Search Results (108)

Invasive fungal infections (IFIs) are one of the most significant public health challenges worldwide. Yet, research and communication thereof were left behind for a long time, until the WHO published a priority pathogens list to guide research, development, and public health action in October 2022. Indeed, due to the rising number of immunocompromised patients at risk and the high level of morbidity, mortality, and economic burden they entail, especially in low- and middle-income countries, IFIs are a serious public health threat. Fungal infections due to dimorphic fungi face additional challenges such as limited knowledge outside of endemic areas and restricted availability of antifungal molecules in areas affected by these infections. The number of related deaths per year is estimated at 2.5 million, but non-governmental organisations make a wider estimation, due to the difficulties in early in vitro diagnostic and troublesome collection and analysis of epidemiological data. Despite this fact, the therapeutic toolbox addressing these infections remains limited, with only four main families of molecules available so far. The antifungal therapeutic supply is composed of very toxic polyenes, the weakly selective and nearly unused 5-fluorocytosine, and azoles, some of which are becoming increasingly inefficient against IFIs. In the 2000–2020s, the fourth arising family consisted of safer semisynthetic echinocandins. Unfortunately, nowadays, more and more fungal isolates encountered in intensive care units exhibit a low susceptibility to echinocandins or are even multiresistant. In this review, we expose the current treatments available to fight against invasive fungal infections. We recall the discovery and physico-chemical aspects of these substances leading to structure/activity and structure/properties relationships. We particularly focus on the to-date resistances and their molecular mechanisms. We finally list some of the most relevant antifungal drug candidates, as they were freshly overviewed by the World Health Organization in April 2025, highlighting the importance of the molecular dimension of this pursuit toward the expansion of the antifungal therapeutic toolbox. Full article

We analysed the socioeconomic, behavioural, and protection factors (PFs) influences on the HIV combined prevention (CP) strategy among Brazilian Amazonian men who have sex with men (MSMs). PFs are resources that reduce the effect of adversity and help people maintain their well-being. Methods: Cross-sectional study employing a convenient sample of MSMs living in the metropolitan region of Belém. A questionnaire containing socioeconomic, behavioural, PFs, and behaviour/knowledge concerning CP questions was used. “Behaviour/knowledge concerning CP” was defined as a dependent variable and received a maximum score of 16 points. The Mann–Whitney and Kruskal–Wallis tests and multiple linear regression were employed. Results: Our sample comprised 384 MSMs scoring an average of 7.83 points (±1.9). Contributing to lower scores were “not talking about sex life with confidants”, “not talking with work colleagues about personal life and sexually transmissible infections”, and “not participating in non-governmental organisations.” On the other hand, “not being happy in the neighbourhood of residency” contributed to higher scores. Conclusion: Peer support and social inclusion are essential for increasing MSMs’ access to CP. Full article

Environmental crime has been increasingly recognised as transnational organised crime, but efforts to build a coherent and effective international response are still in development and under threat from shifts in the funding landscape. This mixed methods study addresses the role of one significant group of actors in environmental crime enforcement, which are non-governmental organisations (NGOs) who gather intelligence that can be shared with law enforcement and regulatory agencies. The study compares their intelligence practices to findings from traditional intelligence sectors, with a focus upon criminal justice and policing. The research generated quantitative and qualitative data from NGO practitioners, which is integrated to discern three overarching themes inherent in these NGOs’ intelligence practices: the implementation of formal intelligence practices is still underway in the sector; there remains a need to improve cooperation to break down silos between agencies and NGOs, which requires an improvement in trust between these entities; the operating environment provides both opportunities and challenges to the abilities of the NGOs to deliver impact. The study concludes by positing that the characteristics of NGOs mean that this situation constitutes ‘green intelligence’, contextualising intelligence theory and highlighting areas in which agencies can further combat environmental crime. Full article

Climate change is one of the most important environmental problems of the modern world. Without an effective solution to this problem, it is not possible to implement sustainable development. For this reason, in the European development strategies, including the European Green Deal (EGD), the reduction in greenhouse gas (GHG) emissions is one of the priorities. This also applies to sectoral strategies, including those related to agriculture. In this context, the monitoring of changes in GHG emissions becomes particularly important, and its key condition is an applicative estimation method, adapted to the available data and levels of assessment (globally, country, sector, economic unit). GHG emission calculations at the level of the agricultural sector are officially estimated by the state and non-governmental organisations. However, calculations at the level of the agricultural unit-farm remain a challenge due to the lack of detailed data or its incomplete scope to estimate GHG emissions. The other issue is the necessity of a representative data nature, taking into consideration the different profiles of various farms. The research focused on presenting a methodological approach to utilising FADN (Farm Accountancy Data Network) data for estimating GHG emissions at the farm level. The Intergovernmental Panel on Climate Change (IPCC) methodology was adopted to use available farm-level data. Some assumptions were needed to achieve this goal. The article presents the subsequent stages of GHG calculation using the FADN data. The results reveal significant differences in GHG emissions among farm types. The presented results indicated the primary sources of emissions from agriculture, including energy (e.g., fuel and electricity consumption), thus outlining the scope of action that should be taken to reduce emissions effectively. The study confirms that the method used helps estimate emissions at the farm level. Its application can lead to better targeting of climate policy in agriculture. Full article

This study addresses the performance of digital platforms in enhancing ocean governance by improving communication and collaboration among stakeholders. It analyses several platforms based on their collaborative initiatives, digital tools, and ability to function as networks of knowledge. The findings show that these platforms bridge gaps between regional, national, and non-governmental organisations, promoting informed decision making. Their online presence enhances transparency and engagement, especially post-COVID-19. This study highlights the need for hybrid platforms combining informative and interactive elements to better serve both experts and the public. From this analysis, some recommendations are drawn to provide rules and design for the cooperation and co-design of a platform to foster better communication, collaboration, and sustainable ocean management practices. Full article

This article describes the challenges and possibilities of implementing social justice language education in a difficult context in the Global South. Six Argentinian English language university teachers and tutors developed and implemented a social justice project during 2017–2018 in a nongovernmental organisation (NGO) in Argentina. The project aimed at challenging the ‘conditions of possibility’ of underserved children aged 8–12 who attended the NGO for school support and extra-curricular activities. Data comprise reflection logs written by the university teachers and tutors during project implementation and a survey applied after project completion. Qualitative data analysis reveals two specific difficulties involved in enacting social justice language education locally, namely a disconnection between theory and practice and difficulty in grasping local conditions and developing sensitivity to the context. The analysis also led to the identification of two areas with potential to impact positively on social justice language education: an experientially grounded project and teachers’ self-perception as moral agents. Implications for social justice teacher education are discussed. Full article

As damage from natural hazards has increased globally, governments and aid agencies must have practical tools for post-disaster livelihood recovery to foster self-sufficiency among affected populations. This study presents a framework of essential components for livelihood recovery, utilising a comparative case study with interviews from communities impacted by major earthquakes in Lushan, China, and Christchurch and Kaikōura, New Zealand. Communities in both countries highly value housing, employment, well-being, and external assistance for livelihood recovery after disasters. However, people in China credit housing functionality and income resources more, while New Zealand people rely more on commercial insurance for their recovery. The insights from this comparative study can help governments and non-governmental organisations strengthen livelihood recovery efforts and enhance resilience to future disasters. Full article

Between the eighth and ninth centuries, the world entered a second period of strong winter monsoons, which precipitated a series of recurrent natural disasters, including reduced summer rainfall and prolonged droughts. The various types of droughts that occurred in southeastern China are documented in historical records, which also include the official-led ritual prayers to the local deities that were conducted during these challenging periods. As evidenced in these historical records, officials implemented a series of measures to provide solace to the populace, including the restoration of shrines and temples and the offering of sacrifices and prayers to the local deities, such as the Wutang God 吳塘神 and the Chutan God 儲潭神. These actions were intended to leverage the influence of the local deities to mobilise labour and financial resources for the implementation of public works, including the reclamation of barren land and the construction of dikes and ponds. These initiatives ultimately proved instrumental in enabling the populace to withstand the adverse effects of disasters. This approach represents a distinctive strategy for coping with drought in ancient China. It may provide insights into how governments and non-governmental organisations can utilise the influence of religious beliefs to unite people in addressing the climate crisis in the present era. Full article

The alarming increase in single-use plastic (SUP) consumption, exacerbated by the COVID-19 pandemic and its detrimental effects on environmental and public health, underscores the urgent need for the public to adopt more environmentally responsible behaviours. This study presents citizen science (CS) initiatives undertaken two years after the onset of the pandemic as an effective means to engage and mobilise citizens in reducing plastic consumption. It combines an inventory of CS actions targeting SUP with a self-designed and implemented CS project. Unlike the predominantly technical focus of existing initiatives, our ‘Plastic Detective’ project was designed to collect behavioural data related to SUP use. The majority of completed and ongoing CS projects addressing SUPs focused on beach clean-ups, which primarily involved reporting the distribution and composition of plastic litter. However, no initiatives were found to address consumer behaviour. CS activities were predominantly initiated in a bottom-up manner, largely coordinated by non-governmental organisations (NGOs), and were mostly confined to the Northern Hemisphere. In our project, volunteers were asked to observe, sample and categorise behaviours in their surroundings using a model that distinguished between SUP use and the adoption of alternative materials or practices. Additionally, participants’ perceptions of SUP were assessed through pre- and post-surveys. Our findings reveal that young people, in particular, are eager to participate in CS initiatives. Regardless of age, gender or location, all respondents—despite acknowledging the need to reduce SUP consumption—identified producers as the key group responsible for addressing plastic pollution. We conclude that CS can act as an effective knowledge broker between research and non-research communities, fostering behavioural change towards more sustainable practices. Moreover, CS initiatives can play a vital role in popularising scientific findings and influencing policy-making processes to promote environmentally friendly alternatives to SUPs. Full article

The third expansion of the Islamic Caliphate (AD950–1450) produced the need for formalising an ethical framework to create an institutionalised approach to market regulations. During these times significant contribution to the literature was made regarding the modelling of the ethical premise of the duty to subscribe good and prohibit wrongs. It ranged from the formation of vigilante-styled civil duties to the institutionalisation of ethics in the form of the institution of hisbah, which is broadly understood as a quasi-autonomous non-governmental organisation (quango) designed to establish the ethical mandate within the medieval Muslim world. Our investigation maps the development of thoughts on embedding ethical rules in markets and within society between AD950–1450. This study explores and conceptualises the models for market regulations proposed by Al-Mawardi (d.AD1058), Al-Ghazali (d.AD1111), Ibn Taymiyya (d.AD1328), and Ibn Khaldun (d.AD1406). We formulate and compare the ethical models of these scholars in the context of their political–social positionings. The rationale for choosing these four scholars is the wide articulation and recognition of their logical ideas throughout Islamic history. This research examines the historic–ethical patterns within the corpus of Islamic thoughts that provide a discourse deixis for constructing regulatory models as conceptualised by these scholars for the institutionalised governance of markets and society in general. Full article

Background: Obesity is continually growing not only in medium- and high-income countries but also in low-income countries, from where increasing numbers of migrants arrive in Western countries. We aimed to investigate the frequency and characteristics of obesity in a sample of undocumented migrants, a population for which official health data are not available. Methods: We collected demographic and socio-economic data and information on medical diagnoses and pharmacologic treatments for 341 undocumented migrants consecutively attending the outpatient clinic of a big non-governmental organisation in Milan, Italy, from March to July 2023. To measure obesity, we used both body mass index (BMI) and waist circumference (WC). We used multivariate robust Poisson regression models to calculate prevalence ratios (PRs) and 95% Confidence Intervals (CIs) of overweight or obesity according to socio-demographic conditions and other risk factors. Results: Using BMI, the proportion of migrants with obesity was 28.7% (95% CI 24.0–33.0%) and those with overweight represented 32.3% (95% CI 27.3–37.5%). Obesity was more frequent among Asians (53.9%, 95% CI 37.2–69.9%), followed by Latinos (38.7%, 95% CI 29.6–48.5%) and Eastern Europeans (38.2%, 95% CI 25.4–52.3%). Using WC, 68.3% (95% CI 63.1–73.2%) of migrants had values suggestive of overweight or obesity. In the multivariate analyses, overweight and obesity were more frequent in migrants with older age, with a stable employment, and who had been present in Italy for a long time, as well as in those with CV diseases. Moreover, individuals with obesity needed more medications for the cardiovascular system and for the alimentary tract and metabolism. Conclusions: In our sample of undocumented migrants, overweight and obesity were frequent, representing an important public health issue, considering the difficulty experienced by such individuals in finding access to both prevention and healthcare services. Full article

Given the resistance of local communities to mineral extraction (“Not in My Back Yard” NIMBY), the energy transition and the new global economic model, which presupposes a sharp increase in the production of mineral raw materials, represent an opportunity for new approaches to mining. Considering that greenfield mines take years to be licensed and developed, the new attitudes should include the support and launch of policies and regulations that can enhance the growth of mining, realistic acceptance by non-governmental organisations (NGOs) that everything supporting our current way of life comes from Mother Earth, and responsible and fair treatment of local communities (systematic information from day one, strengthening community partnerships, granting offset benefits, etc.). Thus, BULGCOLD Inc. (TSXV: ZLTO) and its subsidiary, Stredne Slovensko s.r.o., which explores for metals in Bulgaria and Slovakia, are committed to having the Social License to Operate at the heart of their sustainable operations to alleviate the NIMBY effect. Full article

As the digital environment progresses, the complexities of cyber threats also advance, encompassing both hostile cyberattacks and sophisticated cyber espionage. In the face of these difficulties, cooperative endeavours between state and non-state actors have attracted considerable interest as crucial elements in improving global cyber resilience. This study examines cybersecurity governance’s evolving dynamics, specifically exploring non-state actors’ roles and their effects on global security. This highlights the increasing dangers presented by supply chain attacks, advanced persistent threats, ransomware, and vulnerabilities on the Internet of Things. Furthermore, it explores how non-state actors, such as terrorist organisations and armed groups, increasingly utilise cyberspace for strategic objectives. This issue can pose a challenge to conventional state-focused approaches to security management. Moreover, the research examines the crucial influence of informal governance processes on forming international cybersecurity regulations. The study emphasises the need for increased cooperation between governmental and non-governmental entities to create robust and flexible cybersecurity measures. This statement urges policymakers, security experts, and researchers to thoroughly examine the complex relationship between geopolitics, informal governance systems, and growing cyber threats to strengthen global digital resilience. Full article

The environmental impact of the fashion and textile industry (FTI) is measured and communicated through several interrelated methods, tools and platforms. In this paper, scholarly and grey literature have informed the mapping of the sector’s environmental impact assessment (EIA) landscape to identify key gaps and challenges in effectively quantifying and communicating environmental product performance. These preliminary insights informed the design of multiple focus group discussions where the on-the-ground challenges of EIA implementation were discussed with 85 FTI stakeholders, including industry professionals, academics, non-governmental organisations and local government. Key findings highlight the need for further refinement and harmonisation of assessment methodologies and approaches such as Life Cycle Analysis (LCA) to consider a wider range of impact categories to increase the comparability of results. Similarly, the communication asymmetries linked to a profusion of eco-labelling and ranking systems necessitates the development of better tools to communicate the environmental performance for the sector. Furthermore, as all EIA methods require the movement of data between various actors, there is a need for improvement and innovation in data-gathering and management systems to ensure greater quality and reliability. Full article

The current economic and political crisis has brought about a change in the environment in which non-governmental development organisations (NGDOs) have traditionally operated. This change can be summed up as a reduction in the funds they receive and an increase in the population they must serve. The need then arises to have mechanisms that allow an analysis of the good work performed by the NGDOs. Knowing the efficiency of the NGDOs in the management of their previous projects can contribute towards improving their future achievements. The aim of this research is to establish some objective indicators that allow an evaluation of the efficiency of these organisations. Firstly, a detailed analysis of the regulation of the three agencies is conducted (Spanish-AECID, European-EuropeAid, and American-USAID). This allows us to synthesise the indicators of good performance of the NGDO based on the study of the eligibility criteria of public donors. The research concludes with the study of the efficiency following the Promethee Approach. Our results reveal that 44.6% of the NGDOs (33 out of the 74 studied) operate inefficiently, compared to 29.7%, which are efficient. Full article