Search Results (2,143)

This research examines the relationship between socio-demographic characteristics of the survivors and their changing social situations after the earthquake and post-traumatic stress disorder (PTSD) and survivor’s guilt. It also examines the mediating role of survivor guilt between early maladaptive schemas and PTSD severity. The study involved 127 people exposed to the 6 February 2023, southern and central Türkiye and northern and western Syria earthquake. Participants’ sociodemographic characteristics, changing living conditions due to the earthquake, and feelings and thoughts of survivor guilt were evaluated with online data forms. Young Schema-Short Form, Post-Traumatic Stress Disorder Symptom Control Checklist, Beck Depression Inventory, and Beck Anxiety Inventory were employed. There was a notable connection between survivor guilt, the pessimism schema, and the PTSD severity. Additionally, changes in the participants’ living conditions especially occurring during posttraumatic periods were associated with survivor guilt and PTSD levels. The mediation analysis indicated that survivor guilt partially mediates the relationship between the pessimism schema and PTSD severity. Focusing on the social conditions of survivors, pessimism schema, and survivor guilt will be beneficial in preventive interventions and treatment approaches for PTSD. Full article

Background/Objectives: Uniformed personnel are highly exposed to occupational stress, which increases the risk of mental health problems. This study examined whether coping styles moderate the relationship between perceived stress and satisfaction with life among uniformed personnel treated for bodily distress disorder or post-traumatic stress disorder. Methods: A cross-sectional study was conducted with 183 participants (81% male, aged 30–66 years). Standardized questionnaires were administered: the Perceived Stress Scale (PSS-10), Satisfaction with Life Scale (SWLS), and Coping Inventory for Stressful Situations (CISS). Pearson correlations with 95% confidence intervals were computed, and moderation analyses were conducted using separate regression models for each coping style with bootstrap estimation (1000 samples). Gender differences were examined using t-tests with Cohen’s d. Results: Perceived stress was negatively correlated with life satisfaction (r = −0.43, 95% CI [−0.54, −0.29], moderate effect). Emotion-oriented coping correlated negatively with life satisfaction (r = −0.28, 95% CI [−0.42, −0.14]), while social diversion correlated positively (r = 0.21, 95% CI [0.07, 0.35]). Women reported higher stress (Cohen’s d = 0.60) and lower life satisfaction (Cohen’s d = −0.50) than men. Moderation analysis revealed that emotion-oriented coping significantly intensified the negative effect of stress on life satisfaction (B = −0.01, p = 0.019). Conclusions: Perceived stress strongly impairs life satisfaction in uniformed personnel, particularly among those relying on emotion-oriented coping. Targeted interventions, such as emotion regulation training, mindfulness, and cognitive restructuring, may enhance resilience and mitigate stress-related declines in well-being in this high-risk occupational group. Full article

Post-traumatic stress symptoms (PTSSs) are associated with an imbalanced time perspective (TP) as well as with unhealthy substance use. Although neurodevelopmental processes during adolescence may impact PTSS, most etiological models of post-traumatic stress disorder (PTSD) are derived from studies with adults and neglect possible distinctive characteristics in adolescent PTSD. This study examined possible direct and mediated relations between exposure to potentially traumatic experiences (EPTEs) and PTSS with TP as a potential mediator. In addition, the study investigated the direct and indirect effects of EPTE, TP, and PTSS on cannabis use. The aim of this study was to investigate whether findings from adult studies can be transferred to adolescent PTSD. One hundred and five patients between 14 and 20 years of age were recruited from child and adolescent psychiatric units. They answered questionnaires to assess EPTE, PTSS, TP, and cannabis use. Participants with clinically relevant PTSS showed imbalanced TP with a high orientation to negative past and a low orientation to positive past and future. Higher EPTE was associated with higher level of PTSS, but TP mediated the level of PTSS in this relation. PTSS predicted the frequency of cannabis use. It may therefore be beneficial to consider TP in PTSD therapy with the aim of reducing deviation from balanced TP and PTSS and preventing comorbid substance use. Full article

Adipose tissue micrografts (ATM) and dermis micrografts (DMG) have emerged as promising autologous therapies in regenerative wound care, leveraging mechanically disaggregated cell–matrix constructs to modulate the wound microenvironment and promote tissue repair. This scoping review systematically analyzed clinical studies investigating ATMs and DMGs in acute and chronic wounds. Eight studies, comprising randomized controlled trials, observational studies, and case series, were identified, involving diverse wound types such as burns, ulcers, surgical dehiscence, and posttraumatic defects. All interventions utilized mechanical disaggregation (Rigenera^® system) to produce micrografts, which were applied via perilesional injection, scaffold-assisted delivery, or topical administration. Outcomes consistently demonstrated accelerated re-epithelialization, enhanced angiogenesis, improved scar remodeling, and low complication rates. In select studies, micrografts were combined with platelet-rich fibrin or stromal vascular fraction, suggesting potential synergistic effects. While one randomized trial showed superior healing outcomes with DMGs over collagen scaffolds, others yielded mixed results, likely reflecting heterogeneity in methodology and outcome measures. Overall, the available clinical evidence supports the safety, feasibility, and biological activity of micrograft-based therapies. However, larger, standardized, and mechanistically driven studies are required to validate their efficacy and define optimal protocols across wound etiologies. Full article

Background: This study explores post-traumatic growth (PTG) among parents of childhood cancer survivors (CCSs), a group often underrepresented in research. Method: A convergent parallel mixed-methods design integrating Bayesian Multilevel Latent Class Analysis and Thematic Analysis was utilized in a longitudinal study involving 58 caregivers (50 mothers, 8 fathers) from the Children’s Clinical University Hospital in Riga. Quantitative data were collected at diagnosis using the Psychosocial Assessment Tool (PAT) and Big Five Inventory-10 (BFI-10). Follow-up assessments post-treatment included the Responses to Stress Questionnaire (RSQ), Impact of Event Scale-Revised (IES-R), and the Post-traumatic Growth Inventory (PTGI). Qualitative data were collected through structured interviews. Results: A 2-class model distinguished parents with low PTG from those with moderate to high PTG. Change in values, detachment from trivial stressors, and acceptance of life emerged as key indicators of growth. PTG was not significantly correlated with overall post-traumatic stress symptoms, but engagement coping strategies showed a positive association with PTG and personality traits like extraversion and openness. Conclusions: The mixed methods approach revealed sample-specific PTG elements not reflected in standardized tools. Initial perceptions of the cancer diagnosis shaped psychological outcomes, with PTG facilitated by adaptive coping, self-reflection, support, emotional disclosure, and psychological struggle. This study offers the first insights into PTG among Latvian parents of CCSs, a previously unexplored area. Full article

Research on the post-deployment reintegration needs of women veterans is limited. Non-traditional support may enhance mental health. Relationships with animals and volunteering may aid those with post-traumatic stress disorder (PTSD). Using the biopsychosocial model, we examined whether participation in an 8-week service dog training program (SDTP) affected telomere length (TL), heart rate variability (HRV), PTSD symptom severity, perceived stress, and anxiety in female veterans with PTSD, as well as whether combat exposure influenced these relationships. Female veterans (ages 32–72, M = 45.9, SD = 11.8) with PTSD were randomized to either the SDTP group (n = 13) or a comparison group (n = 15) that received dog training video content. The interventions lasted one hour weekly for 8 weeks. Outcomes were assessed pre-, mid-, and post-intervention. Linear mixed models with random intercepts examined changes from pre- to post-intervention and compared changes by group and combat exposure. TL changes differed [F(1,11.65) = 3.543, p = 0.085] by intervention. In the SDTP group, TL increased, indicating reduced cellular senescence (i.e., slower biological aging), whereas TL decreased in the CI group. Combat exposure moderated these changes [F(1,12.36) = 5.41, p = 0.038]. HRV changed by intervention group [F(1,389.08) = 10.623, p = 0.001]. HRV decreased (stress increased) in the SDTP group but not in the CI group. Combat exposure did not moderate HRV changes. PTSD symptom severity [F(1,48.04) = 19.22, p < 0.001], perceived stress [F(1,48.48) = 14.65, p < 0.001], and anxiety [F(1,47.30) = 6.624, p = 0.013] decreased significantly from pre- to post-interventions; the decreases did not differ by intervention or combat exposure. Full article

Background: Patients with hematological malignancies undergo intensive treatments, endure prolonged hospitalizations, and face the stress of a life-threatening diagnosis, placing them at high risk for developing post-traumatic stress disorder (PTSD) and related trauma symptoms. Methods: This narrative review synthesizes findings from PubMed-indexed studies examining the prevalence, clinical features, and consequences of PTSD in patients with hematological malignancies. A separate focused search was also conducted to identify PTSD studies in patients undergoing hematopoietic stem cell transplantation, which is a population recognized as being at high psychological risk. Results: Evidence indicates that a substantial proportion of these patients develop full or subthreshold PTSD. Key contributing factors include treatment intensity, fear of relapse, and extended hospital stays. PTSD symptoms are linked to reduced treatment adherence, diminished quality of life, and poorer clinical outcomes. Conclusions: Psychiatric care plays a critical role in addressing PTSD in this population. Routine trauma-informed screening, access to evidence-based pharmacologic and psychotherapeutic interventions, and close interdisciplinary collaboration with hematology teams are essential to improving patient outcomes. Full article

This quantitative study examined the relationships between perceived social support, psychological resilience, and posttraumatic growth (PTG) among university students affected by the 6 February 2023 earthquakes in Türkiye. Utilizing a correlational design, the study tested whether psychological resilience mediated the relationship between perceived social support and PTG. The sample consisted of 769 undergraduate students from Kahramanmaraş Sütçü İmam University and Malatya Turgut Özal University, selected through convenience sampling. Data were collected via standardized instruments: the Multidimensional Scale of Perceived Social Support, the Resilience Scale for Adults, and the Posttraumatic Growth Inventory. A mediation analysis was conducted using the path analysis and bootstrapping methods with the IBM AMOS 24.0 software. The results revealed that perceived social support positively predicted both psychological resilience and PTG, and psychological resilience positively predicted PTG. The mediation analysis confirmed that psychological resilience partially mediated the relationship between perceived social support and PTG. Additionally, significant differences in PTG, resilience, and perceived social support levels were found across gender, housing conditions, psychological impact levels, and access to support. Notably, female students, those who lost loved ones, and those who received psychological or family support reported higher PTG levels. The results emphasize the critical role of social and individual resources in trauma adaptation. It is recommended that post-disaster psychosocial interventions prioritize strengthening both perceived social networks and individual resilience capacities to foster posttraumatic growth in affected populations. Full article

In the current study, we conducted a preliminary test of whether adding evidence-based PTSD treatment may influence intensive ED treatment outcomes by comparing individuals with co-occurring ED-PTSD diagnoses who received PTSD treatment to those who did not. We hypothesized that receiving PTSD treatment would moderate outcomes, such that individuals who received PTSD treatment throughout their course of ED treatment would demonstrate improved outcomes compared to those with PTSD who did not. The participants were 104 adults with DSM-5 EDs and PTSD admitted to a partial-hospital ED program. The participants either completed a course of evidence-based PTSD treatment within the context of intensive ED treatment or completed ED treatment as usual (n = 58 PTSD treatment, n = 46 TAU). Multilevel modeling was used to examine changes in symptoms as moderated by receipt of PTSD treatment over the course of treatment and at follow-up. Models exploring changes in anxiety, depression, clinical impairment, and ED symptoms suggested no differences across groups. The findings indicated that individuals who received PTSD treatment began with higher body dissatisfaction compared to their peers and experienced a significant decrease over the course of treatment. This investigation provides preliminary support for improved body dissatisfaction outcomes when PTSD treatment is incorporated into intensive ED treatment. Full article

Pregnant and postpartum people (PPPs) face heightened risk for HIV acquisition, yet depression and trauma-related symptoms can undermine adherence to pre-exposure prophylaxis (PrEP). To inform the development of a brief mental health-focused adherence intervention, we explored the impacts of depression and posttraumatic stress disorder (PTSD) symptoms on PrEP use among PPPs in Cape Town, South Africa. Twenty-eight PPPs with elevated symptoms of depression and/or PTSD and recent PrEP adherence challenges completed qualitative interviews. Six antenatal providers were also interviewed. Thematic analysis revealed three key findings with subthemes that deepen exploration of each theme: (1) depression and PTSD symptoms contributed to missed PrEP doses or late pickups by increasing doubt about PrEP efficacy, amplifying pill burden, intensifying avoidance and withdrawal (e.g., hypersomnia and disengagement from providers), and disrupting memory through rumination and emotional overload; (2) most PPPs preferred support from professional counselors, while a minority preferred informal support; and (3) intervention design considerations included aligning patient and provider goals, selecting between individual or group formats, and addressing integration barriers such as staffing and space constraints. Providers affirmed the need for embedded mental health support. Intervention strategies that increase PrEP knowledge and motivation while targeting emotional withdrawal, fatigue, and cognitive overload may improve adherence and reduce HIV risk in this population. Full article

Violence against nurses in the workplace is a worldwide concern. The high prevalence of these events has negative impacts on professionals, including stress, abandonment of the workplace, and post-traumatic stress syndrome. It is a frequent problem for nurses. As awareness of this problem increases, strategies for prevention and management of aggression and violence have evolved. This study aims to identify strategies, both institutional and personal, to address violence against nurses in the workplace. Methods: A scoping review was conducted with the PRISMA approach, using New Rayyan platform and CEMB for the evaluation of methodological quality. We included all research that studied strategies against workplace violence for nurses in hospitals in Spanish or English published between 2019 and 2024. Results: Among the 28 analyzed full-text studies, two central categories emerged with respect to addressing violence against nurses before (prevention), during (mitigation), and after (response) such events: (1) training and nurses’ action strategies and (2) practical implementation tools. Institutional leadership supporting a zero-tolerance culture; training and resources for early identification of risks; and mitigation strategies with strong emphasis on de-escalation of potential violence, building personal resilience, and support from security personnel are among the effective strategies. Conclusions: Strategies for preventing and handling workplace violence are multidimensional. Leadership engagement, addressing gender biases, conflict management training, resilience building, and security can reduce violence against nurses and its sequelae. It is essential to generate practical knowledge that is easy to apply in healthcare settings. More research is needed, especially in Latin America. Full article

Background/Objectives: Miscarriage (spontaneous abortion) can precipitate post-traumatic stress disorder (PTSD). In Peru, post-loss mental healthcare is limited. We aimed to identify factors associated with PTSD symptoms persisting ≥ 3 months among women who experienced miscarriage and were treated in the emergency department (ED) of a national hospital in Lima, 2021–2023. Methods: We conducted a cross-sectional analytical study of 214 women with spontaneous abortion seen in the ED (January 2021–December 2023). PTSD symptoms were measured with the PTSD Checklist for DSM-5 (PCL-5), anchored to the miscarriage index; sociodemographic and gyneco-obstetric variables were obtained with a validated questionnaire. Multivariable Poisson regression with robust variance estimated the adjusted prevalence ratios (aPRs). Results: Probable PTSD (PCL-5 ≥ 33) was present in 52.8% of participants. Independent correlates included previous miscarriage (aPR 1.75; 95% CI 1.35–2.25), ≥2 pre-gestational medical visits (aPR 1.66; 95% CI 1.21–2.27), and one (aPR 1.36; 95% CI 1.00–1.84) or multiple comorbidities (aPR 1.61; 95% CI 1.12–2.30). No other sociodemographic or obstetric variables were significantly associated. Conclusions: More than half of women assessed ≥ 3 months after miscarriage screened positive for probable PTSD. Previous pregnancy loss increased pre-gestational healthcare contact, and medical comorbidities were associated with higher prevalence. Integrating routine mental health screening and trauma-informed support within ED and reproductive health services could improve detection and care for this population. To our knowledge, this is the first ED-based study in Peru to examine factors associated with post-loss probable PTSD (PCL-5 ≥ 33) after miscarriage. Full article

In terms of occupational health and safety, psychosocial risks in the workplace can lead to temporary or permanent harm. Search and rescue workers assisting earthquake victims may develop PTSD due to the trauma they experience and witness. This study estimates the prevalence of PTSD among search and rescue workers involved in the February 6, 2023, earthquake in Türkiye. This study utilized the PTSD Checklist for DSM-5 (PCL-5) to assess 619 individuals. The results showed that the earthquake significantly affected post-traumatic stress symptoms across all demographic groups. Female participants (x̄ = 2.43) exhibited higher stress levels than male participants (x̄ = 2.24), showing an 8.48% difference. Participants with higher education levels (x̄ = 2.34) showed more stress than those with lower education (x̄ = 1.67). Individuals with over a decade of experience (x̄ = 3.28) experienced more distress compared to those with less than three years of experience (x̄ = 2.83). Participants under 30 (x̄ = 2.30) were more affected than those over 50 (x̄ = 2.25). Firsthand experience of the earthquake (x̄ = 2.49) resulted in greater distress compared to learning about it through communication channels (x̄ = 2.01). Concerning PTSD symptoms, 191 participants (30.86%) scored 33 or higher, which indicates clinically significant PTSD. Among the participants, 22 experienced severe to extremely severe symptoms, with 19 showing extremely severe symptoms on at least one subscale, 3 displaying extremely severe symptoms across all four subscales, and 9 demonstrating extremely severe symptoms in three subscales. Full article

Background: Genetic factors pertinent to Parkinson’s disease (PD) might predispose an individual to post-traumatic stress disorder (PTSD). Humans who are heterozygous for the glucocerebrosidase 1 (GBA) L444P Gaucher mutation have an increased PD risk and elevated levels of alpha synuclein (aSyn). Mice that are heterozygous for the GBA mutation and express aSyn with the A53T mutation show elevated anxiety levels at 20 months of age compared to those expressing only A53T. Objective: This study aims to assess whether A53T and A53T-L444P affect the risk of developing PTSD phenotypes and whether sex and age modulate this risk. Methods: Young (5.1 ± 0.2 months) and older (11.3 ± 0.2 months) A53T and GBA L444P female and male mice were tested for fear learning and memory extinction in the contextual fear conditioning and passive avoidance paradigms. Subsequently, the mice were tested for measures of activity and anxiety in the open field and for depressive-like behavior in the forced swim test. Results: In the contextual fear memory extinction paradigm, only young A53T female mice showed contextual fear memory extinction, while older A53T female mice showed increased activity levels over subsequent days. In the passive avoidance memory paradigm, no mice showed extinction of passive avoidance memory. When the frequency of entering the more anxiety-provoking center of the open field was analyzed, a test history x sex x age interaction was observed. In the forced swim test, test history affected the depressive-like behavior in mice trained; there was more depressive-like behavior in mice trained in the contextual fear memory extinction paradigm than in mice trained in the passive avoidance memory extinction paradigm. Moreover, there was an effect of age with more depressive-like behavior in older than in younger mice, and an effect of genotype with more depressive-like behavior in A53T-L444P compared to A53T mice. When cortical phosphorylated tau (pS 199) levels were analyzed, there was an effects of genotype, a sex x age interaction, and ant age x test history interaction. Conclusions: A53T and A53T-L444P affect the risk of developing PTSD phenotypes. Fear extinction test history, genotype, and age affect depressive-like behavior and tau pathology. Full article

Background/Objectives: Although COVID-19 may cause cognitive impairments for up to six months, the long-term effects of mild cases remain unclear. Given their high exposure and critical role in public health, assessing this impact on healthcare workers is essential. Aim: The present study aimed to examine the cognitive and emotional effects of mild COVID-19 in 92 healthcare workers one year after infection. Methods: In total, 50 had experienced mild COVID-19, while 42 had not been infected. Participants completed a neuropsychological assessment evaluating attention, memory, and executive functions, along with self-reported measures of anxiety, depression, post-traumatic stress, occupational stress, and burnout. Results: No significant cognitive differences were observed between the groups. However, both exhibited moderate-to-severe psychological distress, with the COVID-19 group showing higher trait anxiety (p = 0.032). Emotional symptoms were significantly associated with neuropsychological performance—higher burnout (ρ from −0.20 to −0.28, p < 0.05) and stress (ρ from −0.25 to −0.33, p < 0.01) correlated with slower responses and more errors in tasks such as the D2 variation index, TESEN execution speed, Rey–Osterrieth Figure recall, and Digit Span forward span. Conclusions: These findings suggest no long-term cognitive impairment after mild COVID-19 but highlight the substantial emotional toll of the pandemic on healthcare workers. Future research should explore cognitive reserve as a protective factor. Full article