successful preparation of a new combined delivery system was confirmed by structural analysis using Electron and Fluorescence Microscopy. The dual-composite materials retained the antimicrobial properties of the individual compounds upon release, with the highest increases of ~73.56% against S. epidermidis. Cell viability and in vitro immunology assays using the human keratinocyte cell line (HaCaT) showed a slight decrease in viability and immune response stimulation, while not impairing wound re-epithelisation. These findings highlight the potential of firstly reported novel carrier utilising both PHB-nanofibres and PHB-liposomes, exhibiting simultaneous antioxidant and antimicrobial activity as promising candidates for the treatment of infected wounds under oxidative stress. Full article

Filtration of submicron particles and nanoparticles is an important problem in nano-industry and in air conditioning and ventilation systems. The presence of submicron particles comprising fungal spores, bacteria, viruses, microplastic, and tobacco-smoke tar in ambient air is a severe problem in air conditioning systems. Many nanotechnology material processes used for catalyst, solar cells, gas sensors, energy storage devices, anti-corrosion and hydrophobic surface coating, optical glasses, ceramics, nanocomposite membranes, textiles, and cosmetics production also generate various types of nanoparticles, which can retain in a conveying gas released into the atmosphere. Particles in this size range are particularly difficult to remove from the air by conventional methods, e.g., electrostatic precipitators, conventional filters, or cyclones. For these reasons, nanofibrous filters produced by electrospinning were developed to remove fine particles from the post-processing gases. The physical basis of electrospinning used for nanofilters production is an employment of electrical forces to create a tangential stress on the surface of a viscous liquid jet, usually a polymer solution, flowing out from a capillary nozzle. The paper presents results for investigation of the filtration process of metal oxide nanoparticles: TiO₂, MgO, and Al₂O₃ by electrospun nanofibrous filter. The filter was produced from polyvinylidene fluoride (PVDF). The concentration of polymer dissolved in dimethylacetamide (DMAC) and acetone mixture was 15 wt.%. The flow rate of polymer solution was 1 mL/h. The nanoparticle aerosol was produced by the atomization of a suspension of these nanoparticles in a solvent (methanol) using an aerosol generator. The experimental results presented in this paper show that nanofilters made of PVDF with surface density of 13 g/m² have a high filtration efficiency for nano- and microparticles, larger than 90%. The gas flow rate through the channel was set to 960 and 670 l/min. The novelty of this paper was the investigation of air filtration from various types of nanoparticles produced by different nanotechnology processes by nanofibrous filters and studies of the morphology of nanoparticle deposited onto the nanofibers. Full article

With the rapid development of cities and increasingly serious environmental problems, energy conservation and environmental restoration are particularly important. Due to the high efficiency of membrane technology in wastewater treatment and polluted water recovery, its research has increased exponentially in recent years. Electrospinning technology has been widely used by researchers in the field of nanofibrous membrane manufacturing due to its inherently high porosity, high flux, and easy preparation of various materials. In this review, the application progress of electrospun nanofibrous materials in water treatment is presented, including membrane distillation, oil–water separation, solar evaporation, and water pollutant removal. Moreover, this review also summarizes the structural design and preparation method of these nanofibrous materials in detail. Finally, the challenges and application prospects of electrospinning in water treatment are determined. Full article

As the demand for clean water continues to rise, the development of reliable and environmentally sustainable purification methods has become increasingly important. In this study, we describe the production and characterization of electrospun polyimide (PID) nanofibers modified with MXene (Ti₃C₂Tx), tungsten trioxide (WO₃), and titanium dioxide (TiO₂) nanomaterials for improved photocatalytic degradation of rhodamine 6G (R6G), a model organic dye. Superior photocatalytic performance was achieved by suppressing electron–hole recombination, promoting efficient charge carrier separation, and the significant increase in light absorption through the addition of metal oxide nanowires and MXene to the PID matrix. Comprehensive characterization confirms a core–shell nanofiber architecture with TiO₂, WO₃, and MXene effectively integrated and electronically coupled, consistent with the observed photocatalytic response. The PID/TiO₂/WO₃/MXene composite exhibited the highest photocatalytic activity among the tested configurations, degrading R6G by 74% in 90 min of light exposure. This enhancement was ascribed to the synergistic interactions between MXene and the metal oxides, which reduced recombination losses and promoted effective charge transfer. The study confirms the suitability of PID-based hybrid nanofibers for wastewater treatment applications. It also points toward future directions focused on scalable production and deployment in the field of environmental remediation. Full article

Elevated phosphorus levels in wastewater created significant environmental concerns, including the degradation of surrounding soil structure, inhibition of plant growth, and potential threats to human health. To address this issue, a self-standing nanofibrous composite membrane based on PA-66/PVA-15%La(OH)₃ was fabricated via electrospinning, followed by glutaraldehyde (GA) crosslinking and alkali hydrolysis to create an interpenetrating structure, where PA-66 provided the overall mechanical strength of the membrane, while La served as a functional component for the adsorption of phosphate. The chemical composition, surface morphology, thermal stability, and mechanical properties of the resulting membranes were characterized using ATR-FTIR, SEM, TGA, and tensile testing, respectively. Furthermore, the adsorption performance of the membranes was evaluated systematically through static and dynamic adsorption. The Langmuir isotherm model yielded a theoretical maximum adsorption capacity of 21.39 mg/g for phosphate ions. Notably, over 96% of this capacity was retained even in the presence of interfering ions. Moreover, dynamic adsorption experiments demonstrated that the membrane can deal with 1.74 L of phosphate-containing wastewater at a low flow rate of 1.0 mL/min and 1.46 L at a high flow rate of 2.0 mL/min, respectively, while consistently maintaining a phosphate removal efficiency exceeding 90%. A controlled release of phosphate ions from a phosphate-adsorbed membrane was successfully demonstrated using Mougeotia cultivation, implying the potential for phosphorus resource recovery. Full article

Acne vulgaris is a chronic disease that occurs in the pilosebaceous units and ranks eighth in the global prevalence of all diseases. In its severe forms such as pustules, cysts, and nodules, acne can lead to permanent scarring and post-inflammatory hyperpigmentation, which are often difficult to reverse in the short term and significantly affect patients’ psychological well-being and social interactions. Although a variety of pharmacological treatments are available, including retinoids, antibiotics, anti-androgens, benzoyl peroxide, and corticosteroids, the high recurrence rate and limited efficacy in scar prevention highlight the urgent need for innovative therapeutic strategies. Electrospinning technology has recently gained attention for fabricating nanofibrous patches with high porosity, biocompatibility, and biodegradability. These patches can offer antibacterial activity, absorb exudates, and provide mechanical protection, making them promising platforms for acne wound care. This review first outlines the pathophysiology of acne and the biological mechanisms underlying scar formation. We then present an overview of electrospinning techniques, commonly used polymers, and recent advancements in the field. Finally, we explore the potential of electrospun nanofibers loaded with mesenchymal stem cells or exosomes as next-generation therapeutic systems aimed at promoting scarless acne healing. Full article

In this study, multifunctional nanocomposite membranes were fabricated using biopolymeric polylactic acid (PLA) and cellulose acetate (CA) composites via electrospinning. The hydrophobic nanocomposite membranes were reinforced with varying concentrations of silicon dioxide (silica/SiO₂) nanoparticles. The developed PLA–CA–SiO₂ nanofibrous membranes are characterized using field emission scanning electron microscopy (FE- energy-dispersive SEM), energy-dispersive X-ray (EDX), elemental mapping, X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FT–IR), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC) techniques. Various physical and mechanical properties of the bio-nanocomposite membrane, such as tensile testing, infrared thermal imaging, ultraviolet–visible spectroscopy (UV–Vis), water contact angle, hydrostatic pressure resistance, and breathability are also investigated. The analysis revealed that a small concentration of silica nanoparticles improves the morphological, mechanical, and thermal characteristics of nanocomposite membranes. The addition of silica nanoparticles improves the UV (A & B), visible and infrared blocking efficiency while also enhancing the waterproofness of protective textiles. The PLA–CA–SiO₂ biopolymer nanocomposite membrane has a fibrous microstructure and demonstrated the tensile strength of 11.2 MPa, a Young’s modulus of 329 MPa, an elongation at break of 98.5%, a hydrostatic pressure resistance of 27 kPa, and a water contact angle of 143.7°. The developed electrospun composite membranes with improved properties provide strong potential to replace petroleum-based membranes with biopolymer-based alternatives, promising improved and wider usage for bio-related applications. Full article

The application of conductive polymers in wound dressings presents great potential for accelerated wound healing since their high electrical conductivity and biocompatibility facilitate the delivery of external electrical stimuli to cells and tissues, promoting cell differentiation and proliferation. Electrospinning is a very straightforward method for the preparation of polymeric wound dressings capable of mimicking the extracellular matrix of skin, promoting hemostasis, absorbing wound exudate, allowing atmospheric oxygen permeation and maintaining an appropriately moist environment. In this work, in situ chemically polymerized poly(3,4-ethylenedioxythiophene) (PEDOT) was achieved through hyaluronic acid-doping. The synthesized PEDOT was used for the production of conductive and biodegradable chitosan (CS)/gelatin (GEL)/PEDOT electrospun meshes. Additionally, the randomly aligned meshes were crosslinked with a 1,4-butanediol diglycidyl ether and their physicochemical and mechanical properties were investigated. The results show that the incorporation of a conductive polymer led to an increase in conductivity of the solution, density and fiber diameter that influenced porosity, water uptake, and dissolvability and biodegradability of the meshes, while maintaining appropriate water vapor permeation values. Due to their intrinsic similarity to the extracellular matrix and cell-binding sequences, CS/GEL/PEDOT electrospun nanofibrous meshes show potential as conductive nanofibrous structures for electrostimulated wound dressings in skin tissue engineering applications. Full article

Electrospun nanofibrous mats from bovine, porcine, and fish gelatin were systematically fabricated at varying concentrations (15, 20, 25, and 30 wt.%) to investigate the influence of molecular characteristics on morphology, crystallinity, mechanical properties, thermal behavior, and solubility. Optimal ranges of viscosity (0.08–1.47 Pa·s), surface tension (35–50 mN·m⁻¹), and electrical conductivity (0.18–1.42 mS·cm⁻¹) were determined to successfully produce homogeneous fibers. Bovine and porcine gelatin, characterized by higher molecular weight and greater proline/hydroxyproline content, exhibited thicker (up to 725 ± 41 nm at 30 wt.%) and less uniform nanofibers due to higher viscosity and surface tension, restricting polymer jet stretching. Conversely, fish gelatin, with lower molecular weight and limited proline/hydroxyproline content, produced significantly thinner (as low as 205 ± 28 nm at 20 wt.%) and more uniform nanofibers. X-ray diffraction analysis revealed distinct crystallinity transitions associated with triple-helix and amorphous structures, dependent on gelatin type and concentration, including the emergence of peaks near 7.9° and 20.1° (2θ) for bovine gelatin. Mechanical tests demonstrated superior tensile strength for bovine gelatin (up to 2.9 MPa at 30 wt.%), balanced properties for porcine gelatin, and exceptional elasticity for fish gelatin. Thermal analysis indicated concentration-dependent shifts in viscoelastic behavior and damping performance. Solubility studies showed rapid dissolution of low-concentration fish gelatin fibers, moderate stability for intermediate-concentration porcine gelatin, and excellent structural retention for high-concentration bovine gelatin. These results demonstrate the potential for tailored gelatin nanofiber design to meet specific functional requirements in biomedical applications. Full article

Wound healing is a physiological process including haemostasis, inflammation, proliferation, and remodelling. Acute wounds typically follow a predictable healing process, whereas chronic wounds cause prolonged inflammation and infection, failing to progress through typical healing phases and presenting significant clinical challenges. A combination of wound care techniques and therapeutic agents is required to manage chronic wounds effectively. Curcumin is a bioactive compound derived from Curcuma longa and has gained attention for its potent antioxidant, anti-inflammatory, and antibacterial properties. The first part of this review aims to provide a comprehensive overview of the physiology of wound healing, focusing on the pathophysiology and management of acute and chronic wounds, followed by the biological activity of curcumin in wound healing, emphasising its impact on promoting tissue repair. Finally, this review explores curcumin-loaded dressings, such as hydrogels, nanofibrous membranes, polymeric micelles, and films, offering controlled drug release and targeted curcumin delivery to enhance wound healing. Full article

Produced water, a byproduct of oil and gas extraction, poses significant environmental challenges due to its complex composition and high salinity. Conventional treatment technologies often struggle to achieve efficient contaminant removal while maintaining long-term operational stability. Membrane-based separation processes, particularly forward osmosis (FO), offer a promising alternative due to their low hydraulic pressure requirements, high selectivity, and ability to mitigate fouling and scaling effects. This study fabricated and evaluated a novel dual-layer zwitterion-modified electrospun nanofibrous membrane for enhanced produced water (PW) treatment. The dual-layer design consists of a highly porous electrospun nanofibrous support layer for improved permeability and mechanical strength, coupled with a zwitterionic-modified selective layer to enhance antifouling properties and selective contaminant rejection. The zwitterionic surface modification imparts superior hydration capacity, reducing organic and biological fouling while improving water transport efficiency. The membranes are characterized using scanning electron microscopy (SEM), thermogravimetric analysis (TGA), Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD), contact angle and tensile strength measurements, and nuclear magnetic resonance (NMR) spectroscopy to assess their morphological, structural, and chemical properties. The performance evaluations demonstrated significantly higher water flux (up to 16.05 L m⁻² h⁻¹ for SPW (synthetic produced water) and 6.00 L m⁻² h⁻¹ for PW using NaBr) and excellent solid rejection (up to 96.02% for SPW and 88.90% for PW), reduced concentration polarization, and superior antifouling performance compared to conventional FO membranes. Experimental results from bench-scale trials demonstrate that this advanced membrane technology offers enhanced water recovery and contaminant removal efficiency, making it a viable solution for industrial-scale PW treatment and reuse. The findings underscore the potential of next-generation dual-layer FO membranes in promoting sustainable water resource management within the oil and gas sector while minimizing environmental impact. Full article

In this study, we investigate the effect of varying the loading of molecularly imprinted polymer nanoparticles (MIP-NPs) on the morphology and sensing performance of electrospun nanofibres for the selective detection of linalool, a representative plant-emitted monoterpene. The proposed strategy combines two synergistic technologies: molecular imprinting, to introduce chemical selectivity, and electrospinning, to generate high-surface-area nanofibrous sensing layers with tuneable architecture. Linalool-imprinted MIP-NPs were synthesized via precipitation polymerization using methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA), yielding spherical particles with an average diameter of ~135 nm. These were embedded at increasing concentrations into a polyvinylpyrrolidone (PVP) matrix containing multi-walled carbon nanotubes (MWCNTs) and processed into nanofibrous mats by electrospinning. Atomic force microscopy (AFM) revealed that MIP content modulates fibre roughness and network morphology. Electrical sensing tests performed under different relative humidity (RH) conditions showed that elevated humidity (up to 60% RH) improves response stability by enhancing ion-mediated charge transport. The formulation with the highest MIP-NP loading exhibited the best performance, with a detection limit of 8 ppb (±1) and 84% selectivity toward linalool over structurally related terpenes (α-pinene and R-(+)-limonene). These results demonstrate a versatile sensing approach in which performance can be precisely tuned by adjusting MIP content, enabling the development of humidity-tolerant, selective VOC sensors for environmental and plant-related applications. Full article