Search Results (2,368)

Background and clinical significance. Penetrating cardiothoracic wounds require prompt treatment in order to decrease mortality and morbidity. Surgical therapy, aimed at bleeding control and removal of damaged tissue, varies widely from the direct suture of parenchymal lacerations to pneumonectomy, which is characterized by high mortality rates. We report our experience with a patient in hemorrhagic shock due to a gunshot wound to the chest, successfully treated by pneumorrhaphy under cardiopulmonary bypass (CPB). Case presentation. A 53-year-old man with a gunshot wound to the chest was admitted to our Emergency Department. A bedside ultrasonography revealed left pleural and pericardial effusion. He was hemodynamically instable, so he was immediately transferred to the operating room by the cardiac and Thoracic Surgery teams. Through a median sternotomy approximately 2 L of blood were evacuated and a deep laceration of the left upper lobe was discovered. The massive bleeding could not be controlled, leading to pleural cavity flooding. The surgical team decided to institute emergency CPB and perform lung repair by pneumorrhaphy, under circulatory support. The patient survived and was discharged on p.o. day 20. Conclusions. Clinical expertise, adequate instrumental equipment and a high level of interdisciplinary team-work favorably affected the patient’s outcome. Full article

Background/Objectives: Although systematic reviews and meta-analyses have examined immune-inflammatory indices in cardiovascular disease (CVD), the evidence remains scattered and inconsistent. This umbrella review aims to synthesize findings and evaluate the overall predictive value of these indices for clinical outcomes. Methods: We systematically searched PubMed, Cochrane Library, Web of Science, Embase, Scopus, and Medline for systematic reviews with meta-analyses assessing neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI) in patients with CVD. Study quality and certainty of evidence were appraised using AMSTAR-2 and GRADE, respectively. Results: A total of 35 meta-analyses covering 106 unique outcomes were included, of which 87 showed significant associations. Elevated NLR and SII were consistently linked to higher risks of CVD mortality, major adverse cardiovascular events, myocardial infarction, heart failure, and stroke. PLR and SIRI were primarily associated with poor recovery from stroke and increased mortality in ST-elevation myocardial infarction. Specifically, the methodological quality of the included reviews was generally moderate to high according to AMSTAR-2, whereas none of the associations reached high certainty based on GRADE, with most rated as low or very low and about one-quarter as moderate certainty. Conclusions: The overall certainty of evidence remains limited according to GRADE, alongside methodological heterogeneity, population variability, and inconsistent thresholds that further restrict the direct applicability of these findings in clinical practice. Nevertheless, available evidence indicates that elevated immune-inflammatory indices are likely associated with worse clinical outcomes in patients with CVD. Future research should prioritize establishing standardized cutoffs, improving methodological consistency, and validating these indices across diverse populations to support their integration into clinical risk-stratification frameworks. Full article

This study investigates neutron radiation sources in medical cyclotrons used for PET isotope production, focusing on differences between ¹⁸F and ¹¹C. Neutron and gamma dose rates were measured in the bunker and operator control room during routine production with an 11 MeV Eclipse cyclotron. ¹⁸F production generated approximately 2.5 times higher neutron levels in the bunker than ¹¹C. Shielding performance also varied: the same wall reduced neutron fluxes by factors of k_F = 14,000 for ¹⁸F and k_C = 86,000 for ¹¹C, while gamma shielding was similar for both isotopes (k_γ ≈ 28,000). However, the neutron shielding factor calculated from the data for ¹⁸F should be taken as k_F ≥ 1.4 × 10⁴, because several neutron readings reached the upper limit of the detector range, which indicates a partial underestimation of the dose in the bunker. Consequently, neutron levels in the control room during ¹⁸F production were about 15-fold higher than during ¹¹C production. These differences result from distinct neutron generation mechanisms. The ¹⁸O(p,n)¹⁸F reaction produces primary neutrons with a Maxwellian spectrum (~2.5 MeV), while ¹¹C neutrons arise solely from secondary interactions in structural materials. The findings emphasize the need for composite shielding adapted to isotope-specific spectra. Annual dose estimates (260 ¹⁸F and 52 ¹¹C productions) showed neutron exposure (3.78 mSv/year, 57%) exceeded gamma exposure (2.82 mSv/year, 43%). The total dose of 6.6 mSv/year is ~33% of regulatory limits, supporting compliance but underscoring the need for dedicated neutron dosimetry. Full article

The growing complexity of modern building systems requires advanced monitoring frameworks to improve fault detection, energy efficiency, and operational resilience. Digital Twin (DT) technology, which integrates real-time data with virtual models of physical systems, has emerged as a promising enabler for predictive diagnostics. Despite growing interest, key challenges remain, including the neglect of short- and long-term forecasting across different scenarios, insufficiently robust data preparation, and the rare validation of models on multi-zone buildings over extended test periods. To address these gaps, this study presents a comprehensive DT-enabled framework for predictive monitoring and anomaly detection, validated in a multi-zone educational building in Rhode Island, USA, using a full year of operational data for validation. The proposed framework integrates a robust data processing pipeline and a comparative analysis of machine learning models, including LSTM, RNN, GRU, ANN, XGBoost, and RF, to forecast short-term (1 h) and long-term (24 h) indoor temperature variations. The LSTM model consistently outperformed other methods, achieving R² > 0.98 and RMSE < 0.55 °C for all tested rooms. For real-time anomaly detection, we applied the hybrid LSTM–Interquartile Range (IQR) method on one-step-ahead residuals, which successfully identified anomalous deviations from expected patterns. The model’s predictions remained within a ±1 °C error margin for over 90% of the test data, providing reliable forecasting up to 16 h ahead. This study contributes a validated, generalizable DT methodology that addresses key research gaps, offering practical tools for predictive maintenance and operational optimization in complex building environments. Full article

Traditional multi-stage separated heat pipes (SHPs) face limitations in independently setting operation parameters for each stage. To address this issue, this paper presents a novel independent multi-stage microchannel Separated Gravity Heat Pipe (SGHP) for air compressor room cooling. The innovative structure and working principle of this novel multi-stage SGHP were introduced. Furthermore, numerical investigations on a single stage of the SGHP were then conducted to study the gas–liquid two-phase flow characteristics and phase-change heat transfer performance. Experimental research on a three-stage SGHP was carried out to further explore the impact of the filling ratio combinations and the temperature difference between the hot and cold ends on the heat transfer performance of the SGHP. The results show that the temperature difference between the hot and cold ends affects the flow pattern of the working fluid, which has a vital effect on the heat transfer performance of the SGHP. The optimum filling ratio combination of the three-stage SGHP depends on the temperature difference between the hot and cold ends. The optimum filling ratio combination is 37%/37%/30% at low temperature difference conditions and 43%/37%/37% at high temperature difference conditions, respectively. The highest heat transfer capacity of the three-stage SGHP reaches 15.3 kW, and the peak heat recovery efficiency is 74.0%. The findings provide a crucial foundation for developing novel independent multi-stage SGHP in compressor room cooling and similar industrial settings, promising high potential to reduce energy consumption and operational costs. Full article

Ethylene glycol (EG) is a vital industrial raw material. However, it has the potential to be hazardous to the environment and human health. High operating temperatures and long response/recovery times limit the wide application of EG sensors. Thus, we need to develop high-performance room-temperature EG-sensing materials. This paper proposes the direct hydrothermal carbonization of magnolia hair to prepare porous microtubular carbon (CMH) for room-temperature EG sensing. SEM, TEM, and XPS characterization showed that the CMH exhibited a porous microtubular structure and contained Na, which enhanced the adsorption capacity of the CMH for ethylene glycol gas. The CMH sensor exhibits a high response (156.4) to 500 ppm ethylene glycol gas at room temperature with moderate response/recovery time (14.2/37.3 s). It exhibits good linearity in measuring EG gases in the 10–100 ppm range, with a 0.292 ppm theoretical detection limit. Additionally, CMH sensors provide excellent repeatability and long-term stability. The synergistic effect of microtubule porous structure and Na doping is the main reason for enhancing the response of the sensor to EG gas. On this basis, the gas-sensitive enhancement mechanism of CMH was analyzed. The results show that biomass carbon materials provide a new method to prepare high-performance EG gas sensors. Full article

Background/Objectives: In-hospital cardiac arrest (IHCA) carries high mortality and substantial risk of neurological and functional impairment. Given that contemporary, clinically relevant risk models remain limited, especially within Southern European systems, the aim of this study was to develop a process-aware model for bedside risk stratification. Methods: We retrospectively analyzed a single-center cohort from a prospectively maintained resuscitation registry (AHEPA University General Hospital, Thessaloniki). Adults (≥18 years) with index IHCA in 2017–2019 were included. Utstein-defined variables underwent univariable screening, LASSO selection, and collinearity checks before multivariable logistic regression for in-hospital mortality. We assessed discrimination (AUC) and calibration (Hosmer–Lemeshow). Results: Among 826 IHCAs, 137 survived to discharge and 689 died. Higher mortality was independently associated with longer CPR (aOR = 1.115, 95% CI: 1.080–1.158), older age (aOR = 1.034, 95% CI: 1.014–1.055), and CCU location (aOR = 7.303, 95% CI: 2.557–25.798), while operating room (aOR = 0.029, 95% CI: 0.003–0.252), ICU/HDU (aOR = 0.203, 95% CI: 0.065–0.630), and an initial shockable rhythm (aOR = 0.297, 95% CI: 0.144–0.611) were protective. Longer time to CPR initiation also predicted mortality (aOR = 1.746, 95% CI: 1.001–3.162). Model performance was strong (AUC = 0.897, 95% CI: 0.865–0.928) with good calibration (Hosmer–Lemeshow p = 0.879). Conclusions: A process-aware model integrating patient factors, intra-arrest metrics, and location showed excellent internal performance for predicting IHCA mortality. Findings reaffirm the prognostic importance of age, rhythm, and resuscitation timeliness/intensity and support future work extending prediction to neurological/functional outcomes and testing targeted care bundles in high-risk strata. Full article

A sustainable non-lithium battery is proposed, integrated with renewables to cater for the intermittency and differences between daily supply and demand. A room temperature sodium–sulfur (RT Na-S) battery presented in this study offers a promising energy density of 177 Wh/kg of the pouch cell. A framework is introduced for the design of an RT Na-S battery system, alone and combined with a supercapacitor, and its operating schedule for two case studies: (a) a photovoltaic (PV) system for a household and (b) a wind turbine for an industrial site. Daily power supply and demand profiles are included in both cases. In the first design step, the required mass and volume of the battery cells are determined. In the second step, the system architecture is designed, and simulations of the renewable-energy storage system–demand are carried out for four consecutive days. An RT Na-S battery–supercapacitor system is recommended in association with the wind turbine that involves high frequency and high power pulses, where the supercapacitor caters for power exceeding 0.1 C. A standalone RT Na-S battery is recommended for the PV system. The simulations predicted that each storage system covered all the net power and energy demands without any contributions from the grid. Full article

Removing toxic formaldehyde (HCHO) from environmental water is crucial for human health and the ecosystem. Perovskite-type Lanthanum cobalt oxide (LaCoO₃) has achieved great success in a wide range of catalytic processes; however, this concept has been rarely applied to the degradation of HCHO. Here, we prepared perovskite-type catalysts with different La/Co molar ratios, and the time for HCHO oxidation degradation at room temperature was shortened by 12 times (10 min vs. 119 min) compared to other heterogeneous catalysts. LaCoO₃ exhibits superior catalytic activity for HCHO degradation at room temperature when the La/Co molar ratio is 1:1 compared to lanthanum cobalt oxides with other molar ratios. The X-ray photoelectron spectroscopy (XPS) test results show that increasing the La/Co molar ratio reduces the Co²⁺ content in the catalyst, while Co²⁺ plays the most important role in the catalyst. Quencher experiments indicated that sulfate radicals (SO₄·⁻) and hydroxyl radicals (·OH) were the primary reactive species for the removal of HCHO. This finding suggests that the catalytic oxidation reaction involving HCHO operates as a heterogeneous Fenton-like oxidation reaction. Full article

Silver selenide (Ag₂Se) is a promising thermoelectric material for near-room-temperature applications, yet its scalable fabrication remains challenging due to limitations in conventional synthesis routes and the strong dependence of its properties on processing conditions. In this work, the pack cementation technique is introduced as a novel cost-effective, and industrially viable route for producing β-Ag₂Se powders. The influence of synthesis parameters on phase formation, composition, and microstructure is examined, and their correlation with thermoelectric behavior is studied to establish clear structure–property relationships. The resulting Ag₂Se is comprehensively evaluated for quality and performance. Phase-pure orthorhombic β-Ag₂Se with near-stoichiometric composition and a uniform microstructure was successfully synthesized, with phase purity preserved after consolidation without secondary phases. The material exhibited competitive thermoelectric performance, achieving a maximum ZT = 0.63 at 352 K and stable operation up to ~375 K. These findings demonstrate that pack cementation can deliver high-quality Ag₂Se with competitive efficiency, highlighting its potential for future optimization and large-scale production. Full article

Accurate object detection and measurement within indoor environments—particularly unfurnished or minimalistic spaces—pose unique challenges for conventional computer vision methods. Previous research has been limited to small objects that can be fully detected by applications such as YOLO, or to outdoor environments where reference elements are more abundant. However, in indoor scenarios with limited detectable references—such as walls that exceed the camera’s field of view—current models exhibit difficulties in producing complete detections and accurate distance estimates. This paper introduces a geometry-driven, redundancy-based framework that leverages proportional laws and architectural heuristics to enhance the measurement accuracy of walls and spatial divisions using standard smartphone cameras. The model was trained on 204 labeled indoor images over 25 training iterations (500 epochs) with augmentation, achieving a mean average precision (mAP@50) of 0.995, precision of 0.995, and recall of 0.992, confirming convergence and generalisation. Applying the redundancy correction method reduced distance deviation errors to approximately 10%, corresponding to a mean absolute error below 2% in the use case. Unlike depth-sensing systems, the proposed solution requires no specialised hardware and operates fully on 2D visual input, allowing on-device and offline use. The framework provides a scalable, low-cost alternative for accurate spatial measurement and demonstrates the feasibility of camera-based geometry correction in real-world indoor settings. Future developments may integrate the proposed redundancy correction with emerging multimodal models such as SpatialLM to extend precision toward full-room spatial reasoning in applications including construction, real estate evaluation, energy auditing, and seismic assessment. Full article

Background/Objectives: This retrospective study aimed to evaluate the five-year clinical performance of removable partial dentures (RPDs) made of chromium–cobalt–molybdenum alloy, comparing two different post-casting cooling methods: slow furnace cooling (LRF) and room temperature air cooling (RATA). The investigation aimed to determine whether LRF treatment could reduce the incidence of technical complications, such as fractures and clasp deformations, particularly on RPD with thin clasps for aesthetic reasons. Methods: In total, 22 RPDs were examined, 11 of which were treated with LRF (test group) and 11 with RATA (control group). The prostheses in the LRF group had clasps intentionally reduced by 2/3 tenths of a millimeter compared to those in the RATA group. All the prostheses were made and evaluated by the same operator, who analyzed the presence of changes, fractures, or clasp widening after five years. Statistical analysis was performed using Fisher’s exact test with a significance level of p < 0.05. Results: Clinical data showed a lower complication rate in the LRF group compared to the RATA group in all parameters evaluated: prosthesis modification (9.1% vs. 18.2%), clasp fractures (9.1% vs. 36.4%), and enlarged clasps (54.4% vs. 72.7%). However, the statistical comparison between the two groups did not show significant differences, p-value ˃ 0.05 for all parameters. Conclusions: Despite the lack of statistical significance, likely due to the limited size of the cambium and the confounding variable of clasp thickness, clinical trends indicate a potential superiority of the LRF method in the parameters examined, such as modification prosthesis, fractured clasp, and enlarged clasp. The reduction in complication rates in the LRF group suggests that the superior mechanical properties conferred by this treatment may compensate for the potential structural weakening caused by clasp thickness. Future studies with a larger sample size and a prospective design will be needed to validate these results and confirm LRF as the preferred protocol for the production of aesthetic RPD. Full article

Conventional whole-blood flow assays for quantifying thrombus formation are typically performed at room temperature and are technically demanding, which limits their translational applicability. We engineered a novel, disposable, mountable, and single-channel microfluidic chip (MC-2S), which is based on the Maastricht chamber (MC) and designed for automated evaluation of platelet function, coagulation and fibrinolysis under physiological conditions. The MC-2S chip allows customizable choices of thrombogenic surfaces, such as collagen and tissue factor. The chip was used in combination with an adapted, 1.3 kg brightfield/fluorescence microscope, operating at physiological temperature (37 °C), and with scripts for automated multicolor analysis of image features. The integrated system enables a robust, rapid, and high-content quantification of the kinetics of thrombus formation and dissolution. In platelet-sensitive mode, MC-2S demonstrated high sensitivity to antiplatelet therapy with aspirin or cangrelor. In coagulation-sensitive mode, it detected the anticoagulant effect of rivaroxaban plus its reversal by andexanet-α. In fibrinolysis-sensitive mode, it monitored tissue-type plasminogen activator-induced thrombus dissolution, inhibited by tranexamic acid. Collectively, the MC-2S platform was found to provide a versatile, physiologically relevant tool for functional hemostasis testing, with high potential for the acute and subacute evaluation of patient blood samples in the context of bleeding disorders, thrombosis risk, and drug monitoring. Full article

Rupture discs are critical safety devices for pressure vessels, yet defining replacement intervals for discs that have not ruptured remains challenging due to limited quantitative life-prediction methods. This study investigates forward-acting rupture discs made of 316 L stainless steel and Inconel 600 under three test conditions: low pressure at room temperature, low pressure at elevated temperature, and ultra-high pressure at elevated temperature. Static hold life and fatigue life were measured over a range of operating ratios R = P_w/P_b. To model life–ratio relationships while avoiding far-reaching extrapolation, static life was fitted with a log-normal accelerated-life (AFT) model and fatigue life with a Basquin relation following ASTM E739, reporting 95% prediction bands. Predictions were restricted to validated domains (static: R ≥ 0.86) and truncated at five times the groupwise maximum observed life/cycles. Results show a consistent trend for both materials and all conditions: life decreases as R increases, with steep sensitivities within the observed range. At matched R, Inconel 600 generally exhibits longer life than 316 L. Qualitative failure analysis under constant and cyclic loading indicates progressive plastic deformation, local thinning, and a concomitant reduction in bursting pressure until failure. The proposed in-range predictive framework provides actionable guidance for determining conservative replacement intervals for rupture discs. Full article

The effectiveness of periodate-assisted photocatalysis in removing the cationic dye Safranin O (SO) was evaluated using a UV/TiO₂/IO₄⁻ process operated at room temperature under near-neutral pH conditions. Under base conditions ([IO₄⁻] = 0.15 mM, [TiO₂] = 0.4 g/L, [SO] = 10 mg/L), the ternary system achieved a pseudo-first-order rate constant of 0.6212 min⁻¹, outperforming the UV/TiO₂ and UV/IO₄⁻ processes by approximately 21- and 29-fold, respectively. This yielded a synergy ratio of about 12 compared to the sum of the binary processes. Targeted quenching experiments revealed the operative pathways. Strong inhibition by ascorbic acid and phenol indicates that interfacial holes and ^•OH are key oxidants. Methanol caused a moderate slowdown, consistent with ^•OH and hole scavenging. Benzoquinone and oxalate suppressed removal by intercepting the electron and O₂^•− pathways, respectively. Dichromate markedly inhibited the process via optical screening and competition for electrons. Azide had little effect, suggesting a minor role for singlet oxygen. Matrix studies showed progressively slower kinetics from deionized water to mineral water to seawater. This was due to halides, sulfate, alkalinity, and TiO₂ aggregation driven by ionic strength. Additional tests confirmed that the dominant modulators of performance were humic acid (site fouling and light screening), chloride and sulfate (radical speciation and surface effects), nitrite (near-diffusion radical quenching), and bicarbonate at pH 8.3 (conversion of ^•OH to CO₃^•−). Nonionic surfactants (Tween 80, Triton X-100) also depressed SO removal through micellar sequestration and competitive adsorption on TiO₂. The study confirms the potential of UV/TiO₂/IO₄⁻ as a tunable AOP capable of delivering rapid and reliable dye degradation under a wide range of water quality conditions. The mechanistic mapping unifies two roles for IO₄⁻, an electron acceptor that inhibits recombination and a photochemical precursor of iodine centered and ^•OH radicals and connect these roles to the observed synergy and to the trend across deionized water, mineral water, and seawater. The scavenger outcomes assign the main oxidant flux to holes and ^•OH radicals with a contributory electron or O₂^•− branch from IO₄⁻ reduction. Full article