Search Results (63,640)

Accurate monitoring of settlement in high-speed railway embankments is critical for operational safety and long-term serviceability. This study investigates the applicability of Persistent Scatterer Interferometric Synthetic Aperture Radar (PS-InSAR) for quantifying millimeter-scale deformations and emphasizes how surrounding environmental factors influence measurement accuracy. Using 29 TerraSAR-X images acquired between 2016 and 2018, PS-InSAR-derived settlements were compared with precise leveling survey data across twelve representative embankment sections of the Honam High-Speed Railway in South Korea. Temporal and spatial discrepancies between the two datasets were harmonized through preprocessing, allowing robust accuracy assessment using mean absolute error (MAE) and standard deviation (SD). Results demonstrate that PS-InSAR reliably captures settlement trends, with MAE ranging from 1.7 to 4.2 mm across different scenes. However, significant variability in accuracy was observed depending on local land-cover composition. Correlation analysis revealed that vegetation-dominated areas, such as agricultural and forest land, reduce persistent scatterer density and increase measurement variability, whereas high-reflectivity surfaces, including transportation facilities and buildings, enhance measurement stability and precision. These findings confirm that environmental conditions are decisive factors in determining the performance of PS-InSAR. The study highlights the necessity of integrating site-specific land-cover information when designing and interpreting satellite-based monitoring strategies for railway infrastructure management. Full article

The growing demand for sustainable solutions in the plastics industry has highlighted the need to reintroduce post-industrial polymer waste into high-performance applications. This study focuses on the mechanical recycling of automotive scraps containing variable proportions of polycarbonate (PC), acrylonitrile–butadiene–styrene (ABS), and a commercial PC/ABS blend. After determining the composition of two representative batches, a screening of seven commercial compatibilizers and impact modifiers was performed to improve impact strength. Among them, an ethylene–methyl acrylate–glycidyl methacrylate (E-MA-GMA) terpolymer was identified as the most effective additive. Its influence was further investigated through a mixture design approach, varying the composition of the three polymer phases and the additive content (0–10 wt.%). The resulting response surface model revealed a significant increase in impact resistance in PC-rich formulations with increasing E-MA-GMA content, while ABS and PC/ABS showed more complex trends. Rheological, mechanical, and thermal analyses supported the observed behavior, suggesting improved matrix compatibility and reduced degradation during processing. The proposed model enables the prediction of impact performance across a wide range of compositions, offering a practical tool for the optimization of recycled blends. These findings support the potential of targeted compatibilization strategies for closed-loop recycling in the automotive sector. Full article

Electrospinning is a versatile technique used to manufacture nanofibers by applying an electric field to a polymer solution. This method has gained significant interest in the biomedical, pharmaceutical, and materials engineering fields due to its ability to produce porous structures with a high specific surface area, making it ideal for applications such as wound dressings, controlled drug delivery systems, and tissue engineering. The materials used in electrospinning play a crucial role in determining the final properties of the obtained nonwoven nanofibers. Among the most studied substances are chitosan, collagen, and fish-derived gelatin, which are biopolymers with high biocompatibility. These materials are especially used in the medical and pharmaceutical fields due to their bioactive properties. In combination with synthetic polymers such as polyethylene glycol (PEG) and polyvinyl alcohol (PVA), these biopolymers can form electrospun fibers with improved mechanical characteristics and enhanced structural stability. The characterization of these materials was performed using modern characterization techniques, such as one-dimensional (1D) proton NMR spectroscopy (¹H), for which the spin–spin relaxation time distributions T₂ were characterized. Additionally, two-dimensional (2D) measurements were conducted, for which EXSY T₂-T₂ and COSY T₁-T₂ exchange maps were obtained. The characterization was complemented with FT-IR spectra measurements, and the nanofiber morphology was observed using SEM. As a novelty, machine learning methods, including artificial neural networks (ANNs), were applied to characterize the local structural order of the produced nanofibers. In this study, it was shown that the nanofiber nonwoven materials made from PVA are characterized by a degree of order in the range of 0.27 to 0.61, which are more ordered than the nanofibers made from chitosan and fish gelatin, characterized by an order degree ranging from 0.051 to 0.312, where 0 represents the completely unordered network and 1 a fully ordered fabric. Full article

Background/Objectives: This systematic review with meta-analysis synthesizes current evidence on the effectiveness of non-immersive virtual reality (VR) interventions in enhancing gross motor function, balance, and functional independence in children with cerebral palsy (CP). Methods: A systematic search was performed across six databases (PubMed, Web of Science, Scopus, MEDLINE, CINAHL Complete, and Psychology and Behavioral Sciences Collection) to identify randomized controlled trials (RCTs) published up to July 2025. Primary outcomes included gross motor function (GMFM-D/E), balance (Pediatric Balance Scale, PBS), and functional independence (WeeFIM). Risk of bias was assessed using the RoB 2 tool, and the certainty of evidence was evaluated with GRADE. Results: From 1233 retrieved records, 13 RCTs involving 624 participants fulfilled the inclusion criteria. Pooled analyses demonstrated significant improvements with non-immersive VR in gross motor function (GMFM-D: ES = 2.04, p = 0.02; GMFM-E: ES = 2.02, p < 0.001), balance (PBS: ES = 1.34, p = 0.02), and functional independence (WeeFIM: ES = 0.99, p < 0.001). Conclusions: Non-immersive VR interventions were associated with meaningful gains in gross motor function, balance, and independence in children with CP. Significant differences were consistently observed in GMFM-D, GMFM-E, PBS, and WeeFIM outcomes when compared with control groups. Full article

Background/Objectives: The prison environment presents a unique context for examining the impact of addiction on physical and psychological functioning. Individuals with substance use disorders (SUDs) are overrepresented in correctional facilities and often experience greater emotional difficulties and impaired physical capacity. This study aimed to conduct a comparative analysis of psychological and functional profiles between addicted and non-addicted male inmates in a semi-open correctional facility. Methods: The study included 47 male prisoners (19 addicted, 28 non-addicted). Physical performance was assessed using the Countermovement Jump (CMJ), handgrip strength, the Functional Movement Screen (FMS), and the FitLight reaction time test. Psychological functioning was evaluated using six standardized questionnaires: problem-focused, emotion-focused, and avoidant coping strategies, depression (PHQ-9), perceived stress (PSS-10), and self-compassion (SCS). Results: No statistically significant differences (p > 0.05) were found between addicted and non-addicted inmates in physical performance parameters. Addicted individuals demonstrated slightly higher handgrip strength with lower variability, while non-addicted inmates showed slightly better lower-body power in the CMJ test. Functional movement quality and reaction speed were similar between groups. Psychological assessments also revealed no significant differences between the groups. Coping styles, depressive symptoms, perceived stress levels, and self-criticism scores were comparable in both populations. In the addicted group, deeper squats correlated with lower stress (rho = −0.46, p = 0.047), and better hurdle step performance correlated with emotion-focused coping (rho = 0.46, p = 0.048). Conclusions: Although no statistically significant differences were found between addicted and non-addicted male inmates in the assessed physical and psychological outcomes, the limited sample size and context-specific nature of this pilot study suggest that these findings should be viewed as preliminary and interpreted with caution. Nonetheless, the observed associations between physical performance and psychological variables indicate subtle interconnections between motor capacity, stress perception, and coping mechanisms that merit further investigation in larger, longitudinal studies. Full article

Building archetypes are essential for advancing architectural theory and energy modeling, providing a foundation for scalable assessments of building performance and sustainability worldwide. In Saudi Arabia, educational buildings, especially those in public universities, are predominantly constructed using standardized and repetitive design templates, such as courtyard and prototype models, which have significant implications for energy efficiency, indoor environmental quality, and sustainability outcomes. Despite their prevalence, there is a notable lack of systematic research on the classification and distribution of these archetypes within the Saudi context, particularly regarding their impact on energy consumption and sustainable campus planning. This study addresses this gap by systematically collecting and analyzing data from 29 public universities across Saudi Arabia, employing GIS mapping to document building characteristics including age, region, urban context, masterplan typology, and architectural design. A cumulative weighting factor was applied to quantify the representativeness of archetypes, while chi-square tests and effect size metrics assessed the statistical concentration and significance of observed patterns. The results reveal a pronounced dominance of a small number of archetypes, especially standardized courtyard and identical design models, across the national stock, with the top 10% of archetype ranks accounting for the majority of buildings. This high degree of standardization enables efficient modeling, benchmarking, and targeted energy interventions, while also highlighting the need for greater contextual adaptation in future campus planning. While this study does not directly simulate building energy performance, it establishes a national-scale typological foundation that can support future simulation, benchmarking, and policy design. The developed GIS-based framework primarily serves managerial and planning objectives, offering a standardized reference for facility management, retrofitting prioritization, and strategic energy-efficiency planning in Saudi public universities. Full article

Endometriosis is a chronic condition characterized by the presence of endometrial-like tissue outside the uterine cavity. It affects ~10% of reproductive-aged individuals and is associated with dysmenorrhea and infertility. Although imaging modalities have improved diagnosis, laparoscopy is required in many cases, contributing to 4–11 years of diagnostic delay. Non-invasive biomarkers could improve diagnosis and clinical decision-making, yet no candidate has achieved sufficient accuracy for routine use. Galectins, a family of β-galactoside-binding lectins involved in angiogenesis, immune regulation, and fibrosis, have emerged as promising biomarkers. In this study, we measured serum Galectin-1 (Gal-1) concentrations in 80 women with endometriosis and 15 controls using ELISA at four time points. Preoperative Gal-1 levels were significantly higher in endometriosis patients, particularly in Stage III–IV disease. ROC analysis yielded a modest diagnostic performance (AUC 0.692; p = 0.011) with high sensitivity (91.3%) and excellent negative predictive value (96.8%) but low specificity (46.7%) at a study-derived threshold (>14.06 ng/mL). Longitudinally, Gal-1 levels decreased immediately after surgery and rose above baseline by one year, while no significant correlations with preoperative pain severity were observed. These findings suggest that serum Gal-1 alone is insufficient as a diagnostic test but may be useful for multi-marker strategies to improve early diagnosis. Full article

Effective thermal management is essential in metal additive manufacturing to ensure process stability and desirable material properties. Directed energy deposition using a laser beam and wire (DED-LB/w) enables the production of large, high-performance components but remains sensitive to adverse thermal effects during multi-layer deposition due to heat accumulation. While prior studies have investigated interlayer temperature control and substrate preheating in DED modalities, including laser-powder and arc-based systems, the influence of substrate preheating in DED-LB/w has not been thoroughly examined. This study employs substrate preheating to simulate heat accumulation and assess its effects on melt pool geometry, wire–melt pool interaction, and the microstructural evolution of Alloy 718. Experimental results demonstrate that increased substrate temperatures lead to a gradual expansion of the melt pool, with a notable transition occurring beyond 400 °C. Microstructural analysis reveals that elevated preheat temperatures promote coarser secondary dendrite arm spacing and the development of wider columnar grains. Moreover, Nb-rich secondary phases, including the Laves phase, exhibit increased size but relatively unchanged area fractions. Observations from electrical conductance measurements and coaxial visual imaging show that preheat temperature significantly affects the process dynamics and microstructural evolution, providing a basis for advanced process control strategies. Full article

Background: AMR causes a large global health burden, with approximately 4.95 million deaths linked to bacterial AMR in 2019, 1.27 million due to AMR directly. Although Brazil mandated prescriptions for systemic antibiotics in 2010/2011, self-medication and access without prescriptions continue, with community pharmacists playing a vital part in antimicrobial stewardship (AMS). This study examined antibiotic misuse and AMR in Brazil through community pharmacists’ perspectives, emphasising their dual role as professional actors and frontline observers of public behaviour. Methods: We conducted 20 semi-structured interviews with community pharmacists and performed reflexive thematic analysis of their accounts, repeating five independent analytic cycles to confirm thematic robustness. Results: Six themes were consistently identified as recounted by pharmacists in their practice contexts: Access and Self-Medication; Relationships with Healthcare Professionals; Knowledge and Beliefs about Antibiotics; Use and Adherence; Healthcare System Barriers; and Regulation and Enforcement. Pharmacists mentioned regular requests for antibiotics without prescriptions, drug reuse, and significant impact from community, i.e., from relatives, and peers. The common misunderstanding was that antibiotics treat viral illnesses. Structural issues, for instance GP appointment costs and long waits, made patients seek help from pharmacies. Due to regulation being applied inconsistently, pharmacies struggled to refuse unsuitable requests. Conclusions: Framed through pharmacists’ dual vantage as professionals and frontline observers, the findings highlight intertwined factors underpinning inappropriate antibiotic use in Brazil and support a multi-pronged intervention spanning health system strengthening, professional education, economic considerations, and community engagement. Full article

This research evaluates the performance of the Final Run remote sensing precipitation products from the Integrated Multi-satellite Retrievals for GPM (IMERG-F) in complex terrain river basins (2014–2023). Utilizing decade-long daily precipitation data from 2415 manned national-level ground stations, the evaluation employs eight statistical metrics—probability of detection, false alarm ratio, accuracy, critical success index, Pearson correlation coefficient (PCC), root mean square difference, mean difference, and relative difference—to analyze detection accuracy, correlation, and bias on daily, monthly, and annual scales. The main findings include the following: (1) IMERG-F’s daily precipitation detection capability follows a three-tier spatial pattern (northwest to southeast), aligning with the stepped terrain of China. (2) Stronger correlations (PCC = 0.7–0.9) with gauge data emerge in southeastern regions despite higher biases, while northwestern areas show weaker correlations but fewer deviations. (3) IMERG-F overestimates annual rainy days, but slightly underestimates precipitation intensity compared with ground observations. (4) Annual precipitation estimates exceed gauge measurements, particularly in the Songhua and Liao River Basins (18–20% overestimation). Monthly analysis shows fewer errors during rainy seasons versus winter dry periods, with pronounced seasonal variations in northwestern basins. These findings emphasize the need for terrain-aware calibration to improve satellite precipitation monitoring in hydrologically diverse basins, particularly addressing seasonal and spatial error patterns in water resource management applications in northern China. Full article

Dizygostemon riparius is an endemic tropical Brazilian species whose physiological responses to salinity are poorly understood. This study evaluated the effects of NaCl (0, 50, and 100 mM) on in vitro-grown D. riparius by integrating growth, anatomical, photosynthetic, and biochemical analyses. Salinity significantly reduced biomass and growth parameters, indicating impaired development. Photosystem II efficiency declined, as evidenced by decreases in the performance index and chlorophyll content, while anatomical changes such as epidermal thickening and reduced vascular bundles reflected structural adjustments under stress. At the biochemical level, salinity altered polyamine metabolism, with reductions in total free polyamines, suggesting potential limitations in defense mechanisms. Hyperhydricity observed under high salinity indicated a non-adaptive response. Overall, D. riparius displayed limited tolerance to salt stress, with physiological and biochemical impairments outweighing structural plasticity. This study provides the first data-driven characterization of salinity effects in this species and highlights the value of in vitro culture as a tool to investigate stress responses. Full article

Background/Objectives: Accurate and prompt tube thoracostomy (TT) placement within the safety zone while avoiding diaphragmatic injury remains challenging, particularly in trauma patients with distorted thoracic anatomy. This study evaluated the accuracy and safety of landmark-based TT techniques, including a novel mid-sternum method. Methods: In this retrospective study, chest computed tomography scans of 245 adult trauma patients who presented to a Level I trauma center in Korea between February and June 2022 were analyzed. TT insertion routes using the mid-sternum, nipple, and mid-arm point methods were compared against the conventional fifth intercostal space (ICS) method. Results: Of the 245 enrolled patients, the median age was 55.0 years (interquartile range, 42.0–64.0), and 186 (75.9%) were male. On the right side, routes avoiding the diaphragm were observed in 82.0% (fifth ICS), 92.7% (mid-sternum), 55.5% (nipple), and 90.2% (mid-arm point) of patients. The mid-sternum method showed a significantly higher avoidance rate than the fifth ICS method (p < 0.001), with 91.1% sensitivity and 77.4% specificity for identifying TT routes within the safety zone. On the left side, routes avoiding the diaphragm were observed in 97.6% (fifth ICS), 98.8% (mid-sternum), 86.9% (nipple), and 95.1% (mid-arm point) of patients, with no significant difference between the fifth ICS and mid-sternum methods (p = 0.375). The mid-sternum method showed 90.4% sensitivity and 85.2% specificity for routes within the safety zone. Conclusions: The mid-sternum method demonstrated high anatomical safety and performance comparable to or superior to the conventional fifth ICS method, particularly in minimizing the risk of diaphragmatic injury. It may offer a practical and safe alternative for TT placement in trauma care. Full article

Reliable simulations of any flow require proper preservation of the fundamental principles governing the mechanics of its motion, whether in differential or integral form. When these principles are solved in differential form, discretization schemes introduce errors by transforming the continuous physical domain into a discrete representation that only approximates it. This paper analyzes the numerical performance of the solver for supersonic chemically active flows, rhoCentralRfFoam, using integral conservation principles of mass, momentum, energy, and chemical species as a validation tool in a classical test case with a highly refined mesh under nonlinear pre-established reference conditions. The analysis is conducted on this specific test case; however, the methodology presented here can be applied to any problem under study. It may serve as an a posteriori verification tool or be integrated into the solver’s workflow, enabling automatic verification of conservation at each time step. The resulting deviations are evaluated, and it is observed that the numerical errors remain below $0.25\%$, even in cases with a high degree of nonlinearity. These results provide preliminary validation of the solver’s accuracy, as well as its ability to capture physically consistent solutions using only information generated internally by the solver for validation. This represents a significant advantage over validation methods that require external comparison with reference solutions, numerical benchmarks, or exact solutions. Full article

Background/Objectives: Pharmacogenetic variability plays a crucial role in determining both the efficacy and toxicity of chemotherapy for gastrointestinal cancers. However, data on allele frequencies and their clinical relevance in Russian populations remain scarce. Methods: We conducted a prospective observational study of 412 patients with gastrointestinal malignancies between 2020 and 2023. Pharmacogenetic testing was performed prior to the initiation of chemotherapy using real-time allele-specific PCR and microarray hybridization technology. Polymorphisms in the DPYD, UGT1A1, CYP2C8, CYP3A5, GSTP1, ERCC1, XPC, CDA, MTHFR, TYMS, and SLC31A1 genes were analyzed. Results: The frequency of most variants was consistent with those reported in European populations, reflecting the ethnic proximity of the studied cohort. Several clinically relevant variants were identified: DPYD rs2297595 occurred more frequently than in European cohorts, and UGT1A1 rs8175347 was observed at a higher prevalence, underscoring the potential risk of irinotecan-related neutropenia and diarrhea. CYP2C8 rs10509681 was present at frequencies comparable to European populations and is associated with an increased risk of taxane-induced peripheral neuropathy. Other markers (GSTP1, ERCC1, CDA, SLC31A1, MTHFR, TYMS) demonstrated variable associations with chemotherapy efficacy and toxicity, consistent with findings from previous international studies. Conclusions: This study provides the first comprehensive description of pharmacogenetic polymorphisms in a Russian cohort of patients with gastrointestinal cancers. Our findings confirm the clinical importance of DPYD and UGT1A1 testing and highlight additional variants of potential interest. Full article

Background: Adjunctive antibiotics are frequently used alongside mechanical debridement (MD) for peri-implantitis, yet their additional clinical benefit remains uncertain. Objective: To systematically assess whether adding local or systemic antibiotics to non-surgical MD improves clinical outcomes in peri-implantitis. Methods: The review protocol was registered in PROSPERO (CRD42022380401). We included randomised controlled trials (RCTs) involving peri-implantitis patients treated with MD plus local or systemic antibiotics, compared to MD alone, with at least 3 months of follow-up. Searches were conducted in PubMed, Cochrane Library, LILACS, Web of Science, and Embase up to 9 April 2025. Eleven RCTs (634 patients) were included in the qualitative synthesis. The Cochrane RoB 2.0 tool evaluated the risk of bias. Random-effects meta-analyses of data from 10 studies, adjusting results to an equivalent 6-month follow-up time-frame, assessed treatment efficacy based on changes in probing pocket depth (PPD) and bleeding on probing (BoP), the primary outcomes. Meta-regressions examined the influence of mean patient age and implant-to-patient ratio on adjusted outcomes. Results: Systemic antibiotics resulted in generally greater PPD reduction and BoP reduction over MD alone or plus chlorhexidine, with the greatest benefits observed in amoxicillin-based multi-agent regimens and longer follow-up duration. Comparatively, local antimicrobial adjuncts performed less effectively on PPD reduction. No implant losses were reported, and adverse events were rare. Limitations: Some included trials had a high risk of bias and considerable heterogeneity. Follow-up was limited to the short term, and definitions of clinical “success” varied across studies. Conclusions: Adjunctive systemic antibiotics, particularly amoxicillin-based combinations, substantially improve short-term clinical outcomes of non-surgical peri-implantitis treatment compared to MD alone. Nevertheless, given the variability in study quality and potential risks associated with antibiotic use, their application should be judicious. Further long-term RCTs are warranted to confirm sustained efficacy and safety. Full article