Search Results (21,764)

This study examined how complexes formed between breadfruit starch, lauric acid (LA), and phenolic acids (gallic/GA, 3,4-dihydroxyphenylacetic/DOPAC, caffeic/CA) affect starch digestibility and properties. All complexes increased resistant starch (RS) content from 47.19% (native) to 49.12–70.14%, with the caffeic acid-starch binary complex showing the highest RS (70.14%) and lowest hydrolysis index (52.60). LA-containing samples formed V-type inclusion complexes, evidenced by a cooling-phase viscosity peak, while polyphenol-only samples did not. The formation of the complex raised the starch gelatinization peak temperature from 78.6 °C to 100.6–120.9 °C. Structural analysis indicated increased short-range order and crystallinity. Ternary complexes exhibited lower short-range order but higher crystallinity than binary complexes, suggesting LA primarily influences long-range order, while polyphenols affect both short- and long-range structure. These findings clarify interaction mechanisms in starch–lipid–polyphenol systems for designing low-digestibility foods. Full article

Glycosylation depends on luminal nucleotide sugars delivered by solute carrier 35 (SLC35) transporters. SLC35A3 is a uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) transporter. In humans, biallelic mutations in SLC35A3 cause arthrogryposis, mental retardation, and seizures (AMRS). To define how loss of SLC35A3 function reshapes the neural glycome, we profiled N-, O-, and glycosaminoglycans (GAGs) in Slc35a3 knockout mouse brains. N- and O-glycans were analyzed by MALDI-TOF MS, and GAG disaccharides were quantified by anion-exchange HPLC. Knockout mouse brains exhibited attenuation of complex-type N-glycans with a reciprocal rise in high-mannose species, as revealed by MALDI-TOF MS profiling. In contrast, ConA lectin blotting showed no significant change, consistent with its preferential detection of mannose-rich glycans. Branching analysis revealed loss of tri- and tetra-antennary structures compared with biantennary species. O-glycan profiling showed core-2-type species (Hex₂HexNAc₂ backbone) decreased. The dominant disialyl core-1 remained stable. Total GAG output (chondroitin/dermatan sulfate, heparan sulfate, and hyaluronan) was preserved. These findings support a microdomain model in which SLC35A3 acts as a locally effective supplier of UDP-GlcNAc to MGAT4 (branching N-acetylglucosaminyltransferase that installs the β1,4-GlcNAc arm) in the brain, while alternative routes buffer UDP-GlcNAc delivery for GAG and mucin-type O-glycan biosynthesis. Accordingly, AMRS may be attributed to impaired higher-order N-glycan branching in the brain. Full article

After a shear-type strongly braced steel frame suffers from non-sway buckling, the effective length factor for columns in a non-sway frame should be selected for stability calculations, and the P-δ effect should be considered for second-order analysis. However, an unreasonable design may result if the shear-type bracing cannot be accurately and practically designed to meet the strong bracing requirements. In this paper, an analytical method for the critical bracing design of shear-type strongly braced steel frames is proposed. First, the relationship between the shear-type bracing stiffness and buckling load of structures is analyzed, and then the calculation formula for the story critical bracing stiffness is derived based on the critical bracing stiffness of the separation column. Furthermore, the relationship between the cross-sectional properties of the shear-type brace members and the critical bracing lateral stiffness is established. Based on this, a direct calculation formula for the critical brace area of shear-type strongly braced steel frames is derived. This formula can determine whether a shear-type braced steel frame will experience sidesway or non-sway buckling, thereby providing a basis for selecting the appropriate approach for calculating the column effective length factor and second-order effects. Full article

Introduction: Urinary incontinence (UI) is one of the most common pelvic floor disorders after childbirth and depends on hormonal changes, anatomical damage that occurs after childbirth, muscle and connective tissue weakness, fascia and nerves. UI is distinguished into three subtypes, including stress urinary incontinence (SUI), urgent urinary incontinence (UUI) and mixed urinary incontinence (MUI). Aim: The purpose of this review is to collect and summarize the results of studies related to the risk factors of urinary incontinence, to disseminate this information to scientists so that this major issue can be prevented, identified and managed. Methodology: This review followed the methodology of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and PECO eligibility criteria were used. We included studies published up to 2025 and not before 2019. The review was limited to studies published within the last six years in order to reflect contemporary diagnostic criteria, assessment tools and current postpartum care practices related to urinary incontinence. We searched PubMed, Google Scholar and Scopus for studies concerning the relationship between risk factors and postpartum UI. Results: A total of 1321 citations were identified. Following our exclusion criteria, 36 papers were selected to identify the risk factors for UI. All the research focused on the associated factors of any type of urinary incontinence. Vaginal and instrumental delivery, obesity, maternal age and the neonate’s birth weight were the main risk factors. The multiparity and incontinence symptoms before and during pregnancy were also strong risk factors. Heterogeneity across studies in assessment tools, in outcome measures and timing of postpartum assessment are some of the limitations of the study. Restriction to English-language publications and the absence of protocol registration were some of the additional limitations of the study. Conclusions: This problem affects the inclusion of women in society, the family, limits social activities and even their ability to work. Detection of the type of urinary incontinence by healthcare professionals, lifestyle modifications, monitoring women’s body weight and encouraging them to follow a program of pelvic floor muscle exercises should be a priority for professionals. The strategy of developing prognostic models in the coming years will be the only way to ensure the early identification and follow-up of women at high risk for urinary disorders. Full article

Species of the ascomycetous genus Cladobotryum (Hypocreales, Hypocreaceae) are ecologically and economically important mycoparasites that cause cobweb disease in cultivated and wild mushrooms. Despite their significance as fungal pathogens and producers of bioactive metabolites, the taxonomy of Cladobotryum remains unresolved due to extensive morphological plasticity, complex teleomorph–anamorph connections, and the presence of cryptic species. This study employs an integrative approach combining micro- and macromorphological characterization, multi-locus phylogeny (ITS, rpb2, and tef-1a), and comparative genomics to clarify the taxonomic position of the Greek isolate Cladobotryum sp. ATHUM 6904, previously designated as an unclassified red-pigmented (URP) strain. Phylogenetic analyses demonstrated that URP strains form a distinct, well-supported clade closely related to C. tenue and C. rubrobrunnescens, yet genetically and morphologically distinct from both. Comparative genomic analyses of isolate ATHUM 6904 and the ex-type strains of C. tenue and C. rubrobrunnescens revealed pronounced divergence in transposable element content, mitochondrial genome architecture, gene order, orthologous gene composition, secondary metabolite biosynthetic potential, and overall genomic distance. Micro- and macromorphological comparisons further supported the differentiation of isolate ATHUM 6904 from both reference species. Based on the combined molecular, morphological, and genomic evidence, the Greek isolate ATHUM 6904 is described as a novel species, Cladobotryum rhodochroum sp. nov. Full article

Cavitation erosion is a critical problem for many engineering components, such as ship propellers, diesel engine exhaust valves, cylinder liners, pump impeller blades, hydraulic turbines, and bearings, which are exposed to high-velocity flowing fluids or to vibratory fluid motion. It represents a mechanical degradation of the surface caused by the continuous collapse of bubbles in the surrounding liquid, which seriously affects flow efficiency and component service life, increasing maintenance frequency and refurbishment costs. The intensity and evolution of the cavitation erosion phenomenon depend on the hydrodynamic conditions to which the component surface is exposed, the properties of the liquid, and the judicious selection of the most suitable material. This paper aims to modify the microstructure of a Ni-based superalloy by applying recrystallization annealing heat treatment in order to obtain surfaces resistant to cavitation erosion for components that handle fluids under local pressure fluctuations. Experimental tests are carried out using a vibratory apparatus with piezoceramic crystals operating at a frequency of 20 kHz and an amplitude of 50 µm. The cavitation erosion performance of the Ni-based superalloy INCONEL 625, heat treated by recrystallization annealing, are compared with that of austenitic stainless steel AISI 316L subjected to solution treatment. For both metallic alloys, based on mass loss measurements, the characteristic time-dependent curves of the mean cumulative erosion penetration depth, MDE(t), and the mean erosion rate, MDER(t), are determined. The comparison of these curves and of the parameters defined and recommended by the ASTM G32 standard demonstrates that, for the Inconel 625 superalloy, resistance to cavitation erosion increases by 77–81% compared to that of AISI 316L austenitic stainless steel. X-ray diffraction analyses (XRD) show that, in the microstructure of the Inconel 625 superalloy, in addition to austenite, MC-type carbides, M₂₃C₆ carbides, and intermetallic phases γ″ = Ni₃(Nb, Al, Ti) and δ = Ni₃(Nb, Mo) are also present. Full article

Large language models (LLMs) have begun to function as assistants or teammates in language learning, teaching, and research. However, what prerequisites are required for LLMs to reliably play these roles, and how such prerequisites should be measured, remains under-discussed. This study focuses on measuring Pedagogical Grammar Pattern Recognition (P-GPR) and establishes the Chinese Pedagogical Grammar Evaluation (CPG-EVAL), a multi-tiered benchmark designed to evaluate P-GPR within International Chinese Language Education. CPG-EVAL operationalizes grammar–instance correspondence through five task types that progressively increase contextual load and interference. We evaluate multiple proprietary and open-source LLMs as well as human participants. Results show a monotonic ordering across groups (humans > larger-scale models > semi-larger-scale models > smaller-scale models). In comparison with human participants, LLM performance is more sensitive to task-format complexity. In addition, we identify a set of completely failed items that consistently mislead all evaluated LLMs, exposing shared and systematic weaknesses in current models’ pedagogical grammar recognition. Overall, this study provides an operational framework for diagnosing the capabilities and risks of LLMs when they are deployed as assistants or teammates in grammar-related language-education tasks and offers empirical reference for safer and more syllabus-aligned use of LLMs in educational settings. Full article

Surface subsidence has grown to be a major geological problem for big and medium-sized cities in the context of urbanization and climate change. Changchun, a city of moderate size and rapid development, was chosen as the study region for this project. The Enhanced Permanent Scatterer Interferometric Synthetic Aperture Radar (E-PS-InSAR) technique was used based on Sentinel-1A imagery to gather time-series surface deformation information in order to perform long-term, high-precision monitoring and a mechanistic study of surface deformation in urban–rural integration areas. Subsequently, temperature and land-use type data were then integrated for a thorough investigation using techniques including correlation analysis and functional fitting. The following are the primary conclusions: (1) The E-PS-InSAR technique integrating both PS and DS targets can significantly improve the density of monitoring points compared to traditional methods, providing the complete spatial coverage. (2) Changchun has an average annual subsidence rate of −0.14 mm and an average cumulative subsidence of −0.08 mm. The highest cumulative subsidence is up to −41.31 mm, and the maximum subsidence rate is −17.27 mm/yr. (3) Surface subsidence was correlated with land use types, and cultivated land was the primary contributor to subsidence. (4) Surface subsidence exhibits distinct seasonal fluctuations, and climatic factors exhibit a lagged influence on surface subsidence. These results are crucial for safe infrastructure operation, urban planning, and promptly preventing geological dangers in mid-sized cities. Full article

Pearlitic (stainless) steel is used in automotive, aerospace, and other industries where high strength, hardness, and wear resistance are required. Its quality control can be performed using mechanical tests or by examining the lamellar microstructure, namely, determining interlamellar distance. One of the related approaches is the circular line method (CLM). This paper reviews the challenges to automate employment of the CLM using custom Python code in order to reduce human time costs during image-based quality assessment of pearlite. The goal is to perform intersection counting automatically once the human operator has configured the application and selected the locations of measuring circles. Performance assessment using manually processed data from some 465 images is performed. We divide the imaged pearlite microstructures into different “types” when the code performs well or, respectively, not so well. We conclude with possible extensions of the work presented here. Full article

This study evaluates the impact of a comprehensive design integrating precursor type, reduction and freeze-casting on the development of aerogels with high sorption capacity for engine oil. In this respect, the graphene oxide was varied from commercial to expanded; the reduction approach relied either on purely hydrothermal or combined hydrothermal–chemical reduction approaches. Following the synthesis, freeze-casting was applied at −5 °C and −196 °C. To further improve the reduction degree, annealing in an inert atmosphere was employed upon drying. The effects of precursors, reduction approach, freeze-casting and annealing were systematically investigated. Characterization techniques, including FT-IR, Raman spectroscopy, SEM, and EDS, were used to correlate the degree of reduction and morphological features of the porous structure with the absorption properties. The use of expanded GO as a precursor yielded aerogels with more homogeneous three-dimensional networks, a reduced bulk density of 3 mg cm⁻³, and lower oxygen-containing functional group content, thereby achieving consistently superior oil absorption of 270 g g⁻¹, with an oil occupancy of 94%. The process was found to fit well with the pseudo-first-order kinetic model. The results demonstrate that a comprehensive approach—considering combined reduction, freeze-casting, and thermal annealing—enables the tailored optimization of both the structure and absorption performance of GO aerogels for the remediation of oil spills. Full article

The present study focuses on scientific and experimental research on corrosion damage to the bodies of subway cars. The main purpose of the research is to assess the degree of corrosive wear on the main load-bearing metal structures of the subway cars after the end of their service life in order to determine the possibility of their further operation. Scientific and experimental research was conducted under the conditions of the municipal enterprise “Kyiv Metro” on subway cars of the series (models) Yezh, 81-714/717 and 81-714.5/717.5, which had reached the end of their service life. The main methodological approach of the research consisted of conducting technical diagnostics of the subway cars using standardized non-destructive testing methods. The goal of the research was achieved by solving two main tasks. The first task was to determine mathematical expressions describing the dynamics of changes in the thickness and degree of corrosive wear of the metal structures of the studied subway cars, depending on number of years in operation. The second task was to determine the possibility of extending the service of the subway cars after reaching the end of their service life. The scientific novelty of this study lies in determining the degree of thinning and the development of corrosive wear of the metal structures of the studied subway cars depending on the type of structure and service life. The practical significance of the obtained results lies in the possibility to predict the residual strength resources of the individual elements of the metal structures of the studied cars using the corrosive wear criterion. It was established that the 092GS material of the main metal structures of the subway car bodies is sufficiently resistant to corrosion processes. The results of the research show that the metal structures of the subway cars studied had a margin of safety and, therefore, their service life could be extended. Full article

Acoustic emission testing is a non-destructive inspection method in which ultrasonic waves emitted by defects in an object are detected and assessed based on their time of arrival and waveform, which strongly depends on the geometry of the object. Those waves appear in different modes with their own velocity and dispersion and different degrees of attenuation can occur for different wave modes. In previous work, a new method for (semi-)automatic recognition of the arrival time of wave modes was presented and validated on a dataset obtained in laboratory conditions on a flat plate. This paper builds upon the previous research and presents a modified method that can be applied to data obtained from an industrial gas storage sphere. The following two wave modes were commonly detected for this sphere: one similar to the zero-order anti-symmetrical mode (A₀) and the other similar to the zero-order symmetrical Lamb mode (S₀) in a plate. The method was adapted to solve the new challenges that were encountered for the sphere. The performance of the adapted automatic mode recognition method was assessed using a dataset with the following four different source types: Hsu–Nielsen sources, sensor pulses, impact by a metallic object and natural sources. The resulting wave mode recognition was compared to manual recognition to determine the rates of successful recognition. The resulting successful recognition rates range from 97% for A₀ and S₀ for Hsu–Nielsen sources down to 73% for A₀ in signals due to natural sources and 74% for A₀ in signals due to impact by a metallic object. Full article

The endocannabinoid system is a ubiquitous neuromodulatory network that links internal physiological state to neural circuit function across the brain. While its roles in memory, reward, pain, and motor control are well established, its contribution to olfactory processing has only recently gained attention. This review synthesizes the current knowledge on the anatomical, cellular, and functional interactions between the endocannabinoid system and the olfactory pathway, from the olfactory epithelium and main olfactory bulb to higher order cortical targets. We highlight how endocannabinoid signaling, primarily via cannabinoid receptor type 1 (CB1), shapes synaptic transmission within olfactory bulb microcircuits, modulates centrifugal feedback, and adjusts sensory gain in a state-dependent manner, particularly in relation to hunger, feeding behavior, stress, and reward. In addition, we review evidence that the endocannabinoid system regulates olfactory neurodevelopment and adult neurogenesis by influencing neural stem cell proliferation, migration, and integration into existing circuits. Emerging links between endocannabinoid signaling, olfactory dysfunction, neuropsychiatric disease, metabolic disorders, and neurodegeneration underscore the translational relevance of this system. We also discuss methodological challenges inherent to studying endocannabinoid signaling and outline future directions, including circuit-specific targeting and intranasal delivery strategies. Together, these findings position the olfactory system as a powerful and accessible model for understanding how endocannabinoids couple internal state to perception and behavior, with important implications for therapeutic development. Full article

Background/Objectives: Several studies in the literature support that endovascular aortic repair (EVAR) could exert a harmful effect on heart function, causing myocardial injury. The aim of this study is to investigate the correlation of high-sensitivity cardiac troponin I (hs-cTnI) levels during the immediate postoperative period after EVAR with various factors. Methods: A total of 104 patients were enrolled from February to December 2024 prospectively and consecutively. Patient demographics, cardiovascular comorbidities, laboratory tests, including hemoglobin and hs-cTnI levels, EVAR procedure duration and type of anesthesia were recorded. A generalized linear mixed model with a Gamma distribution and log link was fitted to analyze postoperative hs-cTnI concentrations across three time points (6 h, 24 h, and 48 h). Results: The mean age of patients was 71.6 ± 7.3 years, the mean transverse AAA diameter was 5.7 ± 1.1 cm and the mean preoperative hemoglobin was 14.2 ± 1.64 g/dL. In total, 72 patients received general anesthesia and 32 patients regional anesthesia. A total of 18 patients presented myocardial injury. Patients under general anesthesia had significantly higher mean hs-cTnI than those under regional anesthesia (p < 0.01). Older age, longer operations, and higher baseline hs-cTnI all predict higher follow-up hs-cTnI. Meanwhile higher preoperative hemoglobin predicts lower hs-cTnI. Conclusions: General anesthesia compared to regional anesthesia, older age, longer surgery, and higher baseline hs-cTnI are associated with higher postoperative hs-cTnI levels, while higher preoperative hemoglobin predicts lower hs-cTnI levels. Understanding the factors that are related to myocardial injury during EVAR could contribute to the improvement in procedures in order to minimize the harmful effect of EVAR on heart function. Full article

This study selected a simplified water intake tower model, simplifying the physical structure into a cantilever model, and MATLAB software (R2010b) was used to develop a rapid seismic response analysis program for the structure. Thirty near-fault pulse and non-pulse ground motions were selected as the input ground motions for this analysis. Peak ground velocity (PGV) was used as the intensity parameter for the ground motions. The acceleration, cross-sectional rotation, and lateral curvature of the simplified water intake tower model were calculated for ground motions modulated with different PGA amplitudes. The acceleration, maximum shear force, and cross-sectional rotation of the simplified water intake tower model were also calculated for ground motions modulated with improved effective peak acceleration (IEPA) and improved effective peak velocity (IEPV). The study showed that the seismic response of the simplified water intake tower model for near-fault ground motions modulated with different intensities of PGV amplitude modulation was closer to the unmodulated response order. PGV as an intensity parameter did not affect the acceleration response amplification factor of the water intake tower and hoist chamber. The AC coefficient indicated that PGV was less suitable for pulse-type earthquake amplitude modulation than PGA. Compared with PGA amplitude modulation, IEPA amplitude modulation is more suitable for pulse-type seismic motion, while IEPV amplitude modulation has less impact on pulse-type seismic motion. Full article