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27 pages, 8384 KiB  
Article
CFD-APSO Co-Optimization for Enhanced Heat Dissipation in a Camellia oleifera Harvester Engine Compartment
by Wenfu Tong, Kai Liao, Lefeng Zhou, Haifei Chen, Hong Luo and Jichao Liang
Agriculture 2025, 15(11), 1141; https://doi.org/10.3390/agriculture15111141 - 26 May 2025
Viewed by 162
Abstract
Camellia oleifera harvester is a compact agricultural vehicle utilized in plantations located in China’s red soil hilly regions. To enhance its functionality and off-road performance, additional electronic devices and a more powerful powertrain system have been integrated within the engine compartment. However, the [...] Read more.
Camellia oleifera harvester is a compact agricultural vehicle utilized in plantations located in China’s red soil hilly regions. To enhance its functionality and off-road performance, additional electronic devices and a more powerful powertrain system have been integrated within the engine compartment. However, the increased component density has resulted in constrained heat dissipation space, leading to critical issues including insufficient engine power, delayed control response, and reduced vibration frequency of the harvesting device. These thermal problems significantly compromise operational efficiency and pose safety hazards to operators. To address these heat dissipation challenges, this study proposes a collaborative optimization approach integrating computational fluid dynamics (CFD) simulation with an Adaptive Particle Swarm Optimization (APSO) algorithm. Initially, preliminary experiments, coupled with CFD simulations, were conducted to analyze the airflow distribution and temperature field within the engine compartment. Based on these findings, the component arrangement was reconfigured to improve thermal performance. Subsequently, an “engine compartment cover parameters–temperature” correlation model was established, and the dimensional parameters of the engine compartment cover were optimized using the APSO algorithm. Experimental results demonstrate that the optimized configuration achieves an average surface temperature reduction of approximately 17.82% for critical components, enabling prolonged stable operation and significantly enhanced operational reliability of the harvester. Full article
(This article belongs to the Special Issue Agricultural Machinery and Technology for Fruit Orchard Management)
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14 pages, 4970 KiB  
Article
Correlation of the Microstructural, Chemical, Luminescent, and Photocatalytic Properties of SrGd2O4 Doped with Rare Earth Ions
by Tijana Stamenković and Vesna Lojpur
Catalysts 2025, 15(6), 522; https://doi.org/10.3390/catal15060522 - 26 May 2025
Viewed by 155
Abstract
This study evaluated the relationship between the microstructure, photoluminescence, and photocatalytic properties of newly synthesized nanostructured phosphor materials. The combustion method was used to create samples of down-converting SrGd2O4 doped with Dy3+ ions (1, and 7 at%) and up-converting [...] Read more.
This study evaluated the relationship between the microstructure, photoluminescence, and photocatalytic properties of newly synthesized nanostructured phosphor materials. The combustion method was used to create samples of down-converting SrGd2O4 doped with Dy3+ ions (1, and 7 at%) and up-converting SrGd2O4 co-doped with varying quantities of Yb3+ ions (2, and 6 at%) and a constant quantity of Ho3+ ions (1 at%). Transmission electron microscopy (TEM) revealed the existence of porous agglomerated round-shaped particles, with the size around 150 nm, arranged in network-like structures. Energy dispersive X-ray spectroscopy (EDS) confirmed the presence of all structural elements and their homogeneous distribution throughout the particles. The presence of specific emission peaks associated with Dy3+ or Ho3+ dopant ions was demonstrated by luminescent measurement. The degradation processes of specific organic dyes (methylene blue for up-converters and rhodamine B for down-converters) under simulated sun irradiation were used to investigate photocatalytic activity. A reduction in dye concentration in aqueous solutions was measured using UV/Vis absorption spectroscopy. The results showed a successful dye breakdown rate after 4 h, and aliquots of the working solutions were obtained at precise intervals. Additionally, the results indicated that samples with the highest luminescence intensity exhibited superior photocatalytic activity, suggesting a significant promise for usage as multifunctional materials. Full article
(This article belongs to the Special Issue Recent Advances in Photocatalysis for Environmental Applications)
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22 pages, 13863 KiB  
Article
Stacking Sequence Effect of Basalt/Carbon Hybrid Laminated Composites on Solid Particle Erosion Behavior: From Ambient to Elevated Temperatures
by Mehmet İskender Özsoy, Sinan Fidan, Mustafa Özgür Bora and Satılmış Ürgün
Polymers 2025, 17(10), 1349; https://doi.org/10.3390/polym17101349 - 15 May 2025
Viewed by 210
Abstract
This is a research study on the high-temperature solid particle erosion behavior of basalt/carbon hybrid composites with varying ply arrangements (B8, C8, B4C4, C4B4, B2C4B2, [...] Read more.
This is a research study on the high-temperature solid particle erosion behavior of basalt/carbon hybrid composites with varying ply arrangements (B8, C8, B4C4, C4B4, B2C4B2, and C2B4C2). Solid particle erosion experiments were carried out by employing garnet particles at temperatures of 25 °C, 50 °C, 80 °C, and 120 °C at impingement angles of 30° and 90°. The erosion weight loss rate differed substantially with the temperature, angle of impact, and ply arrangement. The highest erosion rates were obtained by single-component composites at 544.9 mg/g (B8, 120 °C, 30°) and 541.3 mg/g (C8, 120 °C, 90°). In contrast, the hybrid composites were more resistant, with the lowest rate being 200.0 mg/g at an ambient temperature (25 °C, 30°) for C4B4. The erosion weight loss at 50 °C increased typically due to thermal softening, whereas at elevated temperatures (80 °C, 120 °C), there was some stabilization seen, reflecting the positive synergies between basalt and carbon fibers. The factorial analysis of ANOVA revealed that material type (43.17%) was the most significant factor, followed by the temperature (19.97%) and impingement angle (0.52%). SEM and profilometry analysis confirmed that hybrid arrangements lower the erosion crater depth by a great extent, affirming the improved wear resistance of balanced basalt-carbon configurations. This work demonstrates the potential applications of optimally designed hybrid composites for durability under erosive high-temperature environments. Full article
(This article belongs to the Section Polymer Composites and Nanocomposites)
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26 pages, 8246 KiB  
Article
An Investigation into the Rescue-Path Planning Algorithm for Multiple Mine Rescue Teams Based on FA-MDPSO and an Improved Force-Directed Layout
by Qiangyu Zheng, Peijiang Ding, Zhixin Qin and Zhenguo Yan
Fire 2025, 8(5), 188; https://doi.org/10.3390/fire8050188 - 8 May 2025
Viewed by 226
Abstract
It is noted that existing mine emergency-rescue algorithms have overlooked the requirement for multi-route sharing at critical nodes and have offered limited network visualisation. Consequently, a multi-team rescue-path-planning algorithm based on FA-MDPSO (Firefly Algorithm-Multiple Constraints Discrete Particle Swarm Optimisation) was proposed, and a [...] Read more.
It is noted that existing mine emergency-rescue algorithms have overlooked the requirement for multi-route sharing at critical nodes and have offered limited network visualisation. Consequently, a multi-team rescue-path-planning algorithm based on FA-MDPSO (Firefly Algorithm-Multiple Constraints Discrete Particle Swarm Optimisation) was proposed, and a graph-structure optimisation method combining a Force-Directed Layout with Breadth-First Search was introduced for node arrangement and visualisation. Methodologically, the superiority of the improved DPSO (Discrete Particle Swarm Optimisation) in route-planning precision was first validated on the DIMACS dataset. Subsequently, the hyperparameters of MDPSO (Multiple Constraints Discrete Particle Swarm Optimisation) were optimised by means of four intelligent algorithms—ACO (Ant Colony Optimization), FA (Firefly Algorithm), GWO (Grey Wolf Optimizer) and WOA (Whale Optimization Algorithm). Finally, simulations of one to three rescue-team deployments were conducted within a mine-fire scenario, and node-importance analysis was performed. Results indicated that FA-MDPSO achieved comprehensive superiority in route precision, search efficiency and convergence speed, with FA-based hyperparameter optimisation proving most effective in comparative experiments. The graph-structure optimisation was found to substantially reduce crossings and enhance hierarchical clarity. Moreover, the three-team deployment yielded the shortest equivalent path (56,357.02), and node-visitation frequency was observed to be highly concentrated on a small number of key nodes. This not only significantly improves the collaborative rescue efficiency but also provides intuitive and practical technical support for intelligent mine rescue operations. It lays an important foundation for optimising mine emergency rescue plans, ensuring the safety of underground personnel, and promoting the intelligent development of mines. Full article
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19 pages, 10390 KiB  
Article
Influence of NaCl Concentration on Compression Characteristics of Marine Soil and Micro-Mechanism Analysis
by Yong Zhang, Hangbo Xu, Xinghu Wang, Tongwei Lv, Minyun Hu, Shuaifeng Wu and Miaojun Sun
Appl. Sci. 2025, 15(9), 5110; https://doi.org/10.3390/app15095110 - 4 May 2025
Viewed by 272
Abstract
The salt concentration of the pore solution can alter the micro-pore and particle structure of soil, thereby affecting its engineering properties. To investigate the compression characteristics of marine soil under different salt concentrations, one-dimensional compression and SEM scanning tests were conducted on marine [...] Read more.
The salt concentration of the pore solution can alter the micro-pore and particle structure of soil, thereby affecting its engineering properties. To investigate the compression characteristics of marine soil under different salt concentrations, one-dimensional compression and SEM scanning tests were conducted on marine reconstituted clay from the Yellow Sea with varying NaCl concentrations (0–5%). The effects of NaCl concentration on the compression characteristics and microstructure of marine sedimentary clay were analyzed. The results indicate that: (1) Compressibility increases up to a NaCl concentration of 2.5%, after which it declines. At 2.5% NaCl threshold concentration, the coefficient of compression, compressibility index, and consolidation coefficient reach their peak values, and the response becomes more pronounced with increasing compression pressure. During the secondary compression stage, as pore water is expelled, the impact of NaCl concentration on compressibility diminishes, while the rebound characteristics remain unaffected by NaCl concentration; (2) SEM analysis reveals that at a NaCl threshold concentration of 2.5%, the pore fractal dimension, particle fractal dimension, pore anisotropy, and particle anisotropy reach their maximum values, with the most complex shape and pores and particles aligning in the same direction. When the concentration is less than 2.5%, the soil exhibits narrow pores and rounded particles upon compression. When the concentration exceeds 2.5%, the microstructure changes in the opposite direction, confirming the particle rearrangement mechanism driven by surface contact under moderate salinity. At the threshold concentration of 2.5%, a balance between electrostatic forces and attractive forces enables stable surface-to-surface contacts, maximizing compressibility. The findings of this study provide valuable references for the foundation design of marine geotechnical engineering in specific sea areas, thereby enhancing the safety and reliability of related projects. Full article
(This article belongs to the Section Marine Science and Engineering)
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16 pages, 2966 KiB  
Article
Finite Element Analysis of Strain-Mediated Direct Magnetoelectric Coupling in Multiferroic Nanocomposites for Material Jetting Fabrication of Tunable Devices
by William Paul Flynn, Sean Garnsey, Amar S. Bhalla and Ruyan Guo
J. Compos. Sci. 2025, 9(5), 228; https://doi.org/10.3390/jcs9050228 - 1 May 2025
Viewed by 425
Abstract
Magnetoelectric composites enable strain-mediated coupling between magnetic and electric fields, supporting applications in sensors, actuators, and tunable devices. This study presents a finite element modeling framework for simulating the direct magnetoelectric effect in core–shell and layered nanocomposites fabricated by material jetting (inkjet printing). [...] Read more.
Magnetoelectric composites enable strain-mediated coupling between magnetic and electric fields, supporting applications in sensors, actuators, and tunable devices. This study presents a finite element modeling framework for simulating the direct magnetoelectric effect in core–shell and layered nanocomposites fabricated by material jetting (inkjet printing). The model incorporates nonlinear magnetostrictive behavior of cobalt ferrite nanoparticles and size-dependent piezoelectric properties of barium titanate, allowing efficient simulation of complex interfacial strain transfer. Results show a strong dependence of coupling on field orientation, particle arrangement, and interfacial geometry. Simulations of printed droplet geometries, including coffee ring droplet morphologies, reveal enhanced performance through increased surface area and directional alignment. These findings highlight the potential of material jetting for customizable, high-performance magnetoelectric devices and provide a foundation for simulation-guided design. Full article
(This article belongs to the Section Composites Applications)
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19 pages, 8898 KiB  
Article
Modeling and Optimization of Structural Parameters for High-Efficiency Multi-Jet Polishing of Optical Glass
by Zhongchen Cao, Yiwei Miao, Ming Wang and Zhenfeng Zhu
Micromachines 2025, 16(5), 551; https://doi.org/10.3390/mi16050551 - 30 Apr 2025
Viewed by 147
Abstract
Multi-jet polishing (MJP) is a promising method for enhanced polishing efficiency by integrating multiple nozzles, allowing for the high-efficiency polishing of large-scale surfaces. However, the optimization of the structural parameters, such as the distribution form of the nozzles and outlet diameter, remains a [...] Read more.
Multi-jet polishing (MJP) is a promising method for enhanced polishing efficiency by integrating multiple nozzles, allowing for the high-efficiency polishing of large-scale surfaces. However, the optimization of the structural parameters, such as the distribution form of the nozzles and outlet diameter, remains a critical challenge for achieving uniform and stable polishing performance. This paper presents a dynamic model of MJP based on the theory of fluid dynamic pressure and particle erosion. The flow field and particle motion characteristics in multi-nozzle jet polishing were studied using simulation experiments. The influence of the nozzle spacing and form and outlet diameter on the flow field characteristics and material removal profile was explored, and the structural parameters of the multi-nozzle polishing tool were optimized. According to the simulation results, two kinds of multi-nozzle polishing tools with a linear arrangement and cross arrangement were processed, and a series of single-point and surface polishing experiments was carried out. The optimized multi-nozzle jet polishing tool has no interference in the removal contour of each point, exhibits high consistency and stability, and is consistent with the theoretical model prediction results, which effectively improve the surface polishing efficiency. The results can provide a theoretical and experimental reference for MJP in the ultra-precision and high-efficiency polishing of large-sized components. Full article
(This article belongs to the Special Issue Precision Optical Manufacturing and Processing)
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25 pages, 19914 KiB  
Article
Research on the HDPE Membrane Leakage Location Using the Electrode Power Supply Mode Outside a Landfill Site
by Wei Hao, Yayu Chen, Feixiang Jia and Xu Zhang
Sustainability 2025, 17(9), 4044; https://doi.org/10.3390/su17094044 - 30 Apr 2025
Viewed by 252
Abstract
To ensure the sustainable development of the surrounding environment and the sustainable operation of landfills, detecting landfill leakage is of great significance. In landfills lacking a leakage monitoring system, the inability to detect and locate damaged High-Density Polyethylene (HDPE) membranes can lead to [...] Read more.
To ensure the sustainable development of the surrounding environment and the sustainable operation of landfills, detecting landfill leakage is of great significance. In landfills lacking a leakage monitoring system, the inability to detect and locate damaged High-Density Polyethylene (HDPE) membranes can lead to the contamination of soil and groundwater by landfill leachate. To address this issue, this study proposes a resistivity tomography inversion model based on the external-electrode power supply mode. Utilizing the resistivity difference between the leakage zone and the surrounding soil, electrodes are arranged symmetrically for both power supply and measurement. Upon applying direct current (DC) excitation, potential data are collected, with the finite volume method employed for inversion and the Gauss–Newton method integrated with an adaptive particle swarm optimization algorithm for parameter fitting. Experimental results show that the combined algorithm provides better clarity in edge recognition of low-resistance models compared with single algorithms. The maximum deviation between inferred leakage coordinates and the actual location is 10.1 cm, while the minimum deviation is 6.4 cm, satisfying engineering requirements. This method can effectively locate point sources and line sources, providing an accurate solution for subsequent leakage point filling and improving repair efficiency. Full article
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21 pages, 15447 KiB  
Article
Optimization Design of Lazy-Wave Dynamic Cable Configuration Based on Machine Learning
by Xudong Zhao, Qingfen Ma, Jingru Li, Zhongye Wu, Hui Lu and Yang Xiong
J. Mar. Sci. Eng. 2025, 13(5), 873; https://doi.org/10.3390/jmse13050873 - 27 Apr 2025
Viewed by 321
Abstract
The safe and efficient design of dynamic submarine cables is critical for the reliability of floating offshore wind turbines, yet traditional time-domain simulation-based optimization approaches are computationally intensive and time consuming. To address this challenge, this study proposes a closed-loop optimization framework that [...] Read more.
The safe and efficient design of dynamic submarine cables is critical for the reliability of floating offshore wind turbines, yet traditional time-domain simulation-based optimization approaches are computationally intensive and time consuming. To address this challenge, this study proposes a closed-loop optimization framework that couples machine learning with intelligent optimization algorithms for a dynamic cable configuration design. A high-fidelity surrogate model based on a backpropagation (BP) neural network was trained to accurately predict cable dynamic responses. Three optimization algorithms—Particle Swarm Optimization (PSO), Ivy Optimization (IVY), and Tornado Optimization (TOC)—were evaluated for their effectiveness in optimizing the arrangement of buoyancy and weight blocks. The TOC algorithm exhibited superior accuracy and convergence stability. Optimization results show an 18.3% reduction in maximum curvature while maintaining allowable effective tension limits. This approach significantly enhances optimization efficiency and provides a viable strategy for the intelligent design of dynamic cable systems. Future work will incorporate platform motions induced by wind turbine operation and explore multi-objective optimization schemes to further improve cable performance. Full article
(This article belongs to the Section Ocean Engineering)
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16 pages, 820 KiB  
Article
End-to-End Detector Optimization with Diffusion Models: A Case Study in Sampling Calorimeters
by Kylian Schmidt, Krishna Nikhil Kota, Jan Kieseler, Andrea De Vita, Markus Klute, Abhishek, Max Aehle, Muhammad Awais, Alessandro Breccia, Riccardo Carroccio, Long Chen, Tommaso Dorigo, Nicolas R. Gauger, Enrico Lupi, Federico Nardi, Xuan Tung Nguyen, Fredrik Sandin, Joseph Willmore and Pietro Vischia
Particles 2025, 8(2), 47; https://doi.org/10.3390/particles8020047 - 23 Apr 2025
Viewed by 435
Abstract
Recent advances in machine learning have opened new avenues for optimizing detector designs in high-energy physics, where the complex interplay of geometry, materials, and physics processes has traditionally posed a significant challenge. In this work, we introduce the end-to-end. AI Detector Optimization framework [...] Read more.
Recent advances in machine learning have opened new avenues for optimizing detector designs in high-energy physics, where the complex interplay of geometry, materials, and physics processes has traditionally posed a significant challenge. In this work, we introduce the end-to-end. AI Detector Optimization framework (AIDO), which leverages a diffusion model as a surrogate for the full simulation and reconstruction chain, enabling gradient-based design exploration in both continuous and discrete parameter spaces. Although this framework is applicable to a broad range of detectors, we illustrate its power using the specific example of a sampling calorimeter, focusing on charged pions and photons as representative incident particles. Our results demonstrate that the diffusion model effectively captures critical performance metrics for calorimeter design, guiding the automatic search for a layer arrangement and material composition that align with known calorimeter principles. The success of this proof-of-concept study provides a foundation for the future applications of end-to-end optimization to more complex detector systems, offering a promising path toward systematically exploring the vast design space in next-generation experiments. Full article
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24 pages, 8639 KiB  
Article
Investigation of the Impact of Particle Shape on Pore Structures and Clogging Properties of Filter Layers
by Wei-Kang Bai, Fa-Ning Dang, Wu-Wei Zhu, Yi Yao, Hai-Bin Xue and Jun Gao
Appl. Sci. 2025, 15(8), 4563; https://doi.org/10.3390/app15084563 - 21 Apr 2025
Viewed by 398
Abstract
This study posits that soil particles in the filter layer are ellipsoidal. The effective pore radius of the filter material was calculated for various particle-shape parameters and distributions. The relationship between the porosity of the filter material and the ratio of the long [...] Read more.
This study posits that soil particles in the filter layer are ellipsoidal. The effective pore radius of the filter material was calculated for various particle-shape parameters and distributions. The relationship between the porosity of the filter material and the ratio of the long axis to the short axis of ellipsoidal particles in a loose arrangement was also examined. The results indicate that the porosity of the filter material initially decreases and subsequently increases with increases in the ratio of the long axis to the short axis; however, the rate of increase progressively slows. A method for transforming irregularly shaped particles into ellipsoidal forms is proposed. The particle-shape parameter, S, is introduced to characterize the shape of irregular particles. The relationship between particle-shape parameters and the ratio of the long axis to the short axis was investigated specifically for ellipsoidal particles. It was found that the particle-shape parameters exhibit an approximately linear relationship with the ratio of the long axis to the short axis within a specific range. The discrete element method was employed to investigate the impact of particle shape on the filtration characteristics of the filter layer and was complemented by comparative experimental analysis. By analyzing the pore structures of spherical and ellipsoidal particles, this study predicts the relationship between pore structure and particle-shape parameters for any irregularly shaped natural-particle filter layer. Full article
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24 pages, 5126 KiB  
Article
The Impact of Nanoparticles on Previtreous Behavior: Glass-Forming Nematogenic E7 Mixture-Based Nanocolloids
by Aleksandra Drozd-Rzoska, Joanna Łoś and Sylwester J. Rzoska
Nanomaterials 2025, 15(8), 597; https://doi.org/10.3390/nano15080597 - 13 Apr 2025
Viewed by 257
Abstract
This report discusses the impact of nanoparticles on glass-forming systems composed of a liquid crystalline (LC) mixture E7 and paraelectric BaTiO3 particles (d50 , globular), tested via broadband dielectric spectroscopy. In the isotropic phase, critical changes [...] Read more.
This report discusses the impact of nanoparticles on glass-forming systems composed of a liquid crystalline (LC) mixture E7 and paraelectric BaTiO3 particles (d50 nm, globular), tested via broadband dielectric spectroscopy. In the isotropic phase, critical changes in the dielectric constant are shown. They are related to the weakly discontinuous nature of the isotropic–nematic transition. In the nematic phase, two primary relaxation times/processes and DC electric conductivity are considered, down to the glass temperature Tg. The prevalence of portrayals via the ‘double exponential’ MYEGA equation and the critical & activated Drozd-Rzoska relation for dynamic properties are shown. For the primary loss curve, critical-like changes of its maximum (peak) are evidenced: εpeak1/TTg* for Tg<T<Tg+25 K, where Tg*<Tg denotes the extrapolated singular temperature. Dielectric constant monitoring revealed the permanent arrangement of rod-like LC molecules by nanoparticles’ endogenic impact in the nematic phase. The heuristic model regarding this unique behavior is presented. It considers a hypothetical link between the glass transition and a hidden near-critical discontinuous phase transition, uniquely avoiding a symmetry change. The uniaxiality of LC molecules enables the detection of critical-like features when approaching the glass transition, hypothetically associated with a specific ‘amorphous’ phase transition. Full article
(This article belongs to the Special Issue The Impact of Nanoparticles on Phase Transitions in Liquid Crystals)
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16 pages, 5416 KiB  
Article
Simulation and Evaluation of the Performance of Pneumatic Residual Film Recycler Comb Teeth
by Sen Jiang, Baiyu Chen, Haojie Jiang, Pengfei Guo, Xufeng Wang, Can Hu and Wensong Guo
Agriculture 2025, 15(8), 811; https://doi.org/10.3390/agriculture15080811 - 8 Apr 2025
Viewed by 331
Abstract
The interaction law between soil and tillage components is the basis for designing and selecting soil tillage components. This paper uses the discrete element method to explore the soil penetration performance of the comb teeth of a pneumatic film-stripping tillage residual film recycler [...] Read more.
The interaction law between soil and tillage components is the basis for designing and selecting soil tillage components. This paper uses the discrete element method to explore the soil penetration performance of the comb teeth of a pneumatic film-stripping tillage residual film recycler under different structural and working state parameters. The soil particle contact model is set up, the virtual prototype of the comb roller is established, and EDEM (Version 2018, DEM Solutions Company, Edinburgh, UK) discrete element software is applied to simulate the interaction between the comb roller and the soil particles during the residual film recycler’s operation. Simulation and test results show that using a spiral arrangement of tooth comb knives (Alar, 843300, China, Zhongyuan Stainless Steel Bending Manufacturing Co.) can reduce the impact load on the machine, improving the soil disturbance and facilitating the penetration of soil mulch. The composite force on the combing roller increases with comb depth in the soil for a combing roller depth of 6–18 cm. Moreover, the rotational speed varies within the range of 60–120 r/min. The forward speed of the recycling machine significantly affects the soil penetration performance of the comb roller; the power it consumes increases with forward speed. This study can provide a reference for the structural design and optimization of working parameters of future deep tillage machines. Full article
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25 pages, 12073 KiB  
Article
Exosome-Seeded Cryogel Scaffolds for Extracellular Matrix Regeneration in the Repair of Articular Cartilage Defects: An In Vitro and In Vivo Rabbit Model Study
by Daniel Yang, Joseph Yang, Shwu-Jen Chang, Jhe-Lun Hu, Yong-Ji Chen and Shan-Wei Yang
Polymers 2025, 17(7), 975; https://doi.org/10.3390/polym17070975 - 3 Apr 2025
Viewed by 632
Abstract
Traumatic or degenerative defects of articular cartilage impair joint function, and the treatment of articular cartilage damage remains a challenge. By mimicking the cartilage extracellular matrix (ECM), exosome-seeded cryogels may enhance cell proliferation and chondral repair. ECM-based cryogels were cryopolymerized with gelatin, chondroitin [...] Read more.
Traumatic or degenerative defects of articular cartilage impair joint function, and the treatment of articular cartilage damage remains a challenge. By mimicking the cartilage extracellular matrix (ECM), exosome-seeded cryogels may enhance cell proliferation and chondral repair. ECM-based cryogels were cryopolymerized with gelatin, chondroitin sulfate, and various concentrations (0%, 0.3%, 0.5%, and 1%) of hyaluronic acid (HA), and their water content, swelling ratio, porosity, mechanical properties, and effects on cell viability were evaluated. The regenerative effects of bone marrow-derived mesenchymal stem cell (BM-MSC)-derived exosome (at a concentration of 106 particles/mL)-seeded 0.3% HA cryogels were assessed in vitro and in surgically induced male New Zealand rabbit cartilage defects in vivo. The water content, swelling ratio, and porosity of the cryogels significantly (p < 0.05) increased and the Young’s modulus values of the cryogels decreased with increasing HA concentrations. MTT assays revealed that the developed biomaterials had no cytotoxic effects. The optimal cryogel composition was 0.3% HA, and the resulting cryogel had favorable properties and suitable mechanical strength. Exosomes alone and exosome-seeded cryogels promoted chondrocyte proliferation (with cell optical densities that were 58% and 51% greater than that of the control). The cryogel alone and the exosome-seeded cryogel facilitated ECM deposition and sulfated glycosaminoglycan synthesis. Although we observed cartilage repair via Alcian blue staining with both the cryogel alone and the exosome-seeded cryogel, the layered arrangement of the chondrocytes was superior to that of the control chondrocytes when exosome-seeded cryogels were used. This study revealed the potential value of using BM-MSC-derived exosome-seeded ECM-based cryogels for cartilage tissue engineering to treat cartilage injury. Full article
(This article belongs to the Special Issue Advances in Synthesis and Application of Biomedical Polymer Materials)
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25 pages, 5044 KiB  
Review
Recent Developments and Perspectives on Optimization Design Methods for Analog Integrated Circuits
by Yunqi Yang, Jiaming Su, Xiaoran Lai, Dongdong Chen, Di Li and Yintang Yang
Symmetry 2025, 17(4), 529; https://doi.org/10.3390/sym17040529 - 31 Mar 2025
Viewed by 724
Abstract
As the cornerstone of the modern information industry, designing a high-performance circuit is crucial. Due to the influence of external environmental and asymmetric arrangements, non-ideal factors in analog integrated circuits (ICs) cannot be ignored, which makes the design process heavily reliant on human [...] Read more.
As the cornerstone of the modern information industry, designing a high-performance circuit is crucial. Due to the influence of external environmental and asymmetric arrangements, non-ideal factors in analog integrated circuits (ICs) cannot be ignored, which makes the design process heavily reliant on human experience, and the design efficiency is low. Recently, scholars have conducted extensive research on optimization design methods for analog ICs by combining artificial intelligence and optimization algorithms. In this article, the developments and perspectives on optimization design methods for analog ICs are reviewed. In traditional design methods, particle swarm optimization (PSO), the genetic algorithm (GA), and reinforcement learning (RL) have been applied with different computer-aided design (CAD) tools. A variety of circuit simulation software have been developed, such as Cadence, Ngspice, Pspice, etc. Due to its high precision, comprehensive functionality, and full-process simulation, Cadence has been widely used in the design of analog ICs. These methods can improve the design efficiency to a certain extent. In the iterative process, running the simulation software to obtain performance metrics can waste a lot of time. Thus, efficient optimization design methods have been proposed to improve the design efficiency by establishing a proxy model of the circuit, which can replace simulation software. Accordingly, three research directions in this field are proposed. In summary, this article can aid scholars in quickly understanding the current status of optimization design methods for analog ICs and provide guidance for future research. Full article
(This article belongs to the Section Engineering and Materials)
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