Search Results (5)

Mobility limitations due to congenital disabilities, accidents, or illnesses pose significant challenges to the daily lives of individuals with disabilities. This study presents a novel design for a multifunctional intelligent vehicle, integrating head recognition, eye-tracking, Bluetooth control, and ultrasonic obstacle avoidance to offer an innovative mobility solution. The smart vehicle supports three driving modes: (1) a nostril-based control system using MediaPipe to track displacement for movement commands, (2) an eye-tracking control system based on the Viola–Jones algorithm processed via an Arduino Nano board, and (3) a Bluetooth-assisted mode for caregiver intervention. Additionally, an ultrasonic sensor system ensures real-time obstacle detection and avoidance, enhancing user safety. Extensive experimental evaluations were conducted to validate the effectiveness of the system. The results indicate that the proposed vehicle achieves an 85% accuracy in nostril tracking, over 90% precision in eye direction detection, and efficient obstacle avoidance within a 1 m range. These findings demonstrate the robustness and reliability of the system in real-world applications. Compared to existing assistive mobility solutions, this vehicle offers non-invasive, cost-effective, and adaptable control mechanisms that cater to a diverse range of disabilities. By enhancing accessibility and promoting user independence, this research contributes to the development of inclusive mobility solutions for disabled and elderly individuals. Full article

Facial morphology is known to be influenced by genetic and environmental factors. Scientific evidence regarding facial parameters in patients with posterior crossbite is lacking. This study aimed to investigate the association between posterior crossbite and facial parameters. This cross-sectional study included 34 adolescents with and 34 adolescents without posterior crossbite in the age range from 13 to 15 years. Facial surface scans were acquired with a 3dMD imaging system, and landmark-based analysis was performed. Data were analyzed using the Mann-Whitney U test and Spearman’s correlations. Individuals in the control group had lower face heights (females: p = 0.003, r = 0.45; males: p = 0.005, r = 0.57). The control group females presented with smaller intercanthal width (p = 0.04; r = 0.31) and anatomical nose width (p = 0.004; r = 0.43) compared with the crossbite group females. The males in the control group had wider nostrils. In the control group, significant correlations among different facial parameters were more common, including the correlations between eye width and other transversal face measurements. On the contrary, the facial width was correlated with nasal protrusion (r = 0.657; p < 0.01) and the morphological width of the nose (r = 0.505; p < 0.05) in the crossbite group alone. In both groups, the philtrum width was linked with the anatomical and morphological widths of the nose. Conclusions: Patients with posterior crossbites have increased face height and different patterns of facial proportions compared with individuals without crossbites. Full article

Facial-expression-based analysis has been widely applied as a pain coding system in horses. Herein, we aimed to identify pain in horses undergoing subcutaneously polylactide-based polymer implantation. The sham group was submitted only to surgical incision. The horses were filmed before and 24 and 48 h after implantation. Five statistical methods for evaluating their facial expressions (FEs) were tested. Primarily, three levels of scores (0, 1, and 2) were applied to the seven FEs (ear movements, eyebrow tension, orbicularis tension, dilated nostrils, eye opening, muzzle tension, and masticatory muscles tension). Subsequently, the scores of the seven FEs were added (SUM). Afterwards, principal component analysis (PCoA) was performed using the scores of the seven FEs obtained using the first method. Subsequently, weights were created for each FE, based on each variable’s contribution variability obtained from the PCoA (SUM.W). Lastly, we applied a general score (GFS) to the animal’s face (0 = without pain; 1 = moderate pain; 2 = severe pain). The mechanical nociceptive threshold (MNT) and cutaneous temperature (CT) values were collected at the same moments. The results show no intra- or intergroup differences, when evaluating each FE separately or in the GFS. In the intragroup comparison and 48 h after implantation, the control group showed higher values for SUM, PCoA, and SUM.W, although the horses implanted with polymers displayed more obvious alterations in the CT and MNT. Our findings show that the five statistical strategies used to analyze the faces of the horses were not able to detect low-grade inflammatory pain. Full article

Mesenchymal stem cell (MSC)-based therapy is a promising therapeutic approach in the management of several pathologies, including central nervous system diseases. Previously, we demonstrated the therapeutic potential of human adipose-derived MSCs for neurological sequelae of oncological radiotherapy using the intranasal route as a non-invasive delivery method. However, a comprehensive investigation of the safety of intranasal MSC treatment should be performed before clinical applications. Here, we cultured human MSCs in compliance with quality control standards and administrated repeated doses of cells into the nostrils of juvenile immunodeficient mice, mimicking the design of a subsequent clinical trial. Short- and long-term effects of cell administration were evaluated by in vivo and ex vivo studies. No serious adverse events were reported on mouse welfare, behavioral performances, and blood plasma analysis. Magnetic resonance study and histological analysis did not reveal tumor formation or other abnormalities in the examined organs of mice receiving MSCs. Biodistribution study reveals a progressive disappearance of transplanted cells that was further supported by an absent expression of human GAPDH gene in the major organs of transplanted mice. Our data indicate that the intranasal application of MSCs is a safe, simple and non-invasive strategy and encourage its use in future clinical trials. Full article

We propose a new telerobotic system for untact swab sampling to prevent the infection of medical staff during upper respiratory sample collection. The system consists of a slave robot and two master devices. The slave robot is designed to move a swab in 6 degrees of freedom within the facial area and to insert and remove the swab under remote control by an operator at the master site based on magnified imaging of the patient’s facial area. The insertion and removal of the swab into and from the nostril are implemented by means of a swab insertion unit; as the counterpart to this unit, the master system also includes a swab insertion device to control the swab insertion unit remotely. A force sensor installed on the swab holder enables monitoring of the force generated when the swab touches the target. In experiments, a virtual specimen was installed on the posterior nasopharynx wall of a life-size head phantom model. The nasopharyngeal swab samplings of the phantom model were successfully performed thanks to the force monitoring capability of the proposed telerobotic system, showing that this system is suitable for remote upper respiratory sample collection. Full article